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1991 …2020

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Article
2014

Mapping the genomic binding sites of the activated retinoid X receptor in murine bone marrow-derived macrophages using chromatin immunoprecipitation sequencing

Daniel, B., Balint, B. L., Nagy, Z. S. & Nagy, L., Jan 1 2014, In : Methods in Molecular Biology. 1204, p. 15-24 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Myofilament carbonylation modulates contractility in human cardiomyocytes

Balogh, Á., Tot́h, A., Pásztorńe, E. T., Nagy, L., Kov́acs, Á., Kalaśz, J., Contreras, G. A., Édes, I. & Papp, Z., 2014, In : Experimental and Clinical Cardiology. 20, 1, p. 2026-2035 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors

Kotlinowski, J., Grochot-Przeczek, A., Taha, H., Kozakowska, M., Pilecki, B., Skrzypek, K., Bartelik, A., Derlacz, R., Horrevoets, A. J. G., Pap, A., Nagy, L., Dulak, J. & Jozkowicz, A., Nov 1 2014, In : Cardiovascular diabetology. 13, 1, 150.

Research output: Contribution to journalArticle

13 Citations (Scopus)

PPARγ-mediated and arachidonic acid-dependent signaling is involved in differentiation and lipid production of human sebocytes

Dozsa, A., Dezso, B., Toth, B. I., Bacsi, A., Poliska, S., Camera, E., Picardo, M., Zouboulis, C. C., Bíró, T., Schmitz, G., Liebisch, G., Rühl, R., Remenyik, E. & Nagy, L., Apr 2014, In : Journal of Investigative Dermatology. 134, 4, p. 910-920 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

Daniel, B., Nagy, G., Hah, N., Horvath, A., Czimmerer, Z., Poliska, S., Gyuris, T., Keirsse, J., Gysemans, C., Van Ginderachter, J. A., Balint, B. L., Evans, R. M., Barta, E. & Nagy, L., Jul 15 2014, In : Genes and Development. 28, 14, p. 1562-1577 16 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2013

A funkcionális genomikai eszköztár szerepe az onkológiai kutatásokban

Translated title of the contribution: The place of functional genomics in oncological researchBálint, B. L. & László, N., 2013, In : Magyar onkologia. 57, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

A novel method to predict regulatory regions based on histone mark landscapes in macrophages

Nagy, G., Dániel, B., Jónás, D., Nagy, L. & Barta, E., Nov 1 2013, In : Immunobiology. 218, 11, p. 1416-1427 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A Versatile Method to Design Stem-Loop Primer-Based Quantitative PCR Assays for Detecting Small Regulatory RNA Molecules

Czimmerer, Z., Hulvely, J., Simandi, Z., Varallyay, E., Havelda, Z., Szabo, E., Varga, A., Dezso, B., Balogh, M., Horvath, A., Domokos, B., Torok, Z., Nagy, L. & Balint, B. L., Jan 31 2013, In : PloS one. 8, 1, e55168.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Genome Wide Mapping Reveals PDE4B as an IL-2 Induced STAT5 Target Gene in Activated Human PBMCs and Lymphoid Cancer Cells

Nagy, Z. S., Ross, J. A., Rodriguez, G., Balint, B. L., Szeles, L., Nagy, L. & Kirken, R. A., Feb 25 2013, In : PloS one. 8, 2, e57326.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis

Szénási, T., Kénesi, E., Nagy, A., Molnár, A., Bálint, B. L., Zvara, G., Csabai, Z., Deák, F., Boros Oláh, B., Mátés, L., Nagy, L., Puskás, L. G. & Kiss, I., Oct 1 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 10, p. 1075-1091 17 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Peripheral blood derived gene panels predict response to infliximab in rheumatoid arthritis and Crohn's disease

Mesko, B., Poliska, S., Váncsa, A., Szekanecz, Z., Palatka, K., Hollo, Z., Horvath, A., Steiner, L., Zahuczky, G., Podani, J. & Nagy, L., Jun 28 2013, In : Genome Medicine. 5, 6, 59.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Pharmacogenetics and pharmacogenomics in rheumatology

Szekanecz, Z., Meskó, B., Poliska, S., Váncsa, A., Szamosi, S., Végh, E., Simkovics, E., Laki, J., Kurkó, J., Besenyei, T., Mikecz, K., Glant, T. T. & Nagy, L., Jul 1 2013, In : Immunologic Research. 56, 2-3, p. 325-333 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms

Nagy, Z. S., Czimmerer, Z., Szanto, A. & Nagy, L., Nov 1 2013, In : Immunobiology. 218, 11, p. 1336-1344 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

RDH10, RALDH2, and CRABP2 are required components of PPAR γ-directed ATRA synthesis and signaling in human dendritic cells

Gyöngyösi, A., Szatmari, I., Pap, A., Dezso, B., Pos, Z., Széles, L., Varga, T. & Nagy, L., Sep 2013, In : Journal of Lipid Research. 54, 9, p. 2458-2474 17 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6

