• 3159 Citations
  • 31 h-Index
1979 …2019

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Article
2009

Molecular modelling of subtypes (α2A, α2B and α2C) of α2-adrenoceptors: A comparative study

Balogh, B., Szilágyi, A., Gyires, K., Bylund, D. B. & Mátyus, P., Nov 1 2009, In : Neurochemistry international. 55, 6, p. 355-361 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pharmacological analysis of α2-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions

Gyires, K., Zádori, Z. S., Shujaa, N., Al-Khrasani, M., Pap, B., Mózes, M. M. & Mátyus, P., Jul 1 2009, In : InflammoPharmacology. 17, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

Van Baelen, G., Hostyn, S., Dhooghe, L., Tapolcsányi, P., Mátyus, P., Lemière, G., Dommisse, R., Kaiser, M., Brun, R., Cos, P., Maes, L., Hajós, G., Riedl, Z., Nagy, I., Maes, B. U. W. & Pieters, L., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7209-7217 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2008

European medicinal chemistry education: The transformational accomplishments and challenges

Cristalli, G., Mátyus, P., Mohr, P., Ronsisvalle, G., De Souza, N. J. & Tsantili-Kakoulidou, A., Apr 14 2008, In : ChemMedChem. 3, 4, p. 561-563 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel extensions of the tert-amino effect: Formation of phenanthridines and diarene-fused azocines from ortho-ortho′-functionalized biaryls

Polonka-Bálint, Á., Saraceno, C., Ludányi, K., Bényei, A. & Mátyus, P., Nov 14 2008, In : Synlett. 18, p. 2846-2850 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Pd-catalyzed intramolecular direct arylations at high temperature

Franck, P., Hostyn, S., Dajka-Halász, B., Polonka-Bálint, Á., Monsieurs, K., Mátyus, P. & Maes, B. U. W., Jun 23 2008, In : Tetrahedron. 64, 26, p. 6030-6037 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Study of tert-amino effect: The role of substituents in isomerization of 5-amino-4-vinyl-3(2H)-pyridazinones

Dajka-Halász, B., Földi, Á. A., Ludányi, K. & Mátyusa, P., 2008, In : Arkivoc. 2008, 3, p. 102-126 25 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
17 Citations (Scopus)
35 Citations (Scopus)

α2B-adrenoceptor agonist ST-91 antagonizes β2-adrenoceptor-mediated relaxation in rat mesenteric artery rings

Kató, E., Lipták, L., Shujaa, N., Mátyus, P., Gyires, K. & Rónai, A. Z., Feb 12 2008, In : European Journal of Pharmacology. 580, 3, p. 361-365 5 p.

Research output: Contribution to journalArticle

2007

3D QSAR models for α2a-adrenoceptor agonists

Balogh, B., Jójárt, B., Wágner, Z., Kovács, P., Máté, G., Gyires, K., Zádori, Z., Falkay, G., Márki, Á., Viskolcz, B. & Mátyus, P., Oct 1 2007, In : Neurochemistry international. 51, 5, p. 268-276 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Analysis of the role of central and peripheral α2-adrenoceptor subtypes in gastric mucosal defense in the rat

Gyires, K., Zádori, Z. S., Shujaa, N., Minorics, R., Falkay, G. & Mátyus, P., Oct 1 2007, In : Neurochemistry international. 51, 5, p. 289-296 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Is samoquasine A indeed benzo[f]phthalazin-4(3H)-one? Unambiguous, straightforward synthesis of benzo[f]phthalazin-4(3H)-one and its regioisomer benzo[f]phthalazin-1(2H)-one

Monsieurs, K., Tapolcsányi, P., Loones, K. T. J., Neumajer, G., Dirk De Ridder, J. A., Goubitz, K., Lemière, G. L. F., Dommisse, R. A., Mátyus, P. & Maes, B. U. W., Apr 30 2007, In : Tetrahedron. 63, 18, p. 3870-3881 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structure-based calculation of binding affinities of α2A- adrenoceptor agonists

Balogh, B., Hetényi, C., Keseru, M. G. & Mátyus, P., Jun 11 2007, In : ChemMedChem. 2, 6, p. 801-805 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2006

