• 1163 Citations
  • 19 h-Index
1982 …2019

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Article
2019

Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8

Oláh, J., Szunyogh, S., Szénási, T., Szaniszló, T., Szabó, A., Lehotzky, A., Berki, T., Nyitray, L. & Ovádi, J., Dec 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118556.

Research output: Contribution to journalArticle

Matrigel patterning reflects multicellular contractility

Méhes, E., Biri-Kovács, B., Isai, D. G., Gulyás, M., Nyitray, L. & Czirók, A., Jan 1 2019, In : PLoS computational biology. 15, 10, e1007431.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Rewiring of RSK–PDZ Interactome by Linear Motif Phosphorylation

Gógl, G., Biri-Kovács, B., Durbesson, F., Jane, P., Nomine, Y., Kostmann, C., Bilics, V., Simon, M., Reményi, A., Vincentelli, R., Trave, G. & Nyitray, L., Mar 15 2019, In : Journal of molecular biology. 431, 6, p. 1234-1249 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural insights into the tyrosine phosphorylation–mediated inhibition of SH3 domain–ligand interactions

Mero, B., Radnai, L., Gógl, G., To ke, O., Leveles, I., Koprivanacz, K., Szeder, B., Dülk, M., Kudlik, G., Virág Vas, X., Cserkaszky, A., Sipeki, S., Nyitray, L., Vértessy, B. G. & Buday, L., Mar 22 2019, In : Journal of Biological Chemistry. 294, 12, p. 4608-4620 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Detection of single alpha-helices in large protein sequence sets using hardware acceleration

Kovács, Á., Dudola, D., Nyitray, L., Tóth, G., Nagy, Z. & Gáspári, Z., Oct 2018, In : Journal of Structural Biology. 204, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dynamic control of RSK complexes by phosphoswitch-based regulation

Gógl, G., Biri-Kovács, B., Póti, Á. L., Vadászi, H., Szeder, B., Bodor, A., Schlosser, G., Ács, A., Turiák, L., Buday, L., Alexa, A., Nyitray, L. & Reményi, A., Jan 2018, In : FEBS Journal. 285, 1, p. 46-71 26 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog

Lukacs, P., Földi, M. C., Valánszki, L., Casanova, E., Biri-Kovács, B., Nyitray, L., Málnási-Csizmadia, A. & Mike, A., Dec 1 2018, In : Scientific reports. 8, 1, 8110.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Ezrin interacts with S100A4 via both its N- and C-terminal domains

Biri-Kovács, B., Kiss, B., Vadászi, H., Gógl, G., Pálfy, G., Török, G., Homolya, L., Bodor, A. & Nyitray, L., May 2017, In : PloS one. 12, 5, e0177489.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway

Erdős, G., Szaniszló, T., Pajkos, M., Hajdu-Soltész, B., Kiss, B., Pál, G., Nyitray, L. & Dosztányi, Z., Dec 1 2017, In : PLoS Computational Biology. 13, 12, e1005885.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding

Ecsédi, P., Kiss, B., Gógl, G., Radnai, L., Buday, L., Koprivanacz, K., Liliom, K., Leveles, I., Vértessy, B., Jeszenői, N., Hetényi, C., Schlosser, G., Katona, G. & Nyitray, L., Aug 1 2017, In : Structure. 25, 8, p. 1195-1207.e5

Research output: Contribution to journalArticle

17 Citations (Scopus)
2016

Metastasis-Associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2

Biri, B., Kiss, B., Kiŕaly, R., Schlosser, G., Ĺang, O., Kohidai, Ĺ., Fésüs, Ĺ. & Nyitray, Ĺ., Jan 1 2016, In : Biochemical Journal. 473, 1, p. 31-42 12 p., A4.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Multilevel Changes in Protein Dynamics upon Complex Formation of the Calcium-Loaded S100A4 with a Nonmuscle Myosin IIA Tail Fragment

Pálfy, G., Kiss, B., Nyitray, L. & Bodor, A., Oct 4 2016, In : ChemBioChem. p. 1829-1838 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Real-time kinetic method to monitor isopeptidase activity of transglutaminase 2 on protein substrate

Thangaraju, K., Biri, B., Schlosser, G., Kiss, B., Nyitray, L., Fésüs, L. & Király, R., Jul 15 2016, In : Analytical Biochemistry. 505, p. 36-42 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
25 Citations (Scopus)

Structural determinants governing S100A4-induced isoform-selective disassembly of nonmuscle myosin II filaments

Kiss, B., Kalmár, L., Nyitray, L. & Pál, G., Jun 1 2016, In : FEBS Journal. 283, 11, p. 2164-2180 17 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes

