• 7138 Citations
  • 42 h-Index
1967 …2019
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Research Output 1967 2019

  • 7138 Citations
  • 42 h-Index
  • 306 Article
  • 3 Chapter
  • 2 Review article
  • 1 Conference contribution
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Article
2019
Ventricular Fibrillation
Masks
Tachycardia
Cardiac Arrhythmias
Ventricular Tachycardia
C-Type Natriuretic Peptide
Voltage-Gated Potassium Channels
Vascular Smooth Muscle
Membrane Potentials
Coronary Vessels
2018
11 Citations (Scopus)

Complex electrophysiological remodeling in postinfarction ischemic heart failure

Hegyi, B., Bossuyt, J., Griffiths, L. G., Shimkunas, R., Coulibaly, Z., Jian, Z., Grimsrud, K. N., Sondergaard, C. S., Ginsburg, K. S., Chiamvimonvat, N., Belardinelli, L., Varró, A., Papp, J., Pollesello, P., Levijoki, J., Izu, L. T., Boyd, W. D., Bányász, T., Bers, D. M. & Chen-Izu, Y., Mar 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 13, p. E3036-E3044

Research output: Contribution to journalArticle

Heart Failure
Action Potentials
Muscle Cells
Cardiac Arrhythmias
Myocardial Infarction

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Oravecz, K., Kormos, A., Gruber, A., Márton, Z., Kohajda, Z., Mirzaei, L., Jost, N., Levijoki, J., Pollesello, P., Koskelainen, T., Otsomaa, L., Tóth, A., Papp, J., Nánási, P., Antoons, G., Varró, A., Acsai, K. & Nagy, N., Jan 5 2018, In : European Journal of Pharmacology. 818, p. 278-286 9 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Muscle Cells
Canidae
Myocardium
Treatment Failure
2 Citations (Scopus)

Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart

Polyák, A., Kui, P., Morvay, N., Leprán, I., Ágoston, G., Varga, A., Nagy, N., Baczkó, I., Farkas, A., Papp, J., Varró, A. & Farkas, A. S., Dec 30 2018, In : Reviews in cardiovascular medicine. 19, 4, p. 135-142 8 p.

Research output: Contribution to journalArticle

Open Access
Athletes
Animal Models
Dogs
Rabbits
Cardiac Electrophysiology
2017

Different electrophysiological effects of the levo- and dextro-rotatory isomers of mexiletine in isolated rabbit cardiac muscle

Gurabi, Z., Patocskai, B., Györe, B., Virág, L., Mátyus, P., Papp, J., Varró, A. & Koncz, I., Jan 1 2017, In : Canadian Journal of Physiology and Pharmacology. 95, 7, p. 830-836 7 p.

Research output: Contribution to journalArticle

Mexiletine
Myocardium
Rabbits
Sodium Channels
Premature Cardiac Complexes
7 Citations (Scopus)

Increased short-term beat-to-beat QT interval variability in patients with impaired glucose tolerance

Orosz, A., Baczkó, I., Nyiraty, S., Körei, A. E., Putz, Z., Takács, R., Nemes, A., Várkonyi, T., Balogh, L., Ábrahám, G., Kempler, P., Papp, J., Varró, A. & Lengyel, C., Jun 13 2017, In : Frontiers in Endocrinology. 8, JUN, 129.

Research output: Contribution to journalArticle

Glucose Intolerance
Glucose
Fasting
Hemoglobins
Body Mass Index
2016
29 Citations (Scopus)

Calcium sensitizers: What have we learned over the last 25 years?

Pollesello, P., Papp, Z. & Papp, J., Jan 15 2016, In : International Journal of Cardiology. 203, p. 543-548 6 p.

Research output: Contribution to journalArticle

Calcium
Heart Failure
Cardiac Glycosides
Vasodilation
Pharmaceutical Preparations
1 Citation (Scopus)

Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits

Papp, H., Sarusi, A., Farkas, A. S., Takacs, H., Kui, P., Vincze, D., Ivany, E., Varró, A., Papp, J., Forster, T. & Farkas, A., Oct 1 2016, In : Journal of Physiology and Pharmacology. 67, 5, p. 731-737 7 p.

