• 3249 Citations
  • 32 h-Index
1981 …2019

Research output per year

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Research Output

Article

4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase

Bokor, É., Kun, S., Docsa, T., Gergely, P. & Somsák, L., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1215-1219 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

5′-Uridyl derivatives of N-glycosyl allophanic acid and biuret

Tóth, M. & Somsák, L., Jan 11 2010, In : Carbohydrate Research. 345, 1, p. 163-167 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Acetylated 1-cyano and 1-cyano-2-hydroxy derivatives of d-galactal and d-arabinal

Somsák, L., Dec 21 1989, In : Carbohydrate Research. 195, 1, p. C1-C2

Research output: Contribution to journalArticle

9 Citations (Scopus)

Addition of malonyl radicals to glycals with C-1 acceptor groups: Remarkable influence of the substituents on the product distribution

Gyollai, V., Schanzenbach, D., Somsák, L. & Linker, T., Jan 1 2002, In : Chemical Communications. 2, 12, p. 1294-1295 2 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

Chrysina, E. D., Bokor, É., Alexacou, K. M., Charavgi, M. D., Oikonomakos, G. N., Zographos, S. E., Leonidas, D. D., Oikonomakos, N. G. & Somsák, L., May 7 2009, In : Tetrahedron Asymmetry. 20, 6-8, p. 733-740 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Kun, S., Begum, J., Kyriakis, E., Stamati, E. C. V., Barkas, T. A., Szennyes, E., Bokor, É., Szabó, K. E., Stravodimos, G. A., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M. S., Kokolaki, M. C., Gkerdi, A., Skamnaki, V. T., Leonidas, D. D., Somsák, L. & Hayes, J. M., Mar 10 2018, In : European Journal of Medicinal Chemistry. 147, p. 266-278 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
57 Citations (Scopus)

A new synthesis of C-β-d-glycopyranosylmethyl sulfides by metal-free coupling of anhydro-aldose tosylhydrazones with thiols

Kaszás, T., Tóth, M. & Somsák, L., Jan 1 2017, In : New Journal of Chemistry. 41, 22, p. 13871-13880 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
7 Citations (Scopus)
22 Citations (Scopus)

Assessment of synthetic methods for the preparation of N-β-d-glucopyranosyl-N′-substituted ureas, -thioureas and related compounds

Somsák, L., Felföldi, N., Kónya, B., Hüse, C., Telepó, K., Bokor, É. & Czifrák, K., Aug 11 2008, In : Carbohydrate Research. 343, 12, p. 2083-2093 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A straightforward route to hydantocidin analogues with pyranose ring structure

Osz, E., Sós, E., Somsák, L., Szilágyi, L. & Dinya, Z., Apr 21 1997, In : Tetrahedron. 53, 16, p. 5813-5824 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Binding of N-acetyl-N′-β-D-glucopyranosyl urea and N-benzoyl-N′-β-D-glucopyranosyl urea to glycogen phosphorylase b. Kinetic and crystallographic studies

Oikonomakos, N. G., Kosmopoulou, M., Zographos, S. E., Leonidas, D. D., Chrysina, E. D., Somsák, L., Nagy, V., Praly, J. P., Docsa, T., Tóth, B. & Gergely, P., Apr 23 2002, In : European Journal of Biochemistry. 269, 6, p. 1684-1696 13 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

C-(2-Deoxy-d-arabino-hex-1-enopyranosyl)-oxadiazoles: Synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors

Bokor, É., Szennyes, E., Csupász, T., Tóth, N., Docsa, T., Gergely, P. & Somsák, L., Jun 14 2015, In : Carbohydrate Research. 412, p. 71-79 9 p., 6993.

