• 2946 Citations
  • 27 h-Index
1990 …2020

Research output per year

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Research Output

2020

Late sodium current in human, canine and guinea pig ventricular myocardium

Horváth, B., Hézső, T., Szentandrássy, N., Kistamás, K., Árpádffy-Lovas, T., Varga, R., Gazdag, P., Veress, R., Dienes, C., Baranyai, D., Almássy, J., Virág, L., Nagy, N., Baczkó, I., Magyar, J., Bányász, T., Varró, A. & Nánási, P. P., Feb 2020, In : Journal of Molecular and Cellular Cardiology. 139, p. 14-23 10 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis

Kiss, B., Szántó, M., Hegedűs, C., Antal, D., Szödényi, A., Márton, J., Méhes, G., Virág, L., Szegedi, A. & Bai, P., Jan 1 2020, In : Experimental Dermatology. 29, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Open Access
2019

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

Tomek, J., Bueno-Orovio, A., Passini, E., Zhou, X., Minchole, A., Britton, O., Bartolucci, C., Severi, S., Shrier, A., Virag, L., Varro, A. & Rodriguez, B., Dec 2019, In : eLife. 8, e48890.

Research output: Contribution to journalArticle

Open Access

Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native i Kr Currents and on Cardiac Action Potential

Orvos, P., Kohajda, Z., Szlovák, J., Gazdag, P., Árpádffy-Lovas, T., Tóth, D., Geramipour, A., Tálosi, L., Jost, N., Varró, A. & Virág, L., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 365-380 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing

Nánási, P. P., Szabó, Z., Kistamás, K., Horváth, B., Virág, L., Jost, N., Bányász, T., Almássy, J. & Varró, A., Jan 1 2019, (Accepted/In press) In : Progress in biophysics and molecular biology.

Research output: Contribution to journalReview article

Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer

Kovács, P., Csonka, T., Kovács, T., Sári, Z., Ujlaki, G., Sipos, A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., Jankó, L., Kiss, M., Kiss, B., Laoui, D., Virág, L., Méhes, G., Bai, P. & Mikó, E., Sep 2019, In : Cancers. 11, 9, 1255.

Research output: Contribution to journalArticle

Open Access

PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition

Tokarz, P., Płoszaj, T., Regdon, Z., Virág, L. & Robaszkiewicz, A., Feb 1 2019, In : Free Radical Biology and Medicine. 131, p. 218-224 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Robinson, N., Ganesan, R., Hegedűs, C., Kovács, K., Kufer, T. A. & Virág, L., Sep 2019, In : Redox Biology. 26, 101239.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)

Self-defense of macrophages against oxidative injury: Fighting for their own survival

Virág, L., Jaén, R. I., Regdon, Z., Boscá, L. & Prieto, P., Sep 2019, In : Redox Biology. 26, 101261.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)

Spilanthol inhibits inflammatory transcription factors and iNOS expression in macrophages and exerts anti-inflammatory effects in dermatitis and pancreatitis

Bakondi, E., Singh, S. B., Hajnády, Z., Nagy-Pénzes, M., Regdon, Z., Kovács, K., Hegedűs, C., Madácsy, T., Maléth, J., Hegyi, P., Demény, M., Nagy, T., Kéki, S., Szabó, É. & Virág, L., Sep 1 2019, In : International journal of molecular sciences. 20, 17, 4308.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

Comparison of the effects of IK,ACh, IKr, and INa block in conscious dogs with atrial fibrillation and on action potentials in remodeled atrial trabeculae

Juhász, V., Hornyik, T., Benák, A., Nagy, N., Husti, Z., Pap, R., Sághy, L., Virág, L., Varró, A. & Baczkó, I., Jan 1 2018, In : Canadian journal of physiology and pharmacology. 96, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Diverse effect of BMP-2 homodimer on mesenchymal progenitors of different origin

