• 4698 Citations
  • 33 h-Index
1968 …2018

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Article
2018

High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort

Gráf, L., Barabás, L., Madaras, B., Garam, N., Maláti, É., Horváth, L., Prohászka, Z., Horváth, Z. & Kocsis, J., Jan 1 2018, In : Cancer Biomarkers. 23, 4, p. 539-547 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Platelet Count, ADAMTS13 Activity, von Willebrand Factor Level and Survival in Patients with Colorectal Cancer: 5-Year Follow-up Study

Garam, N., Maláti, É., Sinkovits, G., Gombos, T., Szederjesi, A., Barabás, L., Gráf, L., Kocsis, J. & Prohászka, Z., Jan 1 2018, In : Thrombosis and Haemostasis. 118, 1, p. 123-131 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer

Jubran, R., Kocsis, J., Garam, N., Maláti, É., Gombos, T., Barabás, L., Gráf, L., Prohászka, Z. & Fishelson, Z., Dec 1 2017, In : International Journal of Cancer. 141, 11, p. 2329-2335 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

Biochemical characterisation of chymotrypsin from the midgut gland of yellowleg shrimp, Penaeus californiensis

Navarrete-Del-Toro, M. A., García-Carreño, F. L., Hernández-Cortés, P., Molnár, T. & Gráf, L., Apr 15 2015, In : Food Chemistry. 173, p. 147-155 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
7 Citations (Scopus)

The role of structural flexibility and stability in the interaction of serine proteases with their inhibitors

Gráf, L., Molnár, T., Kardos, J., Gáspári, Z. & Katona, G., Jul 1 2015, In : Current Protein and Peptide Science. 16, 6, p. 521-531 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Biochemical characterization of Acacia schweinfurthii serine proteinase inhibitor

Odei-Addo, F., Frost, C., Smith, N., Ogawa, T., Muramoto, K., Oliva, M. L. V., Gráf, L. & Naude, R., Oct 1 2014, In : Journal of enzyme inhibition and medicinal chemistry. 29, 5, p. 633-638 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2013

Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor - The key to achieving extreme stability?

Molnár, T., Vörös, J., Szeder, B., Takáts, K., Kardos, J., Katona, G. & Gráf, L., Nov 1 2013, In : FEBS Journal. 280, 22, p. 5750-5763 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Reversible heat-induced dissociation of β2-microglobulin amyloid fibrils

Kardos, J., Micsonai, A., Pál-Gábor, H., Petrik, É., Gráf, L., Kovács, J., Lee, Y. H., Naiki, H. & Goto, Y., Apr 19 2011, In : Biochemistry. 50, 15, p. 3211-3220 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Serum fetuin-A in metabolic and inflammatory pathways in patients with myocardial infarction

Vörös, K., Gráf, L., Prohászka, Z., Gráf, L., Szenthe, P., Kaszás, E., Böröcz, Z., Cseh, K. & Kalabay, L., Jul 1 2011, In : European Journal of Clinical Investigation. 41, 7, p. 703-709 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Temperature dependence of internal friction in enzyme reactions

Rauscher, A. Á., Simon, Z., Szöllosi, G. J., Gráf, L., Derényi, I. & Malnasi-Csizmadia, A., Aug 1 2011, In : FASEB Journal. 25, 8, p. 2804-2813 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
14 Citations (Scopus)
2010

Anoxia leads to a rapid translocation of human trypsinogen 4 to the plasma membrane of cultured astrocytes

Tárnok, K., Szilágyi, L., Berki, T., Németh, P., Gráf, L. & Schlett, K., Oct 1 2010, In : Journal of neurochemistry. 115, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Isolation, biochemical characterization, and molecular modeling of American lobster digestive cathepsin D1

Rojo, L., Sotelo-Mundo, R., García-Carreño, F. & Gráf, L., Dec 1 2010, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 157, 4, p. 394-400 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

Mechanism of lysophosphatidic acid-induced amyloid fibril formation of β2-microglobulin in vitro under physiological conditions

