• 927 Citations
  • 20 h-Index
20052019
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Research Output 2005 2019

  • 927 Citations
  • 20 h-Index
  • 45 Article
  • 1 Chapter
2019

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells

Valcz, G., Búzás, E., Kittel, A., Krenács, T., Visnovitz, T., Spisák, S., Török, G., Homolya, L., Zsigrai, S., Kiszler, G., Antalffy, G., Pálóczi, K., Szállási, Z., Szabó, V., Sebestyén, A., Solymosi, N., Kalmár, A., Dede, K., Lőrincz, P., Tulassay, Z. & 2 others, Igaz, P. & Molnár, B., Jan 1 2019, In : Journal of Extracellular Vesicles. 8, 1, 1596668.

Research output: Contribution to journalArticle

Open Access
Multivesicular Bodies
Colorectal Neoplasms
Cell Membrane
Extracellular Vesicles
Exocytosis
2018
27 Citations (Scopus)

A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

Takeda, D. Y., Spisák, S., Seo, J. H., Bell, C., O'Connor, E., Korthauer, K., Ribli, D., Csabai, I., Solymosi, N., Szállási, Z., Stillman, D. R., Cejas, P., Qiu, X., Long, H. W., Tisza, V., Nuzzo, P. V., Rohanizadegan, M., Pomerantz, M. M., Hahn, W. C. & Freedman, M. L., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Genes
Epigenomics
Amplification
2017
19 Citations (Scopus)

Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples

Barták, B. K., Kalmár, A., Péterfia, B., Patai, Á. V., Galamb, O., Valcz, G., Spisák, S., Wichmann, B., Nagy, Z. B., Tóth, K., Tulassay, Z., Igaz, P. & Molnár, B., Sep 2 2017, In : Epigenetics. 12, 9, p. 751-763 13 p.

Research output: Contribution to journalArticle

Adenoma
Methylation
Colorectal Neoplasms
DNA Methylation
Area Under Curve
4 Citations (Scopus)

Limitations of high throughput methods for miRNA expression profiles in non-functioning pituitary adenomas

Darvasi, O., Szabo, P. M., Nemeth, K., Szabo, K., Spisák, S., Liko, I., Czirják, S., Rácz, K., Igaz, P., Patócs, A. & Butz, H., Oct 18 2017, (Accepted/In press) In : Pathology and Oncology Research. p. 1-14 14 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
MicroRNAs
Computational Biology
2016
26 Citations (Scopus)

Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer

Galamb, O., Kalmár, A., Péterfia, B., Csabai, I., Bodor, A., Ribli, D., Krenács, T., Patai, Á. V., Wichmann, B., Barták, B. K., Tóth, K., Valcz, G., Spisák, S., Tulassay, Z. & Molnár, B., Jun 30 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

DNA Methylation
Colorectal Neoplasms
Adenoma
Genes
Methylation
10 Citations (Scopus)

Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass

Valcz, G., Galamb, O., Krenács, T., Spisák, S., Kalmár, A., Patai, Á. V., Wichmann, B., Dede, K., Tulassay, Z. & Molnár, B., May 6 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Exosomes
Glass
Colorectal Neoplasms
Adenoma
Multivesicular Bodies
2015
47 Citations (Scopus)

CAUSEL: An epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

Spisák, S., Lawrenson, K., Fu, Y., Csabai, I., Cottman, R. T., Seo, J. H., Haiman, C., Han, Y., Lenci, R., Li, Q., Tisza, V., Szállási, Z., Herbert, Z. T., Chabot, M., Pomerantz, M., Solymosi, N., Gayther, S. A., Joung, J. K. & Freedman, M. L., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Pipelines
Genes
Cell Line
12 Citations (Scopus)

Cell free DNA of tumor origin induces a 'metastatic' expression profile in HT-29 cancer cell line

Furi, I., Kalmár, A., Wichmann, B., Spisák, S., Schöller, A., Barták, B., Tulassay, Z. & Molnár, B., Jul 2 2015, In : PLoS One. 10, 7, e0131699.

Research output: Contribution to journalArticle

HT29 Cells
Tumors
Cells
cell lines
Cell Line
10 Citations (Scopus)

Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells

Kiss, K., Baghy, K., Spisák, S., Szanyi, S., Tulassay, Z., Zalatnai, A., Löhr, J. M., Jesenofsky, R., Kovalszky, I. & Firneisz, G., May 26 2015, In : PLoS One. 10, 5, e0128059.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
pancreatic neoplasms
Peroxisome Proliferator-Activated Receptors
Phosphorylation
hyperglycemia
27 Citations (Scopus)

Comprehensive DNA methylation analysis reveals a common ten-gene methylation signature in colorectal adenomas and carcinomas

Patai, Á. V., Valcz, G., Hollósi, P., Kalmár, A., Péterfia, B., Patai, Á., Wichmann, B., Spisák, S., Barták, B. K., Leiszter, K., Tóth, K., Sípos, F., Kovalszky, I., Péter, Z., Miheller, P., Tulassay, Z. & Molnár, B., Aug 20 2015, In : PLoS One. 10, 8, e0133836.

