• 1965 Citations
  • 26 h-Index
1968 …2015

Research output per year

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Article
2015

DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment

Varjú, I., Longstaff, C., Szabó, L., Farkas, Á. Z., Varga-Szabó, V. J., Tanka-Salamon, A., Machovich, R. & Kolev, K., Jan 1 2015, In : Thrombosis and Haemostasis. 113, 6, p. 1289-1299 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Ultrastructure and composition of thrombi in coronary and peripheral artery disease: Correlations with clinical and laboratory findings

Kovács, A., Sótonyi, P., Nagy, A. I., Tenekedjiev, K., Wohner, N., Komorowicz, E., Kovács, E., Nikolova, N., Szabó, L., Kovalszky, I., MacHovich, R., Szelid, Z., Becker, D., Merkely, B. & Kolev, K., Apr 1 2015, In : Thrombosis research. 135, 4, p. 760-766 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Ambivalent roles of carboxypeptidase B in the lytic susceptibility of fibrin

Kovács, A., Szabó, L., Longstaff, C., Tenekedjiev, K., Machovich, R. & Kolev, K., Jan 1 2014, In : Thrombosis research. 133, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Fractal kinetic behavior of plasmin on the surface of fibrin meshwork

Varjú, I., Tenekedjiev, K., Keresztes, Z., Pap, A. E., Szabó, L., Thelwell, C., Longstaff, C., Machovich, R. & Kolev, K., Oct 14 2014, In : Biochemistry. 53, 40, p. 6348-6356 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components

Rottenberger, Z., Komorowicz, E., Szabó, L., Bóta, A., Varga, Z., Machovich, R., Longstaff, C. & Kolev, K., Mar 1 2013, In : Journal of Thrombosis and Haemostasis. 11, 3, p. 529-538 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Modulation of the von Willebrand factor-dependent platelet adhesion through alternative proteolytic pathways

Wohner, N., Kovács, A., MacHovich, R. & Kolev, K., Apr 1 2012, In : Thrombosis research. 129, 4, p. e41-e46

Research output: Contribution to journalArticle

26 Citations (Scopus)
2011

Lytic resistance of fibrin containing red blood cells

Wohner, N., Sótonyi, P., MacHovich, R., Szabó, L., Tenekedjiev, K., Silva, M. M. C. G., Longstaff, C. & Kolev, K., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2306-2313 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2010
3 Citations (Scopus)

Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow

Wohner, N., Keresztes, Z., Sótonyi, P., Szabó, L., Komorowicz, E., Machovich, R. & Kolev, K., Jul 1 2010, In : Journal of Thrombosis and Haemostasis. 8, 7, p. 1624-1631 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Proteolytic resistance conferred to fibrinogen by von Willebrand factor

Tanka-Salamon, A., Kolev, K., Machovich, R. & Komorowicz, E., Feb 1 2010, In : Thrombosis and Haemostasis. 103, 2, p. 291-298 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2008

Modulation of fibrinolysis by the combined action of phospholipids and immunoglobulins

Gombás, J., Tanka-Salamon, A., Skopál, J., Nagy, Z., Machovich, R. & Kolev, K., Jan 1 2008, In : Blood Coagulation and Fibrinolysis. 19, 1, p. 82-88 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
9 Citations (Scopus)
2007

Fibrinolysis in a lipid environment: Modulation through release of free fatty acids

Rábai, G., Váradi, B., Longstaff, C., Sótonyi, P., Kristóf, V., Timár, F., Machovich, R. & Kolev, K., Jun 1 2007, In : Journal of Thrombosis and Haemostasis. 5, 6, p. 1265-1273 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2006
10 Citations (Scopus)
2005
8 Citations (Scopus)
2004

Impaired fibrinolytic potential related to elevated α1-proteinase inhibitor levels in patients with pulmonary thromboembolism

Gombás, J., Kolev, K., Tarján, E. & Machovich, R., Dec 1 2004, In : Annals of Hematology. 83, 12, p. 759-763 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Phospholipid barrier to fibrinolysis. Role for the anionic polar head charge and the gel phase crystalline structure

