• 1734 Citations
  • 21 h-Index
20002019

Research output per year

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Research Output

  • 1734 Citations
  • 21 h-Index
  • 37 Article
  • 3 Comment/debate
  • 2 Review article
2019

Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

Csanády, L. & Töröcsik, B., Jun 2019, In : eLife. 8, e46450.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

Iordanov, I., Tóth, B., Szollosi, A. & Csanády, L., Apr 2 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

Csanády, L., Vergani, P. & Gadsby, D. C., Jan 1 2019, In : Physiological Reviews. 99, 1, p. 707-738 32 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2018

Ion channels as targets to treat cystic fibrosis lung disease

Martin, S. L., Saint-Criq, V., Hwang, T. C. & Csanády, L., Mar 2018, In : Journal of Cystic Fibrosis. 17, 2, p. S22-S27

Research output: Contribution to journalReview article

6 Citations (Scopus)

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

Zhang, Z., Tóth, B., Szollosi, A., Chen, J. & Csanády, L., May 10 2018, In : eLife. 7, e36409.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2017

Asymmetry of movements in CFTR’s two ATP sites during pore opening serves their distinct functions

Sorum, B., Töröcsik, B. & Csanády, L., Sep 25 2017, In : eLife. 6, e29013.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CFTR gating: Invisible transitions made visible

Csanády, L., Apr 1 2017, In : Journal of General Physiology. 149, 4, p. 413-416 4 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Molecular Structure of the Human CFTR Ion Channel

Liu, F., Zhang, Z., Csanády, L., Gadsby, D. C. & Chen, J., Mar 23 2017, In : Cell. 169, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Sensory neurons: A new target for G protein signaling

Csanády, L., Sep 11 2017, In : eLife. 6, e31106.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

A single active catalytic site is sufficient to promote transport in P-glycoprotein

Barsony, O., Szaloki, G., Turk, D., Tarapcsak, S., Gutay-Toth, Z., Bacso, Z., Holb, I. J., Szekvolgyi, L., Szabo, G., Csanady, L., Szakacs, G. & Goda, K., Apr 27 2016, In : Scientific reports. 6, 24810.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

Mihályi, C., Töröcsik, B. & Csanády, L., Jun 21 2016, In : eLife. 5, JUN2016, e18164.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate

Tóth, B., Iordanov, I. & Csanády, L., Jan 1 2015, In : Journal of General Physiology. 145, 5, p. 419-430 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Timing of CFTR Pore Opening and Structure of Its Transition State

Sorum, B., Czégé, D. & Csanády, L., Oct 22 2015, In : Cell. 163, 3, p. 724-733 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2014
14 Citations (Scopus)

Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating

Tóth, B., Iordanov, I. & Csanády, L., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16949-16954 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
9 Citations (Scopus)
2013

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

Csanády, L., Mihályi, C., Szollosi, A., Töröcsik, B. & Vergani, P., Jul 2013, In : Journal of General Physiology. 142, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012
36 Citations (Scopus)
2011

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.

Csanády, L., Vergani, P., Gulyás-Kovács, A. & Gadsby, D. C., Sep 7 2011, In : Methods in molecular biology (Clifton, N.J.). 741, p. 443-469 27 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane

Homolya, L., Orbán, T. I., Csanády, L. & Sarkadi, B., Jan 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating

Szollosi, A., Muallem, D. R., Csanády, L. & Vergani, P., Jun 2011, In : Journal of General Physiology. 137, 6, p. 549-562 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2010

Degenerate ABC composite site is stably glued together by trapped ATP

Csanády, L., May 2010, In : Journal of General Physiology. 135, 5, p. 395-398 4 p.

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

Tóth, B. & Csanády, L., Sep 24 2010, In : Journal of Biological Chemistry. 285, 39, p. 30091-30102 12 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

Szollosi, A., Vergani, P. & Csanády, L., Oct 1 2010, In : Journal of General Physiology. 136, 4, p. 407-423 17 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Permeating proton found guilty in compromising TRPM2 channel activity

Csanády, L., May 1 2010, In : Journal of Physiology. 588, 10, p. 1661-1662 2 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)
77 Citations (Scopus)
2009

A novel kinetic assay of mitochondrial ATP-ADP exchange rate mediated by the ANT

Chinopoulos, C., Vajda, S., Csanády, L., Mándi, M., Mathe, K. & Adam-Vizi, V., Jan 1 2009, In : Biophysical journal. 96, 6, p. 2490-2504 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
7 Citations (Scopus)
64 Citations (Scopus)
2008

Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition

Chan, K. W., Wheeler, A. & Csanády, L., Jan 1 2008, In : Journal of General Physiology. 131, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
4 Citations (Scopus)
2006

Statistical evaluation of ion-channel gating models based on distributions of log-likelihood ratios

Csanády, L., May 2006, In : Biophysical journal. 90, 10, p. 3523-3545 23 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The ABC protein turned chloride channel whose failure causes cystic fibrosis

Gadsby, D. C., Vergani, P. & Csanády, L., Mar 23 2006, In : Nature. 440, 7083, p. 477-483 7 p.

Research output: Contribution to journalReview article

473 Citations (Scopus)
31 Citations (Scopus)

Thermodynamics of CFTR channel gating: A spreading conformational change initiates an irreversible gating cycle

Csanády, L., Nairn, A. C. & Gadsby, D. C., Nov 2006, In : Journal of General Physiology. 128, 5, p. 523-533 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2005

Functional roles of nonconserved structural segments in CFTR's NH 2-terminal nucleotide binding domain

Csanády, L., Chan, K. W., Nairn, A. C. & Gadsby, D. C., Jan 1 2005, In : Journal of General Physiology. 125, 1, p. 43-55 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Preferential phosphorylation of R-domain serine 768 dampens activation of CFTR channels by PKA

Csanády, L., Seto-Young, D., Chan, K. W., Cenciarelli, C., Angel, B. B., Qin, J., Mclachlin, D. T., Krutchinsky, A. N., Chait, B. T., Nairn, A. C. & Gadsby, D. C., Feb 2005, In : Journal of General Physiology. 125, 2, p. 171-186 16 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2004
10 Citations (Scopus)
2003
Open Access
22 Citations (Scopus)
2000

Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms

Csanády, L., Jan 1 2000, In : Biophysical journal. 78, 2, p. 785-799 15 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)

Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains

Csanády, L., Chan, K. W., Seto-Young, D., Kopsco, D. C., Nairn, A. C. & Gadsby, D. C., 2000, In : Journal of General Physiology. 116, 3, p. 477-500 24 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH2-terminal nucleotide binding domain

Chan, K. W., Csanady, L., Seto-Young, D., Nairn, A. C. & Gadsby, D. C., 2000, In : Journal of General Physiology. 116, 2, p. 163-180 18 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)