• 3249 Citations
  • 32 h-Index
1981 …2019

Research output per year

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Research Output

2012

N-(4-Substituted-benzoyl)-N′-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods

Nagy, V., Felföldi, N., Kónya, B., Praly, J. P., Docsa, T., Gergely, P., Chrysina, E. D., Tiraidis, C., Kosmopoulou, M. N., Alexacou, K. M., Konstantakaki, M., Leonidas, D. D., Zographos, S. E., Oikonomakos, N. G., Kozmon, S., Tvaroška, I. & Somsák, L., Mar 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 5, p. 1801-1816 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis of heterocyclic N-(β-d-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase

Kónya, B., Docsa, T., Gergely, P. & Somsák, L., Apr 1 2012, In : Carbohydrate Research. 351, p. 56-63 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2011

Carbohydrates as ligands: Synthetic and biological aspects

Oscarson, S. & Somsák, L., Sep 6 2011, In : Carbohydrate Research. 346, 12, 1 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
44 Citations (Scopus)

Glucose derived inhibitors of glycogen phosphorylase

Somsák, L., Jan 1 2011, In : Comptes Rendus Chimie. 14, 2-3, p. 211-223 13 p.

Research output: Contribution to journalShort survey

68 Citations (Scopus)
7 Citations (Scopus)

Synthesis of variously coupled conjugates of d-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase

Kun, S., Nagy, G. Z., Tóth, M., Czecze, L., Van Nhien, A. N., Docsa, T., Gergely, P., Charavgi, M. D., Skourti, P. V., Chrysina, E. D., Patonay, T. & Somsák, L., Sep 6 2011, In : Carbohydrate Research. 346, 12, p. 1427-1438 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2010

5′-Uridyl derivatives of N-glycosyl allophanic acid and biuret

Tóth, M. & Somsák, L., Jan 11 2010, In : Carbohydrate Research. 345, 1, p. 163-167 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)
62 Citations (Scopus)

Synthesis of new glycosyl biuret and urea derivatives as potential glycoenzyme inhibitors

Felföldi, N., Tóth, M., Chrysina, E. D., Charavgi, M. D., Alexacou, K. M. & Somsák, L., Jan 26 2010, In : Carbohydrate Research. 345, 2, p. 208-213 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Tethered derivatives of d-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase

Cheng, K., Liu, J., Sun, H., Bokor, É., Czifrák, K., Kónya, B., Tóth, M., Docsa, T., Gergely, P. & Somsák, L., Jul 2010, In : New Journal of Chemistry. 34, 7, p. 1450-1464 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2009

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

Chrysina, E. D., Bokor, É., Alexacou, K. M., Charavgi, M. D., Oikonomakos, G. N., Zographos, S. E., Leonidas, D. D., Oikonomakos, N. G. & Somsák, L., May 7 2009, In : Tetrahedron Asymmetry. 20, 6-8, p. 733-740 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase

Nagy, V., Benltifa, M., Vidal, S., Berzsényi, E., Teilhet, C., Czifrák, K., Batta, G., Docsa, T., Gergely, P., Somsák, L. & Praly, J. P., Aug 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 15, p. 5696-5707 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Synthesis and glycogen phosphorylase inhibitory activity of N-(β-d-glucopyranosyl)amides possessing 1,4-benzodioxane moiety

Czakó, Z., Juhász, L., Kenéz, Á., Czifrák, K., Somsák, L., Docsa, T., Gergely, P. & Antus, S., Sep 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 18, p. 6738-6741 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase

Tóth, M., Kun, S., Bokor, É., Benltifa, M., Tallec, G., Vidal, S., Docsa, T., Gergely, P., Somsák, L. & Praly, J. P., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4773-4785 13 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Synthesis of anomeric sulfonamides and their behaviour under radical-mediated bromination conditions

Czifrák, K. & Somsák, L., Feb 17 2009, In : Carbohydrate Research. 344, 3, p. 269-277 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis of some O-, S- and N-glycosides of hept-2-ulopyranosonamides

Nagy, V., Czifrák, K., Bényei, A. & Somsák, L., May 12 2009, In : Carbohydrate Research. 344, 7, p. 921-927 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2008

Advances in glycogen phosphorylase inhibitor design

Oikonomakos, N. G. & Somsák, L., Apr 1 2008, In : Current Opinion in Investigational Drugs. 9, 4, p. 379-395 17 p.

