β-endorphin: Possible involvement in the antihypertensive effect of central α-receptor activation

George Kunos, C. Farsang, Maria Dolores Ramirez-Gonzales

Research output: Contribution to journalArticle

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Abstract

Clonidine and L-α-methylnoradrenaline (but not D-α- methylnoradrenaline) increase the release of a substance with β-endorphin immunoreactivity from slices of brainstem of spontaneously hypertensive rats, but not that of normotensive rats. It was reported earlier that opiate antagonists inhibit the hypotensive action of clonidine and α-methyldopa in spontaneously hypertensive but not in normotensive rats and that β-endorphin has hypotensive effects of its own. Together, these findings indicate that release of β-endorphin by central α-receptor agonists may contribute to the antihypertensive action of these drugs.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalScience
Volume211
Issue number4477
Publication statusPublished - 1981

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Endorphins
Clonidine
Antihypertensive Agents
Opiate Alkaloids
Methyldopa
Opioid Receptors
Inbred SHR Rats
Brain Stem

ASJC Scopus subject areas

  • General

Cite this

β-endorphin : Possible involvement in the antihypertensive effect of central α-receptor activation. / Kunos, George; Farsang, C.; Ramirez-Gonzales, Maria Dolores.

In: Science, Vol. 211, No. 4477, 1981, p. 82-84.

Research output: Contribution to journalArticle

Kunos, George ; Farsang, C. ; Ramirez-Gonzales, Maria Dolores. / β-endorphin : Possible involvement in the antihypertensive effect of central α-receptor activation. In: Science. 1981 ; Vol. 211, No. 4477. pp. 82-84.
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