• 3125 Citations
  • 30 h-Index
1979 …2019

Research output per year

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Research Output

2019

1,2-Dihydrochromeno[2,3-c]pyrrol-3-one Derivatives: Synthesis and HPLC-ECD Analysis

Tóth, L., Kiss-Szikszai, A., Vasvári, G., Fenyvesi, F., Vecsernyés, M., Mátyus, P., Antus, S., Mándi, A. & Kurtán, T., Jan 1 2019, In : Synlett. 30, 7, p. 799-803 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chemically modified derivatives of the activator compound cloxyquin exert inhibitory effect on TRESK (K2P18.1) background potassium channel

Lengyel, M., Erdélyi, F., Pergel, E., Bálint-Polonka, Á., Dobolyi, A., Bozsaki, P., Dux, M., Király, K., Hegedüs, T., Czirják, G., Mátyus, P. & Enyedi, P., Jan 1 2019, In : Molecular pharmacology. 95, 6, p. 652-660 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018
6 Citations (Scopus)

HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo[1,2-a]quinoline derivatives

Tóth, L., Mándi, A., Váradi, D., Kovács, T., Szabados, A., Kiss-Szikszai, A., Gong, Q., Zhang, H., Mátyus, P., Antus, S. & Kurtán, T., Jul 2018, In : Chirality. 30, 7, p. 866-874 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle

Gurabi, Z., Patocskai, B., Györe, B., Virág, L., Mátyus, P., Papp, J., Varró, A. & Koncz, I., Jan 1 2017, In : Canadian Journal of Physiology and Pharmacology. 95, 7, p. 830-836 7 p.

Research output: Contribution to journalArticle

Remarkable regioselectivities in the course of the synthesis of two new Luotonin A derivatives

Atia, M., Bogdán, D., Brügger, M., Haider, N. & Mátyus, P., Jan 1 2017, In : Tetrahedron. 73, 23, p. 3231-3239 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

Meleddu, R., Distinto, S., Cirilli, R., Alcaro, S., Yanez, M., Sanna, M. L., Corona, A., Melis, C., Bianco, G., Mátyus, P., Cottiglia, F. & Maccioni, E., Dec 1 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 264-270 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

A novel 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist

Payrits, M., Sághy, Mátyus, P., Czompa, A., Ludmerczki, R., Deme, R., Sándor, Z., Helyes, Z. & Szöke, E., Jun 2 2016, In : Neuroscience. 324, p. 151-162 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dietary Phenolic Compounds Interfere with the Fate of Hydrogen Peroxide in Human Adipose Tissue but Do Not Directly Inhibit Primary Amine Oxidase Activity

Carpéné, C., Hasnaoui, M., Balogh, B., Matyus, P., Fernández-Quintela, A., Rodríguez, V., Mercader, J. & Portillo, M. P., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 2427618.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida

Meleddu, R., Distinto, S., Corona, A., Maccioni, E., Arridu, A., Melis, C., Bianco, G., Mátyus, P., Cottiglia, F., Sanna, A. & De Logu, A., Jan 7 2016, (Accepted/In press) In : Journal of Enzyme Inhibition and Medicinal Chemistry. p. 1-6 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Light-Enhanced Fluorescence of Multi-Level Cavitands Possessing Pyridazine Upper rim

Janosi, T. Z., Makkai, G., Kegl, T., Mátyus, P., Kollár, L. & Erostyak, J., Mar 1 2016, In : Journal of Fluorescence. 26, 2, p. 679-688 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development

Mátyus, P. & Chai, C. L. L., Jun 20 2016, In : ChemMedChem. p. 1197-1198 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

Baranyi, M., Porceddu, P. F., Gölöncsér, F., Kulcsár, S., Otrokocsi, L., Kittel, A., Pinna, A., Frau, L., Huleatt, P. B., Khoo, M. L., Chai, C. L. L., Dunkel, P., Mátyus, P., Morelli, M. & Sperlágh, B., Jan 13 2016, (Accepted/In press) In : Molecular Neurodegeneration.

Research output: Contribution to journalArticle

19 Citations (Scopus)

One size does not fit all: Challenging some dogmas and taboos in drug discovery

Chai, C. L. L. & Mátyus, P., Jan 1 2016, In : Future Medicinal Chemistry. 8, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
6 Citations (Scopus)

Versatile synthesis of novel tetrahydroquinolines as potentially active semicarbazide-sensitive amine oxidase (SSAO) inhibitors via tert-Amino effect

Deme, R., Schlich, M., Mucsi, Z., Karvaly, G., Tóth, G. & Mátyus, P., Sep 21 2016, In : Arkivoc. 2016, 5, p. 164-196 33 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

Meleddu, R., Distinto, S., Corona, A., Bianco, G., Cannas, V., Esposito, F., Artese, A., Alcaro, S., Matyus, P., Bogdan, D., Cottiglia, F., Tramontano, E. & Maccioni, E., Mar 26 2015, In : European Journal of Medicinal Chemistry. 93, p. 452-460 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Analysis of Edg-Like LPA receptor-ligand interactions

Balogh, B., Pazmany, T. & Matyus, P., Aug 1 2015, In : Current pharmaceutical design. 21, 24, p. 3533-3547 15 p.

