• 1813 Citations
  • 23 h-Index
1982 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1813 Citations
  • 23 h-Index
  • 131 Article
  • 4 Review article
  • 2 Conference contribution
  • 1 Short survey
Filter
Article
2019

Affinity of fentanyl and its derivatives for the σ1-receptor

Lipiński, P. F. J., Szucs, E., Jarończyk, M., Kosson, P., Benyhe, S., Misicka, A., Dobrowolski, J. C. & Sadlej, J., Jan 1 2019, In : MedChemComm. 10, 7, p. 1187-1191 5 p.

Research output: Contribution to journalArticle

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides

Erdei, A. I., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M. P., Luisi, G., Mollica, A. & Benyhe, S., Feb 2019, In : Peptides. 112, p. 106-113 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Discovery of novel µ-opioid receptor inverse agonist from a combinatorial library of tetrapeptides through structure-based virtual screening

Poli, G., Dimmito, M. P., Mollica, A., Zengin, G., Benyhe, S., Zador, F. & Stefanucci, A., Oct 27 2019, In : Molecules. 24, 21, 3872.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Efficacy-based perspective to overcome reduced opioid analgesia of advanced painful diabetic neuropathy in rats

Balogh, M., Zádor, F., Zádori, Z. S., Shaqura, M., Király, K., Mohammadzadeh, A., Varga, B., Lázár, B., Mousa, S. A., Hosztafi, S., Riba, P., Benyhe, S., Gyires, K., Schäfer, M., Fürst, S. & Al-Khrasani, M., Jan 1 2019, In : Frontiers in Pharmacology. 10, APR, 347.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

Alterations in the Activity of Spinal and Thalamic Opioid Systems in a Mice Neuropathic Pain Model

Rojewska, E., Wawrzczak-Bargiela, A., Szucs, E., Benyhe, S., Starnowska, J., Mika, J., Przewlocki, R. & Przewlocka, B., Oct 15 2018, In : Neuroscience. 390, p. 293-302 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions

Erdei, A. I., Borbély, A., Magyar, A., Taricska, N., Perczel, A., Zsíros, O., Garab, G., Szűcs, E., Ötvös, F., Zádor, F., Balogh, M., Al-Khrasani, M. & Benyhe, S., Jan 2018, In : Peptides. 99, p. 205-216 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides

Stefanucci, A., Novellino, E., Macedonio, G., Dimmito, M. P., Mirzaie, S., Caldas Cardoso, F., Lewis, R., Zádor, F., Erdei, A., Dvorácskó, S., Tömböly, C., Benyhe, S., Pieretti, S., Minosi, P. & Mollica, A., Jan 1 2018, In : New Journal of Chemistry. 42, 8, p. 5656-5659 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

Zádor, F., Balogh, M., Váradi, A., Zádori, Z. S., Király, K., Szűcs, E., Varga, B., Lázár, B., Hosztafi, S., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., Nov 5 2017, In : European Journal of Pharmacology. 814, p. 264-273 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile

Stefanucci, A., Carotenuto, A., Macedonio, G., Novellino, E., Pieretti, S., Marzoli, F., Szücs, E., Erdei, A., Zádor, F., Benyhe, S. & Mollica, A., Aug 10 2017, In : ACS Medicinal Chemistry Letters. 8, 8, p. 858-863 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

Mollica, A., Pelliccia, S., Famiglini, V., Stefanucci, A., Macedonio, G., Chiavaroli, A., Orlando, G., Brunetti, L., Ferrante, C., Pieretti, S., Novellino, E., Benyhe, S., Zador, F., Erdei, A., Szucs, E., Samavati, R., Dvrorasko, S., Tömböly, C., Ragno, R., Patsilinakos, A. & 1 others, Silvestri, R., 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 444-451 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
3 Citations (Scopus)

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology

Zádor, F., Király, K., Váradi, A., Balogh, M., Fehér, Á., Kocsis, D., Erdei, A., Lackó, E., Zádori, Z., Hosztafi, S., Noszál, B., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., Jan 1 2017, In : European Journal of Pharmacology. 809, p. 111-121 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge

Stefanucci, A., Novellino, E., Mirzaie, S., Macedonio, G., Pieretti, S., Minosi, P., Szűcs, E., Erdei, A., Zádor, F., Benyhe, S. & Mollica, A., Apr 13 2017, In : ACS Medicinal Chemistry Letters. 8, 4, p. 449-454 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

A novel non-Opioid binding site for endomorphin-1

Lengyel, I., Toth, F., Biyashev, D., Szatmari, I., Monory, K., Tömböly, C., Toth, G., Benyhe, S. & Borsodi, A., Aug 1 2016, In : Journal of Physiology and Pharmacology. 67, 4, p. 605-616 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents

Kleczkowska, P., Hermans, E., Kosson, P., Kowalczyk, A., Lesniak, A., Pawlik, K., Bojnik, E., Benyhe, S., Nowicka, B., Bujalska-Zadrozny, M., Misicka, A. & Lipkowski, A. W., Oct 1 2016, In : Brain Research. 1648, p. 172-180 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and D-Phe-Phe-D-Phe-Leu-Leu-NH2, a substance P analogue

