• 3553 Citations
  • 32 h-Index
1994 …2020

Research output per year

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Research Output

  • 3553 Citations
  • 32 h-Index
  • 142 Article
  • 1 Comment/debate
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Article
2020

Syntheses and reactions of pyrroline, piperidine nitroxide phosphonates

Isbera, M., Bognár, B., Jekő, J., Sár, C., Hideg, K. & Kálai, T., May 2020, In : Molecules. 25, 10, 2430.

Research output: Contribution to journalArticle

Open Access

Synthesis of spin-labelled bergamottin: A potent CYP3A4 inhibitor with antiproliferative activity

Zsidó, B. Z., Balog, M., Erős, N., Poór, M., Mohos, V., Fliszár-Nyúl, E., Hetényi, C., Nagane, M., Hideg, K., Kálai, T. & Bognár, B., Jan 2 2020, In : International journal of molecular sciences. 21, 2, 508.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells

Prabhat, A. M., Kuppusamy, M. L., Bognár, B., Kálai, T., Hideg, K. & Kuppusamy, P., Mar 15 2019, In : Cell Biochemistry and Biophysics. 77, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells

Mast, J. M., Tse, D., Shee, K., Lakshmi Kuppusamy, M., Kmiec, M. M., Kalai, T. & Kuppusamy, P., Jun 15 2019, In : Cell Biochemistry and Biophysics. 77, 2, p. 109-119 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Interaction Kinetics of Sulfadiazine and N-Acetyl-sulfadiazine with Soil Humic Acid: ESR Investigations with Nitroxide Spin Label

Ricke, A., Bondarenko, E., Úr, G., Kálai, T., Hideg, K., Steinhoff, H. J. & Matthies, M., Mar 1 2019, In : Applied Magnetic Resonance. 50, 1-3, p. 171-185 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Specific Features of the Intramolecular Spin Exchange in a Novel Nitroxide Triradical

Kokorin, A. I., Gromov, O. I., Kalai, T., Hideg, K. & Putnikov, A. E., Sep 1 2019, In : Russian Journal of Physical Chemistry B. 13, 5, p. 739-743 5 p.

Research output: Contribution to journalArticle

Synthesis and application of stable nitroxide free radicals fused with carbocycles and heterocycles

Bognár, B., Úr, G., Sár, C., Hankovszky, O. H., Hideg, K. & Kálai, T., Jan 1 2019, In : Current Organic Chemistry. 23, 4, p. 480-501 22 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and evaluation of paramagnetic caffeic acid phenethyl ester (CAPE) analogs

Nagane, M., Yamashita, T., Vörös, P., Kálai, T., Hideg, K. & Bognár, B., Aug 1 2019, In : Monatshefte fur Chemie. 150, 8, p. 1513-1522 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The Structure and Internal Dynamics of R6-p-C6H4-R6 Biradical: EPR, X-ray Crystallography and DFT Calculations

Kokorin, A. I., Gromov, O. I., Dorovatovskii, P. V., Lazarenko, V. A., Khrustalev, V. N., Hideg, K. & Kálai, T., Mar 1 2019, In : Applied Magnetic Resonance. 50, 1-3, p. 425-439 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

A bifunctional anti-amyloid blocks oxidative stress and the accumulation of intraneuronal amyloid-beta

Hilt, S., Altman, R., Kálai, T., Maezawa, I., Gong, Q., Wachsmann-Hogiu, S., Jin, L. W. & Voss, J. C., Aug 12 2018, In : Molecules. 23, 8, 2010.

Research output: Contribution to journalArticle

6 Citations (Scopus)

N-vinylation of imidazole and benzimidazole with a paramagnetic vinyl bromide

Úr, G., Fekete, G. G., Hideg, K. & Kalai, T., Mar 1 2018, In : MolBank. 2018, 1, M980.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tailored Nitroxide Radicals and Biradical Containing 13C Enriched Acetylene Groups: ENDOR and DFT Investigation

Kokorin, A. I., Zaripov, R. B., Gromov, O. I., Hideg, K. & Kálai, T., Feb 1 2018, In : Applied Magnetic Resonance. 49, 2, p. 137-149 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

A Metal-Free Method for Producing MRI Contrast at Amyloid-β

Hilt, S., Tang, T., Walton, J. H., Budamagunta, M., Maezawa, I., Kálai, T., Hideg, K., Singh, V., Wulff, H., Gong, Q., Jin, L. W., Louie, A. & Voss, J. C., 2017, In : Journal of Alzheimer's Disease. 55, 4, p. 1667-1681 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats

Eros, K., Magyar, K., Deres, L., Skazel, A., Riba, A., Vamos, Z., Kalai, T., Gallyas, F., Sumegi, B., Toth, K. & Halmosi, R., Mar 2017, In : PloS one. 12, 3, e0174401.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oligomerization Alters Binding Affinity between Amyloid Beta and a Modulator of Peptide Aggregation

