• 1589 Citations
  • 23 h-Index
1977 …2019

Research output per year

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Research Output

  • 1589 Citations
  • 23 h-Index
  • 109 Article
  • 21 Review article
  • 2 Letter
  • 1 Chapter
2019

An update of SGLT1 and SGLT2 inhibitors in early phase diabetes-type 2 clinical trials

Adeghate, E., Mohsin, S., Adi, F., Ahmed, F., Yahya, A., Kalász, H., Tekes, K. & Adeghate, E. A., Sep 2 2019, In : Expert Opinion on Investigational Drugs. 28, 9, p. 811-820 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An update on therapies for the treatment of diabetes-induced osteoporosis

Mohsin, S., Baniyas, M. M. Y. H., AlDarmaki, R. S. M. H., Tekes, K., Kalász, H. & Adeghate, E. A., Jan 1 2019, In : Expert Opinion on Biological Therapy.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dose-dependent tissue distribution of K117, a bis-pyridinium aldoxime, in rats

Kalász, H., Karvaly, G., Musilek, K., Kuca, K., Young-Sik, J., Malawska, B., Adeghate, E. A., Nurulain, S. M., Szepesy, J., Zelles, T. & Tekes, K., Jan 1 2019, In : Open Medicinal Chemistry Journal. 13, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning

Tekes, K., Karvaly, G., Nurulain, S., Kuca, K., Musilek, K., Adeghate, E., Jung, Y. S. & Kalász, H., Sep 1 2019, In : Chemico-Biological Interactions. 310, 108737.

Research output: Contribution to journalArticle

2018

Circulating nociceptin and CGRP in medication-overuse headache

Munksgaard, S. B., Ertsey, C., Frandsen, E., Bendtsen, L., Tekes, K. & Jensen, R. H., Jan 1 2018, (Accepted/In press) In : Acta Neurologica Scandinavica.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effect of nociceptin on insulin release in normal and diabetic rat pancreas

Adeghate, E., Saeed, Z., D’Souza, C., Tariq, S., Kalász, H., Tekes, K. & Adeghate, E. A., Dec 1 2018, In : Cell And Tissue Research. 374, 3, p. 517-529 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pharmacognostical sources of popular medicine to treat Alzheimer’s disease

Kalász, H., Ojha, S., Tekes, K., Szőke, É., Mohanraj, R., Fahim, M., Adeghate, E. & Adem, A., Feb 16 2018, In : Open Medicinal Chemistry Journal. 12, p. 23-35 13 p.

Research output: Contribution to journalReview article

2017

Effects on sperms’ quality of selegiline in aged rats

Kalász, H., Thuróczy, J., Karvaly, G., Balogh, L., Gyertyán, I., Molnár, E. T., Adeghate, E. & Tekes, K., Nov 1 2017, In : Open Medicinal Chemistry Journal. 11, p. 138-145 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

Kalasz, H., Hunyadi, A., Tekes, K., Dolesal, R. & Karvaly, G., Sep 2017, In : Acta Chromatographica. 29, 3, p. 375-383 9 p.

Research output: Contribution to journalArticle

Monitoring the level of 14C-labelled selegiline following oral administration

Kalász, H., Tekes, K., Faigl, E. B., Pöstényi, Z., Berekméri, E., Karvaly, G. & Adeghate, E., Jan 1 2017, In : Open Medicinal Chemistry Journal. 11, p. 1-8 8 p.

Research output: Contribution to journalArticle

Novel biological therapies for the treatment of diabetic foot ulcers

Adeghate, J., Nurulain, S., Tekes, K., Fehér, E., Kalász, H. & Adeghate, E., Aug 3 2017, In : Expert Opinion on Biological Therapy. 17, 8, p. 979-987 9 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2016

Diabetes-induced changes in the morphology and nociceptinergic innervation of the rat uterus

Tariq, S., Nurulain, S. M., Rashed, H., Lotfy, M., Emerald, S. B., Koturan, S., Tekes, K. & Adeghate, E., Feb 1 2016, In : Journal of Molecular Histology. 47, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pharmacokinetics of selegiline in a rabbit model

Kalász, H., Tekes, K., Pöstényi, Z., Vizvári, E., Sótonyi, P., Szabó, D. & Tóth-Molnár, E., Oct 1 2016, In : Letters in Drug Design and Discovery. 13, 8, p. 752-756 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Comparative lipophilicity of morphine derivatives

Kalász, H., Doležal, R., Tekes, K., Magyar, K., Csermely, T. & Hosztafi, S., Apr 1 2015, In : Journal of Planar Chromatography - Modern TLC. 28, 2, p. 126-132 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Distribution of N-methyl-14C-labeled selegiline in the rat

Tekes, K., Pöstényi, Z., Faigl, E. B., Magyar, K., Polyák, A., Trencsényi, G., Balogh, L. & Kalász, H., Jul 1 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 111, p. 147-152 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Distribution of nociceptin in pancreatic islet cells of normal and diabetic rats

Tariq, S., Rashed, H., Nurulain, S. M., Emerald, B. S., Koturan, S., Tekes, K. & Adeghate, E., May 25 2015, In : Pancreas. 44, 4, p. 602-607 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effects of Nociceptin and Nocistatin on Uterine Contraction

Gáspár, R., Deák, B. H., Klukovits, A., Ducza, E. & Tekes, K., Jan 1 2015, Vitamins and Hormones. Academic Press Inc., p. 223-240 18 p. (Vitamins and Hormones; vol. 97).

