β-endorphin tolerance is inhibited by oxytocin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The repeated administration of β-endorphin to mice resulted in the development of tolerance to the analgesic effect of the opioid peptide. While SC injections of oxytocin failed to modify the magnitude or the duration of the analgesic effect of a single intracerebroventricular (ICV) β-endorphin injection, the development of tolerance to β-endorphin was antagonized by SC and ICV oxytocin treatment. Since both oxytocin and β-endorphin are endogenous peptides in the brain, the data raise the possibility that endogenous oxytocin might be involved in the sensitivity of the central nervous system towards repeated or prolonged opioid stimulation.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1987

Keywords

  • Analgesic effect
  • Oxytocin
  • Tolerance
  • β-Endorphin

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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