Hilt, S., Rojalin, T., Viitala, T., Koivuniemi, A., Bunker, A., Wachsmann-Hogiu, S., Kálai, T., Hideg, K., Yliperttula, M. & Voss, J. C., Nov 2 2017, In : Journal of Physical Chemistry C. 121, 43, p. 23974-23987 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Palladium- and/or Copper-Catalyzed Cross-Coupling Reactions of Paramagnetic Vinyl Bromides and Iodides

Úr, G., Fekete, G. G., Jekå, J., Hideg, K. & Kálai, T., Aug 16 2017, In : Synthesis (Germany). 49, 16, p. 3740-3748 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reaction of β-Bromo-β,γ-unsaturated Pyrroline Nitroxide Aldehydes and Nitriles with Aromatic N,S-Binucleophiles

Bognár, B., Varga, B., Kálai, T., Csokona, V., Gulyás Fekete, G., Sár, C. & Hideg, K., 2017, In : Journal of Heterocyclic Chemistry. 54, 4, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and biological evaluation of curcumin-nitroxide-based molecular hybrids as antioxidant and anti-proliferative agents

Bognár, B., Kuppusamy, M. L., Madan, E., Kalai, T., Balog, M., Jekó́, J., Kuppusamy, P. & Hideg, K., Dec 1 2017, In : Medicinal Chemistry. 13, 8, p. 761-772 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Facile syntheses of 3,4-disubstituted pyrroline nitroxides and their further synthetic applications

Úr, G., Kálai, T. & Hideg, K., Feb 17 2016, In : Tetrahedron Letters. 57, 7, p. 778-780 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Peculiarities of Spin Exchange in Nitroxide Biradicals Containing Two para-Phenylene Groups in the Bridge: EPR Investigation and DFT Calculations

Kokorin, A. I., Gromov, O. I., Kálai, T. & Hideg, K., Nov 1 2016, In : Applied Magnetic Resonance. 47, 11, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Spin Density Distribution in a Nitroxide Biradical Containing 13C-Enriched Acetylene Groups in the Bridge: DFT Calculations and EPR Investigation

Kokorin, A. I., Zaripov, R. B., Gromov, O. I., Sukhanov, A. A., Kálai, T., Lamperth & Hideg, K., Sep 1 2016, In : Applied Magnetic Resonance. 47, 9, p. 1057-1067 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure

Altman, R., Ly, S., Hilt, S., Petrlova, J., Maezawa, I., Kálai, T., Hideg, K., Jin, L. W., Laurence, T. A. & Voss, J. C., Dec 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 12, p. 1860-1870 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of Azoles Condensed with, or Linked to, Nitroxides

Bognár, B., Kálai, T., Gulyás-Fekete, G., Lazsányi, N. & Hideg, K., 2015, In : Synthesis (Germany). 47, 7, p. 985-991 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis of New Pyrroline Nitroxides with Ethynyl Functional Group

Ur, G., Kalai, T., Balog, M., Bognar, B., Gulyas-Fekete, G. & Hideg, K., Sep 17 2015, In : Synthetic Communications. 45, 18, p. 2122-2129 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

Assessing the applicability of singlet oxygen photosensitizers in leaf studies

Kovács, L., Ayaydin, F., Kálai, T., Tandori, J., Kós, P. B. & Hideg, É., Jan 1 2014, In : Photochemistry and photobiology. 90, 1, p. 129-136 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

EPR, the X-ray Structure and DFT Calculations of the Nitroxide Biradical with One Acetylene Group in the Bridge

Gromov, O. I., Golubeva, E. N., Khrustalev, V. N., Kálai, T., Hideg, K. & Kokorin, A. I., Oct 18 2014, In : Applied Magnetic Resonance. 45, 10, p. 981-992 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1 Citation (Scopus)
18 Citations (Scopus)

Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors

Kálai, T., Altman, R., Maezawa, I., Balog, M., Morisseau, C., Petrlova, J., Hammock, B. D., Jin, L. W., Trudell, J. R., Voss, J. C. & Hideg, K., Apr 22 2014, In : European Journal of Medicinal Chemistry. 77, p. 343-350 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthesis of new paramagnetic retinal analogues

Kálai, T., Lazsányi, N., Gulyás-Fekete, G. & Hideg, K., Apr 2014, In : Monatshefte fur Chemie. 145, 4, p. 651-656 6 p.