Research output: Contribution to journalArticle

Methylation
adenoma
DNA methylation
DNA Methylation
colorectal neoplasms
28 Citations (Scopus)

DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

Kalmár, A., Péterfia, B., Hollósi, P., Galamb, O., Spisák, S., Wichmann, B., Bodor, A., Tóth, K., Patai, Á. V., Valcz, G., Nagy, Z. B., Kubák, V., Tulassay, Z., Kovalszky, I. & Molnár, B., Oct 19 2015, In : BMC Cancer. 15, 1, 736.

Research output: Contribution to journalArticle

Adenoma
Colorectal Neoplasms
Messenger RNA
DNA
MicroRNAs
5 Citations (Scopus)

Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples

Kalmár, A., Wichmann, B., Galamb, O., Spisák, S., Tóth, K., Leiszter, K., Nielsen, B. S., Barták, B. K., Tulassay, Z. & Molnár, B., Jul 25 2015, In : Diagnostic Pathology. 10, 1, 126.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Colorectal Neoplasms
Gene Expression
Biopsy
2014
9 Citations (Scopus)
Adenoid Cystic Carcinoma
Salivary Glands
MicroRNAs
Breast
Neoplasms
4 Citations (Scopus)

Intravenous Administration of a Single-Dose Free-Circulating DNA of Colitic Origin Improves Severe Murine DSS-Colitis

Sípos, F., Müzes, G., Fűri, I., Spisák, S., Wichmann, B., Germann, T. M., Constantinovits, M., Krenács, T., Tulassay, Z. & Molnár, B., 2014, In : Pathology and Oncology Research. 20, 4, p. 867-877 11 p.

Research output: Contribution to journalArticle

Colitis
Intravenous Administration
DNA
Inflammatory Bowel Diseases
Nucleic Acids
12 Citations (Scopus)
Matrix Metalloproteinase 3
Colorectal Neoplasms
Ligands
Carcinoma
Proteins
23 Citations (Scopus)

Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect

Valcz, G., Patai, Á. V., Kalmár, A., Péterfia, B., Furi, I., Wichmann, B., Müzes, G., Sípos, F., Krenács, T., Mihály, E., Spisák, S., Molnár, B. & Tulassay, Z., Nov 18 2014, In : PLoS One. 9, 11, 106143.

Research output: Contribution to journalArticle

Myofibroblasts
colorectal neoplasms
Tumors
Colorectal Neoplasms
neoplasms
4 Citations (Scopus)

Preconditioning with Intravenous Colitic Cell-Free DNA Prevents DSS-Colitis by Altering TLR9-Associated Gene Expression Profile

Műzes, G., Sipos, F., Fűri, I., Constantinovits, M., Spisák, S., Wichmann, B., Valcz, G., Tulassay, Z. & Molnár, B., Nov 19 2014, In : Digestive Diseases and Sciences. 59, 12, p. 2935-2946 12 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Transcriptome
DNA
Inflammatory Bowel Diseases
23 Citations (Scopus)

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Andocs, G., Meggyeshazi, N., Balogh, L., Spisák, S., Maros, M. E., Balla, P., Kiszner, G., Teleki, I., Kovago, C. & Krenács, T., Dec 5 2014, In : Cell Stress and Chaperones. 20, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Cell death
Heat-Shock Proteins
Colorectal Neoplasms
Cell Death
Up-Regulation
2013
64 Citations (Scopus)

Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island

Wasserkort, R., Kalmar, A., Valcz, G., Spisák, S., Krispin, M., Toth, K., Tulassay, Z., Sledziewski, A. Z. & Molnár, B., Aug 30 2013, In : BMC Cancer. 13, 398.

Research output: Contribution to journalArticle

Septins
CpG Islands
DNA Methylation
Colorectal Neoplasms
Genes
7 Citations (Scopus)
Protein Methyltransferases
Toll-Like Receptor 9
HT29 Cells
Methylation
Methyltransferases
28 Citations (Scopus)

Complete Genes May Pass from Food to Human Blood

Spisák, S., Solymosi, N., Ittzés, P., Bodor, A., Kondor, D., Vattay, G., Barták, B. K., Sípos, F., Galamb, O., Tulassay, Z., Szállási, Z., Rasmussen, S., Sicheritz-Ponten, T., Brunak, S., Molnár, B. & Csabai, I., Jul 30 2013, In : PLoS One. 8, 7, e69805.