Research output: Contribution to journalReview article

81 Citations (Scopus)

Assessment of synthetic methods for the preparation of N-β-d-glucopyranosyl-N′-substituted ureas, -thioureas and related compounds

Somsák, L., Felföldi, N., Kónya, B., Hüse, C., Telepó, K., Bokor, É. & Czifrák, K., Aug 11 2008, In : Carbohydrate Research. 343, 12, p. 2083-2093 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Electrochemical bromination of peracetylated glycals

Čolović, M., Vukićević, M., Šegan, D., Manojlović, D., Sojic, N., Somsák, L. & Vukićević, R. D., Jan 2008, In : Advanced Synthesis and Catalysis. 350, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

New inhibitors of glycogen phosphorylase as potential antidiabetic agents

Somsák, L., Czifrák, K., Tóth, M., Bokor, É., Chrysina, E. D., Alexacou, K. M., Hayes, J. M., Tiraidis, C., Lazoura, E., Leonidas, D. D., Zographos, S. E. & Oikonomakos, N. G., Dec 1 2008, In : Current medicinal chemistry. 15, 28, p. 2933-2983 51 p.

Research output: Contribution to journalReview article

122 Citations (Scopus)
31 Citations (Scopus)

Remarkable oxidation stability of glycals: Excellent substrates for cerium(IV)-mediated radical reactions

Linker, T., Schanzenbach, D., Elamparuthi, E., Sommermann, T., Fudickar, W., Gyóllai, V., Somsák, L., Demuth, W. & Schmittel, M., Nov 26 2008, In : Journal of the American Chemical Society. 130, 47, p. 16003-16010 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2007

Chromium(II)-complex mediated formation of C-glycosides from glycosyl halides under aqueous biphasic conditions

Juhász, Z., Micskei, K., Gál, E. & Somsák, L., Oct 8 2007, In : Tetrahedron Letters. 48, 41, p. 7351-7353 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2006

Crystallographic studies on two bioisosteric analogues, N-acetyl-β-D-glucopyranosylamine and N-trifluoroacetyl-β-D- glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

Anagnostou, E., Kosmopoulou, M. N., Chrysina, E. D., Leonidas, D. D., Hadjiloi, T., Tiraidis, C., Zographos, S. E., Györgydeák, Z., Somsák, L., Docsa, T., Gergely, P., Kolisis, F. N. & Oikonomakos, N. G., Jan 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 1, p. 181-189 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reactivity of per-O-acetylated 1-thioglycosides and glycosyl sulfones towards chromium(II) complexes in aqueous medium

Micskei, K., Juhász, Z., Ratković, Z. R. & Somsák, L., Aug 21 2006, In : Tetrahedron Letters. 47, 34, p. 6117-6120 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis of N-(β-d-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase

Czifrák, K., Hadady, Z., Docsa, T., Gergely, P., Schmidt, J., Wessjohann, L. & Somsák, L., Jun 12 2006, In : Carbohydrate Research. 341, 8, p. 947-956 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2005
22 Citations (Scopus)

Enzymatic synthesis of a new inhibitor of α-amylases: Acarviosinyl-isomaltosyl-spiro-thiohydantoin

Kandra, L., Remenyik, J., Batta, G., Somsák, L., Gyémánt, G. & Park, K. H., May 23 2005, In : Carbohydrate Research. 340, 7, p. 1311-1317 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Kinetic and crystallographic studies on 2-(β-D-glucopyranosyl)-5- methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

