α-Synuclein gene duplication impairs reward learning

S. Kéri, Ahmed A. Moustafa, Catherine E. Myers, G. Benedek, Mark A. Gluck

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

α-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment learning compared with noncarriers. These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease.

Original languageEnglish
Pages (from-to)15992-15994
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number36
DOIs
Publication statusPublished - Sep 7 2010

Fingerprint

Synucleins
Gene Duplication
Reward
Parkinson Disease
Punishment
Learning
Synaptic Transmission
Siblings
Genes

Keywords

  • Basal ganglia
  • Dopamine
  • Parkinson disease
  • Reinforcement learning

ASJC Scopus subject areas

  • General

Cite this

α-Synuclein gene duplication impairs reward learning. / Kéri, S.; Moustafa, Ahmed A.; Myers, Catherine E.; Benedek, G.; Gluck, Mark A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 36, 07.09.2010, p. 15992-15994.

Research output: Contribution to journalArticle

Kéri, S. ; Moustafa, Ahmed A. ; Myers, Catherine E. ; Benedek, G. ; Gluck, Mark A. / α-Synuclein gene duplication impairs reward learning. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 36. pp. 15992-15994.
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