• 6877 Citations
  • 34 h-Index
1990 …2016
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Research Output 1990 2016

  • 6877 Citations
  • 34 h-Index
  • 73 Article
  • 1 Comment/debate
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Article
2016
17 Citations (Scopus)
Inositol
Epidermal Growth Factor Receptor
Signal Transduction
Biosensing Techniques
Type C Phospholipases
28 Citations (Scopus)

Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-golgi junctions

Sohn, M., Ivanova, P., Brown, H. A., Toth, D. J., Várnai, P., Kim, Y. J. & Balla, T., Apr 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 16, p. 4314-4319 6 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Cell Membrane
Mutation
Short Rib-Polydactyly Syndrome
Enzymes
2015
13 Citations (Scopus)

Investigation of the fate of type I angiotensin receptor after biased activation

Szakadáti, G., Tóth, A. D., Oláh, I., Erdélyi, L. S., Balla, T., Várnai, P., Hunyady, L. & Balla, A., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 972-981 10 p.

Research output: Contribution to journalArticle

Arrestin
Angiotensin Receptors
Endocytosis
Angiotensin II
rab5 GTP-Binding Proteins
12 Citations (Scopus)

Measurement of inositol 1,4,5-trisphosphate in living cells using an improved set of resonance energy transfer-based biosensors

Gulyás, G., Tóth, J., Tóth, D. J., Kurucz, I., Hunyady, L., Balla, T. & Várnai, P., May 1 2015, In : PLoS One. 10, 5, e0125601.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
biosensors
Energy Transfer
Biosensing Techniques
energy transfer
30 Citations (Scopus)

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis

Naghdi, S., Várnai, P. & Hajnóczky, G., Oct 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 41, p. E5590-E5599

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Zebrafish
Fibroblasts
Apoptosis
Ion Transport
13 Citations (Scopus)

Mutation in the V2 vasopressin receptor gene, AVPR2, causes nephrogenic syndrome of inappropriate diuresis

Erdélyi, L. S., Mann, W. A., Morris-Rosendahl, D. J., Groß, U., Nagel, M., Várnai, P., Balla, A. & Hunyady, L., Nov 1 2015, In : Kidney International. 88, 5, p. 1070-1078 9 p.

Research output: Contribution to journalArticle

Vasopressin Receptors
Diuresis
Arrestin
Mutation
Cyclic AMP
66 Citations (Scopus)

Trans-mitochondrial coordination of cristae at regulated membrane junctions

Picard, M., McManus, M. J., Csordás, G., Várnai, P., Dorn, G. W., Williams, D., Hajnóczky, G. & Wallace, D. C., Feb 17 2015, In : Nature Communications. 6, 6259.

Research output: Contribution to journalArticle

Mitochondria
mitochondria
membranes
Membranes
organelles
2014
8 Citations (Scopus)
Nephrogenic Diabetes Insipidus
Arrestin
Deamino Arginine Vasopressin
Vasopressin Receptors
Hemagglutinins
30 Citations (Scopus)

Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion

Weaver, D., Eisner, V., Liu, X., Várnai, P., Hunyady, L., Gross, A. & Hajnóczky, G., Jun 5 2014, In : Molecular Cell. 54, 5, p. 870-878 9 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Membranes
Membrane Proteins
Mitochondrial Proteins
Mitochondria
22 Citations (Scopus)

Improved methodical approach for quantitative BRET analysis of G protein coupled receptor dimerization

Szalai, B., Hoffmann, P., Prokop, S., Erdélyi, L., Várnai, P. & Hunyady, L., Oct 17 2014, In : PLoS One. 9, 10, e109503.

Research output: Contribution to journalArticle

Bioluminescence
dimerization
Dimerization
Energy Transfer
G-Protein-Coupled Receptors
2012
18 Citations (Scopus)

Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor

Tóth, D. J., Tóth, J., Gulyás, G., Balla, A., Balla, T., Hunyady, L. & Várnai, P., Jun 15 2012, In : Journal of Cell Science. 125, 12, p. 3013 1 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor

Tóth, D. J., Tóth, J., Gulyás, G., Balla, A., Balla, T., Hunyady, L. & Várnai, P., May 1 2012, In : Journal of Cell Science. 125, 9, p. 2185-2197 13 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 4,5-Diphosphate
G-Protein-Coupled Receptors
Phosphatidylinositols
Endocytosis
Cell Membrane
30 Citations (Scopus)

Allosteric interactions within the AT 1 angiotensin receptor homodimer: Role of the conserved DRY motif

