γ-l-Glutamyl-taurine (Litoralon®) prevents the micronucleus formation induced by mitomycin C

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have examined whether γ-l-glutamyl-taurine (Litoralon®) could prevent the genotoxic action of mitomycin C (MMC) in the rat bone marrow cells using the mcironucleus test. Litoralon (0.83 mg/kg) administered concurrently with MMC (0.75 mg/kg) did not exhibit any protective action. Pretreatment with a single dose (0.83 mg/kg) of Litoralon 24 h before the administration of MMC (0.75 mg/kg) prevented the micronucleus-inducing effect of MMC. There was no difference between the efficiencies of a single and multiple Litoralon pretreatments. Since Litoralon is known to exhibit both vitamin A-like activity and stimulation of poly-ADP-ribose synthesis, it is presumed that either one of these 2 properties separately, or both in conjunction, can be responsible for the inhibition of micronucleus formation.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalMutation Research Letters
Volume209
Issue number1-2
DOIs
Publication statusPublished - 1988

Fingerprint

Taurine
Mitomycin
Poly Adenosine Diphosphate Ribose
Vitamin A
Bone Marrow Cells
Rats
Bone
Cells
glutaurine

Keywords

  • Antimutagenicity
  • Micronucleus
  • Mitomycin C
  • Poly-ADP-ribose synthesis
  • Vitamin A

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

γ-l-Glutamyl-taurine (Litoralon®) prevents the micronucleus formation induced by mitomycin C. / Tóth, S.; Csaba, G.

In: Mutation Research Letters, Vol. 209, No. 1-2, 1988, p. 85-89.

Research output: Contribution to journalArticle

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