• 3727 Citations
  • 26 h-Index
1991 …2020

Research output per year

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Research Output

  • 3727 Citations
  • 26 h-Index
  • 52 Article
  • 5 Review article
  • 1 Chapter
  • 1 Letter
2020

Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity

Ricci, M., Horváti, K., Juhász, T., Szigyártó, I., Török, G., Sebák, F., Bodor, A., Homolya, L., Henczkó, J., Pályi, B., Mlinkó, T., Mihály, J., Nizami, B., Yang, Z., Lin, F., Lu, X., Románszki, L., Bóta, A., Varga, Z., Bősze, S. & 2 others, Zsila, F. & Beke-Somfai, T., Jan 1 2020, (Accepted/In press) In : Quarterly Reviews of Biophysics. e5.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter

Zámbó, B., Mózner, O., Bartos, Z., Török, G., Várady, G., Telbisz, Á., Homolya, L., Orbán, T. I. & Sarkadi, B., Jan 1 2020, In : Cellular and Molecular Life Sciences. 77, 2, p. 365-378 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity

Apáti, A., Varga, N., Berecz, T., Erdei, Z., Homolya, L. & Sarkadi, B., Jan 2 2019, In : Expert Opinion on Drug Metabolism and Toxicology. 15, 1, p. 61-75 15 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells

Valcz, G., Buzás, E. I., Kittel, Á., Krenács, T., Visnovitz, T., Spisák, S., Török, G., Homolya, L., Zsigrai, S., Kiszler, G., Antalffy, G., Pálóczi, K., Szállási, Z., Szabó, V., Sebestyén, A., Solymosi, N., Kalmár, A., Dede, K., Lőrincz, P., Tulassay, Z. & 2 others, Igaz, P. & Molnár, B., Jan 1 2019, In : Journal of Extracellular Vesicles. 8, 1, 1596668.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

Szabó, E., Türk, D., Telbisz, Á., Kucsma, N., Horváth, T., Szakács, G., Homolya, L., Sarkadi, B. & Várady, G., Jan 2018, In : PloS one. 13, 1, e0190629.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein

Vőfély, G., Berecz, T., Szabó, E., Szebényi, K., Hathy, E., Orbán, T. I., Sarkadi, B., Homolya, L., Marchetto, M. C., Réthelyi, J. M. & Apáti, Á., Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 222-230 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedus, T., Homolya, L. & Sarkadi, B., Dec 1 2018, In : Scientific reports. 8, 1, 7487.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Enhancement of chicken primordial germ cell in vitro maintenance using an automated cell image analyser

Anand, M., Lázár, B., Tóth, R., Páll, E., Patakiné Várkonyi, E., Liptói, K., Homolya, L., Hegyi, Z., Hidas, A. & Gócza, E., Dec 2018, In : Acta veterinaria Hungarica. 66, 4, p. 518-529 12 p.

Research output: Contribution to journalArticle

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells

Erdei, Z., Schamberger, A., Török, G., Szebényi, K., Várady, G., Orbán, T. I., Homolya, L., Sarkadi, B. & Apáti, Á., Apr 2018, In : PloS one. 13, 4, e0194925.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

Ezrin interacts with S100A4 via both its N- and C-terminal domains

Biri-Kovács, B., Kiss, B., Vadászi, H., Gógl, G., Pálfy, G., Török, G., Homolya, L., Bodor, A. & Nyitray, L., May 2017, In : PloS one. 12, 5, e0177489.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional shift with maintained regenerative potential following portal vein ligation

Kovács, T., Máthé, D., Fülöp, A., Jemnitz, K., Bátai-Konczos, A., Veres, Z., Török, G., Veres, D. S., Horváth, I., Szigeti, K., Homolya, L. & Szijártó, A., Dec 1 2017, In : Scientific reports. 7, 1, 18065.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Histone deacetylase inhibitor treatment increases the expression of the plasma membrane Ca2+ pump PMCA4b and inhibits the migration of melanoma cells independent of ERK

Hegedüs, L., Padányi, R., Molnár, J., Pászty, K., Varga, K., Kenessey, I., Sárközy, E., Wolf, M., Grusch, M., Hegyi, Z., Homolya, L., Aigner, C., Garay, T., Hegedüs, B., Tímár, J., Kállay, E. & Enyedi, Á., May 24 2017, In : Frontiers in Oncology. 7, MAY, 95.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma

