• 3241 Citations
  • 32 h-Index
1981 …2019

Research output per year

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Research Output

2019

C-Glycosyl Styrene Type Compounds by Pd-Catalyzed Cross-Coupling Reactions of Anhydro-Aldose Tosylhydrazones with Benzyl Bromides

Kaszás, T., Tóth, M., Langer, P. & Somsák, L., Jan 11 2019, In : Advanced Synthesis and Catalysis. 361, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition

Kun, S., Kánya, N., Galó, N., Páhi, A., Mándi, A., Kurtán, T., Makleit, P., Veres, S., Sipos, Á., Docsa, T. & Somsák, L., Jun 19 2019, In : Journal of Agricultural and Food Chemistry. 67, 24, p. 6884-6891 8 p.

Research output: Contribution to journalArticle

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Szabó, K. E., Kyriakis, E., Psarra, A. M. G., Karra, A. G., Sipos, Á., Docsa, T., Stravodimos, G. A., Katsidou, E., Skamnaki, V. T., Liggri, P. G. V., Zographos, S. E., Mándi, A., Király, S. B., Kurtán, T., Leonidas, D. D. & Somsák, L., Jun 18 2019, In : Journal of Medicinal Chemistry. 62, 13, p. 6116-6136 21 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of C-β-D-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies

Barr, D., Szennyes, E., Bokor, É., Al-Oanzi, Z. H., Moffatt, C., Kun, S., Docsa, T., Sipos, Á., Davies, M. P., Mathomes, R. T., Snape, T. J., Agius, L., Somsák, L. & Hayes, J. M., Jul 19 2019, In : ACS Chemical Biology. 14, 7, p. 1460-1470 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

New syntheses towards C-glycosyl type glycomimetics

Somsák, L., Bokor, É., Juhász, L., Kun, S., Lázár, L., Juhász-Tóth, É. & Tóth, M., Jul 1 2019, In : Pure and Applied Chemistry. 91, 7, p. 1159-1175 17 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Synthesis of C-β-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase

Szennyes, E., Bokor, É., Docsa, T., Sipos, Á. & Somsák, L., Jan 15 2019, In : Carbohydrate Research. p. 33-41 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Thio-click reaction of 2-deoxy-exo-glycals towards new glycomimetics: stereoselective synthesis of C-2-deoxy-d-glycopyranosyl compounds

József, J., Juhász, L. & Somsák, L., Jan 1 2019, In : New Journal of Chemistry. 43, 15, p. 5670-5686 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Kun, S., Begum, J., Kyriakis, E., Stamati, E. C. V., Barkas, T. A., Szennyes, E., Bokor, É., Szabó, K. E., Stravodimos, G. A., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M. S., Kokolaki, M. C., Gkerdi, A., Skamnaki, V. T., Leonidas, D. D., Somsák, L. & Hayes, J. M., Mar 10 2018, In : European Journal of Medicinal Chemistry. 147, p. 266-278 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Glycogen phosphorylase inhibition improves beta cell function

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L. & Bai, P., Jan 1 2018, In : British journal of pharmacology. 175, 2, p. 301-319 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pd-catalyzed coupling reactions of anhydro-aldose tosylhydrazones with aryl bromides to produce substituted exo-glycals

Kaszás, T., Ivanov, A., Tóth, M., Ehlers, P., Langer, P. & Somsák, L., Aug 2018, In : Carbohydrate Research. 466, p. 30-38 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors

Kyriakis, E., Solovou, T. G. A., Kun, S., Czifrák, K., Szőcs, B., Juhász, L., Bokor, É., Stravodimos, G. A., Kantsadi, A. L., Chatzileontiadou, D. S. M., Skamnaki, V. T., Somsák, L. & Leonidas, D. D., Apr 2018, In : Bioorganic Chemistry. 77, p. 485-493 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
7 Citations (Scopus)

Synthesis of thiomaltooligosaccharides by a thio-click approach

Lázár, L., Borbás, A. & Somsák, L., Dec 1 2018, In : Carbohydrate Research. 470, p. 8-12 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The first general synthesis of 2-C-(β-d-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes

Szennyes, E., Bokor, E., Langer, P., Gyémánt, G., Docsa, T., Sipos, Á. & Somsák, L., Jan 1 2018, In : New Journal of Chemistry. 42, 21, p. 17439-17446 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

A new synthesis of C-β-d-glycopyranosylmethyl sulfides by metal-free coupling of anhydro-aldose tosylhydrazones with thiols

