• 5324 Citations
  • 27 h-Index
1981 …2019

Research output per year

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Research Output

  • 5324 Citations
  • 27 h-Index
  • 67 Article
  • 8 Review article
  • 2 Comment/debate
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Article
2019

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Kobolák, J., Molnár, K., Varga, E., Bock, I., Jezsó, B., Téglási, A., Zhou, S., Lo Giudice, M., Hoogeveen-Westerveld, M., Pijnappel, WWM. P., Phanthong, P., Varga, N., Kitiyanant, N., Freude, K., Nakanishi, H., László, L., Hyttel, P. & Dinnyés, A., Jul 15 2019, In : Experimental Cell Research. 380, 2, p. 216-233 18 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Eduscho coffee extract effectively inhibits the formation of amyloid-like fibrils by trypsin in aqueous ethanol

Kasi, P. B., Borics, A., Molnár, K., László, L. & Kotormán, M., Jan 1 2018, In : Natural product communications. 13, 12, p. 1695-1698 4 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7

Sukseree, S., László, L., Gruber, F., Bergmann, S., Narzt, M. S., Nagelreiter, I. M., Höftberger, R., Molnár, K., Rauter, G., Birngruber, T., Larue, L., Kovacs, G. G., Tschachler, E. & Eckhart, L., Nov 1 2018, In : Molecular Neurobiology. 55, 11, p. 8425-8437 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Grapefruit seed extract inhibits the formation of amyloid-like fibrils by trypsin in aqueous ethanol

Kasi, P. B., Borics, A., Varga, M., Endre, G., Molnár, K., László, L. & Kotormán, M., Jan 1 2018, In : Natural Product Communications. 13, 11, p. 1437-1440 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy

Puska, G., Lutz, M. I., Molnar, K., Regelsberger, G., Ricken, G., Pirker, W., László, L. & Kovacs, G. G., Jun 1 2018, In : Neurobiology of Disease. 114, p. 140-152 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The inhibitory effect of Panax ginseng extract on amyloid-like fibril formation of trypsin in aqueous ethanol

Kasi, P. B., Kotormán, M., Borics, A., Hervay, B. G., Molnár, K. & László, L., Jan 1 2018, In : Protein and Peptide Letters. 25, 3, p. 253-259 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

Chandrasekaran, A., Avci, H. X., Ochalek, A., Rösingh, L. N., Molnár, K., László, L., Bellák, T., Téglási, A., Pesti, K., Mike, A., Phanthong, P., Bíró, O., Hall, V., Kitiyanant, N., Krause, K. H., Kobolák, J. & Dinnyés, A., Dec 1 2017, In : Stem Cell Research. 25, p. 139-151 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, A., Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, J. E., Holst, B., Freude, K., Hyttel, P., Kobolák, J. & Dinnyés, A., Dec 1 2017, In : Alzheimer's Research and Therapy. 9, 1, 90.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2014

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Kovacs, G. G., Breydo, L., Green, R., Kis, V., Puska, G., Lorincz, P., Perju-Dumbrava, L., Giera, R., Pirker, W., Lutz, M., Lachmann, I., Budka, H., Uversky, V. N., Molnár, K. & László, L., Sep 2014, In : Neurobiology of Disease. 69, p. 76-92 17 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2013

Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?

Kovacs, G. G., Peden, A., Weis, S., Höftberger, R., Berghoff, A. S., Yull, H., Ströbel, T., Koppi, S., Katzenschlager, R., Langenscheidt, D., Assar, H., Zaruba, E., Gröner, A., Voigtländer, T., Puska, G., Hametner, E., Grams, A., Muigg, A., Knoflach, M., László, L. & 3 others, Ironside, J. W., Head, M. W. & Budka, H., 2013, In : Acta neuropathologica communications. 1, 1, p. 72 1 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation

Welker, E., Kulcsár, P. I., Fodor, E., Ayaydin, F., Kalmár, L., Borsy, A. É., László, L. & Welker, E., May 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1199-1211 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2012

