10.2.2. Pathological considerations to irradiation of cavernous malformations

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Stereotactic radiosurgery is a controversial treatment modality in the management of cerebral cavernous malformations (CVMs). Systematic pathological studies of irradiated specimens probably could help to resolve the controversy. Light microscopic investigation of a surgically resected thalamic CVM 1 year after 40-Gy irradiation revealed endothelial cell destruction in the cavernous channels, and marked fibrosis with scar tissue formation in the connective stroma of the lesion. These histopathological findings were similar to those described in arteriovenous malformations after Gamma Knife surgery, and suggest that the ionizing effect of radiation energy evokes vascular and connective tissue stroma changes in CVMs as well.

Original languageEnglish
Title of host publicationProgress in Neurological Surgery
Pages231-234
Number of pages4
Volume20
DOIs
Publication statusPublished - 2007

Publication series

NameProgress in Neurological Surgery
Volume20
ISSN (Print)00796492
ISSN (Electronic)16623924

Fingerprint

Central Nervous System Cavernous Hemangioma
Radiosurgery
Arteriovenous Malformations
Ionizing Radiation
Connective Tissue
Cicatrix
Blood Vessels
Fibrosis
Endothelial Cells
Light
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Nyáry, I., Major, O., Hanzély, Z., & Szeifert, G. (2007). 10.2.2. Pathological considerations to irradiation of cavernous malformations. In Progress in Neurological Surgery (Vol. 20, pp. 231-234). (Progress in Neurological Surgery; Vol. 20). https://doi.org/10.1159/000100122

10.2.2. Pathological considerations to irradiation of cavernous malformations. / Nyáry, I.; Major, O.; Hanzély, Z.; Szeifert, G.

Progress in Neurological Surgery. Vol. 20 2007. p. 231-234 (Progress in Neurological Surgery; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nyáry, I, Major, O, Hanzély, Z & Szeifert, G 2007, 10.2.2. Pathological considerations to irradiation of cavernous malformations. in Progress in Neurological Surgery. vol. 20, Progress in Neurological Surgery, vol. 20, pp. 231-234. https://doi.org/10.1159/000100122
Nyáry I, Major O, Hanzély Z, Szeifert G. 10.2.2. Pathological considerations to irradiation of cavernous malformations. In Progress in Neurological Surgery. Vol. 20. 2007. p. 231-234. (Progress in Neurological Surgery). https://doi.org/10.1159/000100122
Nyáry, I. ; Major, O. ; Hanzély, Z. ; Szeifert, G. / 10.2.2. Pathological considerations to irradiation of cavernous malformations. Progress in Neurological Surgery. Vol. 20 2007. pp. 231-234 (Progress in Neurological Surgery).
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