• 4304 Citations
  • 36 h-Index
1994 …2020

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2020

Acid-Catalyzed 1,3-Dipolar Cycloaddition of 2 H-Azirines with Nitrones: An Unexpected Access to 1,2,4,5-Tetrasubstituted Imidazoles

Angyal, A., Demjén, A., Wölfling, J., Puskás, L. G. & Kanizsai, I., Mar 6 2020, In : Journal of Organic Chemistry. 85, 5, p. 3587-3595 9 p.

Research output: Contribution to journalArticle

Polyploid Adipose Stem Cells Shift the Balance of IGF1/IGFBP2 to Promote the Growth of Breast Cancer

Fajka-Boja, R., Szebeni, G. J., Hunyadi-Gulyás, É., Puskás, L. G. & Katona, R. L., Feb 18 2020, In : Frontiers in Oncology. 10, 157.

Research output: Contribution to journalArticle

Open Access
Open Access
2019
4 Citations (Scopus)

A convenient approach for the preparation of imidazo[1,2-: A] -fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

Makra, Z., Puskás, L. G. & Kanizsai, I., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 40, p. 9001-9007 7 p.

Research output: Contribution to journalArticle

Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212

Sárközy, M., Gáspár, R., Zvara, Á., Siska, A., Kővári, B., Szűcs, G., Márványkövi, F., Kovács, M. G., Diószegi, P., Bodai, L., Zsindely, N., Pipicz, M., Gömöri, K., Kiss, K., Bencsik, P., Cserni, G., Puskás, L. G., Földesi, I., Thum, T., Bátkai, S. & 1 others, Csont, T., Dec 1 2019, In : Scientific reports. 9, 1, 1302.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Enantioselective synthesis of 8-hydroxyquinoline derivative, Q134 as a hypoxic adaptation inducing agent

Hackler, L., Gyuris, M., Huzián, O., Alföldi, R., Szebeni, G. J., Madácsi, R., Knapp, L., Kanizsai, I. & Puskás, L. G., Nov 23 2019, In : Molecules. 24, 23, 4269.

Research output: Contribution to journalArticle

Open Access

Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex

Csajbók, É. A., Kocsis, Á. K., Faragó, N., Furdan, S., Kovács, B., Lovas, S., Molnár, G., Likó, I., Zvara, Á., Puskás, L. G., Patócs, A. & Tamás, G., Apr 1 2019, In : Diabetologia. 62, 4, p. 717-725 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism

Fenteany, G., Gaur, P., Hegedűs, L., Dudás, K., Kiss, E., Wéber, E., Hackler, L., Martinek, T., Puskás, L. G. & Haracska, L., Dec 1 2019, In : Scientific reports. 9, 1, 12801.

Research output: Contribution to journalArticle

Open Access

Sensory neuropathy affects cardiac mirna expression network targeting igf-1, slc2a-12, eif-4e, and ulk-2 mrnas

Bencsik, P., Kiss, K., Ágg, B., Baán, J. A., Ágoston, G., Varga, A., Gömöri, K., Mendler, L., Faragó, N., Zvara, A., Sántha, P., Puskás, L., Jancsó, G. & Ferdinandy, P., Feb 2 2019, In : International journal of molecular sciences. 20, 4, 991.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Signatures of cell death and proliferation in perturbation transcriptomics data-from confounding factor to effective prediction

Szalai, B., Subramanian, V., Holland, C. H., Alföldi, R., Puskás, L. G. & Saez-Rodriguez, J., Nov 4 2019, In : Nucleic acids research. 47, 19, p. 10010-10026 17 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Synthesis and biological evaluation of 4,5,6,7-tetrahydrothieno[2,3-c]pyridine–based β-aminonitriles and their derivatives: β-amino carboxamides, (thio)ureas, and tetracycles

Madácsi, R., Traj, P., Hackler, L., Nagy, L. I., Kari, B., Puskás, L. G. & Kanizsai, I., Jan 1 2019, (Accepted/In press) In : Journal of Heterocyclic Chemistry.

Research output: Contribution to journalArticle

Synthesis of N-Peptide-6-Amino-d-Luciferin Conjugates with Optimized Fragment Condensation Strategy

Kovács, A. K., Hegyes, P., Szebeni, G. J., Bogár, K., Puskás, L. G. & Tóth, G. K., Sep 1 2019, In : International Journal of Peptide Research and Therapeutics. 25, 3, p. 1209-1215 7 p.