Intraneuronal immunoreactivity for the prion protein distinguishes a subset of E200K genetic from sporadic Creutzfeldt-Jakob disease

Kovacs, G. G., Molnár, K., Keller, E., Botond, G., Budka, H. & László, L., Mar 1 2012, In : Journal of Neuropathology and Experimental Neurology. 71, 3, p. 223-232 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia

Woehrer, A., Laszlo, L., Finsterer, J., Stöllberger, C., Furtner, J., Rinner, W., Molnar, K., Budka, H. & Kovacs, G. G., Oct 1 2012, In : Acta neuropathologica. 124, 4, p. 583-591 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

A peculiar constellation of tau pathology defines a subset of dementia in the elderly

Kovacs, G. G., Molnár, K., László, L., Ströbel, T., Botond, G., Hönigschnabl, S., Reiner-Concin, A., Palkovits, M., Fischer, P. & Budka, H., Aug 1 2011, In : Acta neuropathologica. 122, 2, p. 205-222 18 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: Characterization of a complex proteinopathy

Kovacs, G. G., Seguin, J., Quadrio, I., Höftberger, R., Kapás, I., Streichenberger, N., Biacabe, A. G., Meyronet, D., Sciot, R., Vandenberghe, R., Majtenyi, K., László, L., Ströbel, T., Budka, H. & Perret-Liaudet, A., Jan 1 2011, In : Acta neuropathologica. 121, 1, p. 39-57 19 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2010

Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease

Matej, R., Botond, G., László, L., Kopitar-Jerala, N., Rusina, R., Budka, H. & Kovacs, G. G., Sep 1 2010, In : Experimental Neurology. 225, 1, p. 133-139 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2008

MAPT S305I mutation: Implications for argyrophilic grain disease

Kovacs, G. G., Pittman, A., Revesz, T., Luk, C., Lees, A., Kiss, E., Tariska, P., Laszlo, L., Molnár, K., Molnar, M. J., Tolnay, M. & de Silva, R., Jul 1 2008, In : Acta neuropathologica. 116, 1, p. 103-118 16 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2007

Emberi prionbetegségek: magyarországi tapasztalatok.

Translated title of the contribution: Human prion diseases: the Hungarian experienceKovács, G. G., Bakos, A., Mitrova, E., Minárovits, J., László, L. & Majtényi, K., Nov 30 2007, In : Ideggyógyászati szemle. 60, 11-12, p. 447-452 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2006

Alterations of NADPH:protochlorophyllide oxidoreductase quantity and lipid composition in etiolated barley seedlings infected by Barley stripe mosaic virus (BSMV)

Harsányi, A., Ryberg, M., Andersson, M. X., Bóka, K., László, L., Botond, G., Böddi, B. & Gáborjányi, R., Oct 26 2006, In : Molecular Plant Pathology. 7, 6, p. 533-541 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Subcellular distribution of components of the ubiquitin-proteasome system in non-diseased human and rat brain

Ádori, C., Low, P., Moszkovkin, G., Bagdy, G., László, L. & Kovács, G. G., Feb 1 2006, In : Journal of Histochemistry and Cytochemistry. 54, 2, p. 263-267 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2005

Increased incidence of genetic human prion disease in Hungary

Kovács, G. G., László, L., Bakos, A., Minárovits, J., Bishop, M. T., Ströbel, T., Vajna, B., Mitrova, E. & Majtényi, K., Nov 2005, In : Neurology. 65, 10, p. 1666-1669 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The ubiquitin-proteasome system in Creutzfeldt-Jakob and Alzheimer disease: Intracellular redistribution of components correlates with neuronal vulnerability

Ádori, C., Kovács, G. G., Low, P., Molnár, K., Gorbea, C., Fellinger, E., Budka, H., Mayer, R. J. & László, L., Aug 1 2005, In : Neurobiology of Disease. 19, 3, p. 427-435 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2004
25 Citations (Scopus)