Brignull, L. M., Czimmerer, Z., Saidi, H., Daniel, B., Villela, I., Bartlett, N. W., Johnston, S. L., Meira, L. B., Nagy, L. & Nohturfft, A., Dec 5 2013, In : BMC genomics. 14, 1, 853.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration

Varga, T., Mounier, R., Gogolak, P., Poliska, S., Chazaud, B. & Nagy, L., Dec 1 2013, In : Journal of Immunology. 191, 11, p. 5695-5701 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2012
12 Citations (Scopus)

Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells

Tsakiris, I., Torocsik, D., Gyongyosi, A., Dozsa, A., Szatmari, I., Szanto, A., Soos, G., Nemes, Z., Igali, L., Marton, I., Takats, Z., Nagy, L. & Dezso, B., Mar 1 2012, In : Laboratory Investigation. 92, 3, p. 345-361 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cells

Oros, M., Zavaczki, E., Vadasz, C., Jeney, V., Tosaki, A., Lekli, I., Balla, G., Nagy, L. & Balla, J., Sep 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 9, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages

Czimmerer, Z., Varga, T., Poliska, S., Nemet, I., Szanto, A. & Nagy, L., Dec 1 2012, In : Immunobiology. 217, 12, p. 1301-1314 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Peripheral blood gene expression and IgG glycosylation profiles as markers of tocilizumab treatment in rheumatoid arthritis

Mesko, B., Poliska, S., Szamosi, S., Szekanecz, Z., Podani, J., Varadi, C., Guttman, A. & Nagy, L., May 1 2012, In : Journal of Rheumatology. 39, 5, p. 916-928 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The triad of success in personalised medicine: Pharmacogenomics, biotechnology and regulatory issues from a Central European perspective

Mesko, B., Zahuczky, G. & Nagy, L., Sep 15 2012, In : New Biotechnology. 29, 6, p. 741-750 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

Poliska, S., Csanky, E., Szanto, A., Szatmari, I., Mesko, B., Szeles, L., Dezso, B., Scholtz, B., Podani, J., Kilty, I., Takacs, L. & Nagy, L., May 1 2011, In : Respiration. 81, 6, p. 499-510 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility

Brazda, P., Szekeres, T., Bravics, B., Tóth, K., Vámosi, G. & Nagy, L., Nov 1 2011, In : Journal of cell science. 124, 21, p. 3631-3642 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells

Nakken, B., Varga, T., Szatmari, I., Szeles, L., Gyongyosi, A., Illarionov, P. A., Dezso, B., Gogolak, P., Rajnavolgyi, E. & Nagy, L., Jul 1 2011, In : Journal of Immunology. 187, 1, p. 240-247 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

Oberoi, J., Fairall, L., Watson, P. J., Yang, J. C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., Nagy, L., Neuhaus, D. & Schwabe, J. W. R., Feb 1 2011, In : Nature Structural and Molecular Biology. 18, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2010

Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli

Töröcsik, D., Baráth, M., Benko, S., Széles, L., Dezso, B., Póliska, S., Hegyi, Z., Homolya, L., Szatmári, I., Lányi, Á. & Nagy, L., May 15 2010, In : Journal of Immunology. 184, 10, p. 5456-5465 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodies

Simandi, Z., Balint, B. L., Poliska, S., Ruhl, R. & Nagy, L., Jul 1 2010, In : FEBS letters. 584, 14, p. 3123-3130 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study

Penyige, A., Poliska, S., Csanky, E., Scholtz, B., Dezso, B., Schmelczer, I., Kilty, I., Takacs, L. & Nagy, L., Nov 4 2010, In : BMC Medical Genetics. 11, 1, 152.

Research output: Contribution to journalArticle

21 Citations (Scopus)
21 Citations (Scopus)

Magyar szkizofrénia-biobank a szkizofréniakutatás és a személyre szabott orvoslás szolgálatában

Translated title of the contribution: SCHIZOBANK - The Hungarian national schizophrenia biobank and its role in schizophrenia researchInczédy-Farkas, G., Benkovits, J., Balogh, N., Álmos, P., Scholtz, B., Zahuczky, G., Török, Z., Nagy, K., Réthelyi, J., Makkos, Z., Kassai-Farkas, Á., Igerházy, A., Tuzko, J., Janka, Z., Bitter, I., Németh, G., Nagy, L. & Molnár, M. J., Aug 1 2010, In : Orvosi hetilap. 151, 35, p. 1403-1408 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
64 Citations (Scopus)

Research resource: Transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells

Széles, L., Póliska, S., Nagy, G., Szatmari, I., Szanto, A., Pap, A., Lindstedt, M., Santegoets, S. J. A. M., Rühl, R., Dezsö, B. & Nagy, L., Nov 1 2010, In : Molecular Endocrinology. 24, 11, p. 2218-2231 14 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

Szanto, A., Balint, B. L., Nagy, Z. S., Barta, E., Dezso, B., Pap, A., Szeles, L., Poliska, S., Oros, M., Evans, R. M., Barak, Y., Schwabe, J. & Nagy, L., Nov 24 2010, In : Immunity. 33, 5, p. 699-712 14 p.