Szalai, B., Barkai, L., Turu, G., Szidonya, L., Várnai, P. & Hunyady, L., Aug 15 2012, In : Biochemical Pharmacology. 84, 4, p. 477-485 9 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Protein Subunits
Dimers
Bioluminescence
Conformations
33 Citations (Scopus)

Calcium transport across the inner mitochondrial membrane: Molecular mechanisms and pharmacology

Csordás, G., Várnai, P., Golenár, T., Sheu, S. S. & Hajnóczky, G., Apr 28 2012, In : Molecular and Cellular Endocrinology. 353, 1-2, p. 109-113 5 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Pharmacology
Calcium
Membranes
RNA Interference
13 Citations (Scopus)

Mapping of the localization of type 1 angiotensin receptor in membrane microdomains using bioluminescence resonance energy transfer-based sensors

Balla, A., Tóth, D. J., Soltész-Katona, E., Szakadáti, G., Erdélyi, L. S., Várnai, P. & Hunyady, L., Mar 16 2012, In : Journal of Biological Chemistry. 287, 12, p. 9090-9099 10 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Bioluminescence
Angiotensin Type 1 Receptor
Energy Transfer
Cell membranes
19 Citations (Scopus)

Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation

Yi, M., Weaver, D., Eisner, V., Várnai, P., Hunyady, L., Ma, J., Csordás, G. & Hajnóczky, G., Nov 2012, In : Cell Calcium. 52, 5, p. 355-365 11 p.

Research output: Contribution to journalArticle

Myoblasts
Sarcoplasmic Reticulum
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle Fibers
Endoplasmic Reticulum
2011
6 Citations (Scopus)
Bioluminescence
trans-Golgi Network
Energy Transfer
Biosensing Techniques
Biosensors
30 Citations (Scopus)

The effect of OPA1 on mitochondrial Ca 2+ signaling

Fülöp, L., Szanda, G., Enyedi, B., Várnai, P. & Spät, A., Sep 29 2011, In : PLoS One. 6, 9, e25199.

Research output: Contribution to journalArticle

Mitochondria
Membranes
uptake mechanisms
mitochondria
Autosomal Dominant Optic Atrophy
2010
146 Citations (Scopus)

Activation of STIM1-Orai1 involves an intramolecular switching mechanism

Korzeniowski, M. K., Manjarrés, I. M., Várnai, P. & Balla, T., Nov 16 2010, In : Science Signaling. 3, 148, ra82.

Research output: Contribution to journalArticle

Chemical activation
Molecules
Mutation
Stromal Interaction Molecule 1
Clamping devices
98 Citations (Scopus)
Phosphatidylinositols
Cell Membrane
Phosphoric Monoester Hydrolases
Vesicular Transport Adaptor Proteins
Phosphatidylinositol 4,5-Diphosphate
9 Citations (Scopus)

Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cells

Hargitai, D., Pataki, Á., Raffai, G., Füzi, M., Dankó, T., Csernoch, L., Várnai, P., Szigeti, G. & Zsembery, A., Jan 31 2010, In : Respiratory Physiology and Neurobiology. 170, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Purinergic P2X Receptors
Cystic Fibrosis
Adenosine Triphosphate
Epithelial Cells
Divalent Cations
363 Citations (Scopus)

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

Csordás, G., Várnai, P., Golenár, T., Roy, S., Purkins, G., Schneider, T. G., Balla, T. & Hajnóczky, G., Jul 2010, In : Molecular Cell. 39, 1, p. 121-132 12 p.

Research output: Contribution to journalArticle

Mitochondria
Calcium
Calcium Signaling
Cell Membrane
Apoptosis
88 Citations (Scopus)

Redox state of the endoplasmic reticulum is controlled by ero1l-alpha and intraluminal calcium

Enyedi, B., Várnai, P. & Geiszt, M., Sep 15 2010, In : Antioxidants and Redox Signaling. 13, 6, p. 721-729 9 p.

Research output: Contribution to journalArticle

Protein folding
Endoplasmic Reticulum
Disulfides
Oxidation-Reduction
Protein Disulfide-Isomerases
6 Citations (Scopus)

Relating underrepresented genomic DNA patterns and tiRNAs: The rule behind the observation and beyond

Cserzo, M., Turu, G., Várnai, P. & Hunyady, L., Sep 22 2010, In : Biology Direct. 5, 56.

