• 670 Citations
  • 16 h-Index
20012019

Research output per year

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Research Output

  • 670 Citations
  • 16 h-Index
  • 48 Article
  • 2 Review article
2019

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides

Erdei, A. I., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M. P., Luisi, G., Mollica, A. & Benyhe, S., Feb 2019, In : Peptides. 112, p. 106-113 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficacy-based perspective to overcome reduced opioid analgesia of advanced painful diabetic neuropathy in rats

Balogh, M., Zádor, F., Zádori, Z. S., Shaqura, M., Király, K., Mohammadzadeh, A., Varga, B., Lázár, B., Mousa, S. A., Hosztafi, S., Riba, P., Benyhe, S., Gyires, K., Schäfer, M., Fürst, S. & Al-Khrasani, M., Jan 1 2019, In : Frontiers in Pharmacology. 10, APR, 347.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Glycine transporter inhibitors: A new avenue for managing neuropathic pain

Al-Khrasani, M., Mohammadzadeh, A., Balogh, M., Király, K., Barsi, S., Hajnal, B., Köles, L., Zádori, Z. S. & Harsing, L. G., Oct 2019, In : Brain Research Bulletin. 152, p. 143-158 16 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration

Balogh, M., Varga, B. K., Karádi, D. Á., Riba, P., Puskár, Z., Kozsurek, M., Al-Khrasani, M. & Király, K., Apr 2019, In : Brain Research Bulletin. 147, p. 78-85 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions

Erdei, A., Borbély, A., Magyar, A., Taricska, N., Perczel, A., Zsíros, O., Garab, G., Szűcs, E., Ötvös, F., Zádor, F., Balogh, M., Al-Khrasani, M. & Benyhe, S., Jan 1 2018, In : Peptides. 99, p. 205-216 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats

Balogh, M., Zádori, Z., Lázár, B., Karádi, D., László, S., Mousa, S. A., Hosztafi, S., Zádor, F., Riba, P., Schäfer, M., Fürst, S. & Al-Khrasani, M., May 3 2018, (Accepted/In press) In : Neurochemical Research. p. 1-8 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

Zádor, F., Balogh, M., Váradi, A., Zádori, Z. S., Király, K., Szűcs, E., Varga, B., Lázár, B., Hosztafi, S., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., Nov 5 2017, In : European Journal of Pharmacology. 814, p. 264-273 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
12 Citations (Scopus)

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology

Zádor, F., Király, K., Váradi, A., Balogh, M., Fehér, Á., Kocsis, D., Erdei, A., Lackó, E., Zádori, Z., Hosztafi, S., Noszál, B., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., Jan 1 2017, In : European Journal of Pharmacology. 809, p. 111-121 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility

Zádori, Z. S., Fehér, Á., Tóth, V. E., Al-Khrasani, M., Köles, L., Sipos, S., Del Bello, F., Pigini, M. & Gyires, K., Jun 1 2016, In : Digestive Diseases and Sciences. 61, 6, p. 1512-1523 12 p.

Research output: Contribution to journalArticle

Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium-Induced Acute Intestinal Inflammation in Mice

Zádori, Z., Tóth, V. E., Fehér, Á., Al-Khrasani, M., Puskár, Z., Kozsurek, M., Timár, J., Tábi, T., Helyes, Z., Hein, L., Holzer, P. & Gyires, K., Sep 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 483-491 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects

Shaqura, M., Li, X., Al-Khrasani, M., Shakibaei, M., Tafelski, S., Fürst, S., Beyer, A., Kawata, M., Schäfer, M. & Mousa, S. A., Dec 1 2016, In : Neuropharmacology. 111, p. 1-13 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

Köles, L., Kató, E., Hanuska, A., Zádori, Z. S., Al-Khrasani, M., Zelles, T., Rubini, P. & Illes, P., Mar 1 2016, In : Purinergic Signalling. 12, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

New morphine analogs produce peripheral antinociception within a certain dose range of their systemic administration

Lackó, E., Riba, P., Giricz, Z., Váradi, A., Cornic, L., Balogh, M., Király, K., Cseko, K., Mousa, S. A., Hosztafi, S., Schäfer, M., Zádori, Z., Helyes, Z., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., Oct 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 171-181 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

A new potent analgesic agent with reduced liability to produce morphine tolerance

Kiraly, K., Caputi, F. F., Hanuska, A., Kató, E., Balogh, M., Köles, L., Palmisano, M., Riba, P., Hosztafi, S., Romualdi, P., Candeletti, S., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., Aug 1 2015, In : Brain Research Bulletin. 117, p. 32-38 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy

Shaqura, M., Khalefa, B. I., Shakibaei, M., Zöllner, C., Al-Khrasani, M., Fürst, S., Schäfer, M. & Mousa, S. A., Oct 2014, In : Neuropharmacology. 85, p. 142-150 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Az addikció kialakulásának új neurobiológiai mechanizmusai