Novel antiarrhythmic compounds with combined class IB and class III mode of action

Mátyus, P., Varga, I., Rettegi, T., Simay, A., Kovács, P., Károlyházy, L., Kocsis, Á., Vajda, S., Varró, A., Pénzes, I. & Papp, J. G., Jan 2006, In : Frontiers in Medicinal Chemistry. 3, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of novel 1-methyl-1H-pyridazino[3,4-b]indoles

Riedl, Z., Monsieurs, K., Krajsovszky, G., Dunkel, P., Maes, B. U. W., Tapolcsányi, P., Egyed, O., Boros, S., Mátyus, P., Pieters, L., Lemière, G. L. F. & Hajós, G., Jan 2 2006, In : Tetrahedron. 62, 1, p. 121-129 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synthesis of substituted phenanthrenes via intramolecular condensation based on temperature-dependent deprotonation using a weak carbonate base

Monsieurs, K., Rombouts, G., Tapolcsányi, P., Mátyus, P. & Maes, B. U. W., Dec 1 2006, In : Synlett. 19, p. 3225-3230 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats

Benedek, A., Móricz, K., Jurányi, Z., Gigler, G., Lévay, G., Hársing, L. G., Mátyus, P., Szénási, G. & Albert, M., Oct 20 2006, In : Brain research. 1116, 1, p. 159-165 7 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
2005

Alignment-free descriptors for quantitative structure-rate constant relationships of [4+2] cycloadditions

Borosy, A. P., Balogh, B. & Mátyus, P., Sep 30 2005, In : Journal of Molecular Structure: THEOCHEM. 729, 3, p. 169-176 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect

Kaval, N., Halasz-Dajka, B., Vo-Thanh, G., Dehaen, W., Van Der Eycken, J., Mátyus, P., Loupy, A. & Van Der Eycken, E., Sep 19 2005, In : Tetrahedron. 61, 38, p. 9052-9057 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Cyclizations to new azolopyridazines and related ring systems

Hajós, G., Riedl, Z., Mátyus, P., Maes, B. U. W. & Lemière, G. L. F., Apr 2005, In : Journal of Heterocyclic Chemistry. 42, 3, p. 421-426 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound

Van Miert, S., Hostyn, S., Maes, B. U. W., Cimanga, K., Brun, R., Kaiser, M., Mátyus, P., Dommisse, R., Lemière, G., Vlietinck, A. & Pieters, L., May 1 2005, In : Journal of Natural Products. 68, 5, p. 674-677 4 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Reaction of chloropyridazin-3(2H)-ones with iodide. Part I. A mechanistic study

Krajsovszky, G., Károlyházy, L., Riedl, Z., Csámpai, A., Dunkel, P., Lernyei, Á., Dajka-Halász, B., Hajós, G. & Mátyus, P., Jan 14 2005, In : Journal of Molecular Structure: THEOCHEM. 713, 1-3, p. 235-243 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis of the benzo-β-carboline isoneocryptolepine: The missing indoloquinoline isomer in the alkaloid series cryptolepine, neocryptolepine and isocryptolepine

Hostyn, S., Maes, B. U. W., Pieters, L., Lemière, G. L. F., Mátyus, P., Hajós, G. & Dommisse, R. A., Feb 7 2005, In : Tetrahedron. 61, 6, p. 1571-1577 7 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2004

A 5-HT 7 heteroreceptor-mediated inhibition of [ 3H]serotonin release in raphe nuclei slices of the rat: Evidence for a serotonergic-glutamatergic interaction

Harsing, L. G., Prauda, I., Barkoczy, J., Matyus, P. & Juranyi, Z., Aug 1 2004, In : Neurochemical research. 29, 8, p. 1487-1497 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Convenient and rapid microwave-assisted synthesis of pyrido-fused ring systems applying the tert-amino effect

Kaval, N., Dehaen, W., Mátyus, P. & Van der Eycken, E., Mar 4 2004, In : Green Chemistry. 6, 3, p. 125-127 3 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