Varga, G., Mikala, G., Kiss, K. P., Kosóczki, É., Szabó, E., Meggyesi, N., Balassa, K., Kövy, P., Tegze, B., Szombath, G., Tordai, A., Andrikovics, H., Homolya, L. & Masszi, T., Nov 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 11, p. 734-742 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level

Nerada, Z., Hegyi, Z., Szepesi, Á., Tóth, S., Hegedüs, C., Várady, G., Matula, Z., Homolya, L., Sarkadi, B. & Telbisz, Á., Sep 1 2016, In : Cytometry Part A. 89, 9, p. 826-834 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Characterization of NF-κB reporter U937 cells and their application for the detection of inflammatory immune-complexes

Kecse-Nagy, C., Szittner, Z., Papp, K., Hegyi, Z., Rovero, P., Migliorini, P., Lóránd, V., Homolya, L. & Prechl, J., May 2016, In : PloS one. 11, 5, e0156328.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Comparative study of CYP2B1/2 induction and the transport of bilirubin and taurocholate in rat hepatocyte-mono- and hepatocyte-Kupffer cell co-cultures

Bátai-Konczos, A., Veres, Z., Szabó, M., Ioja, E., László, G., Török, G., Homolya, L. & Jemnitz, K., Nov 1 2016, In : Journal of Pharmacological and Toxicological Methods. 82, p. 1-8 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Expression of the prion protein family member Shadoo causes drug hypersensitivity that is diminished by the coexpression of the wild type prion protein

Nyeste, A., Bencsura, P., Vida, I., Hegyi, Z., Homolya, L., Fodor, E. & Welker, E., Feb 26 2016, In : Journal of Biological Chemistry. 291, 9, p. 4473-4486 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Functional cooperativity between ABCG4 and ABCG1 isoforms

Hegyi, Z. & Homolya, L., May 1 2016, In : PloS one. 11, 5, e0156516.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function

Telbisz, Á. & Homolya, L., Apr 2 2016, In : Expert Opinion on Therapeutic Targets. 20, 4, p. 501-514 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2015

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle, B., Török, G., Apáti, Á., Sarkadi, B., Schaff, Z., Kiss, A. & Homolya, L., Sep 28 2015, In : Pathology and Oncology Research. 21, 4, p. 1059-1070 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

Szebenyi, K., Füredi, A., Kolacsek, O., Pergel, E., Bosze, Z., Bender, B., Vajdovich, P., Tovari, J., Homolya, L., Szakacs, G., Heja, L., Enyedi, A., Sarkadi, B., Apati, A. & Orban, T. I., Aug 3 2015, In : Scientific reports. 5, 12645.

Research output: Contribution to journalArticle

8 Citations (Scopus)
13 Citations (Scopus)

Two liver transporters, ABCB11 and ABCC6; novel therapeutic approaches in the related disorders

Váradi, A. & Homolya, L., Jan 1 2015, ABC Transporters - 40 Years on. Springer International Publishing, p. 257-276 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

LKB1/AMPK and PKA Control ABCB11 trafficking and polarization in hepatocytes

Homolya, L., Fu, D., Sengupta, P., Jarnik, M., Gillet, J. P., Vitale-Cross, L., Gutkind, J. S., Lippincott-Schwartz, J. & Arias, I. M., Mar 18 2014, In : PloS one. 9, 3, e91921.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2013

Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1

De Athayde Moncorvo Collado, A., Corbalán, N., Homolya, L., Morero, R. & Minahk, C., Aug 2 2013, In : FEBS letters. 587, 15, p. 2359-2363 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Calcium signaling in pluripotent stem cells

Apáti, Á., Pászty, K., Erdei, Z., Szebényi, K., Homolya, L. & Sarkadi, B., Apr 28 2012, In : Molecular and Cellular Endocrinology. 353, 1-2, p. 57-67 11 p.

Research output: Contribution to journalReview article

24 Citations (Scopus)
2011

Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane

Homolya, L., Orbán, T. I., Csanády, L. & Sarkadi, B., Jan 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2010

Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli

Töröcsik, D., Baráth, M., Benko, S., Széles, L., Dezso, B., Póliska, S., Hegyi, Z., Homolya, L., Szatmári, I., Lányi, Á. & Nagy, L., May 15 2010, In : Journal of Immunology. 184, 10, p. 5456-5465 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Evaluation of ABCG2 expression in human embryonic stem cells: Crossing the same river twice?

Sarkadi, B., Orbán, T. I., Szakács, G., Várady, G., Schamberger, A., Erdei, Z., Szebényi, K., Homolya, L. & Apáti, Á., Jan 1 2010, In : Stem Cells. 28, 1, p. 174-176 3 p.