Translated title of the contribution: New approach to the neurobiological mechanisms of addictionFurst, S., Riba, P. & Al-Khrasani, M., Dec 1 2013, In : Neuropsychopharmacologia Hungarica. 15, 4, p. 189-205 17 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Functionalization of the carbonyl group in position 6 of morphinan-6-ones. development of novel 6-amino and 6-guanidino substituted 14-alkoxymorphinans

Schmidhammer, H., Spetea, M., Windisch, P., Schütz, J., Riba, P., Al-Khrasani, M. & Fürst, S., Dec 1 2013, In : Current pharmaceutical design. 19, 42, p. 7391-7399 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Imidazoline versus alpha2-adrenoceptors in the control of gastric motility in mice

Zádori, Z. S., Fehér, Á., Al-Khrasani, M., Lackó, E., Tóth, V. E., Brancati, S. B., Hein, L., Mátyus, P. & Gyires, K., Apr 5 2013, In : European Journal of Pharmacology. 705, 1-3, p. 61-67 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Peripheral antinociceptive efficacy and potency of a novel opioid compound 14-O-MeM6SU in comparison to known peptide and non-peptide opioid agonists in a rat model of inflammatory pain

Khalefa, B. I., Mousa, S. A., Shaqura, M., Lackó, E., Hosztafi, S., Riba, P., Schäfer, M., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., Jun 4 2013, In : European Journal of Pharmacology. 713, 1-3, p. 54-57 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Reduced number, G protein coupling, and antinociceptive efficacy of spinal mu-opioid receptors in diabetic rats are reversed by nerve growth factor

Shaqura, M., Khalefa, B. I., Shakibaei, M., Winkler, J., Al-Khrasani, M., Fürst, S., Mousa, S. A. & Schäfer, M., Jul 1 2013, In : Journal of Pain. 14, 7, p. 720-730 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice

Szentirmay, A. K., Király, K. P., Lenkey, N., Lackó, E., Al-Khrasani, M., Friedmann, T., Timár, J., Gyarmati, S., Tóth, G., Fürst, S. & Riba, P., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Viselkedési vizsgálatok a gesztációs-laktációs ido{double acute}szakban morfn-kezelt patkányon

Translated title of the contribution: Behavioural studies during the gestational-lactation period in morphine treated ratsMelinda, S., Júlia, T., Pál, R., Király, K. P., Al-Khrasani, M., Zsuzsanna, G. & Zsuzsanna, F., Dec 1 2013, In : Neuropsychopharmacologia Hungarica. 15, 4, p. 239-251 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

A novel μ-opioid receptor ligand with high in vitro and in vivo agonist efficacy

Lackó, E., Váradi, A., Rapavi, R., Zádor, F., Riba, P., Benyhe, S., Borsodi, A., Hosztafi, S., Timár, J., Noszál, B., Fürst, S. & Al-Khrasani, M., Jan 1 2012, In : Current medicinal chemistry. 19, 27, p. 4699-4707 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
9 Citations (Scopus)

Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.

Khalefa, B. I., Shaqura, M., Al-Khrasani, M., Fürst, S., Mousa, S. A. & Schäfer, M., May 2012, In : European journal of pain (London, England). 16, 5, p. 690-705 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain

Al-Khrasani, M., Lackó, E., Riba, P., Király, K., Sobor, M., Timár, J., Mousa, S., Schäfer, M. & Fürst, S., Feb 10 2012, In : Brain Research Bulletin. 87, 2-3, p. 238-243 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2011

Effects of opioid agonist and antagonist in dams exposed to morphine during the perinatal period

Sobor, M., Timar, J., Riba, P., Friedmann, T., Király, K. P., Gyarmati, S., Al-Khrasani, M. & Fürst, S., Jan 15 2011, In : Brain Research Bulletin. 84, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies

Spetea, M., Windisch, P., Guo, Y., Bileviciute-Ljungar, I., Schütz, J., Asim, M. F., Berzetei-Gurske, I. P., Riba, P., Kiraly, K., Fürst, S., Al-Khrasani, M. & Schmidhammer, H., Feb 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 980-988 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
7 Citations (Scopus)
2010
7 Citations (Scopus)
26 Citations (Scopus)

Novel approach to demonstrate high efficacy of μ opioids in the rat vas deferens: A simple model of predictive value

Riba, P., Friedmann, T., Király, K. P., Al-Khrasani, M., Sobor, M., Asim, M. F., Spetea, M., Schmidhammer, H. & Furst, S., Jan 15 2010, In : Brain Research Bulletin. 81, 1, p. 178-184 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Peri, pre and postnatal morphine exposure: Exposure-induced effects and sex differences in the behavioural consequences in rat offspring

