• 6499 Citations
  • 42 h-Index
1978 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Acute physiological changes caused by complement activators and amphotericin b-containing liposomes in mice

Őrfi, E., Mészáros, T., Hennies, M., Fülöp, T., Dézsi, L., Nardocci, A., Rosivall, L., Hamar, P., Neun, B. W., Dobrovolskaia, M. A., Szebeni, J. & Szénási, G., Jan 1 2019, In : International journal of nanomedicine. 14, p. 1563-1573 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
Open Access

Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs

Bavli, Y., Winkler, I., Chen, B. M., Roffler, S., Cohen, R., Szebeni, J. & Barenholz, Y., Jul 28 2019, In : Journal of Controlled Release. 306, p. 138-148 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs

Fülöp, T., Kozma, G. T., Vashegyi, I., Mészáros, T., Rosivall, L., Urbanics, R., Storm, G., Metselaar, J. M. & Szebeni, J., Sep 10 2019, In : Journal of Controlled Release. 309, p. 333-338 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

Kozma, G. T., Mészáros, T., Vashegyi, I., Fülöp, T., Örfi, E., Dézsi, L., Rosivall, L., Bavli, Y., Urbanics, R., Mollnes, T. E., Barenholz, Y. & Szebeni, J., Aug 27 2019, In : ACS Nano. 13, 8, p. 9315-9324 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

Anticoagulants influence the performance of in vitro assays intended for characterization of nanotechnology-based formulations

Cedrone, E., Neun, B. W., Rodriguez, J., Vermilya, A., Clogston, J. D., McNeil, S. E., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., Jan 1 2018, In : Molecules. 23, 1, 12.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model: Correlation with physicochemical features and clinical information

Fülöp, T., Nemes, R., Mészáros, T., Urbanics, R., Kok, R. J., Jackman, J. A., Cho, N., Storm, G. & Szebeni, J., Jan 28 2018, In : Journal of Controlled Release. 270, p. 268-274 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: Evaluation of size-dependent imaging properties, storage stability and safety

Unterweger, H., Dézsi, L., Matuszak, J., Janko, C., Poettler, M., Jordan, J., Bäuerle, T., Szebeni, J., Fey, T., Boccaccini, A. R., Alexiou, C. & Cicha, I., Mar 28 2018, In : International journal of nanomedicine. 13, p. 1899-1915 17 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
5 Citations (Scopus)

Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics

Børresen, B., Henriksen, J. R., Clergeaud, G., Jørgensen, J. S., Melander, F., Elema, D. R., Szebeni, J., Engelholm, S. A., Kristensen, A. T., Kjær, A., Andresen, T. L. & Hansen, A. E., Nov 27 2018, In : ACS Nano. 12, 11, p. 11386-11398 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Understanding the role of anti-PEG antibodies in the complement activation by Doxil in vitro

Neun, B. W., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., Jan 1 2018, In : Molecules. 23, 7, 1700.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

Wibroe, P. P., Anselmo, A. C., Nilsson, P. H., Sarode, A., Gupta, V., Urbanics, R., Szebeni, J., Hunter, A. C., Mitragotri, S., Mollnes, T. E. & Moghimi, S. M., Jun 6 2017, In : Nature Nanotechnology. 12, 6, p. 589-594 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo

Buscema, M., Matviykiv, S., Mészáros, T., Gerganova, G., Weinberger, A., Mettal, U., Mueller, D., Neuhaus, F., Stalder, E., Ishikawa, T., Urbanics, R., Saxer, T., Pfohl, T., Szebeni, J., Zumbuehl, A. & Müller, B., Oct 28 2017, In : Journal of Controlled Release. 264, p. 14-23 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Non-immunogenic dextran-coated superparamagnetic iron oxide nanoparticles: A biocompatible, size-tunable contrast agent for magnetic resonance imaging

Unterweger, H., Janko, C., Schwarz, M., Dézsi, L., Urbanics, R., Matuszak, J., Őrfi, E., Fülöp, T., Bäuerle, T., Szebeni, J., Journé, C., Boccaccini, A. R., Alexiou, C., Lyer, S. & Cicha, I., Jul 24 2017, In : International journal of nanomedicine. 12, p. 5223-5238 16 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2016

Aggregation of PEGylated liposomes driven by hydrophobic forces

Bozó, T., Mészáros, T., Mihály, J., Bóta, A., Kellermayer, M. S. Z., Szebeni, J. & Kálmán, B., Nov 1 2016, In : Colloids and Surfaces B: Biointerfaces. 147, p. 467-474 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: Foundation of a validatable immune toxicity model

Jackman, J. A., Mészáros, T., Fülöp, T., Urbanics, R., Szebeni, J. & Cho, N. J., May 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 4, p. 933-943 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro

