β-Amyloid(1-42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat

T. Harkany, G. I. De Jong, K. Soós, B. Penke, P. G.M. Luiten, K. Gulya

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Abstract

β-Amyloid(1-42) peptide (βAP(1-42)) was injected into the medial septum of rats. After a 14-day survival time, neuronal alterations in the septal cholinergic and GABAergic systems were visualized by means of histo- and immunocytochemical methods. Neurons insulted by the peptide were primarily choline acetyltransferase-immunoreactive (ir), while only minor effects of βAP(1-42) were observed on parvalbumin-ir interneurons. These results indicate that the changes in intracellular Ca2+ level elicited by βAP(1-42) may contribute to β-amyloid neurotoxicity, and Ca2+-binding proteins may play an important role in the protection against the neurotoxic effects of βAP(1-42).

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalBrain research
Volume698
Issue number1-2
DOIs
Publication statusPublished - Nov 6 1995

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Keywords

  • Calcium-binding protein
  • Choline acetyltransferase
  • Cholinotoxicity
  • Medial septum
  • Parvalbumin
  • β-Amyloid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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