[(η6-p-cym)Ru(H2O)3]2+ binding capability of N-methylimidazole to model the interaction between the metal ion and surface histidine residues of peptides

Zsolt Bihari, Zoltán Nagy, P. Buglyó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Abstract In order to model the biotransformation reactions of half-sandwich type platinum metal complexes with potential antiproliferative activity in the serum the interaction between [(η6-p-cym)Ru(H2O)3]2+ and N-methylimidazole was studied in aqueous 0.20 M KNO3 or KCl medium with the combined use of pH-potentiometric, NMR, UV-Vis and ESI-TOF-MS techniques. The results indicate that up to three ligands can coordinate to the metal ion in rather slow processes resulting in mononuclear species. In the absence of chloride ions various mixed hydroxido complexes are also identified under basic conditions. Chloride was found to take the free coordination site(s) of the metal ion in the 1:1 and 1:2 species and to hinder effectively the hydrolytic processes. Stability constants of the species are reported. The results indicate that even this monodentate model ligand, N-methylimidazole, forms stable complexes with the metal ion under physiologically relevant conditions at 1:3 metal to ligand ratio and prevents it from complete hydrolysis at pH = 7.4.

Original languageEnglish
Article number18851
Pages (from-to)82-88
Number of pages7
JournalJournal of Organometallic Chemistry
Volume782
DOIs
Publication statusPublished - Apr 15 2015

Fingerprint

histidine
Histidine
Peptides
metal surfaces
peptides
Metal ions
metal ions
Metals
Ligands
Ions
ligands
Chlorides
Coordination Complexes
chlorides
Platinum metals
interactions
Metal complexes
serums
metals
hydrolysis

Keywords

  • Chloride medium
  • Half-sandwich ruthenium
  • Histidine
  • N-methylimidazole
  • Stability constant

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Biochemistry

Cite this

@article{89c0f5622c2144d4aa8644fa32923821,
title = "[(η6-p-cym)Ru(H2O)3]2+ binding capability of N-methylimidazole to model the interaction between the metal ion and surface histidine residues of peptides",
abstract = "Abstract In order to model the biotransformation reactions of half-sandwich type platinum metal complexes with potential antiproliferative activity in the serum the interaction between [(η6-p-cym)Ru(H2O)3]2+ and N-methylimidazole was studied in aqueous 0.20 M KNO3 or KCl medium with the combined use of pH-potentiometric, NMR, UV-Vis and ESI-TOF-MS techniques. The results indicate that up to three ligands can coordinate to the metal ion in rather slow processes resulting in mononuclear species. In the absence of chloride ions various mixed hydroxido complexes are also identified under basic conditions. Chloride was found to take the free coordination site(s) of the metal ion in the 1:1 and 1:2 species and to hinder effectively the hydrolytic processes. Stability constants of the species are reported. The results indicate that even this monodentate model ligand, N-methylimidazole, forms stable complexes with the metal ion under physiologically relevant conditions at 1:3 metal to ligand ratio and prevents it from complete hydrolysis at pH = 7.4.",
keywords = "Chloride medium, Half-sandwich ruthenium, Histidine, N-methylimidazole, Stability constant",
author = "Zsolt Bihari and Zolt{\'a}n Nagy and P. Bugly{\'o}",
year = "2015",
month = "4",
day = "15",
doi = "10.1016/j.jorganchem.2014.12.026",
language = "English",
volume = "782",
pages = "82--88",
journal = "Journal of Organometallic Chemistry",
issn = "0022-328X",
publisher = "Elsevier",

}

TY - JOUR

T1 - [(η6-p-cym)Ru(H2O)3]2+ binding capability of N-methylimidazole to model the interaction between the metal ion and surface histidine residues of peptides

AU - Bihari, Zsolt

AU - Nagy, Zoltán

AU - Buglyó, P.

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Abstract In order to model the biotransformation reactions of half-sandwich type platinum metal complexes with potential antiproliferative activity in the serum the interaction between [(η6-p-cym)Ru(H2O)3]2+ and N-methylimidazole was studied in aqueous 0.20 M KNO3 or KCl medium with the combined use of pH-potentiometric, NMR, UV-Vis and ESI-TOF-MS techniques. The results indicate that up to three ligands can coordinate to the metal ion in rather slow processes resulting in mononuclear species. In the absence of chloride ions various mixed hydroxido complexes are also identified under basic conditions. Chloride was found to take the free coordination site(s) of the metal ion in the 1:1 and 1:2 species and to hinder effectively the hydrolytic processes. Stability constants of the species are reported. The results indicate that even this monodentate model ligand, N-methylimidazole, forms stable complexes with the metal ion under physiologically relevant conditions at 1:3 metal to ligand ratio and prevents it from complete hydrolysis at pH = 7.4.

AB - Abstract In order to model the biotransformation reactions of half-sandwich type platinum metal complexes with potential antiproliferative activity in the serum the interaction between [(η6-p-cym)Ru(H2O)3]2+ and N-methylimidazole was studied in aqueous 0.20 M KNO3 or KCl medium with the combined use of pH-potentiometric, NMR, UV-Vis and ESI-TOF-MS techniques. The results indicate that up to three ligands can coordinate to the metal ion in rather slow processes resulting in mononuclear species. In the absence of chloride ions various mixed hydroxido complexes are also identified under basic conditions. Chloride was found to take the free coordination site(s) of the metal ion in the 1:1 and 1:2 species and to hinder effectively the hydrolytic processes. Stability constants of the species are reported. The results indicate that even this monodentate model ligand, N-methylimidazole, forms stable complexes with the metal ion under physiologically relevant conditions at 1:3 metal to ligand ratio and prevents it from complete hydrolysis at pH = 7.4.

KW - Chloride medium

KW - Half-sandwich ruthenium

KW - Histidine

KW - N-methylimidazole

KW - Stability constant

UR - http://www.scopus.com/inward/record.url?scp=84925607809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925607809&partnerID=8YFLogxK

U2 - 10.1016/j.jorganchem.2014.12.026

DO - 10.1016/j.jorganchem.2014.12.026

M3 - Article

AN - SCOPUS:84925607809

VL - 782

SP - 82

EP - 88

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

SN - 0022-328X

M1 - 18851

ER -