• 7178 Citations
  • 45 h-Index
1968 …2019

Research output per year

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Research Output

2019

Exercise effects on physiological function during aging

Radak, Z., Torma, F., Berkes, I., Goto, S., Mimura, T., Posa, A., Balogh, L., Boldogh, I., Suzuki, K., Higuchi, M. & Koltai, E., Feb 20 2019, In : Free Radical Biology and Medicine. 132, p. 33-41 9 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)
2017

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Pajk, M., Cselko, A., Varga, C., Posa, A., Tokodi, M., Boldogh, I., Goto, S. & Radak, Z., Aug 1 2017, In : Biogerontology. 18, 4, p. 593-600 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Aoki, Y., Hashimoto, A. H., Sugawara, Y., Hiyoshi-Arai, K., Goto, S., Masumura, K. & Nohmi, T., 2015, In : Genes and Environment. 37, 1, 7.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W. & Radak, Z., Jul 1 2015, In : Experimental gerontology. 67, p. 9-14 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The biological mechanisms of aging: A historical and critical overview

Goto, S., Jan 1 2015, Aging Mechanisms: Longevity, Metabolism, and Brain Aging. Springer Japan, p. 3-27 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Voluntary exercise can ameliorate insulin resistance by reducing iNOS-mediated S-nitrosylation of Akt in the liver in obese rats

Tsuzuki, T., Shinozaki, S., Nakamoto, H., Kaneki, M., Goto, S., Shimokado, K., Kobayashi, H., Naito, H. & Andrews, Z., Jul 14 2015, In : PloS one. 10, 7

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Cardiorespiratory fitness, body mass index, and cancer mortality: A cohort study of Japanese men

Sawada, S. S., Lee, I. M., Naito, H., Kakigi, R., Goto, S., Kanazawa, M., Okamoto, T., Tsukamoto, K., Muto, T., Tanaka, H. & Blair, S. N., 2014, In : BMC public health. 14, 1, 1012.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The redox-associated adaptive response of brain to physical exercise

Radak, Z., Ihasz, F., Koltai, E., Goto, S., Taylor, A. W. & Boldogh, I., Jan 1 2014, In : Free radical research. 48, 1, p. 84-92 9 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)
2013

Dietary restriction increases protein acetylation in the livers of aged rats

Nakamura, A., Kawakami, K., Kametani, F. & Goto, S., 2013, In : Gerontology. 59, 6, p. 542-548 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of regular exercise on neutrophil functions, oxidative stress parameters and antibody responses against 4-hydroxy-2-nonenal adducts in middle aged humans

Sasaki, S., Matsuura, T., Takahashi, R., Iwasa, T., Watanabe, H., Shirai, K., Nakamoto, H., Goto, S., Akita, S. & Kobayashi, Y., Nov 25 2013, In : Exercise Immunology Review. 19, p. 60-71 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
8 Citations (Scopus)

Redox-regulating sirtuins in aging, caloric restriction, and exercise

Radak, Z., Koltai, E., Taylor, A. W., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I., May 2013, In : Free Radical Biology and Medicine. 58, p. 87-97 11 p.

Research output: Contribution to journalReview article

66 Citations (Scopus)

The complex role of physical exercise and reactive oxygen species on brain

Radak, Z., Marton, O., Nagy, E., Koltai, E. & Goto, S., Jun 2013, In : Journal of Sport and Health Science. 2, 2, p. 87-93 7 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)
2012
82 Citations (Scopus)

Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

Kawakami, K., Nakamura, A. & Goto, S., Feb 24 2012, In : Biochemical and biophysical research communications. 418, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Nitric oxide: Is it the cause of muscle soreness?

Radak, Z., Naito, H., Taylor, A. W. & Goto, S., Feb 15 2012, In : Nitric Oxide - Biology and Chemistry. 26, 2, p. 89-94 6 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)
2011

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Radak, Z., Zhao, Z., Goto, S. & Koltai, E., Aug 1 2011, In : Molecular Aspects of Medicine. 32, 4-6, p. 305-315 11 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)
2010

Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats

Marton, O., Koltai, E., Nyakas, C., Bakonyi, T., Zenteno-Savin, T., Kumagai, S., Goto, S. & Radak, Z., Dec 2010, In : Biogerontology. 11, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

A strategy for successful late life based on biomedical findings in gerontology

Goto, S., Jun 18 2010, In : Japanese Journal of Geriatrics. 47, 2, p. 107-109 3 p.

Research output: Contribution to journalArticle

Biological significance of protein modifications in aging and calorie restriction

Nakamura, A., Kawakami, K., Kametani, F., Nakamoto, H. & Goto, S., Jun 2010, Aging, Cancer, and Age-Related Diseases: Common Mechanisms. Blackwell Publishing Inc., p. 33-39 7 p. (Annals of the New York Academy of Sciences; vol. 1197).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

32 Citations (Scopus)

Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

Koike, K., Kondo, Y., Sekiya, M., Sato, Y., Tobino, K., Iwakami, S. I., Goto, S., Takahashi, K., Maruyama, N., Seyama, K. & Ishigami, A., Jun 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 6, p. L784-L792

Research output: Contribution to journalArticle

41 Citations (Scopus)

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C. & Radak, Z., Jan 2010, In : Mechanisms of Ageing and Development. 131, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)
18 Citations (Scopus)
2009

Age-related difference of site-specific histone modifications in rat liver

Kawakami, K., Nakamura, A., Ishigami, A., Goto, S. & Takahashi, R., Jan 1 2009, In : Biogerontology. 10, 4, p. 415-421 7 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Aging theories and anti-aging: An overview

Goto, S., May 1 2009, In : Japanese Journal of Geriatrics. 46, 3, p. 218-221 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evidence for and against anti-aging effects based on model animal studies

Goto, S., Jul 2009, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 7, p. 1337-1340 4 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity

Radak, Z., Atalay, M., Jakus, J., Boldogh, I., Davies, K. & Goto, S., Jan 15 2009, In : Free Radical Biology and Medicine. 46, 2, p. 238-243 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2008

Anti-aging mechanisms of caloric restriction and regular exercise

Goto, S., Mar 1 2008, In : Japanese Journal of Geriatrics. 45, 2, p. 155-158 4 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Exercise, oxidative stress and hormesis

Radak, Z., Chung, H. Y., Koltai, E., Taylor, A. W. & Goto, S., Jan 1 2008, In : Ageing Research Reviews. 7, 1, p. 34-42 9 p.

