• 5359 Citations
  • 33 h-Index
19942019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Altered dynamics may drift pathological fibrillization in membraneless organelles

Tüű-Szabó, B., Hoffka, G., Duro, N. & Fuxreiter, M., Oct 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 10, p. 988-998 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Editorial overview: Dynamic protein interactions — from complexes to molecular machines

Fuxreiter, M. & Panchenko, A., Jun 2019, In : Current Opinion in Structural Biology. 56, p. vi-viii

Research output: Contribution to journalEditorial

Fold or not to fold upon binding — does it really matter?

Fuxreiter, M., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 19-25 7 p.

Research output: Contribution to journalReview article

32 Citations (Scopus)

Specific and Fuzzy Interactions Cooperate in Modulating Protein Half-Life

Sharma, R., Demény, M., Ambrus, V., Király, S. B., Kurtán, T., Gatti-Lafranconi, P. & Fuxreiter, M., Apr 5 2019, In : Journal of molecular biology. 431, 8, p. 1700-1707 8 p.

Research output: Contribution to journalArticle

2018

Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral NTAIL Domains With Their Functional Partners

Troilo, F., Bignon, C., Gianni, S., Fuxreiter, M. & Longhi, S., 2018, Methods in Enzymology. Rhoades, E. (ed.). Academic Press Inc., p. 137-192 56 p. (Methods in Enzymology; vol. 611).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Fuzziness in Protein Interactions—A Historical Perspective

Fuxreiter, M., Aug 3 2018, In : Journal of molecular biology. 430, 16, p. 2278-2287 10 p.

Research output: Contribution to journalReview article

43 Citations (Scopus)

Protein Phase Separation: A New Phase in Cell Biology

Boeynaems, S., Alberti, S., Fawzi, N. L., Mittag, T., Polymenidou, M., Rousseau, F., Schymkowitz, J., Shorter, J., Wolozin, B., Van Den Bosch, L., Tompa, P. & Fuxreiter, M., Jun 2018, In : Trends in Cell Biology. 28, 6, p. 420-435 16 p.

Research output: Contribution to journalReview article

256 Citations (Scopus)

Simulations of higher-order protein organizations using a fuzzy framework

Tüű-Szabó, B., Kóczy, L. T. & Fuxreiter, M., 2018, In : Complexity. 2018, 6360846.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Towards a stochastic paradigm: From fuzzy ensembles to cellular functions

Fuxreiter, M., Nov 17 2018, In : Molecules. 23, 11, 3008.

Research output: Contribution to journalReview article

6 Citations (Scopus)
2017

Computational analyses of the effect of novel amino acid clusters of human transglutaminase 2 on its structure and function

Thangaraju, K., Király, R., Mótyán, J. A., Ambrus, V. A., Fuxreiter, M. & Fésüs, L., Mar 1 2017, In : Amino Acids. 49, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
47 Citations (Scopus)

Fuzziness enables context dependence of protein interactions

Miskei, M., Gregus, A., Sharma, R., Duro, N., Zsolyomi, F. & Fuxreiter, M., Sep 2017, In : FEBS letters. 591, 17, p. 2682-2695 14 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2

Thangaraju, K., Király, R., Demény, M. A., Mótyán, J. A., Fuxreiter, M. & Fésüs, L., Mar 1 2017, In : PLoS One. 12, 3, e0172189.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Simultaneous quantification of protein order and disorder

Sormanni, P., Piovesan, D., Heller, G. T., Bonomi, M., Kukic, P., Camilloni, C., Fuxreiter, M., Dosztányi, Z., Pappu, R. V., Babu, M. M., Longhi, S., Tompa, P., Dunker, A. K., Uversky, V. N., Tosatto, S. C. E. & Vendruscolo, M., Mar 22 2017, In : Nature Chemical Biology. 13, 4, p. 339-342 4 p.

Research output: Contribution to journalComment/debate

44 Citations (Scopus)
2016

A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1

Nnamani, M. C., Ganguly, S., Erkenbrack, E. M., Lynch, V. J., Mizoue, L. S., Tong, Y., Darling, H. L., Fuxreiter, M., Meiler, J. & Wagner, G. P., Jun 7 2016, In : Cell Reports. 15, 10, p. 2097-2108 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions

Gruet, A., Dosnon, M., Blocquel, D., Brunel, J., Gerlier, D., Das, R. K., Bonetti, D., Gianni, S., Fuxreiter, M., Longhi, S. & Bignon, C., Feb 1 2016, In : FEBS Journal. 283, 4, p. 576-594 19 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

Wu, H. & Fuxreiter, M., May 19 2016, In : Cell. 165, 5, p. 1055-1066 12 p.

