• 4253 Citations
  • 37 h-Index
19962020

Research output per year

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Research Output

2020

Complex regulatory role of the trpa1 receptor in acute and chronic airway inflammation mouse models

Hajna, Z., Csekő, K., Kemény, Á., Kereskai, L., Kiss, T., Perkecz, A., Szitter, I., Kocsis, B., Pintér, E. & Helyes, Z., Jun 1 2020, In : International journal of molecular sciences. 21, 11, p. 1-21 21 p., 4109.

Research output: Contribution to journalArticle

Open Access

Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS?

Curtin, N., Bányai, K., Thaventhiran, J., Le Quesne, J., Helyes, Z. & Bai, P., Jan 1 2020, (Accepted/In press) In : British journal of pharmacology.

Research output: Contribution to journalReview article

Open Access
2019

Erratum: Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (13067–13076) DOI: 10.1073/pnas.1820168116)

Helyes, Z., Tékus, V., Szentes, N., Pohóczky, K., Botz, B., Kiss, T., Kemény, Á., Környei, Z., Tóth, K., Lénárt, N., Ábrahám, H., Pinteaux, E., Francis, S., Sensi, S., Dénes, Á. & Goebel, A., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 29, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex

Szentes, N., Tékus, V., Mohos, V., Borbély, É. & Helyes, Z., Oct 1 2019, In : GeroScience. 41, 5, p. 631-641 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Expression and activity of TRPA1 and TRPV1 in the intervertebral disc: Association with inflammation and matrix remodeling

Kameda, T., Zvick, J., Vuk, M., Sadowska, A., Tam, W. K., Leung, V. Y., Bölcskei, K., Helyes, Z., Applegate, L. A., Hausmann, O. N., Klasen, J., Krupkova, O. & Wuertz-Kozak, K., Apr 1 2019, In : International journal of molecular sciences. 20, 7, 1767.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms

Hunyady, Á., Hajna, Z., Gubányi, T., Scheich, B., Kemény, Á., Gaszner, B., Borbély, É. & Helyes, Z., Apr 2019, In : Brain Research Bulletin. 147, p. 165-173 9 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

IL-22-independent protection from colitis in the absence of Nkx2.3 transcription factor in mice

Kellermayer, Z., Vojkovics, D., Dakah, T. A., Bodó, K., Botz, B., Helyes, Z., Berta, G., Kajtár, B., Schippers, A., Wagner, N., Scotto, L., O'Connor, O. A., Arnold, H. H. & Balogh, P., Jan 1 2019, In : Journal of Immunology. 202, 6, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mechanisms of botulinum toxin type A action on pain

Matak, I., Bölcskei, K., Bach-Rojecky, L. & Helyes, Z., Aug 1 2019, In : Toxins. 11, 8, 459.

Research output: Contribution to journalReview article

Open Access
9 Citations (Scopus)

Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases: Potential therapeutic targets?

Csekő, K., Beckers, B., Keszthelyi, D. & Helyes, Z., Jun 2019, In : Pharmaceuticals. 12, 2, 48.

Research output: Contribution to journalReview article

Open Access
5 Citations (Scopus)

Significance of the Tks4 scaffold protein in bone tissue homeostasis

Vas, V., Kovács, T., Körmendi, S., Bródy, A., Kudlik, G., Szeder, B., Mező, D., Kállai, D., Koprivanacz, K., Merő, B. L., Dülk, M., Tóvári, J., Vajdovich, P., Şenel, N., Özcan, I., Helyes, Z., Dobó-Nagy, C. & Buday, L., Dec 1 2019, In : Scientific reports. 9, 1, 5781.

