[(η6-p-cym)Ru(H2O)3]2+ binding capability of N-methylimidazole to model the interaction between the metal ion and surface histidine residues of peptides

Zsolt Bihari, Zoltán Nagy, Péter Buglyó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Abstract In order to model the biotransformation reactions of half-sandwich type platinum metal complexes with potential antiproliferative activity in the serum the interaction between [(η6-p-cym)Ru(H2O)3]2+ and N-methylimidazole was studied in aqueous 0.20 M KNO3 or KCl medium with the combined use of pH-potentiometric, NMR, UV-Vis and ESI-TOF-MS techniques. The results indicate that up to three ligands can coordinate to the metal ion in rather slow processes resulting in mononuclear species. In the absence of chloride ions various mixed hydroxido complexes are also identified under basic conditions. Chloride was found to take the free coordination site(s) of the metal ion in the 1:1 and 1:2 species and to hinder effectively the hydrolytic processes. Stability constants of the species are reported. The results indicate that even this monodentate model ligand, N-methylimidazole, forms stable complexes with the metal ion under physiologically relevant conditions at 1:3 metal to ligand ratio and prevents it from complete hydrolysis at pH = 7.4.

Original languageEnglish
Article number18851
Pages (from-to)82-88
Number of pages7
JournalJournal of Organometallic Chemistry
Volume782
DOIs
Publication statusPublished - Apr 15 2015

Keywords

  • Chloride medium
  • Half-sandwich ruthenium
  • Histidine
  • N-methylimidazole
  • Stability constant

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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