Hrubi, E., Imre, L., Robaszkiewicz, A., Virág, L., Kerényi, F., Nagy, K., Varga, G., Jenei, A. & Hegedüs, C., Apr 1 2018, In : Human Cell. 31, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Tempka, D., Tokarz, P., Chmielewska, K., Kluska, M., Pietrzak, J., Rygielska, Ż., Virág, L. & Robaszkiewicz, A., May 1 2018, In : Redox Biology. 15, p. 316-326 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes

Robaszkiewicz, A., Wiśnik, E., Regdon, Z., Chmielewska, K. & Virág, L., Jan 1 2018, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PARP1 promoter links cell cycle progression with adaptation to oxidative environment

Pietrzak, J., Spickett, C. M., Płoszaj, T., Virág, L. & Robaszkiewicz, A., Sep 2018, In : Redox Biology. 18, p. 1-5 5 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds

Bodnár, E., Bakondi, E., Kovács, K., Hegedűs, C., Lakatos, P., Robaszkiewicz, A., Regdon, Z., Virág, L. & Szabó, É., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity

Csóka, B., Töro, G., Vindeirinho, J., Varga, Z. V., Koscsó, B., Németh, Z. H., Kókai, E., Antonioli, L., Suleiman, M., Marchetti, P., Cseri, K., Deák, Á., Virág, L., Pacher, P., Bai, P. & Haskó, G., Jan 1 2017, In : FASEB Journal. 31, 11, p. 4985-4997 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

An architecture proposal for V2X communication-centric traffic light controller systems

Varga, N., Bokor, L., Takacs, A., Kovács, J. & Virág, L., Jul 7 2017, Proceedings of 2017 15th International Conference on ITS Telecommunications, ITST 2017. Institute of Electrical and Electronics Engineers Inc., 7972217

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle

Gurabi, Z., Patocskai, B., Györe, B., Virág, L., Mátyus, P., Papp, J., Varró, A. & Koncz, I., Jan 1 2017, In : Canadian Journal of Physiology and Pharmacology. 95, 7, p. 830-836 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2016

A novel transgenic rabbit model with reduced repolarization reserve: Long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene

Major, P., Baczkó, I., Hiripi, L., Odening, K. E., Juhász, V., Kohajda, Z., Horváth, A., Seprényi, G., Kovács, M., Virág, L., Jost, N., Prorok, J., Ördög, B., Doleschall, Z., Nattel, S., Varró, A. & Bõsze, Z., Jun 1 2016, In : British journal of pharmacology. 173, 12, p. 2046-2061 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition

Pueyo, E., Dangerfield, C. E., Britton, O. J., Virág, L., Kistamás, K., Szentandrássy, N., Jost, N., Varró, A., Nánási, P. P., Burrage, K. & Rodríguez, B., Mar 2016, In : PloS one. 11, 3, e0151461.

Research output: Contribution to journalArticle

15 Citations (Scopus)
8 Citations (Scopus)
2 Citations (Scopus)
2015

Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - A safety approach

Orvos, P., Virág, L., Tálosi, L., Hajdú, Z., Csupor, D., Jedlinszki, N., Szél, T., Varró, A. & Hohmann, J., Jan 2015, In : Fitoterapia. 100, p. 156-165 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2014

Effect of inter-subject variability in determining response to IKr block in human ventricular myocytes

Britton, O. J., Bueno-Orovio, A., Virag, L., Varro, A. & Rodriguez, B., Jan 1 2014, In : Computing in Cardiology. 41, January, p. 869-872 4 p., 7043181.

Research output: Contribution to journalConference article

2 Citations (Scopus)

Selective Na +/ Ca 2+ exchanger inhibition prevents Ca 2+ overload-induced triggered arrhythmias

Nagy, N., Kormos, A., Kohajda, Z., Szebeni, Á., Szepesi, J., Pollesello, P., Levijoki, J., Acsai, K., Virág, L., Nánási, P. P., Papp, J. G., Varrõ, A. & Tõth, A., Dec 2014, In : British journal of pharmacology. 171, 24, p. 5665-5681 17 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