Kaszás, T., Tóth, M. & Somsák, L., Jan 1 2017, In : New Journal of Chemistry. 41, 22, p. 13871-13880 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

C-Glycosyl 1,2,4-triazoles: Synthesis of the 3-β-D-glucopyranosyl-1,5-disubstituted and 5-β-D-glucopyranosyl-1,3-disubstituted variants

Szabó, K. E., Páhi, A. & Somsák, L., Jan 1 2017, In : Tetrahedron. 73, 27-28, p. 3810-3822 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Glucopyranosylidene-spiro-thiazolinones: Synthetic studies and determination of absolute configuration by TDDFT-ECD calculations

Szabó, K. E., Kun, S., Mándi, A., Kurtán, T. & Somsák, L., Oct 1 2017, In : Molecules. 22, 10, 1760.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β- D -Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study

Bokor, É., Kyriakis, E., Solovou, T. G. A., Koppány, C., Kantsadi, A. L., Szabó, K. E., Szakács, A., Stravodimos, G. A., Docsa, T., Skamnaki, V. T., Zographos, S. E., Gergely, P., Leonidas, D. D. & Somsák, L., Nov 22 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9251-9262 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

van der Waals interactions govern C-β-D-glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase

Kantsadi, A. L., Stravodimos, G. A., Kyriakis, E., Chatzileontiadou, D. S. M., Solovou, T. G. A., Kun, S., Bokor, É., Somsák, L. & Leonidas, D. D., Jul 2017, In : Journal of Structural Biology. 199, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

Goyard, D., Kónya, B., Chajistamatiou, A. S., Chrysina, E. D., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., Maurel, P., Somsák, L., Docsa, T., Gergely, P., Praly, J. P., Azay-Milhau, J. & Vidal, S., Jan 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 444-454 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles

Petrušová, M., Smrtičová, H., Pribulová, B., Vlčková, S., Uhliariková, I., Docsa, T., Somsák, L. & Petruš, L., Apr 28 2016, In : Tetrahedron. 72, 17, p. 2116-2121 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Kantsadi, A. L., Bokor, É., Kun, S., Stravodimos, G. A., Chatzileontiadou, D. S. M., Leonidas, D. D., Juhász-Tóth, É., Szakács, A., Batta, G., Docsa, T., Gergely, P. & Somsák, L., Jan 1 2016, In : European Journal of Medicinal Chemistry. 123, p. 737-745 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase

Bokor, É., Kun, S., Docsa, T., Gergely, P. & Somsák, L., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1215-1219 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
7 Citations (Scopus)

C-(2-Deoxy-d-arabino-hex-1-enopyranosyl)-oxadiazoles: Synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors

Bokor, É., Szennyes, E., Csupász, T., Tóth, N., Docsa, T., Gergely, P. & Somsák, L., Jun 14 2015, In : Carbohydrate Research. 412, p. 71-79 9 p., 6993.

Research output: Contribution to journalArticle

15 Citations (Scopus)

C-Glucopyranosyl-1,2,4-triazol-5-ones: Synthesis and inhibition of glycogen phosphorylase

Bokor, É., Széles, Z., Docsa, T., Gergely, P. & Somsák, L., Oct 8 2015, (Accepted/In press) In : Carbohydrate Research.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media

Misra, A. K., Bokor, É., Kun, S., Bolyog-Nagy, E., Kathó, Á., Joó, F. & Somsák, L., Oct 28 2015, In : Tetrahedron Letters. 56, 44, p. 5995-5998 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors

Begum, J., Varga, G., Docsa, T., Gergely, P., Hayes, J. M., Juhász, L. & Somsák, L., Jan 1 2015, In : MedChemComm. 6, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Decomposition of N-Chloroglycine in Alkaline Aqueous Solution: Kinetics and Mechanism

Szabó, M., Baranyai, Z., Somsák, L. & Fábián, I., Jun 15 2015, In : Chemical Research in Toxicology. 28, 6, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
21 Citations (Scopus)

Photoinitiated hydrothiolation of pyranoid exo-glycals: The d-galacto and d-xylo cases

József, J., Juhász, L., Illyés, T. Z., Csávás, M., Borbás, A. & Somsák, L., Jun 22 2015, In : Carbohydrate Research. 413, p. 63-69 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthesis of 5-aryl-3-C-glycosyl- and unsymmetrical 3,5-diaryl-1,2,4-triazoles from alkylidene-amidrazones