Research output: Contribution to journalArticle

Hyperventilation
Rabbits
Pressure
Cardiac Arrhythmias
Hypokalemia
5 Citations (Scopus)

New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts

Kui, P., Orosz, S., Takács, H., Sarusi, A., Csík, N., Rárosi, F., Cseko, C., Varró, A., Papp, J., Forster, T., Farkas, A. S. & Farkas, A., Jul 1 2016, In : Journal of Pharmacological and Toxicological Methods. 80, p. 26-34 9 p.

Research output: Contribution to journalArticle

Screening
Guinea Pigs
Cisapride
Catecholamines
Safety

ORM-3819 promotes cardiac contractility through Ca2+ sensitization in combination with selective PDE III inhibition, a novel approach to inotropy

Nagy, L., Pollesello, P., Haikala, H., Végh, A., Sorsa, T., Levijoki, J., Szilágyi, S., Édes, I., Tóth, A., Papp, Z. & Papp, J., Mar 15 2016, In : European Journal of Pharmacology. 775, p. 120-129 10 p.

Research output: Contribution to journalArticle

Heart Ventricles
Troponin C
Cardiotonic Agents
Guinea Pigs
Isoenzymes
1 Citation (Scopus)

Ventricular cycle length irregularity affects the correlation between ventricular rate and coronary flow in isolated, Langendorff perfused guinea pig hearts

Takács, H., Kui, P., Farkas, A. S., Sarusi, A., Forster, T., Papp, J., Varró, A., Curtis, M. J., Shattock, M. J. & Farkas, A., Jan 1 2016, In : Journal of Pharmacological and Toxicological Methods. 77, p. 45-52 8 p.

Research output: Contribution to journalArticle

Guinea Pigs
Perfusion
Ventricular Pressure
Pressure
Heart Rate
2015
13 Citations (Scopus)

Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias

Szepesi, J., Acsai, K., Sebok, Z., Prorok, J., Pollesello, P., Levijoki, J., Papp, J., Varró, A. & Tóth, A., 2015, In : Journal of Physiology and Pharmacology. 66, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion
Sodium-Hydrogen Antiporter
Cardiac Arrhythmias
Reperfusion
Premature Cardiac Complexes
2 Citations (Scopus)

Identification and functional characterisation of a novel KCNJ2 mutation, Val302del, causing andersen–tawil syndrome

Ördög, B., Hategan, L., Kovács, M., Seprényi, G., Kohajda, Z., Nagy, I., Hegedűs, Z., Környei, L., Jost, N., Katona, M., Szekeres, M., Forster, T., Papp, J., Varró, A. & Sepp, R., Mar 11 2015, In : Canadian Journal of Physiology and Pharmacology. 93, 7, p. 569-575 7 p.

Research output: Contribution to journalArticle

Mutation
Alleles
Inwardly Rectifying Potassium Channel
Inborn Genetic Diseases
Membranes
5 Citations (Scopus)

Increased short-term beat-to-beat variability of QT interval in patients with acromegaly

Orosz, A., Csajbók, É., Czékus, C., Gavallér, H., Magony, S., Valkusz, Z., Várkonyi, T., Nemes, A., Baczkó, I., Forster, T., Wittmann, T., Papp, J., Varró, A. & Lengyel, C., Apr 27 2015, In : PLoS One. 10, 4, e0125639.

Research output: Contribution to journalArticle

Acromegaly
Electrocardiography
arrhythmia
Cardiac Arrhythmias
reflexes
2 Citations (Scopus)
Amiodarone
Coronary Occlusion
Cardiac Arrhythmias
Coronary Vessels
Myocardial Infarction
2 Citations (Scopus)
Cardiac Electrophysiology
Purkinje Fibers
Action Potentials
Canidae
Microelectrodes
4 Citations (Scopus)
Hypertrophic Cardiomyopathy
Left Ventricular Hypertrophy
Sudden Cardiac Death
Electrocardiography
Body Surface Area
2014
12 Citations (Scopus)

Absolute beat-to-beat variability and instability parameters of ECG intervals: Biomarkers for predicting ischaemia-induced ventricular fibrillation

Sarusi, A., Rárosi, F., Szúcs, M., Csík, N., Farkas, A. S., Papp, J., Varró, A., Forster, T., Curtis, M. J. & Farkas, A., 2014, In : British Journal of Pharmacology. 171, 7, p. 1772-1782 11 p.

