γ/δT-cell subsets, NKG2A expression and apoptosis of Vδ2+ T cells in pregnant women with or without risk of premature pregnancy termination

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11 Citations (Scopus)

Abstract

Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. Method of study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. Results: The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. Conclusions: These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume50
Issue number6
DOIs
Publication statusPublished - Dec 2003

Fingerprint

T-Lymphocyte Subsets
Pregnant Women
Apoptosis
T-Lymphocytes
Pregnancy
Annexin A5
NK Cell Lectin-Like Receptor Subfamily C
Trophoblasts
Cytotoxic T-Lymphocytes
HLA Antigens
Flow Cytometry

Keywords

  • γ/δ T cells
  • Apoptosis
  • CD94/NKG2A
  • Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

@article{4f75bdf20bf14f33b1c673d8ac9921c8,
title = "γ/δT-cell subsets, NKG2A expression and apoptosis of Vδ2+ T cells in pregnant women with or without risk of premature pregnancy termination",
abstract = "Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. Method of study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. Results: The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. Conclusions: These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.",
keywords = "γ/δ T cells, Apoptosis, CD94/NKG2A, Pregnancy",
author = "L. Szereday and A. Barakonyi and Eva Miko and Peter Varga and J. Szekeres-Barth{\'o}",
year = "2003",
month = "12",
doi = "10.1046/j.8755-8920.2003.00107.x",
language = "English",
volume = "50",
pages = "490--496",
journal = "American Journal of Reproductive Immunology",
issn = "8755-8920",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - γ/δT-cell subsets, NKG2A expression and apoptosis of Vδ2+ T cells in pregnant women with or without risk of premature pregnancy termination

AU - Szereday, L.

AU - Barakonyi, A.

AU - Miko, Eva

AU - Varga, Peter

AU - Szekeres-Barthó, J.

PY - 2003/12

Y1 - 2003/12

N2 - Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. Method of study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. Results: The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. Conclusions: These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.

AB - Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. Method of study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. Results: The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. Conclusions: These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.

KW - γ/δ T cells

KW - Apoptosis

KW - CD94/NKG2A

KW - Pregnancy

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U2 - 10.1046/j.8755-8920.2003.00107.x

DO - 10.1046/j.8755-8920.2003.00107.x

M3 - Article

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SP - 490

EP - 496

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 8755-8920

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ER -