Research output: Contribution to journalArticle

Anti-inflammatory effects of a triple-bond resveratrol analog: Structure and function relationship

Antus, C., Radnai, B., Dombovari, P., Fonai, F., Avar, P., Matyus, P., Racz, B., Sumegi, B. & Veres, B., Feb 5 2015, In : European Journal of Pharmacology. 748, p. 61-67 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

Huleatt, P. B., Khoo, M. L., Chua, Y. Y., Tan, T. W., Liew, R. S., Balogh, B., Deme, R., Gölöncsér, F., Magyar, K., Sheela, D. P., Ho, H. K., Sperlágh, B., Mátyus, P. & Chai, C. L. L., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1400-1419 20 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Sarcosine-based glycine transporter type-1 (GlyT-1) inhibitors containing pyridazine moiety: A further search for drugs with potential to influence schizophrenia negative symptoms

Harsing, L. G., Timar, J., Szabo, G., Udvari, S., Nagy, K. M., Marko, B., Zsilla, G., Czompa, A., Tapolcsanyi, P., Kocsis, A. & Matyus, P., May 1 2015, In : Current pharmaceutical design. 21, 17, p. 2291-2303 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action

Parrino, B., Carbone, A., Ciancimino, C., Spanò, V., Montalbano, A., Barraja, P., Cirrincione, G., Diana, P., Sissi, C., Palumbo, M., Pinato, O., Pennati, M., Beretta, G., Folini, M., Matyus, P., Balogh, B. & Zaffaroni, N., Apr 13 2015, In : European Journal of Medicinal Chemistry. 94, p. 149-162 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2014

Early repositioning through compound set enrichment analysis: A knowledge-recycling strategy

Temesi, G., Bolgár, B., Arany, Á., Szalai, C., Antal, P. & Mátyus, P., Apr 2014, In : Future Medicinal Chemistry. 6, 5, p. 563-575 13 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

'Interrupted' diazotization of 3-aminoindoles and 3-aminopyrroles

Parrino, B., Spanò, V., Carbone, A., Montalbano, A., Barraja, P., Màtyus, P., Cirrincione, G. & Diana, P., Jan 1 2014, In : Tetrahedron. 70, 40, p. 7318-7321 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- And diastereoselective domino knoevenagel-[1,5]-hydride shift cyclization reaction

Tóth, L., Fu, Y., Zhang, H. Y., Mándi, A., Kövér, K. E., Illyés, T. Z., Kiss-Szikszai, A., Balogh, B., Kurtán, T., Antus, S. & Mátyus, P., Nov 6 2014, In : Beilstein Journal of Organic Chemistry. 10, p. 2594-2602 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells

Kósa, J. P., Horváth, P., Wölfing, J., Kovács, D., Balla, B., Mátyus, P., Horváth, E., Speer, G., Takács, I., Nagy, Z., Horváth, H. & Lakatos, P., May 7 2013, In : World journal of gastroenterology. 19, 17, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Drug repositioning for treatment of movement disorders: From serendipity to rational discovery strategies

Bolgár, B., Arany, Á., Temesi, G., Balogh, B., Antal, P. & Mátyus, P., Nov 25 2013, In : Current topics in medicinal chemistry. 13, 18, p. 2337-2363 27 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Imidazoline versus alpha2-adrenoceptors in the control of gastric motility in mice

Zádori, Z. S., Fehér, Á., Al-Khrasani, M., Lackó, E., Tóth, V. E., Brancati, S. B., Hein, L., Mátyus, P. & Gyires, K., Apr 5 2013, In : European Journal of Pharmacology. 705, 1-3, p. 61-67 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Lack of association between VAP-1/SSAO activity and corneal neovascularization in a rabbit model

Énzsöly, A., Markó, K., Tábi, T., Szöko, É., Zelkó, R., Tóth, M., Mark Petrash, J., Mátyus, P. & Németh, J., Jun 1 2013, In : Journal of neural transmission. 120, 6, p. 969-975 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
35 Citations (Scopus)

Multi-aspect candidates for repositioning: Data fusion methods using heterogeneous information sources

Arany, Á., Bolgár, B., Balogh, B., Antal, P. & Mátyus, P., Jan 1 2013, In : Current medicinal chemistry. 20, 1, p. 95-107 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation

Tábi, T., Szöko, É., Mérey, A., Tóth, V., Mátyus, P. & Gyires, K., Jun 1 2013, In : Journal of neural transmission. 120, 6, p. 963-967 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina

Kertesz, S., Szabo, G., Udvari, S., Levay, G., Matyus, P. & Harsing, L. G., Jan 25 2013, In : Brain research. 1492, p. 1-6 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Towards dual antithrombotic compounds-Balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4- benzodioxine derivatives through regio- and stereoisomerism

Ilić, M., Dunkel, P., Ilaš, J., Chabielska, E., Zakrzeska, A., Mátyus, P. & Kikelj, D., Apr 1 2013, In : European Journal of Medicinal Chemistry. 62, p. 329-340 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012
58 Citations (Scopus)

Functionalization of the pyridazin-3(2H)-one ring via palladium-catalysed aminocarbonylation

Takács, A., Czompa, A., Krajsovszky, G., Mátyus, P. & Kollár, L., Sep 23 2012, In : Tetrahedron. 68, 38, p. 7855-7860 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
6 Citations (Scopus)

Interactions between glycine transporter type 1 (GlyT-1) and some inhibitor molecules - Glycine transporter type 1 and its inhibitors (Review)

Harsing, L. G., Zsilla, G., Matyus, P., Nagy, K. M., Marko, B., Gyarmati, Z. & Timar, J., Mar 1 2012, In : Acta physiologica Hungarica. 99, 1, p. 1-17 17 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis

Ilić, M., Ilaš, J., Dunkel, P., Mátyus, P., Boháč, A., Liekens, S. & Kikelj, D., Dec 1 2012, In : European Journal of Medicinal Chemistry. 58, p. 160-170 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Study on the scope of tert-amino effect: New extensions of type 2 reactions to bridged biaryls

Bottino, P., Dunkel, P., Schlich, M., Galavotti, L., Deme, R., Regdon, G., Bényei, A., Pintye-Hódi, K., Ronsisvalle, G. & Mátyus, P., Nov 1 2012, In : Journal of Physical Organic Chemistry. 25, 11, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2011

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

MacCioni, E., Alcaro, S., Cirilli, R., Vigo, S., Cardia, M. C., Sanna, M. L., Meleddu, R., Yanez, M., Costa, G., Casu, L., Matyus, P. & Distinto, S., Sep 22 2011, In : Journal of Medicinal Chemistry. 54, 18, p. 6394-6398 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Lipase-catalyzed synthesis of both enantiomers of 3-chloro-1-arylpropan-1- ols

Pop, L. A., Czompa, A., Paizs, C., Toa, M. I., Vass, E., Mátyus, P. & Irimie, F. D., Aug 4 2011, In : Synthesis. 18, p. 2921-2928 8 p., T49711SS.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization

Énzsöly, A., Dunkel, P., Récsán, Z., Gyorffy, H., Tóth, J., Marics, G., Bori, Z., Tóh, M., Zelkó, R., Di Paolo, M. L., Mátyus, P. & Németh, J., Jul 1 2011, In : Journal of neural transmission. 118, 7, p. 1065-1069 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1: A patent survey

Dunkel, P., Balogh, B., Meleddu, R., MacCioni, E., Gyires, K. & Mátyus, P., Sep 1 2011, In : Expert Opinion on Therapeutic Patents. 21, 9, p. 1453-1471 19 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Suzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring-closure tandem reactions for synthesis of fused nitrogen-containing ring systems

Krajsovszky, G., Károlyházy, L., Dunkel, P., Boros, S., Grillo, A. & Mátyus, P., Sep 21 2011, In : Arkivoc. 2011, 10, p. 229-253 25 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Synthesis and antiproliferative activity of 2-(([1,2,4]triazolo[4,3-b]- pyridazin-6-yloxy)methyl)-2,4-dimethyl-3,4-dihydro-2Hbenzo[b][1,4]oxazine derivatives

Ilić, M., Ilaš, J., Liekens, S., Mátyus, P. & Kikelj, D., Oct 23 2011, In : Arkivoc. 2011, 10, p. 298-311 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
7 Citations (Scopus)
2010

Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone

Nagy, K., Marko, B., Zsilla, G., Matyus, P., Pallagi, K., Szabo, G., Juranyi, Z., Barkoczy, J., Levay, G. & Harsing, L. G., Dec 1 2010, In : Neurochemical research. 35, 12, p. 2096-2106 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Cyclisation reactions of some pyridazinylimidoylketenes

Gaywood, A. P., Hill, L., Imam, S. H., McNab, H., Neumajer, G., O'Neill, W. J. & Mátyus, P., Feb 12 2010, In : New Journal of Chemistry. 34, 2, p. 236-242 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Reaction of chloropyridazin-3(2H)-ones with iodide ion. Part II

Károlyházy, L., Krajsovszky, G., Farkas, L., Boros, S., Csámpai, A. & Mátyusa, P., Nov 29 2010, In : Arkivoc. 2011, 2, 36991.

Research output: Contribution to journalArticle

1 Citation (Scopus)