β-Amyloid-induced increase in the resting intracellular calcium concentration gives support to tell Alzheimer lymphocytes from control ones

András Palotás, János Kálmán, Miklós Palotás, Anna Juhász, Zoltán Janka, Botond Penke

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Senile plaques containing β-amyloid peptide (βAP) comprise the major neuropathological lesions in Alzheimer's disease (AD). In line with ongoing studies investigating alterations of various biochemical processes of cells of peripheral tissues, the authors demonstrate differences in resting intracellular free calcium levels of lymphocytes harvested from sporadic Alzheimer patients and from age-matched controls. Resting intracellular calcium concentration was measured in Fura-2AM-loaded human lymphocytes by dual wavelength spectrofluorimetry. Resting calcium level appeared to be higher in Alzheimer cells when compared to control lymphocytes. After incubating cells in 10-7M of β-amyloid, the resting calcium concentration of the control cells elevated, while that of Alzheimer lymphocytes did not differ considerably.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalBrain Research Bulletin
Volume58
Issue number2
DOIs
Publication statusPublished - Jul 22 2002

Keywords

  • Alzheimer's disease
  • Fluorescence
  • Lymphocyte
  • Resting calcium
  • β-Amyloid

ASJC Scopus subject areas

  • Neuroscience(all)

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