Research output: Contribution to journalArticle

Plant DNA
Blood
Genes
Food
DNA
1 Citation (Scopus)

From chemical genomics to chemical proteomics: The power of microarray technology

Spisák, S. & Guttman, A., Jan 1 2013, Chemical Genomics and Proteomics, Second Edition. CRC Press, p. 81-121 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microarrays
Genomics
Proteomics
Technology
Protein Array Analysis
25 Citations (Scopus)
Gene expression
Paraffin
Formaldehyde
Colorectal Neoplasms
RNA
1 Citation (Scopus)

Mikro-RNS-expresszió vizsgálata adenoid cysticus emlo-és nyálmirigy-carcinomákban

Translated title of the contribution: MicroRNA-profiling in breast-and salivary gland-derived adenoid cystic carcinomasKiss, O., Tőkés, A., Spisák, S., Szilágyi, A., Lippai, N., Szász, A. & Kulka, J., Jun 1 2013, In : Orvosi Hetilap. 154, 25, p. 963-968 6 p.

Research output: Contribution to journalArticle

Adenoid Cystic Carcinoma
Salivary Glands
MicroRNAs
Breast
Gene Expression Regulation
2012
21 Citations (Scopus)

Dysplasia-Carcinoma Transition Specific Transcripts in Colonic Biopsy Samples

Galamb, O., Wichmann, B., Sipos, F., Spisák, S., Krenács, T., Tóth, K., Leiszter, K., Kalmár, A., Tulassay, Z. & Molnár, B., Nov 14 2012, In : PLoS One. 7, 11, e48547.

Research output: Contribution to journalArticle

Biopsy
carcinoma
colorectal neoplasms
biopsy
Colorectal Neoplasms
27 Citations (Scopus)

Genome-Wide Screening of Genes Regulated by DNA Methylation in Colon Cancer Development

Spisák, S., Kalmár, A., Galamb, O., Wichmann, B., Sípos, F., Péterfia, B., Csabai, I., Kovalszky, I., Semsey, S., Tulassay, Z. & Molnár, B., Oct 1 2012, In : PLoS One. 7, 10, e46215.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
colorectal neoplasms
Colonic Neoplasms
Screening
2011
40 Citations (Scopus)

The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer

Tóth, K., Galamb, O., Spisák, S., Wichmann, B., Sípos, F., Valcz, G., Leiszter, K., Molnár, B. & Tulassay, Z., Sep 2011, In : Pathology and Oncology Research. 17, 3, p. 503-509 7 p.

Research output: Contribution to journalArticle

Septins
Colorectal Neoplasms
RNA
Genes
Proteins
2010
13 Citations (Scopus)
Microarrays
Colorectal Neoplasms
Messenger RNA
Antibodies
Genes
4 Citations (Scopus)

Metilációs szabályozás alatt álló gének azonosítása lézerrel kimetszett vastagbéldaganat-sejtekben az adenoma-carcinoma sorrend vizsgálata során

Translated title of the contribution: Identification of methylation related genes from Lacer Capture Microdissected colon samples during investigation of adenoma-carcinoma sequenceSpisák, S., Kalmár, A., Galamb, O., Sípos, F., Wichmann, B., Molnár, B. & Tulassay, Z., May 1 2010, In : Orvosi Hetilap. 151, 20, p. 805-814 10 p.

Research output: Contribution to journalArticle

Adenoma
Methylation
Colon
Carcinoma
DNA Methylation
50 Citations (Scopus)
Cyclooxygenase 2 Inhibitors
Adenoma
Peptide YY
Gene Expression
HT29 Cells
15 Citations (Scopus)
Stem Cells
Follicular Dendritic Cells
Literature
Myofibroblasts
Poisons
2009
31 Citations (Scopus)

Biomedical applications of protein microarrays

Spisák, S. & Guttman, A., 2009, In : Current Medicinal Chemistry. 16, 22, p. 2806-2815 10 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Microarrays
Proteins
Microchip Analytical Procedures
Biomarkers
7 Citations (Scopus)
p53 Genes
Apolipoproteins E
Genetic Polymorphisms
Diabetes Complications
Oligonucleotide Array Sequence Analysis
40 Citations (Scopus)
Osteonectin
Adenoma
Osteopontin
Down-Regulation
Biomarkers
10 Citations (Scopus)

Szabad DNS-alapú vastagbéldaganat-szurés perifériás vérbol: a metilált szeptin-9 génmarker lehetoségei

Translated title of the contribution: Free circulating DNA based colorectal cancer screening from peripheral blood: The possibility of the methylated septin 9 gene markerTóth, K., Galamb, O., Spisák, S., Wichmann, B., Sípos, F., Leiszter, K., Molnár, J., Molnár, B. & Tulassay, Z., May 1 2009, In : Orvosi Hetilap. 150, 21, p. 969-977 9 p.

