• 6988 Citations
  • 46 h-Index
1978 …2020

Research output per year

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Research Output

2020

25th Anniversary of Pathology Oncology Research

Kopper, L. & Tímár, J., Jan 1 2020, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalEditorial

Open Access

EGFR protein expression in KRAS wild-type metastatic colorectal cancer is another negative predictive factor of the cetuximab therapy

Uhlyarik, A., Piurko, V., Papai, Z., Raso, E., Lahm, E., Kiss, E., Sikter, M., Vachaja, J., Kenessey, I. & Timar, J., Mar 2020, In : Cancers. 12, 3, 614.

Research output: Contribution to journalArticle

Open Access

Immunologic and immunogenomic aspects of tumor progression

Ladányi, A. & Tímár, J., Feb 2020, In : Seminars in Cancer Biology. 60, p. 249-261 13 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo

Baranyi, M., Rittler, D., Molnár, E., Shirasawa, S., Jalsovszky, I., Varga, I. K., Hegedűs, L., Németh, A., Dank, M., Aigner, C., Tóvári, J., Tímár, J., Hegedűs, B. & Garay, T., Jan 1 2020, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalArticle

2019

A CUP (Cancer of Unknown Primary) daganatok patológiai diagnosztikája

Translated title of the contribution: Pathological diagnostics of CUP (Cancer of Unknown Primary)Tímár, J., Jun 21 2019, In : Magyar onkologia. 64, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Allélspecifikus inhibitorok nyomában: a RASopátia konzorcium célpontjában a KRAS fehérje onkogén mutációi

Translated title of the contribution: Allele-specific inhibitors of mutant KRAS are in the focus of RASopathy consortiumNyíri, K., Koppány, G., Pálfy, G., Vida, I., Tóth, S., Orgován, Z., Ranðeloviæ, I., Baranyi, M., Molnár, E., Keserû, M. G., Tóvári, J., Perczel, A., Vértessy, B. G. & Tímár, J., Dec 9 2019, In : Magyar onkologia. 63, 4, p. 310-323 14 p.

Research output: Contribution to journalArticle

A prosztatarák molekuláris patológiája

Translated title of the contribution: Molecular pathology of prostate cancerTímár, J., Mar 19 2019, In : Magyar onkologia. 63, 1, p. 5-9 5 p.

Research output: Contribution to journalArticle

Open Access

Dynamic and unpredictable changes in mutant allele fractions of BRAF and NRAS during visceral progression of cutaneous malignant melanoma

Doma, V., Kárpáthy, S., Rásó, E., Barbai, T. & Tímár, J., Aug 7 2019, In : BMC cancer. 19, 1, 786.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

EGFR Protein Expression of KRAS Wild-Type Colorectal Cancer: Predictive Value of the Sidedness for Efficacy of Anti-EGFR Therapy

Uhlyarik, A., Piurko, V., Vizkeleti, L., Pápai, Z., Rásó, E., Lahm, E., Kiss, E., Sikter, M., Vachaja, J., Kenessey, I. & Tímár, J., Jan 1 2019, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

KIT Mutation Incidence and Pattern of Melanoma in Central Europe

Doma, V., Barbai, T., Beleaua, M. A., Kovalszky, I., Rásó, E. & Tímár, J., Jan 1 2019, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalArticle

Open Access

KRAS mutations predict response and outcome in advanced lung adenocarcinoma patients receiving first-line bevacizumab and platinum-based chemotherapy

Ghimessy, A. K., Gellert, A., Schlegl, E., Hegedus, B., Raso, E., Barbai, T., Timar, J., Ostoros, G., Megyesfalvi, Z., Gieszer, B., Moldvay, J., Renyi-Vamos, F., Lohinai, Z., Hoda, M. A., Klikovits, T., Klepetko, W., Laszlo, V. & Dome, B., Oct 2019, In : Cancers. 11, 10, 1514.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression

Molnár, E., Garay, T., Donia, M., Baranyi, M., Rittler, D., Berger, W., Tímár, J., Grusch, M. & Hegedűs, B., Sep 11 2019, In : International journal of molecular sciences. 20, 18

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

PD-L1 Expression of Lung Cancer Cells, Unlike Infiltrating Immune Cells, Is Stable and Unaffected by Therapy During Brain Metastasis

Téglási, V., Pipek, O., Lózsa, R., Berta, K., Szüts, D., Harkó, T., Vadász, P., Rojkó, L., Döme, B., Bagó, A. G., Tímár, J., Moldvay, J., Szállási, Z. & Reiniger, L., Jan 1 2019, In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Prenilációgátlás hatása ras-mutáns daganatokra kísérleti rendszerekben

Translated title of the contribution: Impact of prenylation inhibition on ras mutant tumors in preclini­cal studiesBaranyi, M., Molnár, E., Rittler, D., Hegedűs, B. & Tímár, J., Jan 1 2019, In : Magyar onkologia. 63, 4, p. 320-329 10 p.

