Human plasma α2HS-glycoprotein has been described for more than 35 years. Its biological characteristics are ramifying. A great deal of evidence indicate that α2HS-glycoprotein is the human homologue of the fetal protein fetuin, and takes part in the regulation of embryonal tissue development. The protein, cumulating in bone tissue has also got a regulatory role in bone metabolism. This glycoprotein takes part in host defense mechanisms and acts as a negative acute phase glycoprotein. At the molecular level, α2HS-glycoprotein has an inhibitory activity on the insulin receptor tyrosine kinase, and is an antagonist of other growth factors, eg. transforming growth factor β, hepatocyte growth factor/scatter factor, epidermal growth factor. According to present data, the serum α2HS glycoprotein concentration seems to have no specific diagnostic significance. The determination of the serum level, however, may contribute to the conventional laboratory assays of host defense and liver function.
|Number of pages||8|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Sep 26 1997|
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