• 7607 Citations
  • 46 h-Index
1978 …2020

Research output per year

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Research Output

2020

Pharmacological overview of the BGP-15 chemical agent as a new drug candidate for the treatment of symptoms of metabolic syndrome

Pető, Á., Kósa, D., Fehér, P., Ujhelyi, Z., Sinka, D., Vecsernyés, M., Szilvássy, Z., Juhász, B., Csanádi, Z., Vígh, L. & Bácskay, I., Jan 20 2020, In : Molecules. 25, 2, 429.

Research output: Contribution to journalReview article

Open Access
2019

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Balogi, Z., Multhoff, G., Jensen, T. K., Lloyd-Evans, E., Yamashima, T., Jäättelä, M., Harwood, J. L. & Vígh, L., Apr 1 2019, In : Progress in Lipid Research. 74, p. 18-30 13 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2018

Cerebrovascular pathology in hypertriglyceridemic APOB-100 transgenic mice

Hoyk, Z., Tóth, M. E., Lénárt, N., Nagy, D., Dukay, B., Csefová, A., Zvara, A., Seprényi, G., Kincses, A., Walter, F. R., Veszelka, S., Vígh, J., Barabási, B., Harazin, A., Kittel, A., Puskás, L., Penke, B., Vígh, L., Deli, M. A. & Sántha, M., Oct 25 2018, In : Frontiers in Cellular Neuroscience. 12, 380.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1 Citation (Scopus)
17 Citations (Scopus)

Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness

Mikó, E., Vida, A., Kovács, T., Ujlaki, G., Trencsényi, G., Márton, J., Sári, Z., Kovács, P., Boratkó, A., Hujber, Z., Csonka, T., Antal-Szalmás, P., Watanabe, M., Gombos, I., Csoka, B., Kiss, B., Vígh, L., Szabó, J., Méhes, G., Sebestyén, A. & 2 others, Goedert, J. J. & Bai, P., Sep 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 9, p. 958-974 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis

Márton, J., Péter, M., Balogh, G., Bódi, B., Vida, A., Szántó, M., Bojcsuk, D., Jankó, L., Bhattoa, H. P., Gombos, I., Uray, K., Horváth, I., Török, Z., Balint, B. L., Papp, Z., Vígh, L. & Bai, P., Nov 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 11, p. 1399-1412 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

Budzyński, M. A., Crul, T., Himanen, S. V., Toth, N., Otvos, F., Sistonen, L. & Vigh, L., Sep 1 2017, In : Cell Stress and Chaperones. 22, 5, p. 717-728 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nanotubes connecting B lymphocytes: High impact of differentiation-dependent lipid composition on their growth and mechanics

Tóth, E. A., Oszvald, Á., Péter, M., Balogh, G., Osteikoetxea-Molnár, A., Bozó, T., Szabó-Meleg, E., Nyitrai, M., Derényi, I., Kellermayer, M., Yamaji, T., Hanada, K., Vígh, L. & Matkó, J., Sep 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 9, p. 991-1000 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome

Balajthy, A., Somodi, S., Pethő, Z., Péter, M., Varga, Z., Szabó, G. P., Paragh, G., Vígh, L., Panyi, G. & Hajdu, P., Aug 1 2016, In : Pflugers Archiv European Journal of Physiology. 468, 8, p. 1403-1418 16 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Bacterial Sepsis Increases Survival in Metastatic Melanoma: Chlamydophila Pneumoniae Induces Macrophage Polarization and Tumor Regression

Buzás, K., Marton, A., Vizler, C., Gyukity-Sebestyén, E., Harmati, M., Nagy, K., Zvara, Á., Katona, R. L., Tubak, V., Endrész, V., Németh, I. B., Oláh, J., Vígh, L., Bíró, T. & Kemény, L., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 4, p. 862-865 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease

Kasza, Á., Hunya, Á., Frank, Z., Fülöp, F., Török, Z., Balogh, G., Sántha, M., Bálind, Á., Bernáth, S., Blundell, K. L. I. M., Prodromou, C., Horváth, I., Zeiler, H. J., Hooper, P. L., Vigh, L., Penke, B. & Abisambra, J., Jan 1 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 557-571 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe

