β-Amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats

G. Jancsó, F. Domoki, P. Sántha, József Varga, J. Fischer, Krisztina Orosz, B. Penke, Attila Becskei, M. Dux, Lajos Tóth

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The effects of intracarotid infusions of β-amyloid (1-42) peptide was studied on the permeability of brain vessels. Using a quantitative Evans blue method a dose-dependent increase of brain tissue albumin content was established following intracarotid injections of the peptide. Cerebral vessels of increased permeability were also demonstrated with a vital 'staining' technique. Lectin histochemistry revealed an almost complete abolition of specific lectin binding sites of affected endothelial cells. The findings indicate a significant deterioration by β-amyloid (1-42) peptide of blood-brain barrier function and suggest that this may result from endothelial damage. It is assumed that altered permeability of cerebral vessels may be involved in the development of brain pathologies associated with Alzheimer's disease.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalNeuroscience Letters
Volume253
Issue number2
DOIs
Publication statusPublished - Sep 4 1998

Fingerprint

Blood-Brain Barrier
Amyloid
Permeability
Lectins
Peptides
Brain
Evans Blue
Albumins
Alzheimer Disease
Endothelial Cells
Binding Sites
Pathology
Staining and Labeling
Injections

Keywords

  • β-Amyloid (1-42) peptide
  • Alzheimer's disease
  • Blood-brain barrier
  • Cerebral vessel
  • Lectin binding
  • Permeability
  • Vascular labelling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

β-Amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats. / Jancsó, G.; Domoki, F.; Sántha, P.; Varga, József; Fischer, J.; Orosz, Krisztina; Penke, B.; Becskei, Attila; Dux, M.; Tóth, Lajos.

In: Neuroscience Letters, Vol. 253, No. 2, 04.09.1998, p. 139-141.

Research output: Contribution to journalArticle

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