• 7249 Citations
  • 42 h-Index
1967 …2020

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Article
2020

Novel Na+/Ca2+ exchanger inhibitor ORM-10962 supports coupled function of funny-current and Na+/ Ca2+ exchanger in pacemaking of rabbit sinus node tissue

Kohajda, Z., Tóth, N., Szlovák, J., Loewe, A., Bitay, G., Gazdag, P., Prorok, J., Jost, N., Levijoki, J., Pollesello, P., Papp, J. G., Varró, A. & Nagy, N., Jan 1 2020, In : Frontiers in Pharmacology. 10, 1632.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019
2018

Complex electrophysiological remodeling in postinfarction ischemic heart failure

Hegyi, B., Bossuyt, J., Griffiths, L. G., Shimkunas, R., Coulibaly, Z., Jian, Z., Grimsrud, K. N., Sondergaard, C. S., Ginsburg, K. S., Chiamvimonvat, N., Belardinelli, L., Varró, A., Papp, J. G., Pollesello, P., Levijoki, J., Izu, L. T., Boyd, W. D., Bányász, T., Bers, D. M. & Chen-Izu, Y., Mar 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 13, p. E3036-E3044

Research output: Contribution to journalArticle

18 Citations (Scopus)

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Oravecz, K., Kormos, A., Gruber, A., Márton, Z., Kohajda, Z., Mirzaei, L., Jost, N., Levijoki, J., Pollesello, P., Koskelainen, T., Otsomaa, L., Tóth, A., Papp, J. G., Nánási, P. P., Antoons, G., Varró, A., Acsai, K. & Nagy, N., Jan 5 2018, In : European Journal of Pharmacology. 818, p. 278-286 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart

Polyák, A., Kui, P., Morvay, N., Leprán, I., Ágoston, G., Varga, A., Nagy, N., Baczkó, I., Farkas, A., Papp, J. G., Varró, A. & Farkas, A. S., Jan 1 2018, In : Reviews in cardiovascular medicine. 19, 4, p. 135-142 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2017

Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle

Gurabi, Z., Patocskai, B., Györe, B., Virág, L., Mátyus, P., Papp, J., Varró, A. & Koncz, I., Jan 1 2017, In : Canadian Journal of Physiology and Pharmacology. 95, 7, p. 830-836 7 p.

Research output: Contribution to journalArticle

Increased short-term beat-to-beat QT interval variability in patients with impaired glucose tolerance

Orosz, A., Baczkó, I., Nyiraty, S., Körei, A. E., Putz, Z., Takács, R., Nemes, A., Várkonyi, T., Balogh, L., Ábrahám, G., Kempler, P., Papp, J., Varró, A. & Lengyel, C., Jun 13 2017, In : Frontiers in Endocrinology. 8, JUN, 129.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits

Papp, H., Sarusi, A., Farkas, A. S., Takacs, H., Kui, P., Vincze, D., Ivany, E., Varró, A., Papp, J., Forster, T. & Farkas, A., Oct 1 2016, In : Journal of Physiology and Pharmacology. 67, 5, p. 731-737 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts

Kui, P., Orosz, S., Takács, H., Sarusi, A., Csík, N., Rárosi, F., Cseko, C., Varró, A., Papp, J., Forster, T., Farkas, A. S. & Farkas, A., Jul 1 2016, In : Journal of Pharmacological and Toxicological Methods. 80, p. 26-34 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

ORM-3819 promotes cardiac contractility through Ca2+ sensitization in combination with selective PDE III inhibition, a novel approach to inotropy

Nagy, L., Pollesello, P., Haikala, H., Végh, Á., Sorsa, T., Levijoki, J., Szilágyi, S., Édes, I., Tóth, A., Papp, Z. & Papp, J. G., Mar 15 2016, In : European Journal of Pharmacology. 775, p. 120-129 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ventricular cycle length irregularity affects the correlation between ventricular rate and coronary flow in isolated, Langendorff perfused guinea pig hearts

Takács, H., Kui, P., Farkas, A. S., Sarusi, A., Forster, T., Papp, J. G., Varró, A., Curtis, M. J., Shattock, M. J. & Farkas, A., Jan 1 2016, In : Journal of Pharmacological and Toxicological Methods. 77, p. 45-52 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias

Szepesi, J., Acsai, K., Sebok, Z., Prorok, J., Pollesello, P., Levijoki, J., Papp, J. G., Varro, A. & Toth, A., Jan 1 2015, In : Journal of Physiology and Pharmacology. 66, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Identification and functional characterisation of a novel KCNJ2 mutation, Val302del, causing andersen–tawil syndrome

Ördög, B., Hategan, L., Kovács, M., Seprényi, G., Kohajda, Z., Nagy, I., Hegedűs, Z., Környei, L., Jost, N., Katona, M., Szekeres, M., Forster, T., Papp, J. G., Varró, A. & Sepp, R., Mar 11 2015, In : Canadian journal of physiology and pharmacology. 93, 7, p. 569-575 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Increased short-term beat-to-beat variability of QT interval in patients with acromegaly