Research output: Contribution to journalShort survey

346 Citations (Scopus)

Hormesis and exercise: How the cell copes with oxidative stress

Ji, L. L., Radak, Z. & Goto, S., 2008, In : American Journal of Pharmacology and Toxicology. 3, 1, p. 41-55 15 p.

Research output: Contribution to journalReview article

Open Access
16 Citations (Scopus)

Molecular mechanisms of aging and anti-aging

Goto, S., Jun 1 2008, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 49, 6, p. 367-372 6 p.

Research output: Contribution to journalReview article

Systemic adaptation to oxidative challenge induced by regular exercise

Radak, Z., Chung, H. Y. & Goto, S., Jan 15 2008, In : Free Radical Biology and Medicine. 44, 2, p. 153-159 7 p.

Research output: Contribution to journalReview article

378 Citations (Scopus)

Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice

Furusawa, H., Sato, Y., Tanaka, Y., Inai, Y., Amano, A., Iwama, M., Kondo, Y., Handa, S., Murata, A., Nishikimi, M., Goto, S., Maruyama, N., Takahashi, R. & Ishigami, A., Sep 2008, In : Biological and Pharmaceutical Bulletin. 31, 9, p. 1673-1679 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2007

8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats

Radak, Z., Kumagai, S., Nakamoto, H. & Goto, S., Apr 1 2007, In : Journal of Applied Physiology. 102, 4, p. 1696-1701 6 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Age-related change of endocytic receptors megalin and cubilin in the kidney in rats

Odera, K., Goto, S. & Takahashi, R., Oct 1 2007, In : Biogerontology. 8, 5, p. 505-515 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Beneficial biochemical outcomes of late-onset dietary restriction in rodents

Goto, S., Takahashi, R., Radak, Z. & Sharma, R., Apr 2007, Biogerontology: Mechanisms and Interventions. Blackwell Publishing Inc., p. 431-441 11 p. (Annals of the New York Academy of Sciences; vol. 1100).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

46 Citations (Scopus)

Effects of exercise on brain function: Role of free radicals

Radak, Z., Kumagai, S., Taylor, A. W., Naito, H. & Goto, S., Oct 1 2007, In : Applied Physiology, Nutrition and Metabolism. 32, 5, p. 942-947 6 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)

Hormetic effects of regular exercise in aging: Correlation with oxidative stress

Goto, S., Naito, H., Kaneko, T., Chung, H. & Radák, Z., Oct 1 2007, In : Applied Physiology, Nutrition and Metabolism. 32, 5, p. 948-953 6 p.

Research output: Contribution to journalReview article

61 Citations (Scopus)

Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress

Li, L., Shoji, W., Takano, H., Nishimura, N., Aoki, Y., Takahashi, R., Goto, S., Kaifu, T., Takai, T. & Obinata, M., Apr 13 2007, In : Biochemical and biophysical research communications. 355, 3, p. 715-721 7 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust

Hashimoto, A. H., Amanuma, K., Hiyoshi, K., Sugawara, Y., Goto, S., Yanagisawa, R., Takano, H., Masumura, K. I., Nohmi, T. & Aoki, Y., Oct 1 2007, In : Environmental and Molecular Mutagenesis. 48, 8, p. 682-693 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
5 Citations (Scopus)

Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats

Nakamoto, H., Kaneko, T., Tahara, S., Hayashi, E., Naito, H., Radak, Z. & Goto, S., Apr 1 2007, In : Experimental gerontology. 42, 4, p. 287-295 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2006

Age-related changes of mitochondrial structure and function in Caenorhabditis elegans

Yasuda, K., Ishii, T., Suda, H., Akatsuka, A., Hartman, P. S., Goto, S., Miyazawa, M. & Ishii, N., Oct 2006, In : Mechanisms of Ageing and Development. 127, 10, p. 763-770 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction

Sharma, R., Nakamura, A., Takahashi, R., Nakamoto, H. & Goto, S., Apr 1 2006, In : Free Radical Biology and Medicine. 40, 7, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Defining the mitochondrial proteomes from five rat organs in a physiologically significant context using 2D blue-native/SDS-PAGE

Reifschneider, N. H., Goto, S., Nakamoto, H., Takahashi, R., Sugawa, M., Dencher, N. A. & Krause, F., May 1 2006, In : Journal of Proteome Research. 5, 5, p. 1117-1132 16 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)
6 Citations (Scopus)

Health span extension by later-life caloric or dietary restriction: A view based on rodent studies

Goto, S., Jun 1 2006, In : Biogerontology. 7, 3, p. 135-138 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Roles of biomedical research in gerontology for aged society

Goto, S., May 2006, In : Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics. 43, 3, p. 289-292 4 p.

Research output: Contribution to journalArticle

Open Access

Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy

Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N. & Ishigami, A., Apr 11 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 15, p. 5723-5728 6 p.

Research output: Contribution to journalArticle

179 Citations (Scopus)