• 4292 Citations
  • 37 h-Index
19962020

Research output per year

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Research Output

2016

Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis

Botz, B., Kemény, Á., Brunner, S. M., Locker, F., Csepregi, J., Mócsai, A., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice

Csabai, D., Cseko, K., Szaiff, L., Varga, Z., Miseta, A., Helyes, Z. & Czéh, B., Apr 1 2016, In : Behavioural Brain Research. 302, p. 44-52 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Modeling long-term diabetes and related complications in rats

Hajna, Z., Szabadfi, K., Balla, Z., Biró, Z., Degrell, P., Molnár, G. A., Koszegi, T., Tékus, V., Helyes, Z., Dobos, A., Farkas, S., Szucs, G., Gábriel, R. & Pintér, E., Mar 1 2016, In : Journal of Pharmacological and Toxicological Methods. 78, p. 1-12 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2

Muley, M. M., Reid, A. R., Botz, B., Bölcskei, K., Helyes, Z. & McDougall, J. J., Feb 1 2016, In : British journal of pharmacology. 173, 4, p. 766-777 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

New morphine analogs produce peripheral antinociception within a certain dose range of their systemic administration

Lackó, E., Riba, P., Giricz, Z., Váradi, A., Cornic, L., Balogh, M., Király, K., Cseko, K., Mousa, S. A., Hosztafi, S., Schäfer, M., Zádori, Z., Helyes, Z., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., Oct 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 171-181 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Noxious heat threshold temperature and pronociceptive effects of allyl isothiocyanate (mustard oil) in TRPV1 or TRPA1 gene-deleted mice

Tékus, V., Horváth, Á., Hajna, Z., Borbély, É., Bölcskei, K., Boros, M., Pintér, E., Helyes, Z., Petho, G. & Szolcsányi, J., Jun 1 2016, In : Life sciences. 154, p. 66-74 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

Kormos, V., Gáspár, L., Kovács, L., Farkas, J., Gaszner, T., Csernus, V., Balogh, A., Hashimoto, H., Reglodi, D., Helyes, Z. & Gaszner, B., Aug 25 2016, In : Neuroscience. 330, p. 335-358 24 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees

Borbély, É., Sándor, K., Markovics, A., Kemény, Á., Pintér, E., Szolcsányi, J., Quinn, J. P., McDougall, J. J. & Helyes, Z., Sep 1 2016, In : Inflammation Research. 65, 9, p. 725-736 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models

Scheich, B., Gaszner, B., Kormos, V., László, K., Ádori, C., Borbély, É., Hajna, Z., Tékus, V., Bölcskei, K., Ábrahám, I., Pintér, E., Szolcsányi, J. & Helyes, Z., Feb 1 2016, In : Neuropharmacology. 101, p. 204-215 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structural and Morphometric Comparison of Lower Incisors in PACAP-Deficient and Wild-Type Mice

Sandor, B., Fintor, K., Reglodi, D., Fulop, D. B., Helyes, Z., Szanto, I., Nagy, P., Hashimoto, H. & Tamas, A., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 300-308 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: In vivo study using TRPA1-deficient mice

Horváth, Á., Tékus, V., Boros, M., Pozsgai, G., Botz, B., Borbély, É., Szolcsányi, J., Pintér, E. & Helyes, Z., Jan 8 2016, In : Arthritis Research and Therapy. 18, 1, 6.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Utility of different outcome measures for the nitroglycerin model of migraine in mice

Farkas, S., Bölcskei, K., Markovics, A., Varga, A., Kis-Varga, Á., Kormos, V., Gaszner, B., Horváth, C., Tuka, B., Tajti, J. & Helyes, Z., Jan 1 2016, In : Journal of Pharmacological and Toxicological Methods. 77, p. 33-44 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

Banki, E., Sosnowska, D., Tucsek, Z., Gautam, T., Toth, P., Tarantini, S., Tamas, A., Helyes, Z., Reglodi, D., Sonntag, W. E., Csiszar, A. & Ungvari, Z., 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 6, p. 665-674 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis

Borbély, É., Botz, B., Bölcskei, K., Kenyér, T., Kereskai, L., Kiss, T., Szolcsányi, J., Pintér, E., Csepregi, J. Z., Mócsai, A. & Helyes, Z., Mar 1 2015, In : Brain, Behavior, and Immunity. 45, p. 50-59 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Contribution of the galanin system to inflammation

Kofler, B., Brunner, S., Koller, A., Wiesmayr, S., Locker, F., Lang, R., Botz, B., Kemény, À. & Helyes, Z., Dec 1 2015, In : SpringerPlus. 4, p. 1-32 32 p., L57.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effects of Some Natural Carotenoids on TRPA1- and TRPV1-Induced Neurogenic Inflammatory Processes In Vivo in the Mouse Skin

Horváth, G., Kemény, Á., Barthó, L., Molnár, P., Deli, J., Szente, L., Bozó, T., Pál, S., Sándor, K., Szőke, É., Szolcsányi, J. & Helyes, Z., May 1 2015, In : Journal of Molecular Neuroscience. 56, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