Research output: Contribution to journalArticle

Selective Inhibition of HIF1α Expression by ZnSO4 Has Antitumoral Effects in Human Melanoma

Burián, Z., Ladányi, A., Barbai, T., Piurkó, V., Garay, T., Rásó, E. & Tímár, J., Jan 1 2019, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalArticle

The antitumor effect of lipophilic bisphosphonate BPH1222 in melanoma models: The role of the PI3K/Akt pathway and the small G protein rheb

Rittler, D., Baranyi, M., Molnár, E., Garay, T., Jalsovszky, I., Varga, I. K., Hegedűs, L., Aigner, C., Tóvári, J., Tímár, J. & Hegedűs, B., Oct 1 2019, In : International journal of molecular sciences. 20, 19, 4917.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Tumor necrosis correlates with PD-L1 and PD-1 expression in lung adenocarcinoma

Reiniger, L., Téglási, V., Pipek, O., Rojkó, L., Glasz, T., Vágvölgyi, A., Kovalszky, I., Gyulai, M., Lohinai, Z., Rásó, E., Tímár, J., Döme, B., Szállási, Z. & Moldvay, J., Jan 1 2019, In : Acta Oncologica.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Aquaporin-1 Protein Expression of the Primary Tumor May Predict Cerebral Progression of Cutaneous Melanoma

Imrédi, E., Liszkay, G., Kenessey, I., Plotár, V., Gödény, M., Tóth, B., Fedorcsák, I. & Tímár, J., Jan 1 2018, (Accepted/In press) In : Pathology and Oncology Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A tüdõ és a gasztrointesztinum neuroendokrin daganatainak genetikája: hasonlóságok és különbségek

Translated title of the contribution: Genomics of neuroendocrine tumors of the lung and gastrointestinal tract: similarities and differencesTímár, J. & Patócs, A., Jul 20 2018, In : Magyar onkologia. 62, 2, p. 77-82 6 p.

Research output: Contribution to journalArticle

Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors

Diossy, M., Reiniger, L., Sztupinszki, Z., Krzystanek, M., Timms, K. M., Neff, C., Solimeno, C., Pruss, D., Eklund, A. C., Tóth, E., Kiss, O., Rusz, O., Cserni, G., Zombori, T., Székely, B., Tímár, J., Csabai, I. & Szallasi, Z., Sep 1 2018, In : Annals of Oncology. 29, 9, p. 1948-1954 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Characterization of cellular and humoral immune responses to alkaline phosphatase from fertile hydatid cysts in the human peripheral blood

Vatankhah, A., Ghaffari, S. M. R., Vatankhah, R. G., Piurkó, V., Tímár, J., Avan, A. & Jazayeri, M. H., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients

Rojkó, L., Reiniger, L., Téglási, V., Fábián, K., Pipek, O., Vágvölgyi, A., Agócs, L., Fillinger, J., Kajdácsi, Z., Tímár, J., Döme, B., Szállási, Z. & Moldvay, J., Apr 19 2018, (Accepted/In press) In : Journal of Cancer Research and Clinical Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
5 Citations (Scopus)

Expression of PD-L1 on immune cells shows better prognosis in laryngeal, oropharygeal, and hypopharyngeal cancer

Birtalan, E., Danos, K., Gurbi, B., Brauswetter, D., Halasz, J., Piurko, V. K., Acs, B., Antal, B., Mihalyi, R., Pato, A., Fent, Z., Polony, G., Timar, J. & Tamas, L., Aug 1 2018, In : Applied Immunohistochemistry and Molecular Morphology. 26, 7, p. e79-e85

Research output: Contribution to journalArticle

6 Citations (Scopus)

Inhibition of epidermal growth factor receptor improves antitumor efficacy of vemurafenib in BRAF-mutant human melanoma in preclinical model