Mészáros, T., Csincsi, Á. I., Uzonyi, B., Hebecker, M., Fülöp, T. G., Erdei, A., Szebeni, J. & Józsi, M., May 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 4, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Liposomal doxorubicin: the good, the bad and the not-so-ugly

Szebeni, J., Fülöp, T., Dézsi, L., Metselaar, B. & Storm, G., Apr 26 2016, (Accepted/In press) In : Journal of Drug Targeting. p. 1-3 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nanoparticles for intravascular applications: Pcharacterization and cytotoxicity testing

Matuszak, J., Baumgartner, J., Zaloga, J., Juenet, M., Da Silva, A. E., Franke, D., Almer, G., Texier, I., Faivre, D., Metselaar, J. M., Navarro, F. P., Chauvierre, C., Prassl, R., Dézsi, L., Urbanics, R., Alexiou, C., Mangge, H., Szebeni, J., Letourneur, D. & Cicha, I., Mar 2016, In : Nanomedicine. 11, 6, p. 597-616 20 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro

Bugna, S., Buscema, M., Matviykiv, S., Urbanics, R., Weinberger, A., Meszaros, T., Szebeni, J., Zumbuehl, A., Saxer, T. & Müller, B., Apr 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 3, p. 845-849 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Membrane attack complex formation on a supported lipid bilayer: Initial steps towards a CARPA predictor nanodevice

Yorulmaz, S., Tabaei, S. R., Kim, M., Seo, J., Hunziker, W., Szebeni, J. & Cho, N. J., Jun 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 245-255 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
4 Citations (Scopus)
2014

Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses

Dézsi, L., Fülöp, T., Mészáros, T., Szénási, G., Urbanics, R., Vázsonyi, C., Orfi, E., Rosivall, L., Nemes, R., Kok, R. J., Metselaar, J. M., Storm, G. & Szebeni, J., Dec 10 2014, In : Journal of Controlled Release. 195, p. 2-10 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management

Rampton, D., Folkersen, J., Fishbane, S., Hedenus, M., Howaldt, S., Locatelli, F., Patni, S., Szebeni, J. & Weiss, G., Nov 1 2014, In : Haematologica. 99, 11, p. 1671-1676 6 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Hypersensitivity reactions to intravenous lipid emulsion in Swine: Relevance for lipid resuscitation studies

Bedocs, P., Capacchione, J., Potts, L., Chugani, R., Weiszhar, Z., Szebeni, J. & Buckenmaier, C. C., Nov 4 2014, In : Anesthesia and analgesia. 119, 5, p. 1094-1101 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

Complement activation by PEGylated liposomes containing prednisolone

Van Den Hoven, J. M., Nemes, R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., Storm, G. & Szebeni, J., May 13 2013, In : European Journal of Pharmaceutical Sciences. 49, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2012

Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, tween-80 and tween-20

Weiszhár, Z., Czúcz, J., Révész, C., Rosivall, L., Szebeni, J. & Rozsnyay, Z., Mar 12 2012, In : European Journal of Pharmaceutical Sciences. 45, 4, p. 492-498 7 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Flow cytometric analysis of supravesicular structures in doxorubicin-containing pegylated liposomes

Milosevits, G., Rozsnyay, Z., Kozma, G. T., Milosevits, J., Tömöry, G., Robotka, H., Rosivall, L. & Szebeni, J., May 1 2012, In : Chemistry and Physics of Lipids. 165, 4, p. 482-487 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer

Kuznetsova, N. R., Sevrin, C., Lespineux, D., Bovin, N. V., Vodovozova, E. L., Mészáros, T., Szebeni, J. & Grandfils, C., Jun 10 2012, In : Journal of Controlled Release. 160, 2, p. 394-400 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
52 Citations (Scopus)

Liposome-induced complement activation and related cardiopulmonary distress in pigs: Factors promoting reactogenicity of Doxil and AmBisome

Szebeni, J., Bedocs, P., Rozsnyay, Z., Weiszhár, Z., Urbanics, R., Rosivall, L., Cohen, R., Garbuzenko, O., Báthori, G., Tóth, M., Bünger, R. & Barenholz, Y., Feb 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: A porcine model

Szebeni, J., Bedocs, P., Urbanics, R., Bünger, R., Rosivall, L., Tóth, M. & Barenholz, Y., Jun 10 2012, In : Journal of Controlled Release. 160, 2, p. 382-387 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Structure and biological activity of pathogen-like synthetic nanomedicines

Lorincz, O., Toke, E. R., Somogyi, E., Horkay, F., Chandran, P. L., Douglas, J. F., Szebeni, J. & Lisziewicz, J., May 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 4, p. 497-506 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Új perspektíva a krónikus mieloid leukémia kezelésében? Géncsendesítéses terápia

