• 2785 Citations
  • 32 h-Index
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Patterns of C1-Inhibitor/Plasma Serine Protease Complexes in Healthy Humans and in Hereditary Angioedema Patients

Kajdácsi, E., Jandrasics, Z., Veszeli, N., Makó, V., Koncz, A., Gulyás, D., Köhalmi, K. V., Temesszentandrási, G., Cervenak, L., Gál, P., Dobó, J., de Maat, S., Maas, C., Farkas, H. & Varga, L., May 5 2020, In : Frontiers in immunology. 11, 794.

Research output: Contribution to journalArticle

Open Access

Design and selection of novel C1s inhibitors by in silico and in vitro approaches

Szilágyi, K., Hajdú, I., Flachner, B., Lőrincz, Z., Balczer, J., Gál, P., Závodszky, P., Pirli, C., Balogh, B., Mándity, I. M., Cseh, S. & Dormán, G., Oct 9 2019, In : Molecules. 24, 20, 3641.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

Nagy, Z. A., Szakács, D., Boros, E., Héja, D., Vígh, E., Sándor, N., Józsi, M., Oroszlán, G., Dobó, J., Gál, P. & Pál, G., Jan 1 2019, In : PLoS Pathogens. 15, 12, e1008232.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

MASP-1 Increases Endothelial Permeability

Debreczeni, M. L., Németh, Z., Kajdácsi, E., Schwaner, E., Makó, V., Masszi, A., Doleschall, Z., Rigó, J., Walter, F. R., Deli, M. A., Pál, G., Dobó, J., Gál, P. & Cervenák, L., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MASP-1 of the complement system alters fibrinolytic behaviour of blood clots

Jenny, L., Noser, D., Larsen, J. B., Dobó, J., Gál, P., Pál, G. & Schroeder, V., Oct 2019, In : Molecular Immunology. 114, p. 1-9 9 p.

Research output: Contribution to journalArticle

Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors

Szakács, D., Kocsis, A., Szász, R., Gál, P. & Pál, G., May 17 2019, In : Journal of Biological Chemistry. 294, 20, p. 8227-8237 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Be on target: Strategies of targeting alternative and lectin pathway components in complement-mediated diseases

Dobó, J., Kocsis, A. & Gál, P., Aug 8 2018, In : Frontiers in Immunology. 9, AUG, 1851.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Cutting edge: A new player in the alternative complement pathway, MASP-1 is essential for LPS-induced, but not for zymosan-induced, alternative pathway activation

Parej, K., Kocsis, A., Enyingi, C., Dani, R., Oroszlan, G., Beinrohr, L., Dobo, J., Zavodszky, P., Pal, G. & Gal, P., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2247-2252 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model

Jenny, L., Dobó, J., Gál, P., Pál, G., Lam, W. A. & Schroeder, V., Jan 2018, In : PloS one. 13, 1, e0191292.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2017
7 Citations (Scopus)

Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1

Schwaner, E., Németh, Z., Jani, P. K., Kajdácsi, E., Debreczeni, M. L., Doleschall, Z., Dobó, J., Gál, P., Rigó, J., András, K., Hegedus, T. & Cervenak, L., Dec 1 2017, In : Scientific reports. 7, 1, 10462.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis

Pilely, K., Rosbjerg, A., Genster, N., Gal, P., Pal, G., Halvorsen, B., Holm, S., Aukrust, P., Bakke, S. S., Sporsheim, B., Nervik, I., Niyonzima, N., Bartels, E. D., Stahl, G. L., Mollnes, T. E., Espevik, T. & Garred, P., Jun 15 2016, In : Journal of Immunology. 196, 12, p. 5064-5074 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Complement MASP-1 enhances adhesion between endothelial cells and neutrophils by up-regulating E-selectin expression

Jani, P. K., Schwaner, E., Kajdácsi, E., Debreczeni, M. L., Ungai-Salánki, R., Dobó, J., Doleschall, Z., Rigó, J., Geiszt, M., Szabó, B., Gál, P. & Cervenák, L., Jul 1 2016, In : Molecular Immunology. 75, p. 38-47 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

MASP-1 and MASP-2 do not activate pro-factor D in resting human blood, whereas MASP-3 is a potential activator: Kinetic analysis involving specific MASP-1 and MASP-2 inhibitors