Mouse in red: Red fluorescent protein expression in mouse ES cells, embryos, and adult animals

Vintersten, K., Monetti, C., Gertsenstein, M., Zhang, P., Laszlo, L., Biechele, S. & Nagy, A., Dec 1 2004, In : Genesis. 40, 4, p. 241-246 6 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

Kovács, G. G., László, L., Kovács, J., Jensen, P. H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H. & Ovádi, J., Nov 1 2004, In : Neurobiology of Disease. 17, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

The prion protein in human neuromuscular diseases

Kovács, G. G., Kalev, O., Gelpi, E., Haberler, C., Wanschitz, J., Strohschneider, M., Molnár, M. J., László, L. & Budka, H., Nov 1 2004, In : Journal of Pathology. 204, 3, p. 241-247 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2003

Serum amyloid P component induces neuronal apoptosis and β-amyloid immunoreactivity

Urbányi, Z., László, L., Tomasi, T. B., Tóth, E., Mekes, É., Sass, M. & Pázmány, T., Oct 24 2003, In : Brain research. 988, 1-2, p. 69-77 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2002

Immunohistochemistry for the prion protein: Comparison of different monoclonal antibodies in human prion disease subtypes

Kovács, G. G., Head, M. W., Hegyi, I., Bunn, T. J., Flicker, H., Hainfellner, J. A., McCardle, L., László, L., Jarius, C., Ironside, J. W. & Budka, H., 2002, In : Brain Pathology. 12, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
30 Citations (Scopus)
2001

Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones

Nagy, J., Müller, F. & László, L., Jan 1 2001, In : Drug and Alcohol Dependence. 61, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Inherited prion disease with A117V mutation of the prion protein gene: A novel Hungarian family

Kovács, G. G., Ertsey, C., Majtényi, C., Jelencsik, I., László, L., Flicker, H., Strain, L., Szirmai, I. & Budka, H., Jun 1 2001, In : Journal of Neurology Neurosurgery and Psychiatry. 70, 6, p. 802-805 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Prominent stress response of Purkinje cells in Creutzfeldt-Jakob disease

Kovács, G. G., Kurucz, I., Budka, H., Ádori, C., Müller, F., Ács, P., Klöppel, S., Schätzl, H. M., Mayer, R. J. & László, L., Jan 1 2001, In : Neurobiology of Disease. 8, 5, p. 881-889 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Receptor-like properties of the 26 kDa transmembrane form of TNF

Domonkos, Á., Udvardy, A., László, L., Nagy, T. & Duda, E., 2001, In : European Cytokine Network. 12, 3, p. 411-419 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2000

Clinicopathological phenotype of codon 129 valine homozygote sporadic Creutzfeldt-Jakob disease

Kovacs, G. G., Head, M. W., Bunn, T., Laszlo, L., Will, R. G. & Ironside, J. W., Oct 30 2000, In : Neuropathology and Applied Neurobiology. 26, 5, p. 463-472 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
1999

Ultrastructural localization of Hsp-72 examined with a new polyclonal antibody raised against the truncated variable domain of the heat shock protein

Kurucz, I., Tombor, B., Prechl, J., Erdö, F., Hegedüs, E., Nagy, Z., Vitai, M., Korányi, L. & László, L., Jun 1999, In : Cell Stress and Chaperones. 4, 2, p. 139-152 14 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
1997

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis

Schätzl, H. M., Laszlo, L., Holtzman, D. M., Tatzelt, J., Dearmond, S. J., Weiner, R. I., Mobley, W. C. & Prusiner, S. B., Nov 1997, In : Journal of Virology. 71, 11, p. 8821-8831 11 p.