Research output: Contribution to journalArticle

The anti-inflammatory role of Mannich curcuminoids; special focus on colitis

Szebeni, G. J., Nagy, L. I., Berkó, A., Hoffmann, A., Fehér, L. Z., Bagyánszki, M., Kari, B., Balog, J. A., Hackler, L., Kanizsai, I., Pósa, A., Varga, C. & Puskás, L., Apr 19 2019, In : Molecules. 1546.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas

Angyal, A., Demjén, A., Wölfling, J., Puskás, L. & Kanizsai, I., Jan 3 2018, In : Tetrahedron Letters. 59, 1, p. 54-57 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cerebrovascular pathology in hypertriglyceridemic APOB-100 transgenic mice

Hoyk, Z., Tóth, M. E., Lénárt, N., Nagy, D., Dukay, B., Csefová, A., Zvara, A., Seprényi, G., Kincses, A., Walter, F. R., Veszelka, S., Vígh, J., Barabási, B., Harazin, A., Kittel, A., Puskás, L., Penke, B., Vígh, L., Deli, M. A. & Sántha, M., Oct 25 2018, In : Frontiers in Cellular Neuroscience. 12, 380.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Enhancing the Translational Capacity of E. coli by Resolving the Codon Bias

Lipinszki, Z., Vernyik, V., Farago, N., Sari, T., Puskas, L. G., Blattner, F. R., Posfai, G. & Gyorfy, Z., Nov 16 2018, In : ACS Synthetic Biology. 7, 11, p. 2656-2664 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Highly regioselective 4-hydroxy-1-methylpiperidine mediated aromatic nucleophilic substitution on a perfluorinated phthalimide core

Madácsi, R., Gyuris, M., Wölfling, J., Puskás, L. & Kanizsai, I., Aug 1 2018, In : Journal of Fluorine Chemistry. 212, p. 38-44 7 p.

Research output: Contribution to journalArticle

Imidazo[1,2-b]pyrazole-7-carboxamides induce apoptosis in human leukemia cells at nanomolar concentrations

Szebeni, G. J., Balog, J. A., Demjén, A., Alföldi, R., Végi, V. L., Fehér, L. Z., Mán, I., Kotogány, E., Gubán, B., Batár, P., Hackler, L., Kanizsai, I. & Puskás, L. G., Nov 1 2018, In : Molecules. 23, 11, 2845.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Intelligent image-based in situ single-cell isolation

Brasko, C., Smith, K., Molnar, C., Farago, N., Hegedus, L., Balind, A., Balassa, T., Szkalisity, A., Sukosd, F., Kocsis, K., Balint, B., Paavolainen, L., Enyedi, M. Z., Nagy, I., Puskas, L. G., Haracska, L., Tamas, G. & Horvath, P., Dec 1 2018, In : Nature communications. 9, 1, 226.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Lewis acid-catalyzed diastereoselective synthesis of multisubstituted N-acylaziridine-2-carboxamides from 2 H -Azirines via Joullié-Ugi three-component reaction

Angyal, A., Demjén, A., Wéber, E., Kovács, A. K., Wölfling, J., Puskás, L. G. & Kanizsai, I., Apr 6 2018, In : Journal of Organic Chemistry. 83, 7, p. 3570-3581 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium

Ágg, B., Baranyai, T., Makkos, A., Veto, B., Faragó, N., Zvara, Á., Giricz, Z., Veres, D. V., Csermely, P., Arányi, T., Puskás, L. G., Varga, Z. V. & Ferdinandy, P., Dec 1 2018, In : Scientific reports. 8, 1, 10134.

Research output: Contribution to journalArticle

6 Citations (Scopus)

One-pot synthesis of diverse: N, N ′-disubstituted guanidines from N -chlorophthalimide, isocyanides and amines via N -phthaloyl-guanidines

Demjén, A., Angyal, A., Wölfling, J., Puskás, L. G. & Kanizsai, I., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 12, p. 2143-2149 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Syndecan-4 influences mammalian myoblast proliferation by modulating myostatin signalling and G1/S transition

Keller-Pinter, A., Szabo, K., Kocsis, T., Deak, F., Ocsovszki, I., Zvara, A., Puskas, L., Szilak, L. & Dux, L., Sep 2018, In : FEBS letters. 592, 18, p. 3139-3151 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides

Demjén, A., Alföldi, R., Angyal, A., Gyuris, M., Hackler, L., Szebeni, G. J., Wölfling, J., Puskás, L. & Kanizsai, I., Jul 1 2018, In : Archiv der Pharmazie. 351, 7, 1800062.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and cytoprotective characterization of 8-hydroxyquinoline Betti products

Kanizsai, I., Madácsi, R., Hackler, L., Gyuris, M., Szebeni, G. J., Huzián, O. & Puskás, L., Jan 1 2018, In : Molecules. 23, 8, 1934.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of N-peptide-6-amino-D-luciferin conjugates

Kovács, A. K., Hegyes, P., Szebeni, G. J., Nagy, L. I., Puskás, L. G. & Tóth, G. K., Apr 1 2018, In : Frontiers in Chemistry. 6, APR, 120.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The importance of aquaporin 1 in pancreatitis and its relation to the CFTR Cl- Channel

Venglovecz, V., Pallagi, P., Kemény, L. V., Balázs, A., Balla, Z., Becskeházi, E., Gál, E., Tóth, E., Zvara, Á., Puskás, L. G., Borka, K., Sendler, M., Lerch, M. M., Mayerle, J., Kühn, J. P., Rakonczay, Z. & Hegyi, P., Jul 12 2018, In : Frontiers in Physiology. 9, JUL, 854.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

Achiral Mannich-base curcumin analogs induce unfolded protein response and mitochondrial membrane depolarization in PANC-1 cells

Szebeni, G. J., Balázs, Á., Madarász, I., Pócz, G., Ayaydin, F., Kanizsai, I., Fajka-Boja, R., Alföldi, R., Hackler, L. & Puskás, L. G., Oct 2017, In : International journal of molecular sciences. 18, 10, 2105.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells

Kata, D., Földesi, I., Feher, L. Z., Hackler, L., Puskas, L. G. & Gulya, K., Jun 2017, In : Brain Research Bulletin. 132, p. 61-74 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Decoding DNA labels by melting curve analysis using real-time PCR

Balog, J. A., Fehér, L. Z. & Puskás, L., Dec 1 2017, In : BioTechniques. 63, 6, p. 261-266 6 p.

Research output: Contribution to journalArticle

Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters

Szebeni, G. J., Vizler, C., Kitajka, K. & Puskas, L. G., 2017, In : Mediators of Inflammation. 2017, 9294018.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas

Csonka, C., Baranyai, T., Tiszlavicz, L., Fébel, H., Szucs, G., Varga, Z. V., Sárközy, M., Puskás, L., Antal, O., Siska, A., Földesi, I., Ferdinandy, P., Czakó, L. & Csont, T., Jul 27 2017, In : Lipids in Health and Disease. 16, 1, 144.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mannich Curcuminoids as Potent Anticancer Agents

Gyuris, M., Hackler, L., Nagy, L. I., Alföldi, R., Rédei, E., Marton, A., Vellai, T., Faragó, N., Ózsvári, B., Hetényi, A., Tóth, G., Sipos, P., Kanizsai, I. & Puskás, L., Jul 1 2017, In : Archiv der Pharmazie. 350, 7, e1700005.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects

Papp, D., Kovács, T., Billes, V., Varga, M., Tarnóci, A., Hackler, L., Puskás, L., Liliom, H., Tárnok, K., Schlett, K., Borsy, A., Pádár, Z., Kovács, A., Hegedűs, K., Juhász, G., Komlós, M., Erdős, A., Gulyás, B. & Vellai, T., Jan 1 2016, In : Autophagy. 12, 2, p. 273-286 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Human neuronal changes in brain edema and increased intracranial pressure

Faragó, N., Kocsis, Á. K., Braskó, C., Lovas, S., Rózsa, M., Baka, J., Kovács, B., Mikite, K., Szemenyei, V., Molnár, G., Ozsvár, A., Oláh, G., Piszár, I., Zvara, Á., Patócs, A., Barzó, P., Puskás, L. G. & Tamás, G., Aug 4 2016, In : Acta Neuropathologica Communications. 4, 1, 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Investigation of the antiproliferative properties of natural sesquiterpenes from artemisia asiatica and onopordum acanthium on HL-60 cells in vitro

Molnár, J., Szebeni, G. J., Csupor-Löffler, B., Hajdú, Z., Szekeres, T., Saiko, P., Ocsovszki, I., Puskás, L., Hohmann, J. & Zupkó, I., Feb 1 2016, In : International Journal of Molecular Sciences. 17, 2, 83.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Novel Anti-CRR9/CLPTM1L antibodies with antitumorigenic activity inhibit cell surface accumulation, PI3K interaction, and survival signaling