Altered expression of genes for kir ion channels in dilated cardiomyopathy

Szuts, V., Ménesi, D., Varga-Orvos, Z., Zvara, Á., Houshmand, N., Bitay, M., Bogáts, G., Virág, L., Baczkó, I., Szalontai, B., Geramipoor, A., Cotella, D., Wettwer, E., Ravens, U., Deák, F., Puskás, L. G., Papp, J. G., Kiss, I., Varró, A. & Jost, N., Aug 1 2013, In : Canadian journal of physiology and pharmacology. 91, 8, p. 648-656 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Human electrophysiological and pharmacological properties of XEN-D0101: A novel atrial-selective Kv1.5/IKur inhibitor

Ford, J., Milnes, J., Wettwer, E., Christ, T., Rogers, M., Sutton, K., Madge, D., Virag, L., Jost, N., Horvath, Z., Matschke, K., Varro, A. & Ravens, U., May 1 2013, In : Journal of cardiovascular pharmacology. 61, 5, p. 408-415 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

Jost, N., Virág, L., Comtois, P., Ördög, B., Szuts, V., Seprényi, G., Bitay, M., Kohajda, Z., Koncz, I., Nagy, N., Szél, T., Magyar, J., Kovács, M., Puskás, L. G., Lengyel, C., Wettwer, E., Ravens, U., Nánási, P. P., Papp, J. G., Varró, A. & 1 others, Nattel, S., Sep 1 2013, In : Journal of Physiology. 591, 17, p. 4189-4206 18 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

L-364,373 (R-L3) enantiomers have opposite modulating effects on Iks in mammalian ventricular myocytes

Corici, C., Kohajda, Z., Kristóf, A., Horváth, A., Virág, L., Szél, T., Nagy, N., Szakonyi, Z., Fülöp, F., Muntean, D. M., Varró, A. & Jost, N., Aug 1 2013, In : Canadian journal of physiology and pharmacology. 91, 8, p. 586-592 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts

Kemény, L. V., Schnúr, A., Czepán, M., Rakonczay, Z., Gál, E., Lonovics, J., Lázár, G., Simonka, Z., Venglovecz, V., Maléth, J., Judák, L., Németh, I. B., Szabó, K., Almássy, J., Virág, L., Geisz, A., Tiszlavicz, L., Yule, D. I., Wittmann, T., Varró, A. & 1 others, Hegyi, P., Oct 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 8, p. G552-G563

Research output: Contribution to journalArticle

14 Citations (Scopus)

ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N., Nagy, N., Corici, C., Kohajda, Z., Horváth, A., Acsai, K., Biliczki, P., Levijoki, J., Pollesello, P., Koskelainen, T., Otsomaa, L., Tõth, A., Papp, J. G., Varrõ, A. & Virág, L., Oct 1 2013, In : British journal of pharmacology. 170, 4, p. 768-778 11 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)
2012

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve

Kristóf, A., Husti, Z., Koncz, I., Kohajda, Z., Szél, T., Juhász, V., Biliczki, P., Jost, N., Baczkó, I., Papp, J. G., Varró, A. & Virág, L., Dec 31 2012, In : PloS one. 7, 12, e53255.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis

Pueyo, E., Corrias, A., Virág, L., Jost, N., Szél, T., Varró, A., Szentandrássy, N., Nánási, P. P., Burrage, K. & Rodríguez, B., Dec 21 2011, In : Biophysical journal. 101, 12, p. 2892-2902 11 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Analysis of the contribution of I to to repolarization in canine ventricular myocardium

Virág, L., Jost, N., Papp, R., Koncz, I., Kristóf, A., Kohajda, Z., Harmati, G., Carbonell-Pascual, B., Ferrero, J. M., Papp, J. G., Nánási, P. P. & Varró, A., Sep 1 2011, In : British journal of pharmacology. 164, 1, p. 93-105 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Atrial remodeling and novel pharmacological strategies for antiarrhythmic therapy in atrial fibrillation