Research output: Contribution to journalArticle

Ventricular Fibrillation
Electrocardiography
Ischemia
Biomarkers
Cardiac Arrhythmias
3 Citations (Scopus)

Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve

Orosz, S., Sarusi, A., Csík, N., Papp, J., Varró, A., Farkas, S., Forster, T., Farkas, A. S. & Farkas, A., Sep 1 2014, In : Journal of Cardiovascular Pharmacology. 64, 3, p. 266-276 11 p.

Research output: Contribution to journalArticle

Biomarkers
Sinus Arrhythmia
Rabbits
Torsades de Pointes
Pharmaceutical Preparations
8 Citations (Scopus)

Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion

Kormos, A., Nagy, N., Acsai, K., Váczi, K., Ágoston, S., Pollesello, P., Levijoki, J., Szentandrássy, N., Papp, J., Varró, A. & Tóth, A., Oct 5 2014, In : European Journal of Pharmacology. 740, p. 539-551 13 p.

Research output: Contribution to journalArticle

Reperfusion
Action Potentials
Ischemia
NAD
Cardiac Myocytes
2 Citations (Scopus)
4-Aminopyridine
Mesenteric Arteries
Ion Channels
Rats
Potassium Channels
24 Citations (Scopus)

Selective Na +/ Ca 2+ exchanger inhibition prevents Ca 2+ overload-induced triggered arrhythmias

Nagy, N., Kormos, A., Kohajda, Z., Szebeni, Á., Szepesi, J., Pollesello, P., Levijoki, J., Acsai, K., Virág, L., Nánási, P., Papp, J., Varró, A. & Tóth, A., 2014, In : British Journal of Pharmacology. 171, 24, p. 5665-5681 17 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Anemone
Action Potentials
Cardiac Arrhythmias
Anti-Arrhythmia Agents
2013
14 Citations (Scopus)

Altered expression of genes for kir ion channels in dilated cardiomyopathy

Szűts, V., Ménesi, D., Varga-Orvos, Z., Zvara, A., Houshmand, N., Bitay, M., Bogáts, G., Virág, L., Baczkó, I., Szalontai, B., Geramipoor, A., Cotella, D., Wettwer, E., Ravens, U., Deák, F., Puskás, L., Papp, J., Kiss, I., Varró, A. & Jost, N., 2013, In : Canadian Journal of Physiology and Pharmacology. 91, 8, p. 648-656 9 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Ion Channels
Gene Expression
Genes
Down-Regulation
17 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Action Potentials
Canidae
Myocardium
Potassium
13 Citations (Scopus)
Calcium-Activated Potassium Channels
Muscle
Nitric Oxide
Nitric Oxide Donors
Arteries
65 Citations (Scopus)

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

Jost, N., Virág, L., Comtois, P., Ördög, B., Szűts, V., Seprényi, G., Bitay, M., Kohajda, Z., Koncz, I., Nagy, N., Szél, T., Magyar, J., Kovács, M., Puskás, L., Lengyel, C., Wettwer, E., Ravens, U., Nánási, P., Papp, J., Varró, A. & 1 others, Nattel, S., Sep 2013, In : Journal of Physiology. 591, 17, p. 4189-4206 18 p.

Research output: Contribution to journalArticle

Dogs
Canidae
Mink
pamidronate
Cardiac Myocytes
33 Citations (Scopus)

ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

Jost, N., Nagy, N., Corici, C., Kohajda, Z., Horváth, A., Acsai, K., Biliczki, P., Levijoki, J., Pollesello, P., Koskelainen, T., Otsomaa, L., Tóth, A., Papp, J., Varró, A. & Virág, L., Oct 2013, In : British Journal of Pharmacology. 170, 4, p. 768-778 11 p.

Research output: Contribution to journalArticle

Canidae
Action Potentials
Guinea Pigs
Papillary Muscles
Microelectrodes
2012
8 Citations (Scopus)

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve

Kristóf, A., Husti, Z., Koncz, I., Kohajda, Z., Szél, T., Juhász, V., Biliczki, P., Jost, N., Baczkó, I., Papp, J., Varró, A. & Virág, L., Dec 31 2012, In : PLoS One. 7, 12, e53255.