Kowalczyk, A., Kleczkowska, P., Rękawek, M., Kulik, K., Lesniak, A., Erdei, A., Borics, A., Martin, C., Pawlik, K., Lipkowski, A. W., Benyhe, S., Makulska-Nowak, H., Ballet, S. & Bujalska-Zadrozny, M., Oct 10 2016, In : European Journal of Pharmaceutical Sciences. 93, p. 11-20 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia

Szűcs, E., Dvorácskó, S., Tömböly, C., Büki, A., Kékesi, G., Horváth, G. & Benyhe, S., Oct 28 2016, In : Neuroscience Letters. 633, p. 87-93 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates

Monti, L., Stefanucci, A., Pieretti, S., Marzoli, F., Fidanza, L., Mollica, A., Mirzaie, S., Carradori, S., De Petrocellis, L., Schiano Moriello, A., Benyhe, S., Zádor, F., Szűcs, E., Ötvös, F., Erdei, A., Samavati, R., Dvorácskó, S., Tömböly, C. & Novellino, E., Apr 11 2016, (Accepted/In press) In : Journal of Enzyme Inhibition and Medicinal Chemistry. p. 1-10 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia

Szucs, E., Büki, A., Kékesi, G., Horváth, G. & Benyhe, S., Apr 21 2016, In : Neuroscience Letters. 619, p. 29-33 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand

Tóth, F., Mallareddy, J. R., Tourwé, D., Lipkowski, A. W., Bujalska-Zadrozny, M., Benyhe, S., Ballet, S., Tóth, G. & Kleczkowska, P., Jun 1 2016, In : Neuropeptides. 57, p. 15-20 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The effects of estrogen on the α2-adrenergic receptor subtypes in rat uterine function in late pregnancy in vitro

Hajagos-Tóth, J., Bóta, J., Ducza, E., Csányi, A., Tiszai, Z., Borsodi, A., Samavati, R., Benyhe, S. & Gáspár, R., 2016, In : Croatian Medical Journal. 57, 2, p. 100-109 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The effects of progesterone on the alpha2-adrenergic receptor subtypes in late-pregnant uterine contractions in vitro

Hajagos-Tóth, J., Bóta, J., Ducza, E., Samavati, R., Borsodi, A., Benyhe, S. & Gáspár, R., Jun 14 2016, In : Reproductive Biology and Endocrinology. 14, 1, 33.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Biochemistry of opioid (morphine) receptors: Binding, structure and molecular modelling

Benyhe, S., Zádor, F. & Ötvös, F., 2015, In : Acta Biologica Szegediensis. 59, p. 17-37 21 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

Verbeken, M., Wynendaele, E., Mauchauffée, E., Bracke, N., Stalmans, S., Bojnik, E., Benyhe, S., Peremans, K., Polis, I., Burvenich, C., Gjedde, A., Hernandez, J. F. & De Spiegeleer, B., Jan 2015, In : Peptides. 63, p. 10-21 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav2.2 Blocker Multitarget Ligands

Mollica, A., Costante, R., Novellino, E., Stefanucci, A., Pieretti, S., Zador, F., Samavati, R., Borsodi, A., Benyhe, S., Vetter, I. & Lewis, R. J., Jan 1 2015, In : Chemical Biology and Drug Design. 86, 2, p. 156-162 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Further characterization of hemopressin peptide fragments in the opioid and cannabinoid systems

Szlavicz, E., Perera, P. S., Tomboly, C., Helyes, Z., Zador, F., Benyhe, S., Borsodi, A. & Bojnik, E., Dec 1 2015, In : Anesthesia and analgesia. 121, 6, p. 1488-1494 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium

Bóta, J., Hajagos-Tóth, J., Ducza, E., Samavati, R., Borsodi, A., Benyhe, S. & Gáspár, R., Dec 15 2015, In : European Journal of Pharmacology. 769, p. 177-184 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Bioactivity studies on atypical natural opioid hexapeptides processed from proenkephalin (PENK) precursor polypeptides

Bojnik, E., Kleczkowska, P., de Velasco, E. M. F., Corbani, M., Babos, F., Lipkowski, A. W., Magyar, A. & Benyhe, S., Aug 2014, In : Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology. 174, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors

Benyhe, Z., Toth, G., Wollemann, M., Borsodi, A., Helyes, Z., Rougeot, C. & Benyhe, S., 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 525-530 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner

Zádor, F., Lénárt, N., Csibrány, B., Sántha, M., Molnár, M., Tuka, B., Samavati, R., Klivényi, P., Vécsei, L., Marton, A., Vizler, C., Nagy, G. M., Borsodi, A., Benyhe, S. & Páldy, E., Feb 2014, In : Neuropharmacology. 89, p. 298-307 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
23 Citations (Scopus)