Szcs, B., Bokor, É., Szabó, K. E., Kiss-Szikszai, A., Tóth, M. & Somsák, L., Jan 1 2015, In : RSC Advances. 5, 54, p. 43620-43629 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Thio-click approach to the synthesis of stable glycomimetics

Lázár, L., Csávás, M., Tóth, M., Somsák, L. & Borbá, A., Jun 1 2015, In : Chemical Papers. 69, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2014

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: Synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods

Czifrák, K., Páhi, A., Deák, S., Kiss-Szikszai, A., Kövér, K. E., Docsa, T., Gergely, P., Alexacou, K. M., Papakonstantinou, M., Leonidas, D. D., Zographos, S. E., Chrysina, E. D. & Somsák, L., Aug 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4028-4041 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase

Kun, S., Bokor, É., Varga, G., Szocs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P. & Somsák, L., Apr 9 2014, In : European Journal of Medicinal Chemistry. 76, p. 567-579 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Structure-activity relationships of glycogen phosphorylase inhibitor FR258900 and its analogues: A combined synthetic, enzyme kinetics, and computational study

Juhász, L., Varga, G., Sztankovics, A., Béke, F., Docsa, T., Kiss-Szikszai, A., Gergely, P., Kóňa, J., Tvaroška, I. & Somsák, L., Nov 2014, In : ChemPlusChem. 79, 11, p. 1558-1568 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase

Somsák, L., Bokor, É., Czibere, B., Czifrák, K., Koppány, C., Kulcsár, L., Kun, S., Szilágyi, E., Tóth, M., Docsa, T. & Gergely, P., Nov 18 2014, In : Carbohydrate Research. 399, p. 38-48 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013
18 Citations (Scopus)

C-glucopyranosyl-1,2,4-triazoles as new potent inhibitors of glycogen phosphorylase

Bokor, É., Docsa, T., Gergely, P. & Somsák, L., Jul 11 2013, In : ACS Medicinal Chemistry Letters. 4, 7, p. 612-615 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
35 Citations (Scopus)

Radical-mediated brominations at ring-positions of carbohydrates - 35 years later

Somsák, L. & Czifrák, K., 2013, Carbohydrate Chemistry. Royal Society of Chemistry, p. 1-37 37 p. (Carbohydrate Chemistry; vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Relaxometric determination of binding between Mn(II)-UDP and Mn(II)-UDP-glucose in aqueous solution

Farkas, E., Szabó, O., Tircsó, G. & Somsák, L., Mar 7 2013, In : Carbohydrate Research. 368, p. 68-72 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors

Polyák, M., Varga, G., Szilágyi, B., Juhász, L., Docsa, T., Gergely, P., Begum, J., Hayes, J. M. & Somsák, L., Sep 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 18, p. 5738-5747 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
10 Citations (Scopus)

Synthesis of 2-(β-d-glucopyranosylamino)-5-substituted-1,3,4- oxadiazoles for inhibition of glycogen phosphorylase

Tóth, M., Szocs, B., Kaszás, T., Docsa, T., Gergely, P. & Somsák, L., Jan 1 2013, In : Carbohydrate Research. 381, p. 196-204 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis of substituted 2-(β-d-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase

Bokor, É., Szilágyi, E., Docsa, T., Gergely, P. & Somsák, L., Jan 1 2013, In : Carbohydrate Research. 381, p. 179-186 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors

Varga, G., Docsa, T., Gergely, P., Juhász, L. & Somsák, L., Mar 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 6, p. 1789-1792 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Systematic study on free radical hydrothiolation of unsaturated monosaccharide derivatives with exo- and endocyclic double bonds

Lázár, L., Csávás, M., Hadházi, Á., Herczeg, M., Tóth, M., Somsák, L., Barna, T., Herczegh, P. & Borbás, A., Aug 28 2013, In : Organic and Biomolecular Chemistry. 11, 32, p. 5339-5350 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012
10 Citations (Scopus)

N-(4-Substituted-benzoyl)-N′-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods

Nagy, V., Felföldi, N., Kónya, B., Praly, J. P., Docsa, T., Gergely, P., Chrysina, E. D., Tiraidis, C., Kosmopoulou, M. N., Alexacou, K. M., Konstantakaki, M., Leonidas, D. D., Zographos, S. E., Oikonomakos, N. G., Kozmon, S., Tvaroška, I. & Somsák, L., Mar 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 5, p. 1801-1816 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)