Research output: Contribution to journalArticle

Open Access

Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms

Helyes, Z., Tékus, V., Szentes, N., Pohóczky, K., Botz, B., Kiss, T., Kemény, Á., Környei, Z., Tóth, K., Lénárt, N., Ábrahám, H., Pinteaux, E., Francis, S., Sensi, S., Dénes, Á. & Goebel, A., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 26, p. 13067-13076 10 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

TRPA1 ion channel determines beneficial and detrimental effects of GYY4137 in murine serum-transfer arthritis

Bátai, I. Z., Sár, C. P., Horváth, Á., Borbély, É., Bölcskei, K., Kemény, Á., Sándor, Z., Nemes, B., Helyes, Z., Perkecz, A., Mócsai, A., Pozsgai, G. & Pintér, E., Jan 1 2019, In : Frontiers in Pharmacology. 10, 964.

Research output: Contribution to journalArticle

Open Access
2018
8 Citations (Scopus)

A transgenic mouse model for detection of tissue-specific thyroid hormone action

Mohácsik, P., Erdélyi, F., Baranyi, M., Botz, B., Szabó, G., Tóth, M., Haltrich, I., Helyes, Z., Sperlágh, B., Tóth, Z., Sinkó, R., Lechan, R. M., Bianco, A. C., Fekete, C. & Gereben, B., Feb 2018, In : Endocrinology. 159, 2, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Body fat of rats of different age groups and nutritional states: Assessment by micro-CT and skinfold thickness

Tekus, E., Miko, A., Furedi, N., Rostas, I., Tenk, J., Kiss, T., Szitter, I., Balasko, M., Helyes, Z., Wilhelm, M. & Petervari, E., Feb 2018, In : Journal of Applied Physiology. 124, 2, p. 268-275 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation

Sághy, É., Payrits, M., Bíró-Sütő, T., Skoda-Földes, R., Szánti-Pintér, E., Erostyák, J., Makkai, G., Sétáló, G., Kollár, L., Kőszegi, T., Csepregi, R., Szolcsányi, J., Helyes, Z. & Szőke, É., Jan 1 2018, In : Journal of Lipid Research. 59, 10, p. 1851-1863 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines

Feller, D., Kun, J., Ruzsics, I., Rapp, J., Sarosi, V., Kvell, K., Helyes, Z. & Pongrácz, J., Jul 25 2018, In : Frontiers in Immunology. 9, JUL, 1724.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse

Borbély, É., Kiss, T., Szabadfi, K., Pintér, E., Szolcsányi, J., Helyes, Z. & Botz, B., Dec 1 2018, In : Scientific reports. 8, 1, 15916.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures

Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., Kocsis, K., Tóth, E., Kincses, B., Bagoly, T., Helyes, Z., Vécsei, L. & Kincses, Z. T., Sep 18 2018, In : Neurology. 91, 12, p. e1166-e1174

Research output: Contribution to journalArticle

4 Citations (Scopus)

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

Király, K., Kozsurek, M., Lukácsi, E., Barta, B., Alpár, A., Balázsa, T., Fekete, C., Szabon, J., Helyes, Z., Bölcskei, K., Tékus, V., Tóth, Z. E., Pap, K., Gerber, G. & Puskár, Z., Dec 1 2018, In : Scientific reports. 8, 1, 3490.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2 Citations (Scopus)
6 Citations (Scopus)

Long-term stress and concomitant marijuana smoke exposure affect physiology, behavior and adult hippocampal neurogenesis

Rusznák, K., Cseko, K., Varga, Z., Csabai, D., Bóna, Á., Mayer, M., Kozma, Z., Helyes, Z. & Czéh, B., Jul 23 2018, In : Frontiers in Pharmacology. 9, JUL, 786.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse

Horváth, Á., Borbély, É., Bölcskei, K., Szentes, N., Kiss, T., Belák, M., Rauch, T., Glant, T., Zákány, R., Juhász, T., Karanyicz, E., Boldizsár, F., Helyes, Z. & Botz, B., Dec 3 2018, In : Journal of Neuroinflammation. 15, 1, 335.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats

