10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery

G. Szeifert, W. Timperley, D. Forster, A. Kemeny

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Citations (Scopus)

Abstract

Histological, immunohistochemical and electron microscopic investigations were carried out in a series of surgical pathology material that was removed from 7 patients. They were harboring cerebral arteriovenous malformations (AVMs) that had been previously treated with Leksell Gamma Knife radiosurgery, and presented subsequent bleeding 10-52 months after treatment. Light microscopic studies revealed a spindle cell proliferation in the connective tissue stroma and in the subendothelial region of the irradiated AVM vessels. The histological, immunohistochemical and ultrastructural characteristics of the spindle cell population in the Leksell Gamma Knife-treated AVMs are similar to those designated as myofibroblasts in wound healing processes and pathological fibromatoses. Considering that similar cell modifications have not been demonstrated in control, nonirradiated AVM specimens, these myofibroblasts might contribute to the shrinking process and final occlusion of AVMs after radiosurgery.

Original languageEnglish
Title of host publicationProgress in Neurological Surgery
Pages212-219
Number of pages8
Volume20
DOIs
Publication statusPublished - 2007

Publication series

NameProgress in Neurological Surgery
Volume20
ISSN (Print)00796492
ISSN (Electronic)16623924

Fingerprint

Intracranial Arteriovenous Malformations
Radiosurgery
Arteriovenous Malformations
Myofibroblasts
Surgical Pathology
Fibroma
Pathologic Processes
Connective Tissue
Wound Healing
Cell Proliferation
Electrons
Hemorrhage
Light
Population

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Szeifert, G., Timperley, W., Forster, D., & Kemeny, A. (2007). 10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery. In Progress in Neurological Surgery (Vol. 20, pp. 212-219). (Progress in Neurological Surgery; Vol. 20). https://doi.org/10.1159/000100119

10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery. / Szeifert, G.; Timperley, W.; Forster, D.; Kemeny, A.

Progress in Neurological Surgery. Vol. 20 2007. p. 212-219 (Progress in Neurological Surgery; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Szeifert, G, Timperley, W, Forster, D & Kemeny, A 2007, 10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery. in Progress in Neurological Surgery. vol. 20, Progress in Neurological Surgery, vol. 20, pp. 212-219. https://doi.org/10.1159/000100119
Szeifert G, Timperley W, Forster D, Kemeny A. 10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery. In Progress in Neurological Surgery. Vol. 20. 2007. p. 212-219. (Progress in Neurological Surgery). https://doi.org/10.1159/000100119
Szeifert, G. ; Timperley, W. ; Forster, D. ; Kemeny, A. / 10.1.2. Histopathological changes in cerebral arteriovenous malformations following gamma knife radiosurgery. Progress in Neurological Surgery. Vol. 20 2007. pp. 212-219 (Progress in Neurological Surgery).
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