Sághy, É., Szoke, É., Payrits, M., Helyes, Z., Börzsei, R., Erostyák, J., Jánosi, T. Z., Sétáló, G. & Szolcsányi, J., Aug 17 2015, In : Pharmacological Research. 100, p. 101-116 16 p., 2890.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Further characterization of hemopressin peptide fragments in the opioid and cannabinoid systems

Szlavicz, E., Perera, P. S., Tomboly, C., Helyes, Z., Zador, F., Benyhe, S., Borsodi, A. & Bojnik, E., Dec 1 2015, In : Anesthesia and analgesia. 121, 6, p. 1488-1494 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse

Hajna, Z., Borbély, É., Kemény, Á., Botz, B., Kereskai, L., Szolcsányi, J., Pintér, E., Paige, C. J., Berger, A. & Helyes, Z., Feb 2015, In : Peptides. 64, p. 1-7 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption

Botz, B., Bölcskei, K., Kemény, Á., Sándor, Z., Tékus, V., Sétáló, G., Csepregi, J., Mócsai, A., Pintér, E., Kollár, L. & Helyes, Z., Jan 1 2015, In : Journal of biomedical optics. 20, 1, 016022.

Research output: Contribution to journalArticle

7 Citations (Scopus)
4 Citations (Scopus)

Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine

Tajti, J., Tuka, B., Botz, B., Helyes, Z. & Vécsei, L., May 1 2015, In : CNS and Neurological Disorders - Drug Targets. 14, 4, p. 540-553 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons

Sághy, E., Payrits, M., Helyes, Z. S., Reglodi, D., Bánki, E., Tóth, G., Couvineau, A. & Szoke, E., Nov 12 2015, In : Neuroscience. 308, p. 144-156 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthesis of novel 13α-18-norandrostane-ferrocene conjugates via homogeneous catalytic methods and their investigation on TRPV1 receptor activation

Szánti-Pintér, E., Wouters, J., Gömöry, Á., Sághy, É., Szoke, É., Helyes, Z., Kollár, L. & Skoda-Földes, R., Dec 1 2015, In : Steroids. 104, p. 284-293 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2014

A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome

Tékus, V., Hajna, Z., Borbély, É., Markovics, A., Bagoly, T., Szolcsányi, J., Thompson, V., Kemény, Á., Helyes, Z. & Goebel, A., Feb 2014, In : Pain. 155, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Analgesic topical capsaicinoid therapy increases somatostatin-like immunoreactivity in the human plasma

Horváth, K., Boros, M., Bagoly, T., Sándor, V., Kilár, F., Kemény, Á., Helyes, Z., Szolcsányi, J. & Pintér, E., Dec 1 2014, In : Neuropeptides. 48, 6, p. 371-378 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury

Bukovics, P., Czeiter, E., Amrein, K., Kovacs, N., Pal, J., Tamas, A., Bagoly, T., Helyes, Z., Buki, A. & Reglodi, D., Oct 2014, In : Peptides. 60, p. 18-22 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Corrigendum to Neuropeptides in learning and memory

Borbély, É., Scheich, B. & Helyes, Z., Apr 2014, In : Neuropeptides. 48, 2, 1 p.

Research output: Contribution to journalComment/debate

Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model

Botz, B., Bölcskei, K., Kereskai, L., Kovács, M., Németh, T., Szigeti, K., Horváth, I., Máthé, D., Kovács, N., Hashimoto, H., Reglödi, D., Szolcsányi, J., Pintér, E., Mõcsai, A. & Helyes, Z., Oct 1 2014, In : Arthritis and Rheumatology. 66, 10, p. 2739-2750 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors

Benyhe, Z., Toth, G., Wollemann, M., Borsodi, A., Helyes, Z., Rougeot, C. & Benyhe, S., 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 525-530 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Irritable eye syndrome: Neuroimmune mechanisms and benefits of selected nutrients

Feher, J., Pinter, E., Kovács, I., Helyes, Z., Kemény, A., Markovics, A., Plateroti, R., Librando, A. & Cruciani, F., Apr 2014, In : Ocular Surface. 12, 2, p. 134-145 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
34 Citations (Scopus)

Plasma somatostatin-like immunoreactivity increases in the plasma of septic patients and rats with systemic inflammatory reaction: Experimental evidence for its sensory origin and protective role

Suto, B., Szitter, I., Bagoly, T., Pinter, E., Szolcsányi, J., Loibl, C., Nemeth, T., Tanczos, K., Molnar, T., Leiner, T., Varnai, B., Bardonicsek, Z. & Helyes, Z., Apr 1 2014, In : Peptides. 54, p. 49-57 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Role of neurokinin 1 receptors in dextran sulfate-induced colitis: Studies with gene-deleted mice and the selective receptor antagonist netupitant