Glatz, A., Pilbat, A. M., Németh, G. L., Vince-Kontár, K., Jósvay, K., Hunya, Á., Udvardy, A., Gombos, I., Péter, M., Balogh, G., Horváth, I., Vígh, L. & Török, Z., Mar 1 2016, In : Cell Stress and Chaperones. 21, 2, p. 327-338 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila

Laurinyecz, B., Péter, M., Vedelek, V., Kovács, A. L., Juhász, G., Maróy, P., Vígh, L., Balogh, G. & Sinka, R., Jan 2016, In : Open Biology. 6, 1, 150169.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper, P. L., Durham, H. D., Török, Z., Hooper, P. L., Crul, T. & Vígh, L., Sep 1 2016, In : Cell Stress and Chaperones. 21, 5, p. 745-753 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

Salah, H., Li, M., Cacciani, N., Gastaldello, S., Ogilvie, H., Akkad, H., Venkat Namuduri, A., Morbidoni, V., Artemenko, K. A., Balogh, G., Martinez-Redondo, V., Jannig, P., Hedström, Y., Dworkin, B., Bergquist, J., Ruas, J., Vigh, L., Salviati, L. & Larsson, L., Aug 3 2016, In : Science Translational Medicine. 8, 350, p. 350ra103

Research output: Contribution to journalArticle

28 Citations (Scopus)
2015

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Nimmervoll, B., Chtcheglova, L. A., Juhasz, K., Cremades, N., Aprile, F. A., Sonnleitner, A., Hinterdorfer, P., Vigh, L., Preiner, J. & Balogi, Z., Sep 14 2015, In : FEBS letters. 589, 19, p. 2747-2753 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: Effects of oxidized low-density lipoprotein treatment

Lénárt, N., Walter, F. R., Bocsik, A., Sántha, P., Tóth, M. E., Harazin, A., Tóth, A. E., Vizler, C., Török, Z., Pilbat, A. M., Vígh, L., Puskás, L. G., Sántha, M. & Deli, M. A., Jul 17 2015, In : Fluids and Barriers of the CNS. 12, 1, 17.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells

Antal, O., Péter, M., Hackler, L., Mán, I., Szebeni, G., Ayaydin, F., Hideghéty, K., Vigh, L., Kitajka, K., Balogh, G. & Puskás, L. G., Jul 4 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 9, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Membrane fluidity in the center of fever-enhanced immunity

Gombos, I. & Vígh, L., Jan 1 2015, In : Cell cycle (Georgetown, Tex.). 14, 19, p. 3014-3015 2 p.

Research output: Contribution to journalComment/debate

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Escribá, P. V., Busquets, X., Inokuchi, J. I., Balogh, G., Török, Z., Horváth, I., Harwood, J. L. & Vígh, L., Jun 11 2015, In : Progress in Lipid Research. 59, p. 38-53 16 p.

Research output: Contribution to journalReview article

71 Citations (Scopus)
2014

Alcohol stress, membranes, and chaperones

Tóth, M. E., Vígh, L. & Sántha, M., Jan 1 2014, In : Cell Stress and Chaperones. 19, 3, p. 299-309 11 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies

Literáti-Nagy, B., Tory, K., Peitl, B., Bajza, Á., Korányi, L., Literáti-Nagy, Z., Hooper, P. L., Vígh, L. & Szilvássy, Z., Mar 1 2014, In : Metabolic syndrome and related disorders. 12, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

Vigh, L., Török, Z., Crul, T., Maresca, B., Schütz, G. J., Viana, F., Dindia, L., Piotto, S., Brameshuber, M., Balogh, G., Péter, M., Porta, A., Trapani, A., Gombos, I., Glatz, A., Gungor, B., Peksel, B., Vigh, L., Csoboz, B., Horváth, I. & 3 others, Vijayan, M. M., Hooper, P. L. & Harwood, J. L., Jun 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 6, p. 1594-1618 25 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)
14 Citations (Scopus)

The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes

Hooper, P. L., Balogh, G., Rivas, E., Kavanagh, K. & Vigh, L., Jul 2014, In : Cell Stress and Chaperones. 19, 4, p. 447-464 18 p.