Research output: Contribution to journalArticle

Transcription
RNA
Genomics
genomics
Untranslated RNA
2009
101 Citations (Scopus)

Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides

Korzeniowski, M. K., Popovic, M. A., Szentpetery, Z., Várnai, P., Stojilkovic, S. S. & Balla, T., Jul 31 2009, In : Journal of Biological Chemistry. 284, 31, p. 21027-21035 9 p.

Research output: Contribution to journalArticle

Cell membranes
Phosphatidylinositols
Phosphatidylinositol 4,5-Diphosphate
Cell Membrane
1-Phosphatidylinositol 4-Kinase
21 Citations (Scopus)

Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells

Szekeres, M., Turu, G., Orient, A., Szalai, B., Süpeki, K., Cserzo, M., Várnai, P. & Hunyady, L., Apr 29 2009, In : Molecular and Cellular Endocrinology. 302, 2, p. 244-253 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Zona Glomerulosa
Angiotensin II
Rats
Calcium-Calmodulin-Dependent Protein Kinases
48 Citations (Scopus)

Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptors

Turu, G., Várnai, P., Gyombolai, P., Szidonya, L., Offertaler, L., Bagdy, G., Kunos, G. & Hunyady, L., Jun 19 2009, In : Journal of Biological Chemistry. 284, 25, p. 16914-16921 8 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Cannabinoid Receptor CB1
Angiotensins
Transcriptional Activation
Endocannabinoids
123 Citations (Scopus)

STIM and Orai: the long-awaited constituents of store-operated calcium entry

Várnai, P., Hunyady, L. & Balla, T., Mar 2009, In : Trends in Pharmacological Sciences. 30, 3, p. 118-128 11 p.

Research output: Contribution to journalArticle

Calcium
Endoplasmic Reticulum
Molecules
Proteins
Cell membranes
50 Citations (Scopus)

Visualization of cellular phosphoinositide pools with GFP-fused protein-domains

Balla, T. & Várnai, P., 2009, In : Current Protocols in Cell Biology. SUPPL. 42

Research output: Contribution to journalArticle

Phosphatidylinositols
Membranes
Personnel Selection
Protein Domains
Eukaryotic Cells
2008
15 Citations (Scopus)
Prolactin-Releasing Hormone
Tyrosine 3-Monooxygenase
Rats
Brain
Brain Stem
105 Citations (Scopus)

c-Met must translocate to the nucleus to initiate calcium signals

Gomes, D. A., Rodrigues, M. A., Leite, M. F., Gomez, M. V., Várnai, P., Balla, T., Bennett, A. M. & Nathanson, M. H., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4344-4351 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Calcium
Cytoplasm
Karyopherins
Inositol 1,4,5-Trisphosphate
38 Citations (Scopus)

Live cell imaging of phosphoinositides with expressed inositide binding protein domains

Várnai, P. & Balla, T., Nov 2008, In : Methods. 46, 3, p. 167-176 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Carrier Proteins
Calcium Signaling
Inositol
Imaging techniques
119 Citations (Scopus)

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIα

Balla, A., Yeun, J. K., Várnai, P., Szentpetery, Z., Knight, Z., Shokat, K. M. & Balla, T., Feb 2008, In : Molecular Biology of the Cell. 19, 2, p. 711-721 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Maintenance
Cell Membrane
Hormones
2007
149 Citations (Scopus)

Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains

Cohen, L. A., Honda, A., Várnai, P., Brown, F. D., Balla, T. & Donaldson, J. G., Jun 2007, In : Molecular Biology of the Cell. 18, 6, p. 2244-2253 10 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Cell Membrane
Guanine Nucleotide Exchange Factors
COS Cells
GTP Phosphohydrolases
10 Citations (Scopus)

AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells

Szidonya, L., Süpeki, K., Karip, E., Turu, G., Várnai, P., Clark, A. J. L. & Hunyady, L., May 15 2007, In : Biochemical Pharmacology. 73, 10, p. 1582-1592 11 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
GTP-Binding Proteins
Angiotensin II
Signal Transduction
Signal transduction
202 Citations (Scopus)

Dual regulation of TRPV1 by phosphoinositides

Lukacs, V., Thyagarajan, B., Várnai, P., Balla, A., Balla, T. & Rohacs, T., Jun 27 2007, In : Journal of Neuroscience. 27, 26, p. 7070-7080 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols
Capsaicin
Type C Phospholipases
vanilloid receptor subtype 1
66 Citations (Scopus)

Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate

Van Zeijl, L., Ponsioen, B., Giepmans, B. N. G., Ariaens, A., Postma, F. R., Várnai, P., Balla, T., Divecha, N., Jalink, K. & Moolenaar, W. H., Jun 4 2007, In : Journal of Cell Biology. 177, 5, p. 881-891 11 p.