Research output: Contribution to journalArticle

15 Citations (Scopus)
18 Citations (Scopus)

C-(β-D-glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors

Hadady, Z., Tóth, M. & Somsák, L., Jan 1 2004, In : Arkivoc. 2004, 7, p. 140-149 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Carbanionic reactivity of the anomeric center in carbohydrates

Somsák, L., Jan 1 2001, In : Chemical reviews. 101, 1, p. 81-135 55 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

C-Glucopyranosyl-1,2,4-triazol-5-ones: Synthesis and inhibition of glycogen phosphorylase

Bokor, É., Széles, Z., Docsa, T., Gergely, P. & Somsák, L., Oct 8 2015, (Accepted/In press) In : Carbohydrate Research.

Research output: Contribution to journalArticle

8 Citations (Scopus)

C-glucopyranosyl-1,2,4-triazoles as new potent inhibitors of glycogen phosphorylase

Bokor, É., Docsa, T., Gergely, P. & Somsák, L., Jul 11 2013, In : ACS Medicinal Chemistry Letters. 4, 7, p. 612-615 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

C-Glycosyl 1,2,4-triazoles: Synthesis of the 3-β-D-glucopyranosyl-1,5-disubstituted and 5-β-D-glucopyranosyl-1,3-disubstituted variants

Szabó, K. E., Páhi, A. & Somsák, L., Jan 1 2017, In : Tetrahedron. 73, 27-28, p. 3810-3822 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
21 Citations (Scopus)

C-Glycosyl Styrene Type Compounds by Pd-Catalyzed Cross-Coupling Reactions of Anhydro-Aldose Tosylhydrazones with Benzyl Bromides

Kaszás, T., Tóth, M., Langer, P. & Somsák, L., Jan 11 2019, In : Advanced Synthesis and Catalysis. 361, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media

Misra, A. K., Bokor, É., Kun, S., Bolyog-Nagy, E., Kathó, Á., Joó, F. & Somsák, L., Oct 28 2015, In : Tetrahedron Letters. 56, 44, p. 5995-5998 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Chromium(II)-complex mediated formation of C-glycosides from glycosyl halides under aqueous biphasic conditions

Juhász, Z., Micskei, K., Gál, E. & Somsák, L., Oct 8 2007, In : Tetrahedron Letters. 48, 41, p. 7351-7353 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Circular Dichroism, XC. CD of 1‐Cyano Derivatives of Pyranoses

Farkas, I., Somsák, L. & Snatzke, G., 1989, In : Liebigs Annalen der Chemie. 1989, 6, p. 599-600 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

C-nucleosides, V. Synthesis of 5-(per-0-acyl-β-D-glycosyl)-2-halogenomethyl- and 2-azidomethyl-1,3,4-oxadiazoles

Szabo, I. F., Somsak, L. & Farkas, I., Jan 1 1984, In : Acta Chimica Hungarica. 115, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors

Begum, J., Varga, G., Docsa, T., Gergely, P., Hayes, J. M., Juhász, L. & Somsák, L., Jan 1 2015, In : MedChemComm. 6, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Conformation of C‐1‐Substituted Pyranos‐1‐yl and Pyranosan‐5‐yl Radicals Evidence for a Quasi‐Homo‐Anomeric Stabilization Effect

Korth, HG. G., Sustmann, R., Praly, JP. P. & Somsák, L., 1990, In : Chemische Berichte. 123, 5, p. 1155-1160 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
6 Citations (Scopus)

Crystallographic studies on two bioisosteric analogues, N-acetyl-β-D-glucopyranosylamine and N-trifluoroacetyl-β-D- glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

Anagnostou, E., Kosmopoulou, M. N., Chrysina, E. D., Leonidas, D. D., Hadjiloi, T., Tiraidis, C., Zographos, S. E., Györgydeák, Z., Somsák, L., Docsa, T., Gergely, P., Kolisis, F. N. & Oikonomakos, N. G., Jan 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 1, p. 181-189 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Crystallographic studies on α- and β-D-glucopyranosyl formamide analogues, inhibitors of glycogen phosphorylase