Research output: Contribution to journalReview article

139 Citations (Scopus)
2015

Erratum: Correction to disordered proteinaceous machines (Chemical Reviews (2014) 114:13 (6806-6843) DOI 10.0121/cr4007329)

Fuxreiter, M., Tóth-Petróczy, Á., Kraut, D. A., Matouschek, A., Lim, R. Y. H., Xue, B., Kurgan, L. & Uversky, V. N., Apr 8 2015, In : Chemical reviews. 115, 7, 1 p.

Research output: Contribution to journalComment/debate

Fuzziness endows viral motif-mimicry

Duro, N., Miskei, M. & Fuxreiter, M., Aug 1 2015, In : Molecular BioSystems. 11, 10, p. 2821-2829 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Fuzzy complexes: Specific binding without complete folding

Sharma, R., Raduly, Z., Miskei, M. & Fuxreiter, M., Sep 14 2015, In : FEBS letters. 589, 19, p. 2533-2542 10 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)
30 Citations (Scopus)
2014

Classification of intrinsically disordered regions and proteins

Van Der Lee, R., Buljan, M., Lang, B., Weatheritt, R. J., Daughdrill, G. W., Dunker, A. K., Fuxreiter, M., Gough, J., Gsponer, J., Jones, D. T., Kim, P. M., Kriwacki, R. W., Oldfield, C. J., Pappu, R. V., Tompa, P., Uversky, V. N., Wright, P. E. & Babu, M. M., Jul 9 2014, In : Chemical reviews. 114, 13, p. 6589-6631 43 p.

Research output: Contribution to journalReview article

683 Citations (Scopus)
3 Citations (Scopus)

Disordered proteinaceous machines

Fuxreiter, M., Tóth-Petróczy, Á., Kraut, D. A., Matouschek, A. T., Lim, R. Y. H., Xue, B., Kurgan, L. & Uversky, V. N., Jul 9 2014, In : Chemical reviews. 114, 13, p. 6806-6843 38 p.

Research output: Contribution to journalReview article

63 Citations (Scopus)

Dynamics: A key to protein function

Fuxreiter, M., Jan 1 2014, Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods. CRC Press, p. 3-38 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intrinsically disordered segments affect protein half-life in the cell and during evolution

van der Lee, R., Lang, B., Kruse, K., Gsponer, J., de Groot, N. S., Huynen, M. A., Matouschek, A., Fuxreiter, M. & Babu, M. M., Sep 25 2014, In : Cell Reports. 8, 6, p. 1832-1844 13 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

The role of reorganization energy in rational enzyme design

Fuxreiter, M. & Mones, L., Aug 2014, In : Current Opinion in Chemical Biology. 21, p. 34-41 8 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)
2013

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

Buljan, M., Chalancon, G., Dunker, A. K., Bateman, A., Balaji, S., Fuxreiter, M. & Babu, M. M., Jun 1 2013, In : Current Opinion in Structural Biology. 23, 3, p. 443-450 8 p.

Research output: Contribution to journalReview article

100 Citations (Scopus)

Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity

Kanchan, K., Ergülen, E., Király, R., Simon-Vecsei, Z., Fuxreiter, M. & Fésüs, L., Nov 1 2013, In : Biochemical Journal. 455, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Optimization of reorganization energy drives evolution of the designed Kemp eliminase KE07

Labas, A., Szabo, E., Mones, L. & Fuxreiter, M., May 1 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 5, p. 908-917 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2012

Fuzziness: Linking regulation to protein dynamics

Fuxreiter, M., Jan 1 2012, In : Molecular BioSystems. 8, 1, p. 168-177 10 p.

Research output: Contribution to journalReview article

108 Citations (Scopus)

Fuzzy complexes: A more stochastic view of protein function

Fuxreiter, M. & Tompa, P., Apr 19 2012, Fuzziness: Structural Disorder in Protein Complexes. p. 1-14 14 p. (Advances in Experimental Medicine and Biology; vol. 725).

Research output: Chapter in Book/Report/Conference proceedingChapter

130 Citations (Scopus)

Interactions via intrinsically disordered regions: What kind of motifs?