Research output: Contribution to journalArticle

Diclofenac
Muscle
Muscles
muscles
action potentials
10 Citations (Scopus)

Prolonged Antispasmodic Effect in Isolated Radial Artery Graft and Pronounced Platelet Inhibition Induced by the Inodilator Drug, Levosimendan

Ambrus, N., Szolnoky, J. A., Pollesello, P., Kun, A., Varró, A., Papp, J. & Pataricza, J., Mar 2012, In : Basic and Clinical Pharmacology and Toxicology. 110, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

Parasympatholytics
Radial Artery
Platelets
Grafts
Blood Platelets
4 Citations (Scopus)

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart

Szűts, V., Ötvös, F., Dézsi, L., Vágvölgyi, C., Szalontai, B., Dobrzynski, H., Boyett, M., Zhang, H., Papp, J., Varró, A., Benyhe, S. & Erdélyi, L., 2012, In : Acta Biologica Szegediensis. 56, 2, p. 93-107 15 p.

Research output: Contribution to journalArticle

molecular conformation
Molecular Conformation
Potassium Channels
potassium channels
Genes
2011
15 Citations (Scopus)

Analysis of the contribution of I to to repolarization in canine ventricular myocardium

Virág, L., Jost, N., Papp, R., Koncz, I., Kristóf, A., Kohajda, Z., Harmati, G., Carbonell-Pascual, B., Ferrero, J. M., Papp, J., Nánási, P. & Varró, A., Sep 2011, In : British Journal of Pharmacology. 164, 1, p. 93-105 13 p.

Research output: Contribution to journalArticle

Action Potentials
Canidae
Myocardium
Microelectrodes
Patch-Clamp Techniques
25 Citations (Scopus)

Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

Szél, T., Koncz, I., Jost, N., Baczkó, I., Husti, Z., Virág, L., Bussek, A., Wettwer, E., Ravens, U., Papp, J. & Varró, A., Jul 15 2011, In : European Journal of Pharmacology. 662, 1-3, p. 31-39 9 p.

Research output: Contribution to journalArticle

Dogs
Action Potentials
Purkinje Fibers
Papillary Muscles
Mexiletine
29 Citations (Scopus)

Electrophysiological effects of ivabradine in dog and human cardiac preparations: Potential antiarrhythmic actions

Koncz, I., Szél, T., Bitay, M., Cerbai, E., Jaeger, K., Fülöp, F., Jost, N., Virág, L., Orvos, P., Tálosi, L., Kristóf, A., Baczkó, I., Papp, J. & Varró, A., Oct 15 2011, In : European Journal of Pharmacology. 668, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

ivabradine
Action Potentials
Dogs
Purkinje Fibers
Microelectrodes
15 Citations (Scopus)

Increased short-term variability of the qt interval in professional soccer players: Possible implications for arrhythmia prediction

Lengyel, C., Orosz, A., Hegyi, P., Komka, Z., Udvardy, A., Bosnyák, E., Trájer, E., Pavlik, G., Tóth, M., Wittmann, T., Papp, J., Varró, A. & Baczkó, I., 2011, In : PLoS One. 6, 4, e18751.

Research output: Contribution to journalArticle

Soccer
arrhythmia
Cardiac Arrhythmias
Electrocardiography
heart rate
17 Citations (Scopus)

Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets

Koncz, I., Szél, T., Jaeger, K., Baczkó, I., Cerbai, E., Romanelli, M. N., Papp, J. & Varró, A., Aug 2011, In : Current Medicinal Chemistry. 18, 24, p. 3662-3674 13 p.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
ivabradine
Pacemakers
Protein Isoforms
Sinoatrial Node
2010
12 Citations (Scopus)
Torsades de Pointes
Adrenergic Receptors
Biomarkers
Rabbits
dofetilide
Cromakalim
Canidae
Coronary Vessels
Swine
Calcium
2009
37 Citations (Scopus)

5,7,8-trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury

Koini, E. N., Papazafiri, P., Vassilopoulos, A., Koufaki, M., Horváth, Z., Koncz, I., Virág, L., Papp, J., Varró, A. & Calogeropoulou, T., Apr 23 2009, In : Journal of Medicinal Chemistry. 52, 8, p. 2328-2340 13 p.

