α-atrial natriuretic peptide attenuates ethanol withdrawal symptoms

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Abstract

Mice were rendered tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. Intracerebroventricular (i.c.v.) injection of α-atrial natriuretic peptide (α-ANP) attenuated, whereas that of an antiserum against α-ANP (anti-ANP) intensified the severity of handling-induced convulsions.

Original languageEnglish
Pages (from-to)417-419
Number of pages3
JournalEuropean Journal of Pharmacology
Volume238
Issue number2-3
DOIs
Publication statusPublished - Jul 20 1993

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Keywords

  • Anti-ANP serum
  • Ethanol withdrawal
  • α-ANP (α-atrial natriuretic peptide)

ASJC Scopus subject areas

  • Pharmacology

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