Pál-Gábor, H., Gombos, L., Micsonai, A., Kovács, E., Petrik, É., Kovács, J., Gráf, L., Fidy, J., Naiki, H., Goto, Y., Liliom, K. & Kardos, J., Jun 23 2009, In : Biochemistry. 48, 24, p. 5689-5699 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2008

Probing conformational plasticity of the activation domain of trypsin: The role of glycine hinges

Gombos, L., Kardos, J., Patthy, A., Medveczky, P., Szilágyi, L., Málnási-Csizmadia, A. & Gráf, L., Feb 12 2008, In : Biochemistry. 47, 6, p. 1675-1684 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r

Kardos, J., Harmat, V., Palló, A., Barabás, O., Szilágyi, K., Gráf, L., Náray-Szabó, G., Goto, Y., Závodszky, P. & Gál, P., Mar 1 2008, In : Molecular Immunology. 45, 6, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The crystal structure of a trypsin-like mutant chymotrypsin: The role of position 226 in the activity and specificity of S189D chymotrypsin

Jelinek, B., Katona, G., Fodor, K., Venekei, I. & Gráf, L., Feb 1 2008, In : Protein Journal. 27, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2007
16 Citations (Scopus)
31 Citations (Scopus)

Human trypsin(ogen) 4-like immunoreactivity in the white matter of the cerebral cortex and the spinal cord.

Gallatz, K., Medveczky, P., Németh, P., Szilágyi, L., Gráf, L. & Palkovits, M., Mar 30 2007, In : Ideggyógyászati szemle. 60, 3-4, p. 118-123 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Regional distribution of human trypsinogen 4 in human brain at mRNA and protein level

Tóth, J., Siklódi, E., Medveczky, P., Gallatz, K., Németh, P., Szilágyi, L., Gráf, L. & Palkovits, M., Sep 1 2007, In : Neurochemical research. 32, 9, p. 1423-1433 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Site directed mutagenesis at position 193 of human trypsin 4 alters the rate of conformational change during activation: Role of local internal viscosity in protein dynamics

Tóth, J., Simon, Z., Medveczky, P., Gombos, L., Jelinek, B., Szilágyi, L., Gráf, L. & Málnási-Csizmadia, A., Jun 1 2007, In : Proteins: Structure, Function and Genetics. 67, 4, p. 1119-1127 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine: A possible means to regulate gene expression

Németh, A. L., Medveczky, P., Tóth, J., Siklódi, E., Schlett, K., Patthy, A., Palkovits, M., Ovádi, J., Tõkési, N., Németh, P., Szilágyi, L. & Gráf, L., Mar 1 2007, In : FEBS Journal. 274, 6, p. 1610-1620 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
20 Citations (Scopus)
2006

Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis

Fodor, K., Harmat, V., Neutze, R., Szilágyi, L., Gráf, L. & Katona, G., Feb 21 2006, In : Biochemistry. 45, 7, p. 2114-2121 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding

Gáspári, Z., Szenthe, B., Patthy, A., Westler, W. M., Gráf, L. & Perczel, A., Apr 1 2006, In : FEBS Journal. 273, 8, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4

Medveczky, P., Antal, J., Patthy, A., Kékesi, K., Juhász, G., Szilágyi, L. & Gráf, L., Jan 23 2006, In : FEBS letters. 580, 2, p. 545-552 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue

Tóth, J., Gombos, L., Simon, Z., Medveczky, P., Szilágyi, L., Gráf, L. & Málnási-Csizmadia, A., May 5 2006, In : Journal of Biological Chemistry. 281, 18, p. 12596-12602 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2005

Cloning and expression of ostrich trypsinogen: An avian trypsin with a highly sensitive autolysis site

Szenthe, B., Frost, C., Szilágyi, L., Patthy, A., Naudé, R. & Gráf, L., Apr 15 2005, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1748, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
42 Citations (Scopus)

Inhibition of Colorado potato beetle larvae by a locust proteinase inhibitor peptide expressed in potato

Kondrák, M., Kutas, J., Szenthe, B., Patthy, A., Bánfalvi, Z., Nádasy, M., Gráf, L. & Asbóth, B., Jun 1 2005, In : Biotechnology Letters. 27, 12, p. 829-834 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2004

Ala226, to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease

Jelinek, B., Antal, J., Venekei, I. & Gráf, L., Feb 1 2004, In : Protein Engineering, Design and Selection. 17, 2, p. 127-131 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Colorado potato beetle larvae on potato plants expressing a locust proteinase inhibitor.