Jost, N., Kohajda, Z., Kristóf, A., Kovács, P. P., Husti, Z., Juhász, V., Kiss, L., Varró, A., Virág, L. & Baczkó, I., Aug 1 2011, In : Current medicinal chemistry. 18, 24, p. 3675-3694 20 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

Szél, T., Koncz, I., Jost, N., Baczkó, I., Husti, Z., Virág, L., Bussek, A., Wettwer, E., Ravens, U., Papp, J. G. & Varró, A., Jul 15 2011, In : European Journal of Pharmacology. 662, 1-3, p. 31-39 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Electrophysiological effects of ivabradine in dog and human cardiac preparations: Potential antiarrhythmic actions

Koncz, I., Szél, T., Bitay, M., Cerbai, E., Jaeger, K., Fülöp, F., Jost, N., Virág, L., Orvos, P., Tálosi, L., Kristóf, A., Baczkó, I., Papp, J. G. & Varró, A., Oct 15 2011, In : European Journal of Pharmacology. 668, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Mechanism of reverse rate-dependent action of cardioactive agents

Bányász, T., Bárándi, L., Harmati, G., Virág, L., Szentandrássy, N., Márton, I., Zaza, A., Varró, A. & Nánási, P. P., Aug 1 2011, In : Current medicinal chemistry. 18, 24, p. 3597-3606 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation

O'Hara, T., Virág, L., Varró, A. & Rudy, Y., May 1 2011, In : PLoS computational biology. 7, 5, e1002061.

Research output: Contribution to journalArticle

530 Citations (Scopus)
2010

Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations

Nánási, P. P., Bárándi, L., Virág, L., Jost, N., Horváth, Z., Koncz, I., Papp, R., Harmati, G., Horváth, B., Szentandrássy, N., Bányász, T., Magyar, J., Zaza, A. & Varró, A., May 1 2010, In : Basic research in cardiology. 105, 3, p. 315-323 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

The role of the transient outward current in action potential repolarization: A simulation study

Carbonel, B., Virág, L., Jost, N., Varró, A. & Ferrero, C., Dec 1 2010, Computing in Cardiology 2010, CinC 2010. p. 657-660 4 p. 5738058. (Computing in Cardiology; vol. 37).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2009

5,7,8-trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury

Koini, E. N., Papazafiri, P., Vassilopoulos, A., Koufaki, M., Horváth, Z., Koncz, I., Virág, L., Papp, G. J., Varró, A. & Calogeropoulou, T., Apr 23 2009, In : Journal of Medicinal Chemistry. 52, 8, p. 2328-2340 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Herpesvirus-mediated delivery of a genetically encoded fluorescent ca 2+ sensor to canine cardiomyocytes

Prorok, J., Kovács, P. P., Kristf, A. A., Nagy, N., Tombácz, D., Tth, J. S., Ördg, B., Jost, N., Virág, L., Papp, J. G., Varr, A., Tth, A. & Boldogki, Z., Aug 24 2009, In : Journal of Biomedicine and Biotechnology. 2009, 361795.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Reverse rate dependency is an intrinsic property of canine cardiac preparations

Bányász, T., Horváth, B., Virág, L., Bárándi, L., Szentandrássy, N., Harmati, G., Magyar, J., Marangoni, S., Zaza, A., Varró, A. & Nánási, P. P., Nov 1 2009, In : Cardiovascular research. 84, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
21 Citations (Scopus)
2008

Contributions of HERG K+ current to repolarization of the human ventricular action potential

Fink, M., Noble, D., Virag, L., Varro, A. & Giles, W. R., Jan 1 2008, In : Progress in biophysics and molecular biology. 96, 1-3, p. 357-376 20 p.

Research output: Contribution to journalReview article

67 Citations (Scopus)

Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart

Lengyel, C., Virág, L., Kovács, P. P., Kristóf, A., Pacher, P., Kocsis, E., Koltay, Z. M., Nánási, P. P., Tóth, M., Kecskeméti, V., Papp, J. G., Varró, A. & Jost, N., Mar 1 2008, In : Acta Physiologica. 192, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)