Chrysina, E. D., Kosmopoulou, M. N., Tiraidis, C., Kardakaris, R., Bischler, N., Leonidas, D. D., Hadady, Z., Somsak, L., Docsa, T., Gergely, P. & Oikonomakos, N. G., Apr 1 2005, In : Protein Science. 14, 4, p. 873-888 16 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
18 Citations (Scopus)
14 Citations (Scopus)
2004

C-(β-D-glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors

Hadady, Z., Tóth, M. & Somsák, L., Jan 1 2004, In : Arkivoc. 2004, 7, p. 140-149 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
21 Citations (Scopus)

Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy- β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase

Györgydeák, Z., Hadady, Z., Felfóldi, N., Krakomperger, A., Nagy, V., Tóth, M., Brunyánszki, A., Docsa, T., Gergely, P. & Somsák, L., Sep 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 18, p. 4861-4870 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2003
21 Citations (Scopus)

Crystallographic studies on α- and β-D-glucopyranosyl formamide analogues, inhibitors of glycogen phosphorylase

Chrysina, E. D., Oikonomakos, N. G., Zographos, S. E., Kosmopoulou, M. N., Bischler, N., Leonidas, D. D., Kovács, L., Docsa, T., Gergely, P. & Somsák, L., Aug 1 2003, In : Biocatalysis and Biotransformation. 21, 4-5, p. 233-242 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: Recent developments

Somsák, L., Nagy, V., Hadady, Z., Docsa, T. & Gergely, P., May 28 2003, In : Current pharmaceutical design. 9, 15, p. 1177-1189 13 p.

Research output: Contribution to journalReview article

195 Citations (Scopus)
27 Citations (Scopus)
14 Citations (Scopus)
2002

Addition of malonyl radicals to glycals with C-1 acceptor groups: Remarkable influence of the substituents on the product distribution

Gyollai, V., Schanzenbach, D., Somsák, L. & Linker, T., Jan 1 2002, In : Chemical Communications. 2, 12, p. 1294-1295 2 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Binding of N-acetyl-N′-β-D-glucopyranosyl urea and N-benzoyl-N′-β-D-glucopyranosyl urea to glycogen phosphorylase b. Kinetic and crystallographic studies

Oikonomakos, N. G., Kosmopoulou, M., Zographos, S. E., Leonidas, D. D., Chrysina, E. D., Somsák, L., Nagy, V., Praly, J. P., Docsa, T., Tóth, B. & Gergely, P., Apr 23 2002, In : European Journal of Biochemistry. 269, 6, p. 1684-1696 13 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase b

Oikonomakos, N. G., Skamnaki, V. T., Ösz, E., Szilágyi, L., Somsák, L., Docsa, T., Tóth, B. & Gergely, P., Jan 1 2002, In : Bioorganic and Medicinal Chemistry. 10, 2, p. 261-268 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
10 Citations (Scopus)

Szénhidrátkémiai kutatások Magyarorszá gon: Összefoglaló közlemény

Translated title of the contribution: Carbohydrate researches in HungaryLipták, A., Pintér, I. & Somsák, L., Nov 2002, In : Magyar Kemiai Folyoirat, Kemiai Kozlemenyek. 108, 11, p. 467-491 25 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2001

Carbanionic reactivity of the anomeric center in carbohydrates

Somsák, L., Jan 1 2001, In : Chemical reviews. 101, 1, p. 81-135 55 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)
27 Citations (Scopus)

Mass Spectrometric studies of anomeric glycopyranosyl azides

Dinya, Z., Benke, P., Györgydeák, Z., Somsák, L., Jekö, J., Pintér, I., Kuszman, J. & Praly, J. P., 2001, In : Journal of Mass Spectrometry. 36, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

One-pot transformation of nitriles into aldehyde tosylhydrazones

Tóth, M. & Somsák, L., Apr 2 2001, In : Tetrahedron Letters. 42, 14, p. 2723-2725 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)