Osteikoetxea-Molnár, A., Szabó-Meleg, E., Tóth, E. A., Oszvald, Á., Izsépi, E., Kremlitzka, M., Biri, B., Nyitray, L., Bozó, T., Németh, P., Kellermayer, M., Nyitrai, M. & Matko, J., Apr 28 2016, In : Cellular and Molecular Life Sciences. 73, 23, p. 4531-4545 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2015

A conserved charged single α-helix with a putative steric role in paraspeckle formation

Dobson, L., Nyitray, L. & Gáspári, Z., Dec 2015, In : RNA. 21, 12, p. 2023-2029 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity

Bodor, A., Radnai, L., Hetényi, C., Rapali, P., Láng, A., Kövér, K. E., Perczel, A., Wahlgren, W. Y., Katona, G. & Nyitray, L., Nov 18 2014, In : Biochemistry. 53, 45, p. 7107-7122 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The C-terminal random coil region tunes the Ca2+-binding affinity of S100A4 through conformational activation

Duelli, A., Kiss, B., Lundholm, I., Bodor, A., Petoukhov, M. V., Svergun, D. I., Nyitray, L. & Katona, G., May 15 2014, In : PloS one. 9, 5, e97654.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2013

Structural insights into the Trp-cage folding intermediate formation

Rovõ, P., Stráner, P., Láng, A., Bartha, I., Huszár, K., Nyitray, L. & Perczel, A., Feb 18 2013, In : Chemistry - A European Journal. 19, 8, p. 2628-2640 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2012

Charged single alpha-helices in proteomes revealed by a consensus prediction approach

Gáspári, Z., Süveges, D., Perczel, A., Nyitray, L. & Tóth, G., Apr 1 2012, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 4, p. 637-646 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
40 Citations (Scopus)
2011

Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome

Rapali, P., Radnai, L., Süveges, D., Harmat, V., Tölgyesi, F., Wahlgren, W. Y., Katona, G., Nyitray, L. & Pál, G., Apr 29 2011, In : PloS one. 6, 4, e18818.

Research output: Contribution to journalArticle

41 Citations (Scopus)

LC8 dynein light chain (DYNLL1) binds to the C-terminal domain of ATM-interacting protein (ATMIN/ASCIZ) and regulates its subcellular localization

Rapali, P., García-Mayoral, M. F., Martínez-Moreno, M., Tárnok, K., Schlett, K., Albar, J. P., Bruix, M., Nyitray, L. & Rodriguez-Crespo, I., Oct 28 2011, In : Biochemical and biophysical research communications. 414, 3, p. 493-498 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2010

Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms

Radnai, L., Rapali, P., Hódi, Z., Süveges, D., Molnár, T., Kiss, B., Bécsi, B., Erdödi, F., Buday, L., Kardos, J., Kovács, M. & Nyitray, L., Dec 3 2010, In : Journal of Biological Chemistry. 285, 49, p. 38649-38657 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Folded-unfolded cross-predictions and protein evolution: The case study of coiled-coils

Szappanos, B., Süveges, D., Nyitray, L., Perczel, A. & Gáspári, Z., Apr 1 2010, In : FEBS letters. 584, 8, p. 1623-1627 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2009

Charged single α-helix: A versatile protein structural motif

Süveges, D., Gáspári, Z., Tóth, G. & Nyitray, L., Mar 1 2009, In : Proteins: Structure, Function and Bioinformatics. 74, 4, p. 905-916 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2008

An Unstable Head-Rod Junction May Promote Folding into the Compact Off-State Conformation of Regulated Myosins

Brown, J. H., Yang, Y., Reshetnikova, L., Gourinath, S., Süveges, D., Kardos, J., Hóbor, F., Reutzel, R., Nyitray, L. & Cohen, C., Feb 1 2008, In : Journal of molecular biology. 375, 5, p. 1434-1443 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Calcium inhibition of Physarum myosin in associated with its conformational change

Zhang, Y., Nakamura, A., Yoshiyama, S., Kohama, K., Kawamichi, H., Farkas, L. & Nyitray, L., Jan 1 2008, In : Kitakanto Medical Journal. 58, 3, p. 345-361 17 p.

Research output: Contribution to journalArticle

2007

Calcium inhibition of Physarum myosin as examined by the recombinant heavy mero-myosin.

Kawamichi, H., Zhang, Y., Hino, M., Nakamura, A., Tanaka, H., Farkas, L., Nyitray, L. & Kohama, K., 2007, In : Advances in Experimental Medicine and Biology. 592, p. 265-272 8 p.