Translated title of the contribution: New perspective in the treatment of chronic myeloid leukemia? Gene silencing therapyÉva, K. T., Adrienn, J. S., Péter, K., János, S., Emöke, K. T., László, B. & Bertalan, F., 2012, In : Magyar onkologia. 56, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2011

In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

Merkel, O. M., Urbanics, R., Bedocs, P., Rozsnyay, Z., Rosivall, L., Toth, M., Kissel, T. & Szebeni, J., Jul 1 2011, In : Biomaterials. 32, 21, p. 4936-4942 7 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2010

Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: The challenges ahead

Moghimi, S. M., Andersen, A. J., Hashemi, S. H., Lettiero, B., Ahmadvand, D., Hunter, A. C., Andresen, T. L., Hamad, I. & Szebeni, J., Sep 1 2010, In : Journal of Controlled Release. 146, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Physicochemical parameters affecting liposomal bisphosphonates bioactivity for restenosis therapy: Internalization, cell inhibition, activation of cytokines and complement, and mechanism of cell death

Epstein-Barash, H., Gutman, D., Markovsky, E., Mishan-Eisenberg, G., Koroukhov, N., Szebeni, J. & Golomb, G., Sep 1 2010, In : Journal of Controlled Release. 146, 2, p. 182-195 14 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Sugar-free, glycine-stabilized intravenous immunoglobulin prevents skin but not renal disease in the MRL/lpr mouse model of systemic lupus

Racz, Z., Nagy, E., Rosivall, L., Szebeni, J. & Hamar, P., Apr 1 2010, In : Lupus. 19, 5, p. 599-612 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2008

Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process

Hamad, I., Hunter, A. C., Szebeni, J. & Moghimi, S. M., Dec 1 2008, In : Molecular Immunology. 46, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)
2007

Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes

Romberg, B., Metselaar, J. M., Baranyi, L., Snel, C. J., Bünger, R., Hennink, W. E., Szebeni, J. & Storm, G., Mar 1 2007, In : International Journal of Pharmaceutics. 331, 2, p. 186-189 4 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2006

Activation of the human complement system by cholesterol-rich and PEGylated liposomes - Modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels

Moghimi, S. M., Hamad, I., Bünger, R., Andresen, T. L., Jørgensen, K., Hunter, A. C., Baranji, L., Rosivall, L. & Szebeni, J., Sep 1 2006, In : Journal of Liposome Research. 16, 3, p. 167-174 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Complement activation-related cardiac anaphylaxis in pigs: Role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function

Szebeni, J., Baranyi, L., Sávay, S., Bodó, M., Milosevits, J., Alving, C. R. & Bünger, R., Mar 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 3, p. H1050-H1058

Research output: Contribution to journalArticle

74 Citations (Scopus)

Methylation of the phosphate oxygen moiety of phospholipid- methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production

Moghimi, S. M., Hamad, I., Andresen, T. L., Jørgensen, K. & Szebeni, J., Dec 1 2006, In : FASEB Journal. 20, 14, p. E2057-E2067

Research output: Contribution to journalArticle

136 Citations (Scopus)
2005

Cerebrovascular involvement in liposome-induced cardiopulmonary distress in pigs

Bodo, M., Szebeni, J., Baranyi, L., Savay, S., Pearce, F. J., Alving, C. R. & Bünger, R., Jul 25 2005, In : Journal of Liposome Research. 15, 1-2, p. 3-14 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Comparative in vitro properties and clinical pharmacokinetics of paclitaxel following the administration of taxol® and paxene®

Scripture, C. D., Szebeni, J., Loos, W. J., Figg, W. D. & Sparreboom, A., May 2005, In : Cancer Biology and Therapy. 4, 5, p. 555-560 6 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2004
85 Citations (Scopus)
2003

Complement activation during hemorrhagic shock and resuscitation in swine.

Szebeni, J., Baranyi, L., Savay, S., Götze, O., Alving, C. R., Bünger, R. & Mongan, P. D., Oct 2003, In : Shock (Augusta, Ga.). 20, 4, p. 347-355 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): Possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R. & Muggia, F. M., Sep 1 2003, In : Annals of Oncology. 14, 9, p. 1430-1437 8 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)

Complement-Dependent Shock and Tissue Damage Induced by Intravenous Injection of Cholesterol-Enriched Liposomes in Rats

Baranyi, L., Szebeni, J., Sávay, S., Bodo, M., Basta, M., Bentley, T. B., Bunger, R. & Alving, C. R., Jun 1 2003, In : Journal of Applied Research. 3, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: A novel effector function of immunoglobulins

Basta, M., Van Goor, F., Luccioli, S., Billings, E. M., Vortmeyer, A. O., Baranyi, L., Szebeni, J., Alving, C. R., Carroll, M. C., Berkower, I., Stojilkovic, S. S. & Metcalfe, D. D., Apr 1 2003, In : Nature medicine. 9, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)