Research output: Contribution to journalReview article

58 Citations (Scopus)
2013

Heat stress management in synechocystis PCC 6803: The interplay between membranes and stress protein molecular chaperones

Glatz, A., Török, Z., Vígh, L. & Horváth, I., Jan 1 2013, Stress Biology of Cyanobacteria: Molecular Mechanisms to Cellular Responses. CRC Press, p. 145-154 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hydroximic acid derivatives: Pleiotropic Hsp co-inducers restoring homeostasis and robustness

Crul, T., Toth, N., Piotto, S., Literati-Nagy, P., Tory, K., Haldimann, P., Kalmar, B., Greensmith, L., Torok, Z., Balogh, G., Gombos, I., Campana, F., Concilio, S., Gallyas, F., Nagy, G., Berente, Z., Gungor, B., Peter, M., Glatz, A., Hunya, A. & 20 others, Literati-Nagy, Z., Vigh, L., Hoogstra-Berends, F., Heeres, A., Kuipers, I., Loen, L., Seerden, J. P., Zhang, D., Meijering, R. A. M., Henning, R. H., Brundel, B. J. J. M., Kampinga, H. H., Koranyi, L., Szilvassy, Z., Mandl, J., Sumegi, B., Febbraio, M. A., Horvath, I., Hooper, P. L. & Vigh, L., Jan 1 2013, In : Current pharmaceutical design. 19, 3, p. 309-346 38 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)

Key role of lipids in heat stress management

Balogh, G., Péter, M., Glatz, A., Gombos, I., Török, Z., Horváth, I., Harwood, J. L. & Vígh, L., Jun 27 2013, In : FEBS letters. 587, 13, p. 1970-1980 11 p.

Research output: Contribution to journalReview article

70 Citations (Scopus)

Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma

Juhász, K., Thuenauer, R., Spachinger, A., Duda, E., Horváth, I., Vígh, L., Sonnleitner, A. & Balogi, Z., Jan 1 2013, In : Current pharmaceutical design. 19, 3, p. 430-440 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes

Csoboz, B., Balogh, G. E., Kusz, E., Gombos, I., Peter, M., Crul, T., Gungor, B., Haracska, L., Bogdanovics, G., Torok, Z., Horvath, I. & Vigh, L., Aug 2013, In : International Journal of Hyperthermia. 29, 5, p. 491-499 9 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Synergetic insulin sensitizing effect of rimonabant and BGP-15 in zucker-obes rats

Literati-Nagy, Z., Tory, K., Literáti-Nagy, B., Bajza, Á., Vígh, L., Vígh, L., Mandl, J. & Szilvássy, Z., Jul 1 2013, In : Pathology and Oncology Research. 19, 3, p. 571-575 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics

Literati-Nagy, Z., Tory, K., Literáti-Nagy, B., Kolonics, A., Vígh, L., Vígh, L., Mandl, J. & Szilvássy, Z., Oct 1 2012, In : Pathology and Oncology Research. 18, 4, p. 1071-1076 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Glycerophospholipid profile in oncogene-induced senescence

Cadenas, C., Vosbeck, S., Hein, E. M., Hellwig, B., Langer, A., Hayen, H., Franckenstein, D., Büttner, B., Hammad, S., Marchan, R., Hermes, M., Selinski, S., Rahnenführer, J., Peksel, B., Török, Z., Vígh, L. & Hengstler, J. G., Sep 1 2012, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821, 9, p. 1256-1268 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Heat shock response in photosynthetic organisms: Membrane and lipid connections

Horváth, I., Glatz, A., Nakamoto, H., Mishkind, M. L., Munnik, T., Saidi, Y., Goloubinoff, P., Harwood, J. L. & Vigh, L., Jul 1 2012, In : Progress in Lipid Research. 51, 3, p. 208-220 13 p.