Research output: Contribution to journalArticle

Benzoxazines
Benzopyrans
Reperfusion Injury
Cardiac Arrhythmias
Reperfusion
2 Citations (Scopus)

Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries

Szolnoky, J., Ambrus, N., Szabó-Biczók, A., Bogáts, G., Papp, J., Varró, A. & Pataricza, J., Jul 2009, In : European Journal of Cardio-thoracic Surgery. 36, 1, p. 143-147 5 p.

Research output: Contribution to journalArticle

Radial Artery
Albumins
Endothelium
Transplants
Arteries
60 Citations (Scopus)

Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?

Nagy, N., Szűts, V., Horváth, Z., Seprényi, G., Farkas, A. S., Acsai, K., Prorok, J., Bitay, M., Kun, A., Pataricza, J., Papp, J., Nánási, P., Varró, A. & Tóth, A., Nov 2009, In : Journal of Molecular and Cellular Cardiology. 47, 5, p. 656-663 8 p.

Research output: Contribution to journalArticle

Small-Conductance Calcium-Activated Potassium Channels
Action Potentials
Apamin
pamidronate
Cardiac Myocytes
12 Citations (Scopus)

Herpesvirus-mediated delivery of a genetically encoded fluorescent ca 2+ sensor to canine cardiomyocytes

Prorok, J., Kovács, P. P., Kristf, A. A., Nagy, N., Tombácz, D., Tth, J. S., Ördg, B., Jost, N., Virág, L., Papp, J., Varr, A., Tth, A. & Boldogkői, Z., 2009, In : Journal of Biomedicine and Biotechnology. 2009, 361795.

Research output: Contribution to journalArticle

Herpesviridae
Viruses
Cardiac Myocytes
Canidae
Sensors
21 Citations (Scopus)
Action Potentials
Potassium
Veratrine
Dogs
Architectural Accessibility
19 Citations (Scopus)

The role of the Na +/Ca 2+ exchanger, I Na and I CaL in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts

Farkas, A. S., Makra, P., Csík, N., Orosz, S., Shattock, M. J., Fülöp, F., Forster, T., Csanády, M., Papp, J. G., Varró, A. & Farkas, A., Mar 2009, In : British Journal of Pharmacology. 156, 6, p. 920-932 13 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Torsades de Pointes
Rabbits
Verapamil
Lidocaine
2008
32 Citations (Scopus)

C-Type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries

Kun, A., Kiraly, I., Pataricza, J., Marton, Z., Krassoi, I., Varró, A., Simonsen, U., Papp, J. & Pajor, L., May 2008, In : Journal of Sexual Medicine. 5, 5, p. 1114-1125 12 p.

Research output: Contribution to journalArticle

C-Type Natriuretic Peptide
Arteries
Endothelium
Calcium-Activated Potassium Channels
Acetylcholine
22 Citations (Scopus)
Sodium-Calcium Exchanger
Myocardial Contraction
Rabbits
Action Potentials
Blood Pressure
4 Citations (Scopus)

Potassium channels sensitive to combination of charybdotoxin and apamin regulate the tone of diabetic isolated canine coronary arteries

Pataricza, J., Márton, Z., Lengyel, C., Tóth, M., Papp, J., Varró, A. & Kun, A., Sep 2008, In : Acta Physiologica. 194, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Charybdotoxin
Apamin
Potassium Channels
Canidae
Coronary Vessels
26 Citations (Scopus)

Relevance of anaesthesia for dofetilide-induced torsades de pointes in α 1-adrenoceptor-stimulated rabbits

Vincze, D., Farkas, A. S., Rudas, L., Makra, P., Csík, N., Leprán, I., Forster, T., Csanády, M., Papp, J., Varró, A. & Farkas, A., Jan 2008, In : British Journal of Pharmacology. 153, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

Torsades de Pointes
Chloralose
Adrenergic Receptors
Propofol
Anesthesia
27 Citations (Scopus)

Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart

Lengyel, C., Virág, L., Kovács, P. P., Kristóf, A., Pacher, P., Kocsis, E., Koltay, Z. M., Nánási, P., Tóth, M., Kecskeméti, V., Papp, J., Varró, A. & Jost, N., Mar 2008, In : Acta Physiologica. 192, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

Alloxan
Rabbits
Type 1 Diabetes Mellitus
Sudden Cardiac Death
Rodentia