Puskás, L., Mán, I., Szebeni, G., Tiszlavicz, L., Tsai, S. & James, M. A., May 1 2016, In : Molecular Cancer Therapeutics. 15, 5, p. 985-997 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells

Kata, D., Földesi, I., Feher, L. Z., Hackler, L., Puskas, L. G. & Gulya, K., Feb 9 2016, In : Neuroscience. 314, p. 47-63 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Structural and molecular features of intestinal strictures in rats with Crohn's-like disease

Talapka, P., Berkó, A., Nagy, L. I., Chandrakumar, L., Bagyánszki, M., Puskás, L., Fekete, É. & Bódi, N., Jun 14 2016, In : World Journal of Gastroenterology. 22, 22, p. 5154-5164 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The curcumin analog C-150, influencing NF-κB, UPR and Akt/Notch pathways has potent anticancer activity in vitro and in vivo

Hackler, L., Ózsvári, B., Gyuris, M., Sípos, P., Fábián, G., Molnár, E., Marton, A., Faragó, N., Mihály, J., Nagy, L. I., Szénási, T., Diron, A., Párducz, A., Kanizsai, I. & Puskás, L., Mar 1 2016, In : PLoS One. 11, 3, e0149832.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Characterization of a new class of blue-fluorescent lipid droplet markers for live-cell imaging in plants

Kuntam, S., Puskás, L. G. & Ayaydin, F., Apr 1 2015, In : Plant Cell Reports. 34, 4, p. 655-665 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: Effects of oxidized low-density lipoprotein treatment

Lénárt, N., Walter, F. R., Bocsik, A., Sántha, P., Tóth, M. E., Harazin, A., Tóth, A. E., Vizler, C., Török, Z., Pilbat, A. M., Vígh, L., Puskás, L. G., Sántha, M. & Deli, M. A., Jul 17 2015, In : Fluids and Barriers of the CNS. 12, 1, 17.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Curcumin and its analogue induce apoptosis in leukemia cells and have additive effects with bortezomib in cellular and xenograft models

Nagy, L. I., Fehér, L. Z., Szebeni, G. J., Gyuris, M., Sipos, P., Alföldi, R., Ózsvári, B., Hackler, L., Balázs, A., Batár, P., Kanizsai, I. & Puskás, L. G., Jan 1 2015, In : BioMed research international. 2015, 968981.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: Implications in target identification

Varga, Z. V., Giricz, Z., Bencsik, P., Madonna, R., Gyöngyösi, M., Schulz, R., Mayr, M., Thum, T., Puskás, L. G. & Ferdinandy, P., Aug 1 2015, In : Current drug targets. 16, 8, p. 904-911 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells

Antal, O., Péter, M., Hackler, L., Mán, I., Szebeni, G., Ayaydin, F., Hideghéty, K., Vigh, L., Kitajka, K., Balogh, G. & Puskás, L. G., Jul 4 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 9, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Microarray technology

Zvara, Á., Kitajka, K., Faragó, N. & Puskás, L. G., 2015, In : Acta Biologica Szegediensis. 59, p. 51-67 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Weber, F. C., Németh, T., Csepregi, J. Z., Dudeck, A., Roers, A., Ozsvári, B., Oswald, E., Puskás, L. G., Jakob, T., Mócsai, A. & Martin, S. F., Jan 1 2015, In : Journal of Experimental Medicine. 212, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Novel real-time cell analysis platform for the dynamic monitoring of ionizing radiation effects on human tumor cell lines and primary fibroblasts

Mán, I., Szebeni, G. J., Plangár, I., Szabó, E. R., Tokés, T., Szabó, Z., Nagy, Z., Fekete, G., Fajka-Boja, R., Puskás, L. G., Hideghéty, K. & Hackler, L., Sep 1 2015, In : Molecular Medicine Reports. 12, 3, p. 4610-4619 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats

Sárközy, M., Szucs, G., Pipicz, M., Zvara, Á., Éder, K., Fekete, V., Szucs, C., Bárkányi, J., Csonka, C., Puskás, L. G., Kónya, C., Ferdinandy, P. & Csont, T., Jun 28 2015, In : Cardiovascular diabetology. 14, 1, 85.

Research output: Contribution to journalArticle

9 Citations (Scopus)