12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope

G. Szeifert, K. Bálint, L. Sipos, M. Sarker, S. Czirják, J. Julow

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

Histopathological, ultrastructural and polyacrylamide gel electrophoretic examinations were carried out on biopsy, cyst fluid, surgical pathology and autopsy specimens obtained from 7 cystic craniopharyngioma cases before and after yttrium-90 silicate colloid (90Y) irradiation. Light microscopy revealed that the lining epithelial tumor cell layer of the cyst wall was destroyed, and scar tissue containing large amount of hyaline degenerated collagen bundles replaced it. Proliferative postirradiation vasculopathy was also demonstrated in the cyst wall following 90Y installation. Electrophoretic property of cyst fluid was similar to the normal human serum. Considering that scar tissue has a certain propensity to shrink, the fibrosis in the cyst wall together with destruction of neoplastic epithelium and vascular changes might explain diminished fluid production and cyst volume reduction after 90Y treatment.

Original languageEnglish
Title of host publicationProgress in Neurological Surgery
Pages297-302
Number of pages6
Volume20
DOIs
Publication statusPublished - 2007

Publication series

NameProgress in Neurological Surgery
Volume20
ISSN (Print)00796492
ISSN (Electronic)16623924

Fingerprint

Yttrium Isotopes
Cyst Fluid
Craniopharyngioma
Cysts
Cicatrix
Surgical Pathology
Hyalin
Colloids
Blood Vessels
Microscopy
Autopsy
Fibrosis
Collagen
Epithelium
Epithelial Cells
Biopsy
Light
Serum
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Szeifert, G., Bálint, K., Sipos, L., Sarker, M., Czirják, S., & Julow, J. (2007). 12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. In Progress in Neurological Surgery (Vol. 20, pp. 297-302). (Progress in Neurological Surgery; Vol. 20). https://doi.org/10.1159/000100173

12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. / Szeifert, G.; Bálint, K.; Sipos, L.; Sarker, M.; Czirják, S.; Julow, J.

Progress in Neurological Surgery. Vol. 20 2007. p. 297-302 (Progress in Neurological Surgery; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Szeifert, G, Bálint, K, Sipos, L, Sarker, M, Czirják, S & Julow, J 2007, 12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. in Progress in Neurological Surgery. vol. 20, Progress in Neurological Surgery, vol. 20, pp. 297-302. https://doi.org/10.1159/000100173
Szeifert G, Bálint K, Sipos L, Sarker M, Czirják S, Julow J. 12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. In Progress in Neurological Surgery. Vol. 20. 2007. p. 297-302. (Progress in Neurological Surgery). https://doi.org/10.1159/000100173
Szeifert, G. ; Bálint, K. ; Sipos, L. ; Sarker, M. ; Czirják, S. ; Julow, J. / 12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. Progress in Neurological Surgery. Vol. 20 2007. pp. 297-302 (Progress in Neurological Surgery).
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