Research output: Contribution to journalArticle

Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor

Yang, Y., Gourinath, S., Kovács, M., Nyitray, L., Reutzel, R., Himmel, D. M., O'Neall-Hennessey, E., Reshetnikova, L., Szent-Györgyi, A. G., Brown, J. H. & Cohen, C., May 16 2007, In : Structure. 15, 5, p. 553-564 12 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
18 Citations (Scopus)
2006

Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein

Hódi, Z., Németh, A. L., Radnai, L., Hetényi, C., Schlett, K., Bodor, A., Perczel, A. & Nyitray, L., Oct 17 2006, In : Biochemistry. 45, 41, p. 12582-12595 14 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2005

Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family

Tóth, J., Kovács, M., Wang, F., Nyitray, L. & Sellers, J. R., Aug 26 2005, In : Journal of Biological Chemistry. 280, 34, p. 30594-30603 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Structural evidence for non-canonical binding of Ca 2+ to a canonical EF-hand of a conventional myosin

Debreczeni, J. É., Farkas, L., Harmat, V., Hetényi, C., Hajdú, I., Závodszky, P., Kohama, K. & Nyitray, L., Dec 16 2005, In : Journal of Biological Chemistry. 280, 50, p. 41458-41464 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The structure of the complex of calmodulin with KAR-2: A novel mode of binding explains the unique pharmacology of the drug

Horváth, I., Harmat, V., Perczel, A., Pálfi, V., Nyitray, L., Nagy, A., Hlavanda, E., Náray-Szabó, G. & Ovádi, J., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 8266-8274 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2004
2 Citations (Scopus)

Two-Headed Binding of the Unphosphorylated Nonmuscle Heavy Meromyosin·ADP Complex to Actin

Kovács, M., Tóth, J., Nyitray, L. & Sellers, J. R., Apr 13 2004, In : Biochemistry. 43, 14, p. 4219-4226 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2003

Localization and characterization of the inhibitory Ca2+-binding site of Physarum polycephalum Myosin II

Farkas, L., Málnási-Csizmadia, A., Nakamura, A., Kohama, K. & Nyitray, L., Jul 25 2003, In : Journal of Biological Chemistry. 278, 30, p. 27399-27405 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Visualization of an unstable coiled coil from the scallop myosin rod

Li, Y., Brown, J. H., Reshetnikova, L., Blazsek, A., Farkas, L., Nyitray, L. & Cohen, C., Jul 17 2003, In : Nature. 424, 6946, p. 341-345 5 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2000

Catchin, a novel protein in molluscan catch muscles, is produced by alternative splicing from the myosin heavy chain gene

Yamada, A., Yoshio, M., Oiwa, K. & Nyitray, L., Jan 14 2000, In : Journal of molecular biology. 295, 2, p. 169-178 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
1999

Fluorescence measurements detect changes in scallop myosin regulatory domain

Málnási-Csizmadia, A., Hegyi, G., Tölgyesi, F., Szent-Györgyi, A. G. & Nyitray, L., Apr 15 1999, In : European Journal of Biochemistry. 261, 2, p. 452-458 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1998

Dimerization of the head-rod junction of scallop myosin

Málnási-Csizmadia, A., Shimony, E., Hegyi, G., Szent-Györgyi, A. G. & Nyitray, L., Nov 27 1998, In : Biochemical and biophysical research communications. 252, 3, p. 595-601 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1996

Sequence variations in the surface loop near the nucleotide binding site modulate the ATP turnover rates of molluscan myosins

Perreault-Micale, C. L., Kalabokis, V. N., Nyitray, L. & Szent-Györgyi, A. G., Oct 30 1996, In : Journal of Muscle Research and Cell Motility. 17, 5, p. 543-553 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Structure and distribution of mini-titins

Vibert, P., York, M. L., Castellani, L., Edelstein, S., Elliott, B. & Nyitray, L., Jan 1 1996, In : Advances in Biophysics. 33, p. 199-209 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1994

Purification and properties of caldesmon-like protein from molluscan smooth muscle

Malnasi Csizmadia, A., Bonet-Kerrache, A., Nyitray, L. & Mornet, D., May 1994, In : Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 108, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Scallop striated and smooth muscle myosin heavy-chain isoforms are produced by alternative RNA splicing from a single gene

Nyitray, L., Jancsó, Á., Ochiai, Y., Gráf, L. & Szent-Györgyi, A. G., Dec 20 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 26, p. 12686-12690 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
1991
40 Citations (Scopus)
1990

Isolation of the regulatory domain of scallop myosin: Role of the essential light chain in calcium binding

Kwon, H., Goodwin, E. B., Nyitray, L., Berliner, E., O'Neall-Hennessey, E., Melandri, F. D. & Szent-Györgyi, A. G., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 12, p. 4771-4775 5 p.

Research output: Contribution to journalArticle

Open Access
47 Citations (Scopus)

Nucleotide sequence of full length cDNA for a scallop striated muscle myosin heavy chain

Nyitray, L., Goodwin, E. B. & Szent-Gyorgyi, A. G., Dec 1 1990, In : Nucleic acids research. 18, 23, 1 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)