Novel cyclic biphalin analogue with improved antinociceptive properties

Mollica, A., Carotenuto, A., Novellino, E., Limatola, A., Costante, R., Pinnen, F., Stefanucci, A., Pieretti, S., Borsodi, A., Samavati, R., Zador, F., Benyhe, S., Davis, P., Porreca, F. & Hruby, V. J., Sep 11 2014, In : ACS Medicinal Chemistry Letters. 5, 9, p. 1032-1036 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: Synthesis, biological and structural evaluations

Touati-Jallabe, Y., Bojnik, E., Legrand, B., Mauchauffée, E., Chung, N. N., Schiller, P. W., Benyhe, S., Averlant-Petit, M. C., Martinez, J. & Hernandez, J. F., Jul 25 2013, In : Journal of Medicinal Chemistry. 56, 14, p. 5964-5973 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Hybrid peptides endomophin-2/DAMGO: Design, synthesis and biological evaluation

Mollica, A., Costante, R., Stefanucci, A., Pinnen, F., Luisi, G., Pieretti, S., Borsodi, A., Bojnik, E. & Benyhe, S., Sep 26 2013, In : European Journal of Medicinal Chemistry. 68, p. 167-177 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20

Kleczkowska, P., Bojnik, E., LeAniak, A., Kosson, P., Van Den Eynde, I., Ballet, S., Benyhe, S., Tourwe, D. & Lipkowski, A. W., 2013, In : Pharmacological Reports. 65, 4, p. 836-846 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex

Bayrakdar, E. T., Bojnik, E., Armagan, G., Kanit, L., Benyhe, S., Borsodi, A. & Yalcin, A., Jul 1 2013, In : Epilepsy Research. 105, 1-2, p. 13-19 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Protein kinase C inhibitor BIM suspended TRPV1 effect on mu-opioid receptor

Wollemann, M., Tóth, F. & Benyhe, S., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 114-117 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2012

A novel μ-opioid receptor ligand with high in vitro and in vivo agonist efficacy

Lackó, E., Váradi, A., Rapavi, R., Zádor, F., Riba, P., Benyhe, S., Borsodi, A., Hosztafi, S., Timár, J., Noszál, B., Fürst, S. & Al-Khrasani, M., Jan 1 2012, In : Current medicinal chemistry. 19, 27, p. 4699-4707 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures

Bojnik, E., Turunç, E., Armaĝan, G., Kanit, L., Benyhe, S., Yalçin, A. & Borsodi, A., Mar 1 2012, In : Epilepsy Research. 99, 1-2, p. 64-68 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

Linka, B., Szakonyi, G., Petkovits, T., Nagy, L. G., Papp, T., Vágvölgyi, C., Benyhe, S. & Ötvös, F., Aug 21 2012, In : Life Sciences. 91, 3-4, p. 115-126 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
17 Citations (Scopus)

Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus

Armagan, G., Bojnik, E., Turunc, E., Kanit, L., Gündüz Çinar, Ö., Benyhe, S., Borsodi, A. & Yalcin, A., May 1 2012, In : Neurochemistry international. 60, 6, p. 555-564 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus

Cuellar-Herrera, M., Velasco, A. L., Velasco, F., Chavez, L., Orozco-Suarez, S., Armagan, G., Turunc, E., Bojnik, E., Yalcin, A., Benyhe, S., Borsodi, A., Alonso-Vanegas, M. & Rocha, L., Feb 1 2012, In : Hippocampus. 22, 2, p. 122-127 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Opiorphin highly improves the specific binding and affinity of MERF and MEGY to rat brain opioid receptors

Tóth, F., Tóth, G., Benyhe, S., Rougeot, C. & Wollemann, M., Oct 10 2012, In : Regulatory Peptides. 178, 1-3, p. 71-75 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011
23 Citations (Scopus)

Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A

Bojnik, E., Boynik, E., Corbani, M., Babos, F., Magyar, A., Borsodi, A. & Benyhe, S., Mar 31 2011, In : Neuroscience. 178, p. 56-67 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2010

Agonist-dependent attenuation of μ-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats

Obara, I., Gunduz Cinar, O., Starowicz, K., Benyhe, S., Borsodi, A. & Przewlocka, B., Apr 1 2010, In : Journal of neural transmission. 117, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Bioinformatic and biochemical studies on the phylogenetic variability of proenkephalin-derived octapeptides

Bojnik, E., Babos, F., Magyar, A., Borsodi, A. & Benyhe, S., Jan 20 2010, In : Neuroscience. 165, 2, p. 542-552 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol

Bojnik, E., Babos, F., Fischetti, C., Magyar, A., Camarda, V., Borsodi, A., Bajusz, S., Calo', G. & Benyhe, S., Mar 16 2010, In : Brain Research Bulletin. 81, 4-5, p. 477-483 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

Klukovits, A., Tekes, K., Gündüz Çinar, Ö., Benyhe, S., Borsodi, A., Deák, B. H., Hajagos-Tóth, J., Verli, J., Falkay, G. & Gáspár, R., Jul 2010, In : Biology of Reproduction. 83, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)