• 7136 Citations
  • 45 h-Index
1968 …2019

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Article
2017

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Pajk, M., Cselko, A., Varga, C., Posa, A., Tokodi, M., Boldogh, I., Goto, S. & Radak, Z., Aug 1 2017, In : Biogerontology. 18, 4, p. 593-600 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Aoki, Y., Hashimoto, A. H., Sugawara, Y., Hiyoshi-Arai, K., Goto, S., Masumura, K. & Nohmi, T., Jan 1 2015, In : Genes and Environment. 37, 1, 7.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W. & Radak, Z., Jul 1 2015, In : Experimental gerontology. 67, p. 9-14 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Voluntary exercise can ameliorate insulin resistance by reducing iNOS-mediated S-nitrosylation of Akt in the liver in obese rats

Tsuzuki, T., Shinozaki, S., Nakamoto, H., Kaneki, M., Goto, S., Shimokado, K., Kobayashi, H., Naito, H. & Andrews, Z., Jul 14 2015, In : PloS one. 10, 7

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Cardiorespiratory fitness, body mass index, and cancer mortality: A cohort study of Japanese men

Sawada, S. S., Lee, I. M., Naito, H., Kakigi, R., Goto, S., Kanazawa, M., Okamoto, T., Tsukamoto, K., Muto, T., Tanaka, H. & Blair, S. N., 2014, In : BMC public health. 14, 1, 1012.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Dietary restriction increases protein acetylation in the livers of aged rats

Nakamura, A., Kawakami, K., Kametani, F. & Goto, S., 2013, In : Gerontology. 59, 6, p. 542-548 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of regular exercise on neutrophil functions, oxidative stress parameters and antibody responses against 4-hydroxy-2-nonenal adducts in middle aged humans

Sasaki, S., Matsuura, T., Takahashi, R., Iwasa, T., Watanabe, H., Shirai, K., Nakamoto, H., Goto, S., Akita, S. & Kobayashi, Y., Nov 25 2013, In : Exercise Immunology Review. 19, p. 60-71 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2012
80 Citations (Scopus)

Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

Kawakami, K., Nakamura, A. & Goto, S., Feb 24 2012, In : Biochemical and biophysical research communications. 418, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Radak, Z., Zhao, Z., Goto, S. & Koltai, E., Aug 1 2011, In : Molecular Aspects of Medicine. 32, 4-6, p. 305-315 11 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)
2010

Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats

Marton, O., Koltai, E., Nyakas, C., Bakonyi, T., Zenteno-Savin, T., Kumagai, S., Goto, S. & Radak, Z., Dec 2010, In : Biogerontology. 11, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

A strategy for successful late life based on biomedical findings in gerontology

Goto, S., Jun 18 2010, In : Japanese Journal of Geriatrics. 47, 2, p. 107-109 3 p.

Research output: Contribution to journalArticle

Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

Koike, K., Kondo, Y., Sekiya, M., Sato, Y., Tobino, K., Iwakami, S. I., Goto, S., Takahashi, K., Maruyama, N., Seyama, K. & Ishigami, A., Jun 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 6, p. L784-L792

Research output: Contribution to journalArticle

41 Citations (Scopus)

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C. & Radak, Z., Jan 2010, In : Mechanisms of Ageing and Development. 131, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)
18 Citations (Scopus)
2009

Age-related difference of site-specific histone modifications in rat liver

Kawakami, K., Nakamura, A., Ishigami, A., Goto, S. & Takahashi, R., Jan 1 2009, In : Biogerontology. 10, 4, p. 415-421 7 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Aging theories and anti-aging: An overview

Goto, S., May 1 2009, In : Japanese Journal of Geriatrics. 46, 3, p. 218-221 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity

Radak, Z., Atalay, M., Jakus, J., Boldogh, I., Davies, K. & Goto, S., Jan 15 2009, In : Free Radical Biology and Medicine. 46, 2, p. 238-243 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2008

Anti-aging mechanisms of caloric restriction and regular exercise

Goto, S., Mar 1 2008, In : Japanese Journal of Geriatrics. 45, 2, p. 155-158 4 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice

Furusawa, H., Sato, Y., Tanaka, Y., Inai, Y., Amano, A., Iwama, M., Kondo, Y., Handa, S., Murata, A., Nishikimi, M., Goto, S., Maruyama, N., Takahashi, R. & Ishigami, A., Sep 1 2008, In : Biological and Pharmaceutical Bulletin. 31, 9, p. 1673-1679 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2007

8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats

Radak, Z., Kumagai, S., Nakamoto, H. & Goto, S., Apr 1 2007, In : Journal of Applied Physiology. 102, 4, p. 1696-1701 6 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Age-related change of endocytic receptors megalin and cubilin in the kidney in rats

Odera, K., Goto, S. & Takahashi, R., Oct 1 2007, In : Biogerontology. 8, 5, p. 505-515 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress

Li, L., Shoji, W., Takano, H., Nishimura, N., Aoki, Y., Takahashi, R., Goto, S., Kaifu, T., Takai, T. & Obinata, M., Apr 13 2007, In : Biochemical and biophysical research communications. 355, 3, p. 715-721 7 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust

Hashimoto, A. H., Amanuma, K., Hiyoshi, K., Sugawara, Y., Goto, S., Yanagisawa, R., Takano, H., Masumura, K. I., Nohmi, T. & Aoki, Y., Oct 1 2007, In : Environmental and Molecular Mutagenesis. 48, 8, p. 682-693 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
5 Citations (Scopus)

Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats

Nakamoto, H., Kaneko, T., Tahara, S., Hayashi, E., Naito, H., Radak, Z. & Goto, S., Apr 1 2007, In : Experimental gerontology. 42, 4, p. 287-295 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2006

Age-related changes of mitochondrial structure and function in Caenorhabditis elegans

Yasuda, K., Ishii, T., Suda, H., Akatsuka, A., Hartman, P. S., Goto, S., Miyazawa, M. & Ishii, N., Oct 2006, In : Mechanisms of Ageing and Development. 127, 10, p. 763-770 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction

Sharma, R., Nakamura, A., Takahashi, R., Nakamoto, H. & Goto, S., Apr 1 2006, In : Free Radical Biology and Medicine. 40, 7, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Defining the mitochondrial proteomes from five rat organs in a physiologically significant context using 2D blue-native/SDS-PAGE

Reifschneider, N. H., Goto, S., Nakamoto, H., Takahashi, R., Sugawa, M., Dencher, N. A. & Krause, F., May 1 2006, In : Journal of Proteome Research. 5, 5, p. 1117-1132 16 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)
6 Citations (Scopus)

Health span extension by later-life caloric or dietary restriction: A view based on rodent studies

Goto, S., Jun 1 2006, In : Biogerontology. 7, 3, p. 135-138 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Roles of biomedical research in gerontology for aged society

Goto, S., May 2006, In : Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics. 43, 3, p. 289-292 4 p.

Research output: Contribution to journalArticle

Open Access

Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy

Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N. & Ishigami, A., Apr 11 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 15, p. 5723-5728 6 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking

Sato, T., Seyama, K., Sato, Y., Mori, H., Souma, S., Akiyoshi, T., Kodama, Y., Mori, T., Goto, S., Takahashi, K., Fukuchi, Y., Maruyama, N. & Ishigami, A., Sep 1 2006, In : American Journal of Respiratory and Critical Care Medicine. 174, 5, p. 530-537 8 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain

Radak, Z., Toldy, A., Szabo, Z., Siamilis, S., Nyakas, C., Silye, G., Jakus, J. & Goto, S., Sep 1 2006, In : Neurochemistry international. 49, 4, p. 387-392 6 p.

Research output: Contribution to journalArticle

189 Citations (Scopus)

The seventh Korea-Japan joint symposium on cancer and ageing research: Molecular targets in cancer and ageing research

Park, S. C., Lim, I. K., Koh, G. Y., Surh, Y. J., Lee, Y. S., Fujiki, H., Yamamoto, T., Yuasa, Y., Maruyama, N. & Goto, S., May 2006, In : Journal of cancer research and clinical oncology. 132, 5, p. 339-342 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Unraveling age-dependent variation of the mitochondrial proteome

Dencher, N. A., Goto, S., Reifschneider, N. H., Sugawa, M. & Krause, F., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 116-119 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2005

Active oligomeric ATP synthases in mammalian mitochondria

Krause, F., Reifschneider, N. H., Goto, S. & Dencher, N. A., Apr 8 2005, In : Biochemical and Biophysical Research Communications. 329, 2, p. 583-590 8 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1

Radak, Z., Goto, S., Nakamoto, H., Udud, K., Papai, Z. & Horvath, I., Mar 10 2005, In : Cancer Letters. 219, 2, p. 191-195 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

"My involvement in aging research was just a series of coincidences". An interview with Kenichi Kitani

Goto, S., May 1 2005, In : Biogerontology. 6, 3, p. 211-221 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Possible translation of findings in biomedical gerontology into clinical practice in geriatrics

Goto, S., Mar 2005, In : Japanese Journal of Geriatrics. 42, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

Open Access

The effects of moderate, strenuous, and overtraining on oxidative stress markers and DNA repair in rat liver

Ogonovszky, H., Sasvári, M., Dosek, A., Berkes, I., Kaneko, T., Tahara, S., Nakamoto, H., Goto, S. & Radák, Z., Apr 2005, In : Canadian Journal of Applied Physiology. 30, 2, p. 186-195 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain

Ogonovszky, H., Berkes, I., Kumagai, S., Kaneko, T., Tahara, S., Goto, S. & Radák, Z., Jun 2005, In : Neurochemistry international. 46, 8, p. 635-640 6 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2004
140 Citations (Scopus)

Altered gene expression in the brain of senescence accelerated mouse SAMP8

Takahashi, R. & Goto, S., Feb 1 2004, In : International Congress Series. 1260, C, p. 85-90 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dietary restriction in aged mice can partially restore impaired metabolism of apolipoprotein A-IV and C-III

Araki, S. & Goto, S., Nov 1 2004, In : Biogerontology. 5, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Impaired lipid metabolism in aged mice as revealed by fasting-induced expression of apolipoprotein mRNAs in the liver and changes in serum lipids

Araki, S., Okazaki, M. & Goto, S., Sep 8 2004, In : Gerontology. 50, 4, p. 206-215 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process

Jung, K. J., Ishigami, A., Maruyama, N., Takahashi, R., Goto, S., Yu, B. P. & Chung, H. Y., Aug 1 2004, In : Experimental gerontology. 39, 8, p. 1169-1177 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Regular exercise: An effective means to reduce oxidative stress in old rats

Goto, S., Radák, Z., Nyakas, C., Hae, Y. C., Naito, H., Takahashi, R., Nakamoto, H. & Abe, R., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1019, p. 471-474 4 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)