New pathways towards pyridazino-fused ring systems

Mátyus, P., Maes, B. U. W., Riedl, Z., Hajós, G., Lemière, G. L. F., Tapolcsányi, P., Monsieurs, K., Éliás, O., Dommisse, R. A. & Krajsovszky, G., Jun 3 2004, In : Synlett. 7, p. 1123-1139 17 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Synthesis of 5H-pyridazino[4,5-b]indoles and their benzofurane analogues utilizing an intramolecular Heck-type reaction

Dajka-Halász, B., Monsieurs, K., Éliás, O., Károlyházy, L., Tapolcsányi, P., Maes, B. U. W., Riedl, Z., Hajós, G., Dommisse, R. A., Lemière, G. L. F., Košmrlj, J. & Mátyus, P., Mar 1 2004, In : Tetrahedron. 60, 10, p. 2283-2291 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2003

Generation and analysis of the conformational potential energy surfaces of N-acetyl-N-methyl-L-alanine-N′-methylamide. An exploratory ab initio study

Bágyi, I., Balogh, B., Czajlik, A., Éliás, O., Gáspári, Z., Gergely, V., Hudáky, I., Hudáky, P., Kalászi, A., Károlyházy, L., Keserû, K., Kiss, R., Krajsovszky, G., Láng, B., Nagy, T., Rácz, Á., Szentesi, A., Tábi, T., Tapolcsányi, P., Vaik, J. & 5 others, Koo, J. C. P., Chass, G. A., Farkas, Ö., Perczel, A. & Mátyus, P., May 5 2003, In : Journal of Molecular Structure: THEOCHEM. 625, 1-3, p. 121-136 16 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Hydroformylation of styrene in the presence of rhodium-2,4,6-trialkylphenyl-phosphole in situ catalytic systems

Keglevich, G., Kégl, T., Chuluunbaatar, T., Dajka, B., Mátyus, P., Balogh, B. & Kollár, L., Jun 2 2003, In : Journal of Molecular Catalysis A: Chemical. 200, 1-2, p. 131-136 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Lipophilicity of aminopyridazinone regioisomers

Anwair, M. A. S., Károlyházy, L., Szabó, D., Balogh, B., Kövesdi, I., Harmat, V., Krenyácz, J., Gellért, Á., Takács-Novák, K. & Mátyus, P., Aug 27 2003, In : Journal of Agricultural and Food Chemistry. 51, 18, p. 5262-5270 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Novel ortho- and peri-fused pyridazine ring systems

Éliás, O., Károlyházy, L., Horváth, G., Harmat, V. & Mátyus, P., Dec 29 2003, In : Journal of Molecular Structure: THEOCHEM. 666-667, p. 625-636 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis, in vitro/in vivo Antifungal Evaluation and Structure-Activity Relationship Study of 3(2H)-Pyridazinones

Károlyházy, L., Freile, M., Anwair, M. N. S., Beke, G., Giannini, F., Castelli, M. V., Sortino, M., Ribas, J. C., Zacchino, S., Mátyus, P. & Enriz, R. D., Nov 13 2003, In : Arzneimittel-Forschung/Drug Research. 53, 10, p. 738-743 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis of new polyfused heterocycles of biological importance by means of Pd(O) catalysis

Hajós, G., Riedl, Z., Timári, G., Mátyus, P., Maes, B. U. W. & Lemière, G. L. F., Jun 2003, In : Molecules. 8, 6, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Synthesis of the dibenzo[f,h]phthalazine and dibenzo[f,h]cinnoline skeleton via a 'Suzuki-Pd-catalyzed intramolecular arylation' and a 'Suzuki-Pschorr' approach

Tapolcsányi, P. A., Maes, B. U. W., Monsieurs, K., Lemière, G. L. F., Riedl, Z., Hajós, G., Van Den Driessche, B., Dommisse, R. A. & Mátyus, P., Jul 28 2003, In : Tetrahedron. 59, 31, p. 5919-5926 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The glycine transporter-1 inhibitors NFPS and Org 24461: A pharmacological study

Harsing, L. G., Gacsalyi, I., Szabo, G., Schmidt, E., Sziray, N., Sebban, C., Tesolin-Decros, B., Matyus, P., Egyed, A., Spedding, M. & Levay, G., Mar 2003, In : Pharmacology Biochemistry and Behavior. 74, 4, p. 811-825 15 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Thermochemical study on the ring closure reaction of 5-morpholino-4- vinylpyridazinones by tert-amino effect