Research output: Contribution to journalReview article

86 Citations (Scopus)
7 Citations (Scopus)

Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture

Péter, M., Balogh, G., Gombos, I., Liebisch, G., Horváth, I., Török, Z., Nagy, E., Maslyanko, A., Benk, S., Schmitz, G., Harwood, J. L. & Vígh, L., Nov 1 2012, In : Molecular Membrane Biology. 29, 7, p. 274-289 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics

Literáti-Nagy, Z., Tory, K., Literáti-Nagy, B., Kolonics, A., Török, Z., Gombos, I., Balogh, G., Vígh, L., Horváth, I., Mandl, J., Sümegi, B., Hooper, P. L. & Vígh, L., Jul 1 2012, In : Cell Stress and Chaperones. 17, 4, p. 517-521 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011

Docosahexaenoic acid reduces amyloid β production via multiple pleiotropic mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grosgen, S., Burg, V. K., Hundsdorfer, B., Rothhaar, T. L., Friess, P., De Wilde, M. C., Broersen, L. M., Penke, B., Peter, M., Vígh, L., Grimm, H. S. & Hartmann, T., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14028-14039 12 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells

Balogh, G., Maulucci, G., Gombos, I., Horváth, I., Török, Z., Péter, M., Fodor, E., Páli, T., Benko, S., Parasassi, T., de Spirito, M., Harwood, J. L. & Vígh, L., Jun 22 2011, In : PloS one. 6, 6, e21182.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Membrane-lipid therapy in operation: The HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts

Gombos, I., Crul, T., Piotto, S., Güngör, B., Török, Z., Balogh, G., Péter, M., Slotte, J. P., Campana, F., Pilbat, A. M., Hunya, Á., Tóth, N., Literati-Nagy, Z., Vígh, L., Glatz, A., Brameshuber, M., Schütz, G. J., Hevener, A., Febbraio, M. A., Horváth, I. & 1 others, Vígh, L., Dec 14 2011, In : PloS one. 6, 12, e28818.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

Stangl, S., Gehrmann, M., Riegger, J., Kuhs, K., Riederer, I., Sievert, W., Hube, K., Mocikat, R., Dressel, R., Kremmer, E., Pockley, A. G., Friedrich, L., Vigh, L., Skerra, A. & Multhoff, G., Jan 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 733-738 6 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans

Haldimann, P., Muriset, M., Vígh, L. & Goloubinoff, P., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 18784-18794 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Cell biology: Stability in times of stress

Horváth, I. & Vígh, L., Jan 28 2010, In : Nature. 463, 7280, p. 436-438 3 p.

Research output: Contribution to journalShort survey

26 Citations (Scopus)

Changes in membrane fluid state and heat shock response cause attenuation of virulence

Porta, A., Eletto, A., Törö, Z., Franceschelli, S., Glatz, A., Vígh, L. & Maresca, B., Apr 1 2010, In : Journal of bacteriology. 192, 7, p. 1999-2005 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(-)

Brunelli, R., Balogh, G., Costa, G., De Spirito, M., Greco, G., Mei, G., Nicolai, E., Vigh, L., Ursini, F. & Parasassi, T., Aug 31 2010, In : Biochemistry. 49, 34, p. 7297-7302 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Genetic modification of the Salmonella membrane physical state alters the pattern of heat shock response

Porta, A., Török, Z., Horvath, I., Franceschelli, S., Vígh, L. & Maresca, B., Apr 1 2010, In : Journal of bacteriology. 192, 7, p. 1988-1998 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane

Brameshuber, M., Weghuber, J., Ruprecht, V., Gombos, I., Horváth, I., Vigh, L., Eckerstorfer, P., Kiss, E., Stockinger, H. & Schütz, G. J., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41765-41771 7 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line

Balogh, G., Péter, M., Liebisch, G., Horváth, I., Török, Z., Nagy, E., Maslyanko, A., Benk, S., Schmitz, G., Harwood, J. L. & Vígh, L., Sep 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 9, p. 1036-1047 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Live cell segmentation in fluorescence microscopy via graph cut

Leskó, M., Kato, Z., Nagy, A., Gombos, I., Török, Z., Vígh, L. & Vígh, L., Nov 18 2010, Proceedings - 2010 20th International Conference on Pattern Recognition, ICPR 2010. p. 1485-1488 4 p. 5597303. (Proceedings - International Conference on Pattern Recognition).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)