Kutas, J., Kondrák, M., Szenthe, B., Patthy, A., Bánfalvi, Z., Nádasy, M., Gráf, L. & Asbóth, B., 2004, In : Communications in agricultural and applied biological sciences. 69, 3, p. 281-287 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
27 Citations (Scopus)

Enzymic characterization with progress curve analysis of a collagen peptidase from an enthomopathogenic bacterium, Photorhabdus luminescens

Marokházi, J., Kóczán, G., Hudecz, F., Gráf, L., Fodor, A. & Venekei, I., May 1 2004, In : Biochemical Journal. 379, 3, p. 633-640 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mutant rat trypsin selectively cleaves tyrosyl peptide bonds

Pál, G., Patthy, A., Antal, J. & Gráf, L., Mar 15 2004, In : Analytical Biochemistry. 326, 2, p. 190-199 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
24 Citations (Scopus)
2003

Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins

Biró, A., Hérincs, Z., Fellinger, E., Szilágyi, L., Barad, Z., Gergely, J., Gráf, L. & Sármay, G., Dec 5 2003, In : Biochimica et Biophysica Acta - General Subjects. 1624, 1-3, p. 60-69 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: A study on recombinant catalytic fragments

Ambrus, G., Gál, P., Kojima, M., Szilágyi, K., Balczer, J., Antal, J., Gráf, L., Laich, A., Moffatt, B. E., Schwaeble, W., Sim, R. B. & Závodszky, P., Feb 1 2003, In : Journal of Immunology. 170, 3, p. 1374-1382 9 p.

Research output: Contribution to journalArticle

Open Access
157 Citations (Scopus)
16 Citations (Scopus)

Trypsin: Is there anything new under the Sun?

Gráf, L. & Szilágyi, L., Dec 29 2003, In : Journal of Molecular Structure: THEOCHEM. 666-667, p. 481-485 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2002
38 Citations (Scopus)

Crystal structure reveals basis for the inhibitor resistance of human brain trypsin

Katona, G., Berglund, G. I., Hajdu, J., Gráf, L. & Szilágyi, L., Jan 1 2002, In : Journal of molecular biology. 315, 5, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Remarkable phylum selectivity of a Schistocerca gregaria trypsin inhibitor: The possible role of enzyme-inhibitor flexibility

Patthy, A., Amir, S., Malik, Z., Bódi, Á., Kardos, J., Asbóth, B. & Gráf, L., Feb 15 2002, In : Archives of Biochemistry and Biophysics. 398, 2, p. 179-187 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2001

Comparative in vitro studies on native and recombinant human cationic trypsins: Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis

Szilágyi, L., Kénesi, E., Katona, G., Kaslik, G., Juhász, G. & Gráf, L., Jul 6 2001, In : Journal of Biological Chemistry. 276, 27, p. 24574-24580 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Specificity assay of serine proteinases by reverse-phase high-performance liquid chromatography analysis of competing oligopeptide substrate library

Antal, J., Pál, G., Asbóth, B., Buzás, Z., Patthy, A. & Gráf, L., Jan 15 2001, In : Analytical Biochemistry. 288, 2, p. 156-167 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin

Bódi, Á., Kaslik, G., Venekei, I. & Gráf, L., Dec 22 2001, In : European Journal of Biochemistry. 268, 23, p. 6238-6246 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r1

Kardos, J., Gál, P., Szilágyi, L., Thielens, N. M., Szilágyi, K., Lõrincz, Z., Kulcsár, P., Gráf, L., Arlaud, G. J. & Závodszky, P., Nov 1 2001, In : Journal of Immunology. 167, 9, p. 5202-5208 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1999

Disulfide-linked propeptides stabilize the structure of zymogen and mature pancreatic serine proteases

Kardos, J., Bódi, Á., Závodszky, P., Venekei, I. & Gráf, L., Sep 21 1999, In : Biochemistry. 38, 38, p. 12248-12257 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)