Mice were rendered tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. Intracerebroventricular (i.c.v.) injection of α-atrial natriuretic peptide (α-ANP) attenuated, whereas that of an antiserum against α-ANP (anti-ANP) intensified the severity of handling-induced convulsions.
- Anti-ANP serum
- Ethanol withdrawal
- α-ANP (α-atrial natriuretic peptide)
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