Research output: Chapter in Book/Report/Conference proceedingChapter

Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

Nurulain, S. M., Ojha, S., Tekes, K., Shafiullah, M., Kalasz, H. & Adem, A., Jan 1 2015, In : Oxidative medicine and cellular longevity. 2015, 329306.

Research output: Contribution to journalArticle

4 Citations (Scopus)

HPLC analysis of blood-brain barrier penetration of 4-fluorodeprenyl

Pöstényi, Z., Tekes, K., Tóth-Molnár, E. & Kalász, H., Jan 5 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 102, p. 529-534 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mini review on blood-brain barrier penetration of pyridinium aldoximes

Kalász, H., Nurulain, S. M., Veress, G., Antus, S., Darvas, F., Adeghate, E., Adem, A., Hashemi, F. & Tekes, K., Feb 1 2015, In : Journal of Applied Toxicology. 35, 2, p. 116-123 8 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)
2014
6 Citations (Scopus)

HPLC analysis and detection of L-deprenyl

Csomor, V., Laufer, R., Pöstényi, Z., Kalász, H., Adeghate, E., Nurulain, S. M., Tekes, K. & Adem, A., Dec 1 2014, In : Acta Chromatographica. 26, 4, p. 649-656 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203

Hashemi, F., Laufer, R., Szegi, P., Csomor, V., Kalász, H. & Tekes, K., Mar 1 2014, In : Acta physiologica Hungarica. 101, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Metabolism of selegiline [(-)-Deprenyl)]

Kalász, H., Magyar, K., Szöke, É., Adeghate, E., Adem, A., Hasan, M. Y., Nurulain, S. M. & Tekes, K., Apr 2014, In : Current medicinal chemistry. 21, 13, p. 1522-1530 9 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Oxime-type acetylcholinesterase reactivators in pregnancy: An overview

Nurulain, S. M., Kornelia, T., Naqvi, S. N. H., Sharma, C., Ojha, S. & Adem, A., Mar 1 2014, In : Archives of Toxicology. 88, 3, p. 575-584 10 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2013

Antioxidants in organophosphorus compounds poisoning

Nurulain, S. M., Szegi, P., Tekes, K. & Naqvi, S. N., 2013, In : Arhiv za Higijenu Rada i Toksikologiju. 64, 1, p. 169-177 9 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Deciphering intracellular localization and physiological role of nociceptin and nocistatin

Tariq, S., Nurulain, S. M., Tekes, K. & Adeghate, E., May 1 2013, In : Peptides. 43, p. 174-183 10 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)
26 Citations (Scopus)

HPLC analysis in drug level monitoring of K027

Nurulain, S., Kalász, H., Szegi, P., Kuca, K., Adem, A., Hasan, M., Hashemi, F. & Tekes, K., Dec 1 2013, In : Acta Chromatographica. 25, 4, p. 703-710 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Medicinal chemistry of antimigraine drugs

Tekes, K., Szegi, P., Hashemi, F., Laufer, R., Kalász, H., Siddiq, A. & Ertsey, C., Sep 1 2013, In : Current medicinal chemistry. 20, 26, p. 3300-3316 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Medicinal chemistry of drugs with active metabolites following conjugation

Kalász, H., Petroianu, G., Hosztafi, S., Darvas, F., Csermely, T., Adeghate, E., Siddiq, A. & Tekes, K., Jan 1 2013, In : Mini-Reviews in Medicinal Chemistry. 13, 11, p. 1550-1563 14 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Nociceptinergic system as potential target in Parkinson's disease

Tekes, K., Tariq, S., Adeghate, E., Laufer, R., Hashemi, F., Siddiq, A. & Kalasz, H., Aug 20 2013, In : Mini-Reviews in Medicinal Chemistry. 13, 10, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nocistatin inhibits pregnant rat uterine contractions in vitro: Roles of calcitonin gene-related peptide and calcium-dependent potassium channel

Deák, B. H., Klukovits, A., Tekes, K., Ducza, E., Falkay, G. & Gáspár, R., Jan 1 2013, In : European Journal of Pharmacology. 714, 1-3, p. 96-104 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Study on medicinal chemistry of k203 in wistar rats and beagle dogs