Orosz, A., Csajbók, É., Czékus, C., Gavallér, H., Magony, S., Valkusz, Z., Várkonyi, T. T., Nemes, A., Baczkó, I., Forster, T., Wittmann, T., Papp, J. G., Varró, A. & Lengyel, C., Apr 27 2015, In : PloS one. 10, 4, e0125639.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2 Citations (Scopus)
2 Citations (Scopus)
4 Citations (Scopus)
2014

Absolute beat-to-beat variability and instability parameters of ECG intervals: Biomarkers for predicting ischaemia-induced ventricular fibrillation

Sarusi, A., Rárosi, F., Szúcs, M., Csík, N., Farkas, A. S., Papp, J. G., Varrõ, A., Forster, T., Curtis, M. J. & Farkas, A., Jan 1 2014, In : British journal of pharmacology. 171, 7, p. 1772-1782 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve

Orosz, S., Sarusi, A., Csík, N., Papp, J. G., Varró, A., Farkas, S., Forster, T., Farkas, A. S. & Farkas, A., Sep 1 2014, In : Journal of cardiovascular pharmacology. 64, 3, p. 266-276 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion

Kormos, A., Nagy, N., Acsai, K., Váczi, K., Ágoston, S., Pollesello, P., Levijoki, J., Szentandrássy, N., Papp, J. G., Varró, A. & Tóth, A., Oct 5 2014, In : European Journal of Pharmacology. 740, p. 539-551 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries

Kun, A., Seprényi, G., Varró, A., Papp, J. G. & Pataricza, J., Jan 1 2014, In : Basic and Clinical Pharmacology and Toxicology. 115, 4, p. 315-320 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Selective Na +/ Ca 2+ exchanger inhibition prevents Ca 2+ overload-induced triggered arrhythmias

Nagy, N., Kormos, A., Kohajda, Z., Szebeni, Á., Szepesi, J., Pollesello, P., Levijoki, J., Acsai, K., Virág, L., Nánási, P. P., Papp, J. G., Varrõ, A. & Tõth, A., Dec 2014, In : British journal of pharmacology. 171, 24, p. 5665-5681 17 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

Altered expression of genes for kir ion channels in dilated cardiomyopathy

Szuts, V., Ménesi, D., Varga-Orvos, Z., Zvara, Á., Houshmand, N., Bitay, M., Bogáts, G., Virág, L., Baczkó, I., Szalontai, B., Geramipoor, A., Cotella, D., Wettwer, E., Ravens, U., Deák, F., Puskás, L. G., Papp, J. G., Kiss, I., Varró, A. & Jost, N., Aug 1 2013, In : Canadian journal of physiology and pharmacology. 91, 8, p. 648-656 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
19 Citations (Scopus)
14 Citations (Scopus)

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

Jost, N., Virág, L., Comtois, P., Ördög, B., Szuts, V., Seprényi, G., Bitay, M., Kohajda, Z., Koncz, I., Nagy, N., Szél, T., Magyar, J., Kovács, M., Puskás, L. G., Lengyel, C., Wettwer, E., Ravens, U., Nánási, P. P., Papp, J. G., Varró, A. & 1 others, Nattel, S., Sep 1 2013, In : Journal of Physiology. 591, 17, p. 4189-4206 18 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2012

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve

Kristóf, A., Husti, Z., Koncz, I., Kohajda, Z., Szél, T., Juhász, V., Biliczki, P., Jost, N., Baczkó, I., Papp, J. G., Varró, A. & Virág, L., Dec 31 2012, In : PloS one. 7, 12, e53255.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Prolonged Antispasmodic Effect in Isolated Radial Artery Graft and Pronounced Platelet Inhibition Induced by the Inodilator Drug, Levosimendan

Ambrus, N., Szolnoky, J. A., Pollesello, P., Kun, A., Varró, A., Papp, J. G. & Pataricza, J., Mar 1 2012, In : Basic and Clinical Pharmacology and Toxicology. 110, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

Analysis of the contribution of I to to repolarization in canine ventricular myocardium

Virág, L., Jost, N., Papp, R., Koncz, I., Kristóf, A., Kohajda, Z., Harmati, G., Carbonell-Pascual, B., Ferrero, J. M., Papp, J. G., Nánási, P. P. & Varró, A., Sep 1 2011, In : British journal of pharmacology. 164, 1, p. 93-105 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

Szél, T., Koncz, I., Jost, N., Baczkó, I., Husti, Z., Virág, L., Bussek, A., Wettwer, E., Ravens, U., Papp, J. G. & Varró, A., Jul 15 2011, In : European Journal of Pharmacology. 662, 1-3, p. 31-39 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Electrophysiological effects of ivabradine in dog and human cardiac preparations: Potential antiarrhythmic actions