Pancsa, R. & Fuxreiter, M., Jun 1 2012, In : IUBMB life. 64, 6, p. 513-520 8 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)

Preface

Fuxreiter, M. & Tompa, P., Apr 19 2012, Fuzziness: Structural Disorder in Protein Complexes. p. ix-xiii (Advances in Experimental Medicine and Biology; vol. 725).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

4 Citations (Scopus)

QM/MM simulation of liquid water with an adaptive quantum region

Bernstein, N., Várnai, C., Solt, I., Winfield, S. A., Payne, M. C., Simon, I., Fuxreiter, M. & Csányi, G., Jan 14 2012, In : Physical Chemistry Chemical Physics. 14, 2, p. 646-656 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

Buljan, M., Chalancon, G., Eustermann, S., Wagner, G. P., Fuxreiter, M., Bateman, A. & Babu, M. M., Jun 29 2012, In : Molecular Cell. 46, 6, p. 871-883 13 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)
2011

Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase

Di Paolo, M. L., Lunelli, M., Fuxreiter, M., Rigo, A., Simon, I. & Scarpa, M., Apr 1 2011, In : FEBS Journal. 278, 8, p. 1232-1243 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dynamic protein-DNA recognition: Beyond what can be seen

Fuxreiter, M., Simon, I. & Bondos, S., Aug 1 2011, In : Trends in Biochemical Sciences. 36, 8, p. 415-423 9 p.

Research output: Contribution to journalReview article

103 Citations (Scopus)
2009

Close encounters of the third kind: Disordered domains and the interactions of proteins

Tompa, P., Fuxreiter, M., Oldfield, C. J., Simon, I., Dunker, A. K. & Uversky, V. N., Apr 27 2009, In : BioEssays. 31, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Disordered tails of homeodomains facilitate DNA recognition by providing a trade-off between folding and specific binding

Tóth-Petróczy, Á., Simon, I., Fuxreiter, M. & Levy, Y., Oct 28 2009, In : Journal of the American Chemical Society. 131, 42, p. 15084-15085 2 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Evaluating boundary dependent errors in QM/MM simulations

Solt, I., Kulhánek, P., Simon, I., Winfield, S., Payne, M. C., Csányi, G. & Fuxreiter, M., Apr 30 2009, In : Journal of Physical Chemistry B. 113, 17, p. 5728-5735 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Fuzzy interactome: the limitations of models in molecular biology

Fuxreiter, M. & Tompa, P., Jan 1 2009, In : Trends in Biochemical Sciences. 34, 1, 1 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)

Intrinsically disordered proteins and their recognition functions

Uversky, V. N., Fuxreiter, M., Oldfield, C. J., Dunker, A. K. & Tompa, P., Jan 1 2009, Computational Protein-Protein Interactions. CRC Press, p. 223-252 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family

Pingoud, V., Wende, W., Friedhoff, P., Reuter, M., Alves, J., Jeltsch, A., Mones, L., Fuxreiter, M. & Pingoud, A., Oct 16 2009, In : Journal of molecular biology. 393, 1, p. 140-160 21 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

The energy gap as a universal reaction coordinate for the simulation of chemical reactions

Mones, L., Kulhánek, P., Simon, I., Laio, A. & Fuxreiter, M., Jun 4 2009, In : Journal of Physical Chemistry B. 113, 22, p. 7867-7873 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2008

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

Tompa, P. & Fuxreiter, M., Jan 1 2008, In : Trends in Biochemical Sciences. 33, 1, p. 2-8 7 p.

Research output: Contribution to journalArticle

623 Citations (Scopus)

Malleable machines in transcription regulation: The Mediator complex

Tóth-Petróczy, Á., Oldfield, C. J., Simon, I., Takagi, Y., Dunker, A. K., Uversky, V. N. & Fuxreiter, M., Dec 1 2008, In : PLoS computational biology. 4, 12, e1000243.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Malleable machines take shape in eukaryotic transcriptional regulation

Fuxreiter, M., Tompa, P., Simon, I., Uversky, V. N., Hansen, J. C. & Asturias, F. J., Dec 2008, In : Nature Chemical Biology. 4, 12, p. 728-737 10 p.

Research output: Contribution to journalReview article

143 Citations (Scopus)
2007

An EcoRI-RsrI chimeric restriction endonuclease retains parental sequence specificity

Chuluunbaatar, T., Ivanenko-Johnston, T., Fuxreiter, M., Meleshko, R., Raskó, T., Simon, I., Heitman, J. & Kiss, A., May 1 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 5, p. 583-594 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
19 Citations (Scopus)