Károlyházy, L., Regdon, G., Éliás, O., Beke, G., Tábi, T., Hódi, K., Eros, I. & Mátyus, P., Dec 29 2003, In : Journal of Molecular Structure: THEOCHEM. 666-667, p. 667-680 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2002

A szemikarbazid-szenzitív aminoxidáz enzim élettani és farmakológiai jelentosége

Translated title of the contribution: Semicarbazide-sensitive amine oxidase: Its physiological and pharmacological significanceKálmán, M., Zsuzsa, M. & Péter, M., Dec 1 2002, In : Orvoskepzes. 77, 3, p. 189-196 8 p.

Research output: Contribution to journalArticle

Lipophilicity of regioisomers: A case study on 3(2H)-pyridazinones

Károlyházy, L., Szabó, D., Anwair, M. A. S., Borosy, A. P., Takács-Novák, K. & Mátyus, P., Feb 14 2002, In : Journal of Molecular Structure: THEOCHEM. 578, 1-3, p. 89-91 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Recent development in the chemistry of 4,5-dihalo-3(2H)-pyridazinones

Tapolcsányi, P. & Mátyus, P., Jan 1 2002, In : Targets in Heterocyclic Systems. 6, p. 369-398 30 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis and stereochemistry of dispiro substituted pyridazines: Application of ellipticity-absorbance ratio spectra for proving enantiomeric relationship by HPLC-CD/UV detection

Beke, G., Gergely, A., Szász, G., Szentesi, A., Nyitray, J., Barabás, O., Harmath, V. & Mátyus, P., May 20 2002, In : Chirality. 14, 5, p. 365-371 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis of 4-aryl-5-hydroxy- and 5-aryl-4-hydroxypyridazin-3(2H)-ones and their use in the preparation of 4,5-diarylpyridazin-3(2H)-ones and hitherto unknown isochromeno[3,4-d]pyridazinediones

Maes, B. U. W., Monsieurs, K., Loones, K. T. J., Lemière, G. L. F., Dommisse, R., Mátyus, P., Riedl, Z. & Hajós, G., Nov 25 2002, In : Tetrahedron. 58, 48, p. 9713-9721 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Riedl, Z., Maes, B. U. W., Monsieurs, K., Lemière, G. L. F., Mátyus, P. & Hajós, G., Jul 8 2002, In : Tetrahedron. 58, 28, p. 5645-5650 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Synthesis of some diazino-fused tricyclic systems via Suzuki cross-coupling and regioselective nitrene insertion reactions

Tapolcsányi, P., Krajsovszky, G., Andó, R., Lipcsey, P., Horváth, G., Mátyus, P., Riedl, Z., Hajós, G., Maes, B. U. W. & Lemière, G. L. F., Dec 16 2002, In : Tetrahedron. 58, 51, p. 10137-10143 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
6 Citations (Scopus)
2001

3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent

Villa, S., Barlocco, D., Cignarella, G., Papp, G. J., Baláti, B., Takács, J., Varró, A., Borosy, A., Keserû, K. & Mátyus, P., Jun 1 2001, In : European Journal of Medicinal Chemistry. 36, 6, p. 495-506 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A theoretical study of the scavenging of O2 - by NO in the gas phase and in condensed media

Jensen, S. J. K., Mátyus, P., McAllister, M. A. & Csizmadia, I., Oct 4 2001, In : Journal of Physical Chemistry A. 105, 39, p. 9029-9033 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cardiovascular and related agents

Mátyus, P., Oct 25 2001, In : Pharmazie. 56, SUPPL. 1, p. S50-S55

Research output: Contribution to journalArticle

4 Citations (Scopus)
9 Citations (Scopus)

Dynamic chirality in selected diaryl methane containing drugs. An exploratory ab initio conformational study

Villagra, S. E., Santillán, M. B., Rodríguez, A. M., Chasse, G. A., Freile, M. L., Zacchino, S., Mátyus, P. & Enriz, R. D., Aug 13 2001, In : Journal of Molecular Structure: THEOCHEM. 549, 3, p. 217-228 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)