Koncz, I., Szél, T., Bitay, M., Cerbai, E., Jaeger, K., Fülöp, F., Jost, N., Virág, L., Orvos, P., Tálosi, L., Kristóf, A., Baczkó, I., Papp, J. G. & Varró, A., Oct 15 2011, In : European Journal of Pharmacology. 668, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Increased short-term variability of the qt interval in professional soccer players: Possible implications for arrhythmia prediction

Lengyel, C., Orosz, A., Hegyi, P., Komka, Z., Udvardy, A., Bosnyák, E., Trájer, E., Pavlik, G., Tóth, M., Wittmann, T., Papp, J. G., Varró, A. & Baczkó, I., Apr 25 2011, In : PloS one. 6, 4, e18751.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets

Koncz, I., Szél, T., Jaeger, K., Baczkó, I., Cerbai, E., Romanelli, M. N., Papp, J. G. & Varró, A., Aug 1 2011, In : Current medicinal chemistry. 18, 24, p. 3662-3674 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2010
12 Citations (Scopus)
2009

5,7,8-trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury

Koini, E. N., Papazafiri, P., Vassilopoulos, A., Koufaki, M., Horváth, Z., Koncz, I., Virág, L., Papp, G. J., Varró, A. & Calogeropoulou, T., Apr 23 2009, In : Journal of Medicinal Chemistry. 52, 8, p. 2328-2340 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries

Szolnoky, J., Ambrus, N., Szabó-Biczók, A., Bogáts, G., Papp, J. G., Varró, A. & Pataricza, J., Jul 1 2009, In : European Journal of Cardio-Thoracic Surgery. 36, 1, p. 143-147 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?

Nagy, N., Szuts, V., Horváth, Z., Seprényi, G., Farkas, A. S., Acsai, K., Prorok, J., Bitay, M., Kun, A., Pataricza, J., Papp, J. G., Nánási, P. P., Varró, A. & Tóth, A., Nov 1 2009, In : Journal of Molecular and Cellular Cardiology. 47, 5, p. 656-663 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Herpesvirus-mediated delivery of a genetically encoded fluorescent ca 2+ sensor to canine cardiomyocytes

Prorok, J., Kovács, P. P., Kristf, A. A., Nagy, N., Tombácz, D., Tth, J. S., Ördg, B., Jost, N., Virág, L., Papp, J. G., Varr, A., Tth, A. & Boldogki, Z., Aug 24 2009, In : Journal of Biomedicine and Biotechnology. 2009, 361795.

Research output: Contribution to journalArticle

12 Citations (Scopus)
23 Citations (Scopus)

The role of the Na +/Ca 2+ exchanger, I Na and I CaL in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts

Farkas, A. S., Makra, P., Csík, N., Orosz, S., Shattock, M. J., Fülöp, F., Forster, T., Csanády, M., Papp, J. G., Varró, A. & Farkas, A., Mar 1 2009, In : British journal of pharmacology. 156, 6, p. 920-932 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2008

C-Type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries

Kun, A., Kiraly, I., Pataricza, J., Marton, Z., Krassoi, I., Varro, A., Simonsen, U., Papp, J. G. & Pajor, L., May 1 2008, In : Journal of Sexual Medicine. 5, 5, p. 1114-1125 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
23 Citations (Scopus)

Potassium channels sensitive to combination of charybdotoxin and apamin regulate the tone of diabetic isolated canine coronary arteries

Pataricza, J., Márton, Z., Lengyel, C., Tóth, M., Papp, J. G., Varró, A. & Kun, A., Sep 1 2008, In : Acta Physiologica. 194, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Relevance of anaesthesia for dofetilide-induced torsades de pointes in α 1-adrenoceptor-stimulated rabbits

Vincze, D., Farkas, A. S., Rudas, L., Makra, P., Csík, N., Leprán, I., Forster, T., Csanády, M., Papp, J. G., Varró, A. & Farkas, A., Jan 1 2008, In : British journal of pharmacology. 153, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart

Lengyel, C., Virág, L., Kovács, P. P., Kristóf, A., Pacher, P., Kocsis, E., Koltay, Z. M., Nánási, P. P., Tóth, M., Kecskeméti, V., Papp, J. G., Varró, A. & Jost, N., Mar 1 2008, In : Acta Physiologica. 192, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes

Birinyi, P., Tóth, A., Jóna, I., Acsai, K., Almássy, J., Nagy, N., Prorok, J., Gherasim, I., Papp, Z., Hertelendi, Z., Szentandrássy, N., Bányász, T., Fülöp, F., Papp, J. G., Varró, A., Nánási, P. P. & Magyar, J., Jun 1 2008, In : Cardiovascular research. 78, 3, p. 476-484 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2007
70 Citations (Scopus)
59 Citations (Scopus)