Research output: Contribution to journalArticle

Septins
Early Detection of Cancer
Colorectal Neoplasms
DNA
Genes
3 Citations (Scopus)

Vastagbéldaganatok ellenanyag-microarray-vel kimutatott, TMA-validált progressziós markerei

Translated title of the contribution: Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarraysSpisák, S., Galamb, B., Wichmann, B., Sípos, F., Galamb, O., Solymosi, N., Nemes, B., Tulassay, Z. & Molnár, B., Aug 1 2009, In : Orvosi Hetilap. 150, 34, p. 1607-1613 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Antibodies
Proteins
Cell Cycle
Colon
2008
57 Citations (Scopus)
Adenoma
Colorectal Neoplasms
Microarray Analysis
Transcriptome
Biopsy
23 Citations (Scopus)
Helicobacter pylori
Gene Expression
Vascular Cell Adhesion Molecule-1
Helicobacter Infections
Stomach
64 Citations (Scopus)
Biopsy
Transcriptome
Gene expression
Adenoma
Colon

Vastagbél-biopszia funkcionális mRNS-expressziós vizsgálata és osztályozása általános cDNS microarray technikával

Translated title of the contribution: Functional mRNA expression analysis and classification of colonic biopsy samples using overall cDNA microarray techniqueGalamb, O., Sípos, F., Dinya, E., Spisák, S., Somorácz, Á., Molnár, B. & Tulassay, Z., Feb 3 2008, In : Orvosi Hetilap. 149, 5, p. 219-232 14 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Oligonucleotide Array Sequence Analysis
Receptors, Tumor Necrosis Factor, Member 10c
Biopsy
Messenger RNA
2007
19 Citations (Scopus)
Atrophic Gastritis
Stomach
Gastritis
Biopsy
Messenger RNA
2 Citations (Scopus)

Fehérjechipek elméleti alapjai és alkalmazási lehetoségük az orvosi diagnosztikában és kutatásban

Translated title of the contribution: Theoretical foundations of protein chips and their possible use in medical research and diagnosticsSpisák, S., Molnár, B., Galamb, O., Sípos, F. & Tulassay, Z., Aug 12 2007, In : Orvosi Hetilap. 148, 32, p. 1511-1520 10 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Biomedical Research
Glass
Technology
Costs and Cost Analysis
59 Citations (Scopus)

Protein microchips in biomedicine and biomarker discovery

Spisák, S., Tulassay, Z., Molnár, B. & Guttman, A., Dec 2007, In : Electrophoresis. 28, 23, p. 4261-4273 13 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Biomarkers
Microarrays
Glass
Proteins
6 Citations (Scopus)

Vastagbél-adenoma, vastagbélrák és IBD-specifikus génexpressziós mintázatok meghatározása teljes genomszintu oligonukleotid microarray-rendszerrel

Translated title of the contribution: Identification of colorectal cancer, adenoma, and inflammatory bowel disease specific gene expression patterns using whole genomic oligonucleotide microarray systemGalamb, O., Györffy, B., Sípos, F., Spisák, S., Németh, A., Miheller, P., Dinya, E., Molnár, B. & Tulassay, Z., Nov 4 2007, In : Orvosi Hetilap. 148, 44, p. 2067-2079 13 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Inflammatory Bowel Diseases
Adenoma
Colorectal Neoplasms
Gene Expression
2006
18 Citations (Scopus)
TNF Receptor-Associated Factor 6
Receptors, Tumor Necrosis Factor, Member 10c
Glass
Colon
Complementary DNA
2005
2 Citations (Scopus)

A p53 gén és fehérje 2005-ben: Új eredmények, ígéretes lehetoségek

Translated title of the contribution: The p53 gene and protein in 2005: New results, promising opportunitiesSzoke, D., Sípos, F., Spisák, S., Molnár, B. & Tulassay, Z., 2005, In : Orvosi Hetilap. 146, 30, p. 1587-1594 8 p.

Research output: Contribution to journalArticle

p53 Genes
Cell Division
Neoplasms
Proteins
DNA Damage