Nagy, C. T., Koncsos, G., Varga, Z. V., Baranyai, T., Tuza, S., Kassai, F., Ernyey, A. J., Gyertyán, I., Király, K., Oláh, A., Radovits, T., Merkely, B., Bukosza, N., Szénási, G., Hamar, P., Mathé, D., Szigeti, K., Pelyhe, C., Jelemenský, M., Onódi, Z. & 4 others, Helyes, Z., Schulz, R., Giricz, Z. & Ferdinandy, P., Sep 2018, In : British journal of pharmacology. 175, 18, p. 3713-3726 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Signalling alterations in bones of pituitary adenylate cyclase activating polypeptide (PACAP) gene deficient mice

Józsa, G., Szegeczki, V., Pálfi, A., Kiss, T., Helyes, Z., Fülöp, B., Cserháti, C., Daróczi, L., Tamás, A., Zákány, R., Reglődi, D. & Juhász, T., Sep 2018, In : International journal of molecular sciences. 19, 9, 2538.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model

Aczél, T., Kun, J., Szöke, E., Rauch, T., Junttila, S., Gyenesei, A., Bölcskei, K. & Helyes, Z., Jun 26 2018, In : Frontiers in Molecular Neuroscience. 11, 219.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Traumatic brain injury impairs myogenic constriction of cerebral arteries: Role of mitochondria-derived H 2 O 2 and TRPV4-Dependent Activation of BK ca Channels

Szarka, N., Pabbidi, M. R., Amrein, K., Czeiter, E., Berta, G., Pohoczky, K., Helyes, Z., Ungvari, Z., Koller, A., Buki, A. & Toth, P., Apr 1 2018, In : Journal of Neurotrauma. 35, 7, p. 930-939 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2017

Analysing the effect of I1 imidazoline receptor ligands on DSS-induced acute colitis in mice

Fehér, Á., Tóth, V. E., Al-Khrasani, M., Balogh, M., Lázár, B., Helyes, Z., Gyires, K. & Zádori, Z. S., Feb 1 2017, In : InflammoPharmacology. 25, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Challenges to develop novel anti-inflammatory and analgesic drugs

Botz, B., Bölcskei, K. & Helyes, Z., May 1 2017, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 9, 3, e1427.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain

Bekő, K., Koványi, B., Gölöncsér, F., Horváth, G., Dénes, Környei, Z., Botz, B., Helyes, Z., Müller, C. E. & Sperlágh, B., Jun 2017, In : Journal of Thrombosis and Haemostasis. 15, 6, p. 1223-1235 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Estradiol sensitizes the transient receptor potential vanilloid 1 receptor in pain responses

Payrits, M., Sághy, É., Cseko, K., Pohóczky, K., Bölcskei, K., Ernszt, D., Barabás, K., Szolcsányi, J., Ábrahám, I. M., Helyes, Z. & Szöke, E., Oct 1 2017, In : Endocrinology. 158, 10, p. 3249-3258 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Exploration of the esophageal mucosal barrier in non-erosive reflux disease

Rinsma, N. F., Farré, R., Troost, F. J., Elizalde, M., Keszthelyi, D., Helyes, Z., Masclee, A. A. & Conchillo, J. M., May 19 2017, In : International journal of molecular sciences. 18, 5, 1091.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model

Kemény, Á., Csekő, K., Szitter, I., Varga, Z. V., Bencsik, P., Kiss, K., Halmosi, R., Deres, L., Erős, K., Perkecz, A., Kereskai, L., László, T., Kiss, T., Ferdinándy, P. & Helyes, Z., Jan 1 2017, In : Environmental Pollution. 229, p. 746-759 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice

Matak, I., Tékus, V., Bölcskei, K., Lacković, Z. & Helyes, Z., Sep 1 2017, In : Neuroscience. 358, p. 137-145 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Local upregulation of transient receptor potential ankyrin I and transient receptor potential vanilloid I ion channels in rectosigmoid deep infiltrating endometriosis

Bohonyi, N., Pohóczky, K., Szalontai, B., Perkecz, A., Kovács, K., Kajtár, B., Orbán, L., Varga, T., Szegedi, S., Bódis, J., Helyes, Z. & Koppán, M., Jan 1 2017, In : Molecular Pain. 13