Research output: Contribution to journalArticle

Connexin 43
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols
Cell Communication
Phospholipases
40 Citations (Scopus)
Phosphatidylinositols
Visualization
Lipids
Membranes
Proteins
191 Citations (Scopus)
Cell membranes
Endoplasmic Reticulum
Visualization
Cell Membrane
Membranes
2006
597 Citations (Scopus)

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Szabadkai, G., Bianchi, K., Várnai, P., De Stefani, D., Wieckowski, M. R., Cavagna, D., Nagy, A. I., Balla, T. & Rizzuto, R., Dec 18 2006, In : Journal of Cell Biology. 175, 6, p. 901-911 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Voltage-Dependent Anion Channels
Inositol 1,4,5-Trisphosphate Receptors
Molecular Chaperones
Mitochondrial Membranes
110 Citations (Scopus)

Live cell imaging of phosphoinositide dynamics with fluorescent protein domains

Várnai, P. & Balla, T., Aug 2006, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1761, 8, p. 957-967 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Inositol
Lipids
Membranes
Cell Fractionation
31 Citations (Scopus)

Mitochondrial Ca2+ uptake with and without the formation of high-Ca2+ microdomains

Szanda, G., Koncz, P., Várnai, P. & Spät, A., Nov 2006, In : Cell Calcium. 40, 5-6, p. 527-537 11 p.

Research output: Contribution to journalArticle

Reticulum
Mitochondria
Angiotensin II
Cell Membrane
Luteal Cells
250 Citations (Scopus)

Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

Várnai, P., Thyagarajan, B., Rohacs, T. & Balla, T., Nov 6 2006, In : Journal of Cell Biology. 175, 3, p. 377-382 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
phosphoinositide 5-phosphatase
Tacrolimus Binding Protein 1A
Phosphatidylinositol 4,5-Diphosphate
Cell Membrane
705 Citations (Scopus)

Structural and functional features and significance of the physical linkage between ER and mitochondria

Csordás, G., Renken, C., Várnai, P., Walter, L., Weaver, D., Buttle, K. F., Balla, T., Mannella, C. A. & Hajnóczky, G., Sep 25 2006, In : Journal of Cell Biology. 174, 7, p. 915-921 7 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Cell Survival
Electron Microscope Tomography
Smooth Endoplasmic Reticulum
2005
169 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Cell Membrane
Down-Regulation
Cytoplasmic Vesicles
COS Cells
29 Citations (Scopus)

Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins

Lin, X., Várnai, P., Csordás, G., Balla, A., Nagai, T., Miyawaki, A., Balla, T. & Hajnóczky, G., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12820-12832 13 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Mitochondria
Inositol 1,4,5-Trisphosphate
Carrier Proteins
Calcium
36 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Ligands
Endoplasmic Reticulum
Nucleic Acid Regulatory Sequences
Second Messenger Systems
2004
19 Citations (Scopus)

The pleckstrin homology domain of phosphoinositide-specific phospholipase Cδ4 is not a critical determinant of the membrane localization of the enzyme

Lee, S. B., Várnai, P., Balla, A., Jalink, K., Rhee, S. G. & Balla, T., Jun 4 2004, In : Journal of Biological Chemistry. 279, 23, p. 24362-24371 10 p.

Research output: Contribution to journalArticle

Phospholipases
Phosphatidylinositols
Membranes
Enzymes
Programmable logic controllers
2003
4 Citations (Scopus)

Endocytosis of the AT1A angiotensin receptor is independent of ubiquitylation of its cytoplasmic serine/threonine-rich region

Mihalik, B., Gáborik, Z., Várnai, P., Clark, A. J. L., Catt, K. J. & Hunyady, L., Jun 1 2003, In : International Journal of Biochemistry and Cell Biology. 35, 6, p. 992-1002 11 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Ubiquitination
Threonine
Endocytosis
Serine
2002
95 Citations (Scopus)

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C δ1 and p130

Várnai, P., Lin, X., Lee, S. B., Tuymetova, G., Bondeva, T., Spät, A., Rhee, S. G., Czky, G. H. & Balla, T., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 27412-27422 11 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Inositol
Membrane Lipids
Green Fluorescent Proteins
Membranes