Oroszlán, G., Kortvely, E., Szakács, D., Kocsis, A., Dammeier, S., Zeck, A., Ueffing, M., Závodszky, P., Pál, G., Gál, P. & Dobo, J., Jan 15 2016, In : Journal of Immunology. 196, 2, p. 857-865 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

MASP-3 is the exclusive pro-factor D activator in resting blood: The lectin and the alternative complement pathways are fundamentally linked

Dobó, J., Szakács, D., Oroszlán, G., Kortvely, E., Kiss, B., Boros, E., Szász, R., Závodszky, P., Gál, P. & Pál, G., Aug 18 2016, In : Scientific reports. 6, 31877.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation

Kjaer, T. R., Jensen, L., Hansen, A., Dani, R., Jensenius, J. C., Dobó, J., Gál, P. & Thiel, S., Jul 1 2016, In : Scandinavian Journal of Immunology. 84, 1, p. 12-19 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond

Dobó, J., Pál, G., Cervenak, L. & Gál, P., Nov 1 2016, In : Immunological Reviews. 274, 1, p. 98-111 14 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)
2015

MASP-1 Induced Clotting - The First Model of Prothrombin Activation by MASP-1

Jenny, L., Dobó, J., Gál, P. & Schroeder, V., Dec 1 2015, In : PLoS One. 10, 12, e0144633.

Research output: Contribution to journalArticle

9 Citations (Scopus)

MASP-1 of the complement system promotes clotting via prothrombin activation

Jenny, L., Dobó, J., Gál, P. & Schroeder, V., Jun 1 2015, In : Molecular Immunology. 65, 2, p. 398-405 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2014
15 Citations (Scopus)

MASP-1 induces a unique cytokine pattern in endothelial cells: A novel link between complement system and neutrophil granulocytes

Jani, P. K., Kajdácsi, E., Megyeri, M., Dobó, J., Doleschall, Z., Futosi, K., Tímár, C. I., Mócsai, A., Makó, V., Gál, P. & Cervenak, L., Jan 29 2014, In : PloS one. 9, 1, e87104.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Multiple roles of complement MASP-1 at the interface of innate immune response and coagulation

Dobó, J., Schroeder, V., Jenny, L., Cervenak, L., Závodszky, P. & Gál, P., Oct 2014, In : Molecular Immunology. 61, 2, p. 69-78 10 p.

Research output: Contribution to journalReview article

48 Citations (Scopus)

Serum MASP-1 in complex with MBL activates endothelial cells

Megyeri, M., Jani, P. K., Kajdácsi, E., Dobó, J., Schwaner, E., Major, B., Rigó, J., Závodszky, P., Thiel, S., Cervenak, L. & Gál, P., May 1 2014, In : Molecular Immunology. 59, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2013

Inhibition of the serine proteases of the complement system

Gál, P., Dobó, J., Beinrohr, L., Pál, G. & Závodszky, P., 2013, Complement Therapeutics. Springer New York LLC, p. 23-40 18 p. (Advances in Experimental Medicine and Biology; vol. 734).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Inhibition of the serine proteases of the complement system.

Gál, P., Dobó, J., Beinrohr, L., Pál, G. & Závodszky, P., 2013, In : Advances in Experimental Medicine and Biology. 735, p. 23-40 18 p.

Research output: Contribution to journalArticle

Mannan-binding Lectin-associated Serine Proteases

Schwaeble, W. J., Lynch, N. J., Gal, P. & Zavodszky, P., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 2857-2863 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway

Megyeri, M., Harmat, V., Major, B., Végh, Á., Balczer, J., Héja, D., Szilágyi, K., Datz, D., Pál, G., Závodszky, P., Gál, P. & Dobó, J., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 8922-8934 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

Girija, U. V., Gingras, A. R., Marshall, J. E., Panchal, R., Sheikh, M. A., Gál, P., Schwaeble, W. J., Mitchell, D. A., Moody, P. C. E. & Wallis, R., Jan 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 34, p. 13916-13920 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
36 Citations (Scopus)

The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency

Csuka, D., Munthe-Fog, L., Skjoedt, M. O., Kocsis, A., Zotter, Z., Gál, P., Varga, L., Farkas, H., Füst, G. & Garred, P., Jul 1 2013, In : Molecular Immunology. 54, 3-4, p. 271-277 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation

Hess, K., Ajjan, R., Phoenix, F., Dobó, J., Gál, P. & Schroeder, V., Apr 20 2012, In : PloS one. 7, 4, e35690.