Research output: Contribution to journalArticle

Open Access
228 Citations (Scopus)

Ubiquitinated extracellular matrix proteins in insect cuticle

Löw, P., Borhegyi, N. H., Sass, M., László, L. & Reynolds, S. E., 1997, In : Biochemical Society transactions. 25, 3, p. 379S

Research output: Contribution to journalArticle

1996

Endosome-lysosomes, ubiquitin and neurodegeneration

Mayer, R. J., Tipler, C., Arnold, J., Laszlo, L., Al-Khedhairy, A., Lowe, J. & Landon, M., Dec 1 1996, In : Advances in experimental medicine and biology. 389, p. 261-269 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
25 Citations (Scopus)
1995

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

Taraboulos, A., Scott, M., Semenov, A., Avraham, D., Laszlo, L. & Prusiner, S. B., Apr 1995, In : Journal of Cell Biology. 129, 1, p. 121-132 12 p.

Research output: Contribution to journalArticle

489 Citations (Scopus)

Related organelles of the endosome-lysosome system contain a different repertoire of ubiquitinated proteins in Sf9 insect cells

Löw, P., Doherty, F. J., Fellinger, E., Sass, M., John Mayer, R. & László, L., Jul 10 1995, In : FEBS letters. 368, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The abnormal isoform of the prion protein accumulates in late‐endosome‐like organelles in scrapie‐infected mouse brain

Arnold, J. E., Tipler, C., Laszlo, L., Hope, J., Landon, M. & Mayer, R. J., Aug 1995, In : The Journal of Pathology. 176, 4, p. 403-411 9 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)
1994

Endosome-lysosomes and neurodegeneration

Mayer, R. J., Tipler, C., Laszlo, L., Arnold, J., Lowe, J. & Landon, M., 1994, In : Biomedicine and Pharmacotherapy. 48, 7, p. 282-286 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Is there a common intracellular bioreactor in which amyloid formation is initiated in neurodegenerative diseases?

Mayer, R. J., Landon, M., Lowe, J., Tipler, C., Arnold, J. & Laszlo, L., Jan 1 1994, In : Biochemical Society transactions. 22, 1, p. 151-155 5 p.

Research output: Contribution to journalArticle

1993

Immunogold localisation of ubiquitin-protein conjugates in Sf9 insect cells. Implications for the biogenesis of lysosome-related organelles

Löw, P., Doherty, F. J., Sass, M., Kovács, J., Mayer, R. J. & László, L., Jan 25 1993, In : FEBS letters. 316, 2, p. 152-156 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1992

A role for lysosomes in scrapie pathogenesis

Kenward, N., Laszlo, L., Landon, M., Fergusson, J., Lowe, J., McDermott, H., Hope, J., Brown, J. & Mayer, R. J., Jan 1 1992, In : Biochemical Society transactions. 20, 3, p. 265S

Research output: Contribution to journalArticle

4 Citations (Scopus)

Immunoreactivity to ubiquitin—protein conjugates is present early in the disease process in the brains of scrapie‐infected mice

Lowe, J., Fergusson, J., Kenward, N., Laszlo, L., Landon, M., Farquhar, C., Brown, J., Hope, J. & Mayer, R. J., Oct 1992, In : The Journal of Pathology. 168, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

Laszlo, L., Lowe, J., Self, T., Kenward, N., Landon, M., McBride, T., Farquhar, C., McConnell, I., Brown, J., Hope, J. & Mayer, R. J., Apr 1992, In : The Journal of Pathology. 166, 4, p. 333-341 9 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Protein processing in lysosomes: the new therapeutic target in neurodegenerative disease

Mayer, R. J., Landon, M., Laszlo, L., Lowe, J. & Lennox, G., Jul 18 1992, In : The Lancet. 340, 8812, p. 156-159 4 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Ubiquitin, Lysosomes, and Neurodegenerative Diseases

MAYER, R. JOHN., LASZLO, LAJOS., LANDON, MICHAEL., HOPE, JAMES. & LOWE, JAMES., Dec 1992, In : Annals of the New York Academy of Sciences. 674, 1, p. 149-160 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)