Váradi, B., Kolev, K., Tenekedjiev, K., Mészáros, G., Kovalszky, I., Longstaff, C. & Machovich, R., Sep 17 2004, In : Journal of Biological Chemistry. 279, 38, p. 39863-39871 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2003

Matrix metalloproteinase-9 expression in post-hypoxic human brain capillary endothelial cells: H2O2 as a trigger and NF-κB as a signal transducer

Kolev, K., Skopál, J., Simon, L., Csonka, É., Machovich, R. & Nagy, Z., Sep 1 2003, In : Thrombosis and Haemostasis. 90, 3, p. 528-537 10 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Myosin: A noncovalent stabilizer of fibrin in the process of clot dissolution

Kolev, K., Tenekedjiev, K., Ajtai, K., Kovalszky, I., Gombás, J., Váradi, B. & Machovich, R., Jun 1 2003, In : Blood. 101, 11, p. 4380-4386 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2002

Immunoglobulin G from patients with antiphospholipid syndrome impairs the fibrin dissolution with plasmin

Kolev, K., Gombás, J., Váradi, B., Skopál, J., Mede, K., Pitlik, E., Nagy, Z. & Machovich, R., Jan 1 2002, In : Thrombosis and Haemostasis. 87, 3, p. 502-508 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Protease-activated receptor-2 (PAR-2) in brain microvascular endothelium and its regulation by plasmin and elastase

Dömötör, E., Bartha, K., Machovich, R. & Adam-Vizi, V., Aug 5 2002, In : Journal of neurochemistry. 80, 5, p. 746-754 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2000

Identification of thrombin receptors in rat brain capillary endothelial cells

Bartha, K., Dömötör, E., Lanza, F., Adam-Vizi, V. & Machovich, R., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Inhibition of plasmin activity by sulfated polyvinylalcohol-acrylate copolymers

Vörös, G., Kolev, K., Csomor, K. & Machovich, R., Nov 15 2000, In : Thrombosis research. 100, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
9 Citations (Scopus)

Streptokinase does not activate the complement system

Skopál, J., Vastag, M., Varga, L., Kolev, K., Szegedi, N., Mede, K., Machovich, R., Nagy, Z. & Kramer, J., Nov 18 2000, In : Blood Coagulation and Fibrinolysis. 11, 7, p. 617-622 6 p.

Research output: Contribution to journalArticle

1999

Facilitation of plasminogen activation by denatured prothrombin

Machovich, R., Komorowicz, E., Kolev, K. & Owen, W. G., Jun 15 1999, In : Thrombosis research. 94, 6, p. 389-394 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
1998

Endothelial cells cultured from human brain microvessels produce complement proteins factor H, factor B, C1 inhibitor, and C4

Vastag, M., Skopál, J., Kramer, J., Kolev, K., Vokó, Z., Csonka, É., Machovich, R. & Nagy, Z., Jul 1998, In : Immunobiology. 199, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Fibrinolysis with des-kringle derivatives of plasmin and its modulation by plasma protease inhibitors

Komorowicz, E., Kolev, K. & Machovich, R., Jun 23 1998, In : Biochemistry. 37, 25, p. 9112-9118 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Flow rate-modulated dissolution of fibrin with clot-embedded and circulating proteases

Komorowicz, E., Kolev, K., Léránt, I. & Machovich, R., Jun 1 1998, In : Circulation research. 82, 10, p. 1102-1108 7 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Perturbation of the integrity of the blood-brain barrier by fibrinolytic enzymes

Nagy, Z., Kolev, K., Csonka, É., Vastag, M. & Machovich, R., Jan 1 1998, In : Blood Coagulation and Fibrinolysis. 9, 6, p. 471-478 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
12 Citations (Scopus)
1997

A fibrinolysis alternatív útjai.

Translated title of the contribution: Alternative ways of fibrinolysisMachovich, R., Nov 23 1997, In : Orvosi hetilap. 138, 47, p. 2975-2979 5 p.