Kenessey, I., Kramer, Z., István, L., Cserepes, M. T., Garay, T., Hegedűs, B., Dobos, J., Tímár, J. & Tóvári, J., Dec 1 2018, In : Melanoma Research. 28, 6, p. 536-546 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study

Klikovits, T., Lohinai, Z., Fábián, K., Gyulai, M., Szilasi, M., Varga, J., Baranya, E., Pipek, O., Csabai, I., Szállási, Z., Tímár, J., Hoda, M. A., Laszlo, V., Hegedűs, B., Renyi-Vamos, F., Klepetko, W., Ostoros, G., Döme, B. & Moldvay, J., Dec 1 2018, In : Lung Cancer. 126, p. 139-148 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NSCLC molecular testing in Central and Eastern European countries

Ryska, A., Berzinec, P., Brcic, L., Cufer, T., Dziadziuszko, R., Gottfried, M., Kovalszky, I., Olszewski, W., Oz, B., Plank, L. & Tímár, J., Mar 9 2018, In : BMC Cancer. 18, 1, 269.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Molnár, E., Rittler, D., Baranyi, M., Grusch, M., Berger, W., Döme, B., Tóvári, J., Aigner, C., Tímár, J., Garay, T. & Hegedus, B., May 8 2018, In : BMC Cancer. 18, 1, 542.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The role of lipid signaling in the progression of malignant melanoma

Tímár, J., Hegedüs, B. & Rásó, E., Sep 1 2018, In : Cancer and Metastasis Reviews. 37, 2-3, p. 245-255 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A daganatok immunterápiájának prediktív markerei, a PD-L1-meghatározás gyakorlati kérdései

Translated title of the contribution: Predictive markers of immunotherapy of cancer, practical issues of PD-L1 testingTímár, J. & Ladányi, A., Jun 6 2017, In : Magyar onkologia. 61, 2, p. 158-166 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Az ALK-pozitív tüdõrák korszerû diagnosztikája

Translated title of the contribution: Molecular diagnostics of ALK-positive lung cancerTímár, J., Lotz, G., Rásó, E. & Moldvay, J., Sep 20 2017, In : Magyar onkologia. 61, 3, p. 301-311 11 p.

Research output: Contribution to journalArticle

Beszámoló a MOTESZ 2015-2016. évi tevékenységérol

Tímár, J., Jan 1 2017, In : Lege Artis Medicinae. 27, 3, p. 133-138 6 p.

Research output: Contribution to journalArticle

Comparison of immunophenotypes of primary breast carcinomas and multiple corresponding distant metastases: an autopsy study of 25 patients

Szekely, B., Nagy, Z. I., Farago, Z., Kiss, O., Lotz, G., Kovacs, K. A., Madaras, L., Udvarhelyi, N., Dank, M., Szentmartoni, G., Baranyai, Z., Harsanyi, L., Tőkés, A. M., Timar, J., Szasz, A. M. & Kulka, J., Jan 1 2017, In : Clinical and Experimental Metastasis. 34, 1, p. 103-113 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Differential expression of proteoglycans on the surface of malignant cells and in the tumor stroma

Tímár, J. & Kovalszky, I., Jan 1 2017, Tumor Matrix Biology. CRC Press, p. 23-53 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Histone deacetylase inhibitor treatment increases the expression of the plasma membrane Ca2+ pump PMCA4b and inhibits the migration of melanoma cells independent of ERK

Hegedüs, L., Padányi, R., Molnár, J., Pászty, K., Varga, K., Kenessey, I., Sárközy, E., Wolf, M., Grusch, M., Hegyi, Z., Homolya, L., Aigner, C., Garay, T., Hegedűs, B., Tímár, J., Kállay, E. & Enyedi, A., May 24 2017, In : Frontiers in Oncology. 7, MAY, 95.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Integrin expression in tumor progression - role of signaling mechanisms

Honn, K. V. & Timár, J., Jan 1 2017, Tumor Matrix Biology. CRC Press, p. 145-171 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: Poor prognosis in patients with KRAS mutation and bone metastasis

Lohinai, Z., Klikovits, T., Moldvay, J., Ostoros, G., Raso, E., Timar, J., Fabian, K., Kovalszky, I., Kenessey, I., Aigner, C., Renyi-Vamos, F., Klepetko, W., Dome, B. & Hegedus, B., Jan 4 2017, In : Scientific reports. 7, 39721.