Research output: Contribution to journalArticle

222 Citations (Scopus)
2009

1,25-Dihydroxyvitamin D3 Is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype

Széles, L., Keresztes, G., Töröcsik, D., Balajthy, Z., Krenács, L., Póliska, S., Steinmeyer, A., Zuegel, U., Pruenster, M., Rot, A. & Nagy, L., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2074-2083 10 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor γ expression and activation: Functions in inflammation, lipid metabolism, and pathogenesis

Almeida, P. E., Silva, A. R., Maya-Monteiro, C. M., Töröcsik, D., D'Ávila, H., Dezsö, B., Magalhães, K. G., Castro-Faria-Neto, H. C., Nagy, L. & Bozza, P. T., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1337-1345 9 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology

Tóth, B. I., Géczy, T., Griger, Z., Dózsa, A., Seltmann, H., Kovács, L., Nagy, L., Zouboulis, C. C., Paus, R. & Bíró, T., Feb 1 2009, In : Journal of Investigative Dermatology. 129, 2, p. 329-339 11 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2008

Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling

Dobrosi, N., Tóth, B. I., Nagy, G., Dózsa, A., Géczy, T., Nagy, L., Zouboulis, C. C., Paus, R., Kovács, L. & Bíró, T., Oct 2008, In : FASEB Journal. 22, 10, p. 3685-3695 11 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Functional ABCG1 expression induces apoptosis in macrophages and other cell types

Seres, L., Cserepes, J., Elkind, N. B., Törocsik, D., Nagy, L., Sarkadi, B. & Homolya, L., Oct 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2378-2387 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Structural basis for the activation of PPARγ by oxidized fatty acids

Itoh, T., Fairall, L., Amin, K., Inaba, Y., Szanto, A., Balint, B. L., Nagy, L., Yamamoto, K. & Schwabe, J. W. R., Sep 1 2008, In : Nature Structural and Molecular Biology. 15, 9, p. 924-931 8 p.

Research output: Contribution to journalArticle

279 Citations (Scopus)
2007
90 Citations (Scopus)

Monoclonal antibody proteomics: Discovery and prevalidation of chronic obstructive pulmonary disease biomarkers in a single step

Csanky, E., Olivova, P., Rajnavolgyi, E., Hempel, W., Tardieu, N., Katalin, E. T., Jullien, A., Malderez-Bloes, C., Kuras, M., Duval, M. X., Nagy, L., Scholtz, B., Hancock, W., Karger, B., Guttman, A. & Takacs, L., Dec 2007, In : ELECTROPHORESIS. 28, 23, p. 4401-4406 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

PPARγ regulates the function of human dendritic cells primarily by altering lipid metabolism

Szatmari, I., Töröcsik, D., Agostini, M., Nagy, T., Gurnell, M., Barta, E., Chatterjee, K. & Nagy, L., Nov 1 2007, In : Blood. 110, 9, p. 3271-3280 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA

Székvölgyi, L., Rákosy, Z., Bálint, B. L., Kókai, E., Imre, L., Vereb, G., Bacsó, Z., Goda, K., Varga, S., Balázs, M., Dombrádi, V., Nagy, L. & Szabó, G., Sep 18 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 38, p. 14964-14969 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2006

ChIP-on-beads: Flow-cytometric evaluation of chromatin immunoprecipitation

Székvölgyi, L., Bálint, B. L., Imre, L., Goda, K., Szabó, M., Nagy, L. & Szabó, G., Oct 1 2006, In : Cytometry Part A. 69, 10, p. 1086-1091 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance

Agostini, M., Schoenmakers, E., Mitchell, C., Szatmari, I., Savage, D., Smith, A., Rajanayagam, O., Semple, R., Luan, J., Bath, L., Zalin, A., Labib, M., Kumar, S., Simpson, H., Blom, D., Marais, D., Schwabe, J., Barroso, I., Trembath, R., Wareham, N. & 4 others, Nagy, L., Gurnell, M., O'Rahilly, S. & Chatterjee, K., Oct 2006, In : Cell Metabolism. 4, 4, p. 303-311 9 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
136 Citations (Scopus)

PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells

Szatmari, I., Pap, A., Rühl, R., Ma, J. X., Illarionov, P. A., Besra, G. S., Rajnavolgyi, E., Dezso, B. & Nagy, L., 2006, In : Journal of Experimental Medicine. 203, 10, p. 2351-2362 12 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

Réthi, B., Gogolák, P., Szatmari, I., Veres, Á., Erdõs, E., Nagy, L., Rajnavölgyi, É., Terhorst, C. & Lányi, Á., Apr 1 2006, In : Blood. 107, 7, p. 2821-2829 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)