Research output: Contribution to journalArticle

55 Citations (Scopus)
52 Citations (Scopus)
47 Citations (Scopus)
114 Citations (Scopus)

Structural basis for activation of the complement system by component C4 cleavage

Kidmose, R. T., Laursen, N. S., Dobó, J., Kjaer, T. R., Sirotkina, S., Yatime, L., Sottrup-Jensen, L., Thiel, S., Gál, P. & Andersen, G. R., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15425-15430 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2011

Cleavage of Kininogen and subsequent Bradykinin release by the complement component: Mannose-binding lectin-associated serine protease (MASP)-1

Dobó, J., Major, B., Kékesi, K. A., Szabó, I., Megyeri, M., Hajela, K., Juhász, G., Závodszky, P. & Gál, P., May 27 2011, In : PloS one. 6, 5, e20036.

Research output: Contribution to journalArticle

69 Citations (Scopus)
15 Citations (Scopus)

Serpins and the complement system

Beinrohr, L., Murray-Rust, T. A., Dyksterhuis, L., Závodszky, P., Gál, P., Pike, R. N. & Wijeyewickrema, L. C., 2011, Methods in Enzymology. Academic Press Inc., p. 55-75 21 p. (Methods in Enzymology; vol. 499).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)
2010

Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot

Gulla, K. C., Gupta, K., Krarup, A., Gal, P., Schwaeble, W. J., Sim, R. B., O'Connor, C. D. & Hajela, K., Apr 1 2010, In : Immunology. 129, 4, p. 482-495 14 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
14 Citations (Scopus)

Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system

Degn, S. E., Jensen, L., Gál, P., Dobó, J., Holmvad, S. H., Jensenius, J. C. & Thiel, S., Sep 1 2010, In : Journal of Immunological Methods. 361, 1-2, p. 37-50 14 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r

Major, B., Kardos, J., Kékesi, K. A., Lorincz, Z., Závodszky, P. & Gál, P., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 11863-11869 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Interaction between separated consecutive complement control modules of human C1r: Implications for dimerization of the full-length protease

Láng, A., Major, B., Szilágyi, K., Gáspári, Z., Gál, P., Závodszky, P. & Perczel, A., Nov 19 2010, In : FEBS letters. 584, 22, p. 4565-4569 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: Structural biology

Láng, A., Szilágyi, K., Major, B., Gál, P., Závodszky, P. & Perczel, A., Oct 2010, In : FEBS Journal. 277, 19, p. 3986-3998 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
51 Citations (Scopus)
2009

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death

Than, N. G., Romero, R., Goodman, M., Weckle, A., Xing, J., Dong, Z., Xu, Y., Tarquini, F., Szilagyi, A., Gal, P., Hou, Z., Tarca, A. L., Chong, J. K., Kim, J. S., Haidarian, S., Uddin, M., Bohn, H., Benirschke, K., Santolaya-Forgas, J., Grossman, L. I. & 5 others, Erez, O., Hassan, S. S., Zavodszky, P., Papp, Z. & Wildman, D. E., Jun 16 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 24, p. 9731-9736 6 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function

Megyeri, M., Makó, V., Beinrohr, L., Doleschall, Z., Prohászka, Z., Cervenak, L., Závodszky, P. & Gál, P., Sep 1 2009, In : Journal of Immunology. 183, 5, p. 3409-3416 8 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions

Gál, P., Dobó, J., Závodszky, P. & Sim, R. B. M., Sep 1 2009, In : Molecular Immunology. 46, 14, p. 2745-2752 8 p.

Research output: Contribution to journalReview article

58 Citations (Scopus)

MASP-1, a promiscuous complement protease: Structure of its catalytic region reveals the basis of its broad specificity

Dobó, J., Harmat, V., Beinrohr, L., Sebestyén, E., Závodszky, P. & Gál, P., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1207-1214 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)