Research output: Contribution to journalArticle

27 Citations (Scopus)

P16INK4 expression is of prognostic and predictive value in oropharyngeal cancers independent of human papillomavirus status: a Hungarian study

Brauswetter, D., Birtalan, E., Danos, K., Kocsis, A., Krenacs, T., Tímár, J., Mihalyi, R., Horcsik, D., Polony, G., Tamas, L. & Petak, I., Apr 1 2017, In : European Archives of Oto-Rhino-Laryngology. 274, 4, p. 1959-1965 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

RAS mutation prevalence among patients with metastatic colorectal cancer: A meta-analysis of real-world data

Kafatos, G., Niepel, D., Lowe, K., Jenkins-Anderson, S., Westhead, H., Garawin, T., Traugottová, Z., Bilalis, A., Molnar, E., Tímár, J., Toth, E., Gouvas, N., Papaxoinis, G., Murray, S., Mokhtar, N., Vosmikova, H., Fabian, P., Skalova, A., Wójcik, P., Tysarowski, A. & 3 others, Barugel, M., Van Krieken, J. H. & Trojan, J., Sep 1 2017, In : Biomarkers in Medicine. 11, 9, p. 751-760 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The evidence for and against different modes of tumour cell extravasation in the lung: diapedesis, capillary destruction, necroptosis, and endothelialization

Paku, S., Laszlo, V., Dezso, K., Nagy, P., Hoda, M. A., Klepetko, W., Renyi-Vamos, F., Tímár, J., Reynolds, A. R. & Dome, B., Mar 1 2017, In : Journal of Pathology. 241, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner

Keller-Pinter, A., Ughy, B., Domoki, M., Pettko-Szandtner, A., Letoha, T., Tóvári, J., Tímár, J. & Szilák, L., Nov 1 2017, In : PLoS One. 12, 11, e0187094.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma

Imrédi, E., Tóth, B., Doma, V., Barbai, T., Rásó, E., Kenessey, I. & Tímár, J., Feb 4 2016, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

11 Citations (Scopus)

BRCA Mutation-Related and Claudin-Low Breast Cancer: Blood Relatives or Stepsisters?

Madaras, L., Balint, N., Gyorffy, B., Tokes, A. M., Barshack, I., Yosepovich, A., Friedman, E., Paluch-Shimon, S., Zippel, D., Baghy, K., Timar, J., Kovalszky, I., Kulka, J. & Szasz, A. M., Mar 1 2016, In : Pathobiology. 83, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Genetic evolution during tumor progression: from basic research to clinical practice

Tímár, J., Mar 10 2016, (Accepted/In press) In : Cancer metastasis reviews. p. 1-2 2 p.

Research output: Contribution to journalArticle

Genetic progression of malignant melanoma

Tímár, J., Vizkeleti, L., Doma, V., Barbai, T. & Rásó, E., Mar 12 2016, (Accepted/In press) In : Cancer metastasis reviews. p. 1-15 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

Kenessey, I., Kói, K., Horváth, O., Cserepes, M., Molnár, D., Izsák, V., Dobos, J., Hegedus, B., Tóvári, J. & Tímár, J., 2016, In : Oncotarget. 7, 48, p. 79503-79514 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma - occurence and prognostic significance

Módos, O., Reis, H., Niedworok, C., Rübben, H., Szendröi, A., Szász, A., Tímár, J., Baghy, K., Kovalszky, I., Golabek, T., Chlosta, P., Okon, K., Peyronnet, B., Mathieu, R., Shariat, S. F., Hollósi, P., Nyírády, P. & Szarvas, T., 2016, In : Oncotarget. 7, 26, p. 39293-39301 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer

Fábián, K., Gyulai, M., Furák, J., Várallyay, P., Jäckel, M., Bogos, K., Döme, B., Pápay, J., Tímár, J., Szállási, Z. & Moldvay, J., Aug 26 2016, (Accepted/In press) In : Oncology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

A p16 tumorszuppresszor expressziójának prognosztikai szerepe magyarországi szájüregi laphámrákokban

Translated title of the contribution: The prognostic role of expression of p16 tumor suppressor gene in Hungarian patients with oral squamous cell carcinomaJudit, V. B., Violetta, P., Suba, Z., Németh, Z., Tímár, J. & István, K., Jan 1 2015, In : Magyar Onkologia. 59, 4, p. 352-359 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)