Timár, J., Sobor, M., Király, K. P., Gyarmati, S., Riba, P., Al-Khrasani, M. & Fürst, S., Feb 1 2010, In : Behavioural Pharmacology. 21, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2009

Increase of intracellular Ca2+ by adenine and uracil nucleotides in human midbrain-derived neuronal progenitor cells

Rubini, P., Milosevic, J., Engelhardt, J., Al-Khrasani, M., Franke, H., Heinrich, A., Sperlagh, B., Schwarz, S. C., Schwarz, J., Nörenberg, W. & Illes, P., May 2009, In : Cell Calcium. 45, 5, p. 485-498 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pharmacological analysis of α2-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions

Gyires, K., Zádori, Z. S., Shujaa, N., Al-Khrasani, M., Pap, B., Mózes, M. M. & Mátyus, P., Jul 1 2009, In : InflammoPharmacology. 17, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2008

Endomorphin-2 with a β-turn backbone constraint retains the potent μ-opioid receptor agonist properties

Tömböly, C., Ballet, S., Feytens, D., Köver, K. E., Borics, A., Lovas, S., Al-Khrasani, M., Fürst, Z., Tóth, G., Benyhe, S. & Tourwé, D., Jan 10 2008, In : Journal of Medicinal Chemistry. 51, 1, p. 173-177 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2007
28 Citations (Scopus)
2006

Endomorphin synthesis in rat brain from intracerebroventricularly injected [3H]-Tyr-Pro: A possible biosynthetic route for endomorphins

Rónai, A. Z., Szemenyei, E., Kató, E., Kocsis, L., Orosz, G., Al-Khrasani, M. & Tóth, G., Mar 15 2006, In : Regulatory Peptides. 134, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Partial and full agonism in endomorphin derivatives: Comparison by null and operational model

Rónai, A. Z., Al-Khrasani, M., Benyhe, S., Lengyel, I., Kocsis, L., Orosz, G., Tóth, G., Kató, E. & Tóthfalusi, L., Jun 1 2006, In : Peptides. 27, 6, p. 1507-1513 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Synthesis of enzymatically resistant nociceptin-related peptides containing a carbamic acid residue

Ligeti, M., Bösze, S., Csámpai, A., Gündüz, Ö., Al-Khrasani, M., Rónai, A. Z., Medzihradszky-Schweiger, H., Benyhe, S., Borsodi, A., Hudecz, F. & Magyar, A., Jul 1 2006, In : Journal of Peptide Science. 12, 7, p. 481-490 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2005

Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat

Fürst, S., Riba, P., Friedmann, T., Tímar, J., Al-Khrasani, M., Obara, I., Makuch, W., Spetea, M., Schütz, J., Przewlocki, R., Przewlocka, B. & Schmidhammer, H., Feb 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 609-618 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2004
1 Citation (Scopus)

D 1 but not D 2 dopamine receptors or adrenoceptors mediate dopamine-induced potentiation of N-methyl-D-aspartate currents in the rat prefrontal cortex

Wirkner, K., Krause, T., Köles, L., Thümmler, S., Al-Khrasani, M. & Illes, P., Nov 30 2004, In : Neuroscience Letters. 372, 1-2, p. 89-93 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nociceptin antagonism: Probing the receptor by N-acetyl oligopeptides

Kocsis, L., Orosz, G., Magyar, A., Al-Khrasani, M., Kató, E., Rónai, A. Z., Bes, B., Meunier, J. C., Gündüz, Ö., Tóth, G., Borsodi, A. & Benyhe, S., Nov 15 2004, In : Regulatory Peptides. 122, 3, p. 199-207 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
48 Citations (Scopus)
2003

Subsensitivity of P2X but not vanilloid 1 receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis

Borvendeg, S. J., Al-Khrasani, M., Rubini, P., Fischer, W., Allgaier, C., Wirkner, K., Himmel, H. M., Gillen, C. & Illes, P., Aug 1 2003, In : European Journal of Pharmacology. 474, 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The effect of endomorphins on the release of 3H-norepinephrine from rat nucleus tractus solitarii slices

Al-Khrasani, M., Elor, G., Abbas, M. Y. & Rónai, A. Z., Mar 28 2003, In : Regulatory Peptides. 111, 1-3, p. 97-101 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2002

Side chain modifications change the binding and agonist properties of endomorphin 2

Lengyel, I., Biyashev, D., Tömböly, C., Tóth, G., Borsodi, A., Orosz, G., Kocsis, L., Al-Khrasani, M., Rónai, A. & Fürst, Z., Jan 1 2002, In : Biochemical and biophysical research communications. 290, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2001

Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy

Al-Khrasani, M., Orosz, G., Kocsis, L., Farkas, V., Magyar, A., Lengyel, I., Benyhe, S., Borsodi, A. & Rónai, A. Z., Jun 1 2001, In : European Journal of Pharmacology. 421, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)