Research output: Contribution to journalArticle

Denatured proteins as cofactors for plasminogen activation

Machovich, R. & Owen, W. G., Aug 15 1997, In : Archives of Biochemistry and Biophysics. 344, 2, p. 343-349 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Functional evaluation of the structural features of proteases and their substrate in fibrin surface degradation

Kolev, K., Tenekedjiev, K., Komorowicz, E. & Machovich, R., May 23 1997, In : Journal of Biological Chemistry. 272, 21, p. 13666-13675 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Myosin as cofactor and substrate in fibrinolysis

Machovich, R., Ajtai, K., Kolev, K. & Owen, W. G., Apr 21 1997, In : FEBS letters. 407, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1996

Human brain microvessel endothelial cell culture as a model system to study vascular factors of ischemic brain

Nagy, Z., Vastag, M., Skopál, J., Kolev, K., Machovich, R., Krámer, J., Karádi, I. & Tóth, M., Sep 1996, In : Keio Journal of Medicine. 45, 3, p. 200-206 7 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Quantitative comparison of fibrin degradation with plasmin, miniplasmin, neurophil leukocyte elastase and cathepsin G

Kolev, K., Komorowicz, E., Owen, W. G. & Machovich, R., Jan 1 1996, In : Thrombosis and Haemostasis. 75, 1, p. 140-146 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
1995

Contraction of human brain endothelial cells induced by thrombogenic and fibrinolytic factors: An in vitro cell culture model

Nagy, Z., Kolev, K., Csonka, E., Pek, M. & Machovich, R., Feb 1995, In : Stroke. 26, 2, p. 265-270 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Dual effect of synthetic plasmin substrates on plasminogen activation

Kolev, K., Owen, W. G. & Machovich, R., Mar 15 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1247, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Endotoxin and fibrinogen degradation product-D have different actions on carbohydrate metabolism: role of Kupffer cells

Mandl, J., Wall, C., Lerant, I., Falus, A., Machovich, R. & Thurman, R. G., Nov 27 1995, In : FEBS letters. 376, 1-2, p. 65-66 2 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
18 Citations (Scopus)
1994

Blood coagulation is inhibited by sulphated copolymers of vinyl alcohol and acrylic acid under in vitro as well as in vivo conditions

Csomor, K., Kárpáti, E., Nagy, M., Györgyi-Edelényi, J. & Machovich, R., May 15 1994, In : Thrombosis research. 74, 4, p. 389-398 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
6 Citations (Scopus)

Monocyte tissue factor induction by lipopolysaccharide (LPS): Dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein

Mészáros, K., Aberle, S., Dedrick, R., Machovich, R., Horwitz, A., Birr, C., Theofan, G. & Brian Parent, J., May 1 1994, In : Blood. 83, 9, p. 2516-2525 10 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Regulation of fibrinolytic activity of neutrophil leukocyte elastase, plasmin, and miniplasmin by plasma protease inhibitors

Kolev, K., Léránt, I., Tenekejiev, K. & Machovich, R., Jun 24 1994, In : Journal of Biological Chemistry. 269, 25, p. 17030-17034 5 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
1993

Facilitation of plasminogen activation by a plasmin substrate containing a lysyl residue

Machovich, R. & Owen, W. G., Jan 1 1993, In : Thrombosis and Haemostasis. 70, 5, p. 864-866 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1992

Requirement of Zymogen Modification for Activation of Porcine Plasminogen

Machovich, R., Litwiller, R. D. & Owen, W. G., Feb 1 1992, In : Biochemistry. 31, 46, p. 11558-11561 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1990
5 Citations (Scopus)

Interaction of thrombin with endothelial cells in the presence of fibrinogen and α2-macroglobulin

Lerant, I., Kovacs, T., Papp, B., Mandl, J., Lambin, P. & Machovich, R., Dec 1 1990, In : Haematologia. 23, 3, p. 161-169 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neutrophil proteases in plasminogen activation.

Machovich, R., Himer, A. & Owen, W. G., Aug 1990, In : Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)