α2-Adrenoreceptor subtypes regulate ACTH and β-endorphin secretions during stress in the rat

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32 Citations (Scopus)

Abstract

The effect of different α2-adrenoreceptor subtype agonists and antagonists on adrenocorticotrop hormone (ACTH) and β-endorphin release induced by ether stress was examined. Ether inhalation-induced ACTH and β- endorphin increase was inhibited by ICV administration of 30 μg but not 1 and 10 μg clonidine (α2-adrenoreceptor agonist). ICV oxymetazoline (α(2A)-adrenoreceptor agonist; 1-10-30 μg) or the α1-agonist methoxamine (100 μg/rat) failed to inhibit the stress-induced rise. Pretreatment with the α12(2B,C)-antagonist prazosin (0.5 mg/kg, IP) prevented the effect of clonidine on the ether stress, while the α1/α(2A)-antagonist WB-4101 (0.5 mg/kg, IP) was unable to counteract the inhibitory effect of clonidine. Prazosin alone had no effect on the ether-induced plasma ACTH and β- endorphin elevation. These results suggest that noradrenaline in the central nervous system may inhibit the stress-induced hypothalamo-pituitary-axis and pituitary β-endorphin activation via α(2B,C)-adrenoceptor subtypes and prazosin may antagonize its effect on these receptors.

Original languageEnglish
Pages (from-to)333-343
Number of pages11
JournalPsychoneuroendocrinology
Volume24
Issue number3
DOIs
Publication statusPublished - Apr 1 1999

Keywords

  • Clonidine
  • Ether stress
  • Methoxamine
  • Oxymctazoline
  • Prazosin
  • WB-4101

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

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