Research output: Contribution to journalArticle

2013

Behavior of Nitroxide Biradicals with Acetylene Bridges in Organic Solvents and Ionic Liquids

Kokorin, A. I., Golubeva, E. N., Mladenova, B. Y., Tran, V. A., Kálai, T., Hideg, K. & Grampp, G., Sep 1 2013, In : Applied Magnetic Resonance. 44, 9, p. 1041-1051 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lung

Ravi, Y., Selvendiran, K., Naidu, S. K., Meduru, S., Citro, L. A., Bognár, B., Khan, M., Kálai, T., Hideg, K., Kuppusamy, P. & Sai-Sudhakar, C. B., Mar 2013, In : Hypertension. 61, 3, p. 593-601 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
7 Citations (Scopus)
2012

Synthesis of Deprenyl-like nitroxide free radicals and their diamagnetic derivatives

Sár, C. P., Kálai, T., Jekö, J. & Hideg, K., 2012, In : Arkivoc. 2012, 5, p. 47-59 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Synthesis of nitroxide-annulated carbocycles and heterocycles

Kálai, T., Bognár, B., Zsolnai, D., Berente, Z. & Hideg, K., Oct 31 2012, In : Synthesis (Germany). 44, 23, p. 3655-3660 6 p., SS-2012-N0671-OP.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide

Petrlova, J., Kálai, T., Maezawa, I., Altman, R., Harishchandra, G., Hong, H. S., Bricarello, D. A., Parikh, A. N., Lorigan, G. A., Jin, L. W., Hideg, K. & Voss, J. C., Apr 30 2012, In : PloS one. 7, 4, e35443.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867

Dayton, A., Selvendiran, K., Meduru, S., Khan, M., Kuppusamy, M. L., Naidu, S., Kálai, T., Hideg, K. & Kuppusamy, P., Nov 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 350-357 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

Fawzi, N. L., Fleissner, M. R., Anthis, N. J., Kálai, T., Hideg, K., Hubbell, W. L. & Clore, G. M., Sep 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 105-114 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
12 Citations (Scopus)

Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe

Rayes, R. F., Kálai, T., Hideg, K., Geeves, M. A. & Fajer, P. G., 2011, In : PloS one. 6, 6, e21277.

Research output: Contribution to journalArticle

13 Citations (Scopus)

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

Selvendiran, K., Ahmed, S., Dayton, A., Kuppusamy, M. L., Rivera, B. K., Kálai, T., Hideg, K. & Kuppusamy, P., Nov 1 2011, In : Cancer Biology and Therapy. 12, 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Induction of mitochondrial destabilization and necrotic cell death by apolar mitochondria-directed SOD mimetics

Szabo, A., Balog, M., Mark, L., Montsko, G., Turi, Z., Gallyas, F., Sumegi, B., Kalai, T., Hideg, K. & Kovacs, K., May 1 2011, In : Mitochondrion. 11, 3, p. 476-487 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure

Bartha, E., Solti, I., Szabo, A., Olah, G., Magyar, K., Szabados, E., Kalai, T., Hideg, K., Toth, K., Gero, D., Szabo, C., Sumegi, B. & Halmosi, R., Oct 1 2011, In : Journal of cardiovascular pharmacology. 58, 4, p. 380-391 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy

Fleissner, M. R., Bridges, M. D., Brooks, E. K., Cascio, D., Kálai, T., Hideg, K. & Hubbell, W. L., Sep 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16241-16246 6 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Synthesis and metal ion complexation of spin labeled 18-crown-6 ethers containing an acridone or an acridine fluorophore unit

Kertész, J., Bognár, B., Kormos, A., Móczár, I., Baranyai, P., Kubinyi, M., Kálai, T., Hideg, K. & Huszthy, P., Nov 18 2011, In : Tetrahedron. 67, 46, p. 8860-8864 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds

Kálai, T., Petrlova, J., Balog, M., Aung, H. H., Voss, J. C. & Hideg, K., Apr 2011, In : European Journal of Medicinal Chemistry. 46, 4, p. 1348-1355 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synthesis and study of new paramagnetic resveratrol analogues

Kálai, T., Borza, E., Antus, C., Radnai, B., Gulyás-Fekete, G., Fehér, A., Sümegi, B. & Hideg, K., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7311-7317 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis of new spin labels for Cu-free click conjugation

Kálai, T., Fleissner, M. R., Jek, J., Hubbell, W. L. & Hideg, K., May 25 2011, In : Tetrahedron Letters. 52, 21, p. 2747-2749 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity

Kálai, T., Kuppusamy, M. L., Balog, M., Selvendiran, K., Rivera, B. K., Kuppusamy, P. & Hideg, K., Aug 11 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5414-5421 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2010

Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts

Selvendiran, K., Tong, L., Bratasz, A., Lakshmi Kuppusamy, M., Ahmed, S., Ravi, Y., Trigg, N. J., Rivera, B. K., Kálai, T., Hideg, K. & Kuppusamy, P., May 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1169-1179 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)