Research output: Contribution to journalArticle

4 Citations (Scopus)

Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation, and emphysema in a predictive mouse model not via CB1 receptor activation

Helyes, Z., Kemény, Csekő, K., Szőke, Elekes, K., Mester, M., Sándor, K., Perkecz, A., Kereskai, L., Márk, L., Bona, Benkő, A., Pintér, E., Szolcsányi, J., Ledent, C., Sperlágh, B. & Molnár, T. F., Jan 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 2, p. L267-L277

Research output: Contribution to journalArticle

7 Citations (Scopus)

Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome

Beckers, A. B., Weerts, Z. Z. R. M., Helyes, Z., Masclee, A. A. M. & Keszthelyi, D., Nov 2017, In : Alimentary Pharmacology and Therapeutics. 46, 10, p. 938-952 15 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient

Mosdósi, B., Nyul, Z., Nagy, A., Bölcskei, K., Decsi, T. & Helyes, Z., Dec 1 2017, In : Croatian Medical Journal. 58, 6, p. 424-430 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Activity of botulinum toxin type A in cranial dura: Implications for treatment of migraine and other headaches

Lackovic, Z., Filipovic, B., Matak, I. & Helyes, Z., Jan 1 2016, In : British journal of pharmacology. 173, 2, p. 279-291 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

A novel 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist

Payrits, M., Sághy, Mátyus, P., Czompa, A., Ludmerczki, R., Deme, R., Sándor, Z., Helyes, Z. & Szoke, Jun 2 2016, In : Neuroscience. 324, p. 151-162 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones

Van Avesaat, M., Troost, F. J., Westerterp-Plantenga, M. S., Helyes, Z., Le Roux, C. W., Dekker, J., Masclee, A. A. M. & Keszthelyi, D., Feb 1 2016, In : American Journal of Clinical Nutrition. 103, 2, p. 305-313 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release

Hajna, Z., Sághy, É., Payrits, M., Aubdool, A. A., Szőke, É., Pozsgai, G., Bátai, I. Z., Nagy, L., Filotás, D., Helyes, Z., Brain, S. D. & Pintér, E., Oct 1 2016, In : Journal of Molecular Neuroscience. 60, 2, p. 157-170 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium

Pohóczky, K., Kun, J., Szalontai, B., Szöke, E., Sághy, É., Payrits, M., Kajtár, B., Kovács, K., Környei, J. L., Garai, J., Garami, A., Perkecz, A., Czeglédi, L. & Helyes, Z., Feb 1 2016, In : Journal of Molecular Endocrinology. 56, 2, p. 135-149 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype

Botz, B., Brunner, S. M., Kemény, Á., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Sep 1 2016, In : Experimental Dermatology. 25, 9, p. 725-727 3 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium-Induced Acute Intestinal Inflammation in Mice

Zádori, Z. S., Tóth, V. E., Fehér, Á., Al-Khrasani, M., Puskár, Z., Kozsurek, M., Timár, J., Tábi, T., Helyes, Z., Hein, L., Holzer, P. & Gyires, K., Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 483-491 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis

Botz, B., Kemény, Á., Brunner, S. M., Locker, F., Csepregi, J., Mócsai, A., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice

Csabai, D., Cseko, K., Szaiff, L., Varga, Z., Miseta, A., Helyes, Z. & Czéh, B., Apr 1 2016, In : Behavioural Brain Research. 302, p. 44-52 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Modeling long-term diabetes and related complications in rats

Hajna, Z., Szabadfi, K., Balla, Z., Biró, Z., Degrell, P., Molnár, G. A., Koszegi, T., Tékus, V., Helyes, Z., Dobos, A., Farkas, S., Szucs, G., Gábriel, R. & Pintér, E., Mar 1 2016, In : Journal of Pharmacological and Toxicological Methods. 78, p. 1-12 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)