Chrysina, E. D., Oikonomakos, N. G., Zographos, S. E., Kosmopoulou, M. N., Bischler, N., Leonidas, D. D., Kovács, L., Docsa, T., Gergely, P. & Somsák, L., Aug 1 2003, In : Biocatalysis and Biotransformation. 21, 4-5, p. 233-242 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Decomposition of N-Chloroglycine in Alkaline Aqueous Solution: Kinetics and Mechanism

Szabó, M., Baranyai, Z., Somsák, L. & Fábián, I., Jun 15 2015, In : Chemical Research in Toxicology. 28, 6, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
44 Citations (Scopus)

Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

Osz, E., Somsák, L., Szilágyi, L., Kovács, L., Docsa, T., Tóth, B. & Gergely, P., May 17 1999, In : Bioorganic and Medicinal Chemistry Letters. 9, 10, p. 1385-1390 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Electrochemical bromination of peracetylated glycals

Čolović, M., Vukićević, M., Šegan, D., Manojlović, D., Sojic, N., Somsák, L. & Vukićević, R. D., Jan 2008, In : Advanced Synthesis and Catalysis. 350, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Enzymatic synthesis of a new inhibitor of α-amylases: Acarviosinyl-isomaltosyl-spiro-thiohydantoin

Kandra, L., Remenyik, J., Batta, G., Somsák, L., Gyémánt, G. & Park, K. H., May 23 2005, In : Carbohydrate Research. 340, 7, p. 1311-1317 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Estimation of the Anomeric Effect of the Cyano Group

Somsák, L. & Szabó, M., Jan 1990, In : Journal of Carbohydrate Chemistry. 9, 5, p. 755-759 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
10 Citations (Scopus)
32 Citations (Scopus)
27 Citations (Scopus)

Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition

Kun, S., Kánya, N., Galó, N., Páhi, A., Mándi, A., Kurtán, T., Makleit, P., Veres, S., Sipos, Á., Docsa, T. & Somsák, L., Jun 19 2019, In : Journal of Agricultural and Food Chemistry. 67, 24, p. 6884-6891 8 p.

Research output: Contribution to journalArticle

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Szabó, K. E., Kyriakis, E., Psarra, A. M. G., Karra, A. G., Sipos, Á., Docsa, T., Stravodimos, G. A., Katsidou, E., Skamnaki, V. T., Liggri, P. G. V., Zographos, S. E., Mándi, A., Király, S. B., Kurtán, T., Leonidas, D. D. & Somsák, L., Jun 18 2019, In : Journal of Medicinal Chemistry. 62, 13, p. 6116-6136 21 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: Synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods

Czifrák, K., Páhi, A., Deák, S., Kiss-Szikszai, A., Kövér, K. E., Docsa, T., Gergely, P., Alexacou, K. M., Papakonstantinou, M., Leonidas, D. D., Zographos, S. E., Chrysina, E. D. & Somsák, L., Aug 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4028-4041 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Glucopyranosylidene-spiro-thiazolinones: Synthetic studies and determination of absolute configuration by TDDFT-ECD calculations

Szabó, K. E., Kun, S., Mándi, A., Kurtán, T. & Somsák, L., Oct 2017, In : Molecules. 22, 10, 1760.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase

Nagy, V., Benltifa, M., Vidal, S., Berzsényi, E., Teilhet, C., Czifrák, K., Batta, G., Docsa, T., Gergely, P., Somsák, L. & Praly, J. P., Aug 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 15, p. 5696-5707 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

Goyard, D., Kónya, B., Chajistamatiou, A. S., Chrysina, E. D., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., Maurel, P., Somsák, L., Docsa, T., Gergely, P., Praly, J. P., Azay-Milhau, J. & Vidal, S., Jan 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 444-454 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Glycogen phosphorylase inhibition improves beta cell function

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L. & Bai, P., Jan 1 2018, In : British journal of pharmacology. 175, 2, p. 301-319 19 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
35 Citations (Scopus)