α2HS-glikoprotein: Mit tudunk ma rola?

Translated title of the contribution: α2HS-glycoprotein: What is known about it?

L. Kalabay, L. Jakab, A. Philippe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Human plasma α2HS-glycoprotein has been described for more than 35 years. Its biological characteristics are ramifying. A great deal of evidence indicate that α2HS-glycoprotein is the human homologue of the fetal protein fetuin, and takes part in the regulation of embryonal tissue development. The protein, cumulating in bone tissue has also got a regulatory role in bone metabolism. This glycoprotein takes part in host defense mechanisms and acts as a negative acute phase glycoprotein. At the molecular level, α2HS-glycoprotein has an inhibitory activity on the insulin receptor tyrosine kinase, and is an antagonist of other growth factors, eg. transforming growth factor β, hepatocyte growth factor/scatter factor, epidermal growth factor. According to present data, the serum α2HS glycoprotein concentration seems to have no specific diagnostic significance. The determination of the serum level, however, may contribute to the conventional laboratory assays of host defense and liver function.

Original languageHungarian
Pages (from-to)492-499
Number of pages8
JournalLege Artis Medicinae
Volume7
Issue number7-8
Publication statusPublished - 1997

Fingerprint

Glycoproteins
Hepatocyte Growth Factor
Fetuins
Fetal Proteins
Bone and Bones
Acute-Phase Proteins
Transforming Growth Factors
Serum
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins
Liver
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kalabay, L., Jakab, L., & Philippe, A. (1997). α2HS-glikoprotein: Mit tudunk ma rola? Lege Artis Medicinae, 7(7-8), 492-499.

α2HS-glikoprotein : Mit tudunk ma rola? / Kalabay, L.; Jakab, L.; Philippe, A.

In: Lege Artis Medicinae, Vol. 7, No. 7-8, 1997, p. 492-499.

Research output: Contribution to journalArticle

Kalabay, L, Jakab, L & Philippe, A 1997, 'α2HS-glikoprotein: Mit tudunk ma rola?', Lege Artis Medicinae, vol. 7, no. 7-8, pp. 492-499.
Kalabay L, Jakab L, Philippe A. α2HS-glikoprotein: Mit tudunk ma rola? Lege Artis Medicinae. 1997;7(7-8):492-499.
Kalabay, L. ; Jakab, L. ; Philippe, A. / α2HS-glikoprotein : Mit tudunk ma rola?. In: Lege Artis Medicinae. 1997 ; Vol. 7, No. 7-8. pp. 492-499.
@article{95443254debd49078c00eb444de82a9e,
title = "α2HS-glikoprotein: Mit tudunk ma rola?",
abstract = "Human plasma α2HS-glycoprotein has been described for more than 35 years. Its biological characteristics are ramifying. A great deal of evidence indicate that α2HS-glycoprotein is the human homologue of the fetal protein fetuin, and takes part in the regulation of embryonal tissue development. The protein, cumulating in bone tissue has also got a regulatory role in bone metabolism. This glycoprotein takes part in host defense mechanisms and acts as a negative acute phase glycoprotein. At the molecular level, α2HS-glycoprotein has an inhibitory activity on the insulin receptor tyrosine kinase, and is an antagonist of other growth factors, eg. transforming growth factor β, hepatocyte growth factor/scatter factor, epidermal growth factor. According to present data, the serum α2HS glycoprotein concentration seems to have no specific diagnostic significance. The determination of the serum level, however, may contribute to the conventional laboratory assays of host defense and liver function.",
keywords = "αHS-glycoprotein, Acute phase reaction, Fetuin, Insulin receptor tyrosine kinase",
author = "L. Kalabay and L. Jakab and A. Philippe",
year = "1997",
language = "Hungarian",
volume = "7",
pages = "492--499",
journal = "Lege Artis Medicinae",
issn = "0866-4811",
publisher = "Literatura Medica Publishing House",
number = "7-8",

}

TY - JOUR

T1 - α2HS-glikoprotein

T2 - Mit tudunk ma rola?

AU - Kalabay, L.

AU - Jakab, L.

AU - Philippe, A.

PY - 1997

Y1 - 1997

N2 - Human plasma α2HS-glycoprotein has been described for more than 35 years. Its biological characteristics are ramifying. A great deal of evidence indicate that α2HS-glycoprotein is the human homologue of the fetal protein fetuin, and takes part in the regulation of embryonal tissue development. The protein, cumulating in bone tissue has also got a regulatory role in bone metabolism. This glycoprotein takes part in host defense mechanisms and acts as a negative acute phase glycoprotein. At the molecular level, α2HS-glycoprotein has an inhibitory activity on the insulin receptor tyrosine kinase, and is an antagonist of other growth factors, eg. transforming growth factor β, hepatocyte growth factor/scatter factor, epidermal growth factor. According to present data, the serum α2HS glycoprotein concentration seems to have no specific diagnostic significance. The determination of the serum level, however, may contribute to the conventional laboratory assays of host defense and liver function.

AB - Human plasma α2HS-glycoprotein has been described for more than 35 years. Its biological characteristics are ramifying. A great deal of evidence indicate that α2HS-glycoprotein is the human homologue of the fetal protein fetuin, and takes part in the regulation of embryonal tissue development. The protein, cumulating in bone tissue has also got a regulatory role in bone metabolism. This glycoprotein takes part in host defense mechanisms and acts as a negative acute phase glycoprotein. At the molecular level, α2HS-glycoprotein has an inhibitory activity on the insulin receptor tyrosine kinase, and is an antagonist of other growth factors, eg. transforming growth factor β, hepatocyte growth factor/scatter factor, epidermal growth factor. According to present data, the serum α2HS glycoprotein concentration seems to have no specific diagnostic significance. The determination of the serum level, however, may contribute to the conventional laboratory assays of host defense and liver function.

KW - αHS-glycoprotein

KW - Acute phase reaction

KW - Fetuin

KW - Insulin receptor tyrosine kinase

UR - http://www.scopus.com/inward/record.url?scp=0030880525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030880525&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030880525

VL - 7

SP - 492

EP - 499

JO - Lege Artis Medicinae

JF - Lege Artis Medicinae

SN - 0866-4811

IS - 7-8

ER -