Szitter, I., Pintér, E., Perkecz, A., Kemény, Á., Kun, J., Kereskai, L., Pietra, C., Quinn, J. P., Zimmer, A., Berger, A., Paige, C. J. & Helyes, Z., May 2014, In : Inflammation Research. 63, 5, p. 399-409 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin

Banki, E., Hajna, Z., Kemeny, A., Botz, B., Nagy, P., Bolcskei, K., Toth, G., Reglodi, D. & Helyes, Z., Oct 2014, In : Neuropharmacology. 85, p. 538-547 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Kova´cs, M., Ne´meth, T., Jakus, Z., Sitaru, C., Simon, E., Futosi, K., Botz, B., Helyes, Z., Lowell, C. A. & Mo´csai, A., Jan 1 2014, In : Journal of Experimental Medicine. 211, 10, p. 1993-2011 19 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles

Kun, J., Szitter, I., Kemény, Á., Perkecz, A., Kereskai, L., Pohóczky, K., Vincze, Á., Gódi, S., Szabó, I., Szolcsányi, J., Pintér, E. & Helyes, Z., Sep 29 2014, In : PloS one. 9, 9, e108164.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2013

Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: A role in pain symptom generation?

Keszthelyi, D., Troost, F. J., Jonkers, D. M., Helyes, Z., Hamer, H. M., Ludidi, S., Vanhoutvin, S., Venema, K., Dekker, J., Szolcsányi, J. & Masclee, A. A., Oct 1 2013, In : European Journal of Pain (United Kingdom). 17, 9, p. 1299-1306 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients

Tuka, B., Helyes, Z., Markovics, A., Bagoly, T., Szolcsányi, J., Szabó, N., Tóth, E., Kincses, Z. T., Vécsei, L. & Tajti, J., Oct 1 2013, In : Cephalalgia. 33, 13, p. 1085-1095 11 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Examination of PACAP38-like immunoreactivity in different milk and infant formula samples

Csanaky, K., Reglodi, D., Bánki, E., Tarcai, I., Márk, L., Helyes, Z., Ertl, T., Gyarmati, J., Horváth, K., Sántik, L. & Tamás, A., Mar 1 2013, In : Acta physiologica Hungarica. 100, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neuropeptides in learning and memory

Borbély, É., Scheich, B. & Helyes, Z., Dec 1 2013, In : Neuropeptides. 47, 6, p. 439-450 12 p.

Research output: Contribution to journalReview article

71 Citations (Scopus)

Role of pituitary adenylate-cyclase activating polypeptide and tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions

Botz, B., Imreh, A., Sándor, K., Elekes, K., Szolcsányi, J., Reglodi, D., Quinn, J. P., Stewart, J., Zimmer, A., Hashimoto, H. & Helyes, Z., May 1 2013, In : Peptides. 43, p. 105-112 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse

Borbély, É., Hajna, Z., Sándor, K., Kereskai, L., Tóth, I., Pintér, E., Nagy, P., Szolcsányi, J., Quinn, J., Zimmer, A., Stewart, J., Paige, C., Berger, A. & Helyes, Z., Apr 23 2013, In : PloS one. 8, 4, e61684.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Sulphurous medicinal waters increase somatostatin release: It is a possible mechanism of anti-inflammatory effect of balneotherapy in psoriasis

Boros, M., Kemény, Á., Sebok, B., Bagoly, T., Perkecz, A., Petoházi, Z., Maász, G., Schmidt, J., Márk, L., László, T., Helyes, Z., Szolcsányi, J. & Pintér, E., Apr 1 2013, In : European Journal of Integrative Medicine. 5, 2, p. 109-118 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Changes in PACAP immunoreactivity in human milk and presence of PAC1 receptor in mammary gland during lactation

Csanaky, K., Banki, E., Szabadfi, K., Reglodi, D., Tarcai, I., Czegledi, L., Helyes, Z., Ertl, T., Gyarmati, J., Szanto, Z., Zapf, I., Sipos, E., Shioda, S. & Tamas, A., Nov 1 2012, In : Journal of Molecular Neuroscience. 48, 3, p. 631-637 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Comparative examination of inner ear in wild type and pituitary adenylate cyclase activating polypeptide (PACAP)-Deficient mice

Tamas, A., Szabadfi, K., Nemeth, A., Fulop, B., Kiss, P., Atlasz, T., Gabriel, R., Hashimoto, H., Baba, A., Shintani, N., Helyes, Z. & Reglodi, D., May 2012, In : Neurotoxicity Research. 21, 4, p. 435-444 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
23 Citations (Scopus)
20 Citations (Scopus)

Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility

Brubel, R., Kiss, P., Vincze, A., Varga, A., Varnagy, A., Bodis, J., Mark, L., Jambor, E., Maasz, G., Hashimoto, H., Helyes, Z. S., Toth, G., Tamas, A., Koppan, M. & Reglodi, D., Nov 2012, In : Journal of Molecular Neuroscience. 48, 3, p. 623-630 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Citations (Scopus)