Research output: Contribution to journalLetter

24 Citations (Scopus)
2009

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery

Orbán, T. I., Apáti, Á., Németh, A., Varga, N., Krizsik, V., Schamberger, A., Szebényi, K., Erdei, Z., Várady, G., Karászi, É., Homolya, L., Német, K., Gócza, E., Miskey, C., Mátés, L., Ivics, Z., Izsvák, Z. & Sarkadi, B., May 1 2009, In : Stem Cells. 27, 5, p. 1077-1087 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., Oct 14 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays

Hegedus, C., Szakács, G., Homolya, L., Orbán, T. I., Telbisz, Á., Jani, M. & Sarkadi, B., Jan 31 2009, In : Advanced Drug Delivery Reviews. 61, 1, p. 47-56 10 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)

Model system for the analysis of cell surface expression of human ABCA1

Kasza, I., Hegyi, Z., Szabó, K., Andrikovics, H., Német, K., Váradi, A., Sarkadi, B. & Homolya, L., Dec 21 2009, In : BMC Cell Biology. 10, 93.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2008
16 Citations (Scopus)

Functional ABCG1 expression induces apoptosis in macrophages and other cell types

Seres, L., Cserepes, J., Elkind, N. B., Törocsik, D., Nagy, L., Sarkadi, B. & Homolya, L., Oct 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2378-2387 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells

Apáti, Á., Orbán, T. I., Varga, N., Németh, A., Schamberger, A., Krizsik, V., Erdélyi-Belle, B., Homolya, L., Várady, G., Padányi, R., Karászi, É., Kemna, E. W. M., Német, K. & Sarkadi, B., Dec 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 12, p. 2700-2709 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2007
93 Citations (Scopus)
110 Citations (Scopus)
2006
502 Citations (Scopus)
2005
195 Citations (Scopus)

The caspase-3 cleavage product of the plasma membrane Ca 2+-ATPase 4b is activated and appropriately targeted

Pászty, K., Antalffy, G., Penheiter, A. R., Homolya, L., Padányi, R., Iliás, A., Filoteo, A. G., Penniston, J. T. & Enyedi, Á., Nov 1 2005, In : Biochemical Journal. 391, 3, p. 687-692 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2004

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: Indications for heterodimerization

Cserepes, J., Szentpétery, Z., Seres, L., Özvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi, B. & Elkind, N. B., Jul 30 2004, In : Biochemical and biophysical research communications. 320, 3, p. 860-867 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)
2003

Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells

Ujhelly, O., Özvegy, C., Várady, G., Cervenak, J., Homolya, L., Grez, M., Scheffer, G., Roos, D., Bates, S. E., Váradi, A., Sarkadi, B. & Német, K., Mar 1 2003, In : Human Gene Therapy. 14, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

Hegedüs, T., Sessler, T., Scott, R., Thelin, W., Bakos, É., Váradi, A., Szabó, K., Homolya, L., Milgram, S. L. & Sarkadi, B., Mar 14 2003, In : Biochemical and biophysical research communications. 302, 3, p. 454-461 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
147 Citations (Scopus)

Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells

Sinkó, E., Iliás, A., Ujhelly, O., Homolya, L., Scheffer, G. L., Bergen, A. A. B., Sarkadi, B. & Váradi, A., Aug 22 2003, In : Biochemical and biophysical research communications. 308, 2, p. 263-269 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2001

Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia

Karászi, É., Jakab, K., Homolya, L., Szakács, G., Holló, Z., Telek, B., Kiss, A., Rejtô, L., Nahajevszky, S., Sarkadi, B. & Kappelmayer, J., Mar 12 2001, In : British Journal of Haematology. 112, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2000

Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia

Homolya, L., Steinberg, T. H. & Boucher, R. C., Sep 18 2000, In : Journal of Cell Biology. 150, 6, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

205 Citations (Scopus)
1999

Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl- transport

Cressman, V. L., Lazarowski, E., Homolya, L., Boucher, R. C., Koller, B. H. & Grubb, B. R., Sep 10 1999, In : Journal of Biological Chemistry. 274, 37, p. 26461-26468 8 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y2 receptor (-/-) mice

Homolya, L., Watt, W. C., Lazarowski, E. R., Koller, B. H. & Boucher, R. C., Sep 10 1999, In : Journal of Biological Chemistry. 274, 37, p. 26454-26460 7 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)