Kalász, H., Szegi, P., Jánoki, G., Balogh, L., Pöstényi, Z., Musilek, K., Petroianu, G. A., Siddiq, A. & Tekes, K., May 1 2013, In : Current medicinal chemistry. 20, 16, p. 2137-2144 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Active metabolites resulting from decarboxylation, reduction and ester hydrolysis of parent drugs

Hartyánszky, I., Kalász, H., Adeghate, E., Gulyás, Z., Hasan, M. Y., Tekes, K., Adem, A. & Sótonyi, P., Jul 1 2012, In : Current Drug Metabolism. 13, 6, p. 835-862 28 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes

Csobay-Novák, C. S., Sótonyi, P., Krepuska, M., Zima, E., Szilágyi, N., Tóth, S. Z., Szeberin, Z., Acsády, G. Y., Merkely, B. & Tekes, K., Jun 1 2012, In : Acta physiologica Hungarica. 99, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Medicinal chemistry of drugs with active metabolites (N-, O-, and S-desalkylation and some specific oxidative alterations)

Ram, N., Kalász, H., Adeghate, E., Darvas, F., Hashemi, F. & Tekes, K., Dec 24 2012, In : Current medicinal chemistry. 19, 33, p. 5683-5704 22 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)
2011

Aliphatic and aromatic oxidations, epoxidation and s-oxidation of prodrugs that yield active drug metabolites

Tekes, K., Kalász, H., Hasan, M. Y., Adeghate, E., Darvas, F., Ram, N. & Adem, A., Nov 1 2011, In : Current medicinal chemistry. 18, 32, p. 4885-4900 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antidepresszánsok és aktív metabolitjaik sorsa a szervezetben

Translated title of the contribution: Prodrugs and active metabolites among antidepressive compoundsTekes, K., Hashemi, F., Szegi, P., Sótonyi, P., Laufer, R. & Kalász, H., Jun 1 2011, In : Neuropsychopharmacologia Hungarica. 13, 2, p. 103-110 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain

Tekes, K., Szegi, P., Laufer, R., Hantos, M. & Csaba, G., Apr 1 2011, In : International Journal of Developmental Neuroscience. 29, 2, p. 171-175 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Medicinal chemistry and actions of dual and pan PPAR modulators

Adeghate, E., Adem, A., Hasan, M. Y., Tekes, K. & Kalasz, H., Nov 9 2011, In : Open Medicinal Chemistry Journal. 5, SPEC. ISSUE 2, p. 93-98 6 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

Medicinal chemistry and applications of incretins and DPP-4 inhibitors in the treatment of type 2 diabetes mellitus

Lotfy, M., Singh, J., Kalász, H., Tekes, K. & Adeghate, E., Nov 9 2011, In : Open Medicinal Chemistry Journal. 5, SPEC. ISSUE 2, p. 82-92 11 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases-A pilot study

Krepuska, M., Sótonyi, P., Csobay-Novák, C., Szeberin, Z., Hartyánszky, I., Zima, E., Szilágyi, N., Horkay, F., Merkely, B., Acsády, G. & Tekes, K., Aug 8 2011, In : Regulatory Peptides. 169, 1-3, p. 1-5 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2010

Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment

Gyongyosi, N., Balogh, B., Katai, Z., Molnar, E., Laufer, R., Tekes, K. & Bagdy, G., Mar 1 2010, In : Journal of neural transmission. 117, 3, p. 285-292 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Chromatographic separation of antiviral/anticancer nucleoside reverse transcriptase inhibitor drugs

Kalász, H., Hasan, M. Y., Adeghate, E., Tekes, K. & Adem, A., Sep 1 2010, In : Analytical and Bioanalytical Chemistry. 398, 1, p. 295-312 18 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Medicinal chemistry of antiviral/anticancer prodrugs subjected to phosphate conjugation

Kalász, H., Adem, A., Hasan, M. Y., Adeghate, E., Ram, N., Gulyás, Z. & Tekes, K., Jan 1 2010, In : Mini-Reviews in Medicinal Chemistry. 10, 9, p. 822-845 24 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Medicinal chemistry of drugs used in diabetic cardiomyopathy

Adeghate, E., Kalasz, H., Veress, G. & Tekes, K., Feb 1 2010, In : Current medicinal chemistry. 17, 6, p. 517-551 35 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

Klukovits, A., Tekes, K., Gündüz Çinar, Ö., Benyhe, S., Borsodi, A., Deák, B. H., Hajagos-Tóth, J., Verli, J., Falkay, G. & Gáspár, R., Jul 2010, In : Biology of Reproduction. 83, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Pyridinium aldoxime analysis by HPLC: The method for studies on pharmacokinetics and stability

Szegi, P., Kalász, H., Laufer, R., Kuca, K. & Tekes, K., May 1 2010, In : Analytical and Bioanalytical Chemistry. 397, 2, p. 579-586 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes

Laufer, R., Kalász, H., Musilek, K., Szegi, P., Darvas, F., Kuca, K. & Tekes, K., Jul 30 2010, In : Current Organic Chemistry. 14, 5, p. 447-456 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)