• 724 Citations
  • 14 h-Index
20042019
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Research Output 2004 2019

  • 724 Citations
  • 14 h-Index
  • 28 Article
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Article
2019

Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases

Baska, F., Sipos, A., Őrfi, Z., Nemes, Z., Dobos, J., Szántai-Kis, C., Szabó, E., Szénási, G., Dézsi, L., Hamar, P., Cserepes, M. T., Tóvári, J., Garamvölgyi, R., Krekó, M. & Őrfi, L., Dec 15 2019, In : European Journal of Medicinal Chemistry. 184, 111710.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Phosphotransferases
Acute Myeloid Leukemia
Quinazolines
Aptitude

Targeted drug combination therapy design based on driver genes

Zsákai, L., Sipos, A., Dobos, J., Eros, D., Szántai-Kis, C., Bánhegyi, P., Pató, J., Őrfi, L., Matula, Z., Mikala, G., Kéri, G., Peták, I. & Vályi-Nagy, I., Jan 1 2019, In : Oncotarget. 10, 51, p. 5255-5266 12 p.

Research output: Contribution to journalArticle

Combination Drug Therapy
Genes
Drug Combinations
Neoplasms
Pharmaceutical Preparations
2018
2 Citations (Scopus)

Inhibition of epidermal growth factor receptor improves antitumor efficacy of vemurafenib in BRAF-mutant human melanoma in preclinical model

Kenessey, I., Kramer, Z., István, L., Cserepes, M. T., Garay, T., Hegedűs, B., Dobos, J., Tímár, J. & Tóvári, J., Dec 1 2018, In : Melanoma Research. 28, 6, p. 536-546 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Melanoma
Protein-Tyrosine Kinases
Cell Line
PLX4032
2 Citations (Scopus)

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Czudor, Z., Balogh, M., Bánhegyi, P., Boros, S., Breza, N., Dobos, J., Fábián, M., Horváth, Z., Illyés, E., Markó, P., Sipos, A., Szántai-Kis, C., Szokol, B. & Őrfi, L., Feb 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 769-773 5 p.

Research output: Contribution to journalArticle

Cells
Cyclin-Dependent Kinases
Multiple Myeloma
Cell Cycle
Phosphotransferases

Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML

Nemes, Z., Takács-Novák, K., Völgyi, G., Valko, K., Béni, S., Horváth, Z., Szokol, B., Breza, N., Dobos, J., Szántai-Kis, C., Illyés, E., Boros, S., Kok, R. J. & Őrfi, L., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

fms-Like Tyrosine Kinase 3
Acute Myeloid Leukemia
Amino Acids
Leukemia
Bearings (structural)
2017
2 Citations (Scopus)
Lignans
High performance liquid chromatography
Chromatography
High Pressure Liquid Chromatography
Fruits
2016
11 Citations (Scopus)

Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells

Garamvölgyi, R., Dobos, J., Sipos, A., Boros, S., Illyés, E., Baska, F., Kékesi, L., Szabadkai, I., Szántai-Kis, C., Kéri, G. & Őrfi, L., Jan 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 623-643 21 p.

Research output: Contribution to journalArticle

Scaffolds
Melanoma
Skin
Cells
Derivatives
2015
5 Citations (Scopus)

Chemoenzymatic route to Tyrphostins involving lipase-catalyzed kinetic resolution of 1-phenylethanamine with alkyl cyanoacetates as novel acylating agents

Csuka, P., Boros, Z., Őrfi, L., Dobos, J., Poppe, L. & Hornyánszky, G., 2015, In : Tetrahedron Asymmetry. 26, 12-13, p. 644-649 6 p.

Research output: Contribution to journalArticle

Tyrphostins
Enzyme kinetics
Lipases
Antarctic regions
Lipase
9 Citations (Scopus)

Prenylation inhibition-induced cell death in melanoma: Reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells

Garay, T., Kenessey, I., Molnár, E., Juhász, É., Réti, A., László, V., Rózsás, A., Dobos, J., Döme, B., Berger, W., Klepetko, W., Tóvári, J., Tímár, J. & Hegedűs, B., Feb 3 2015, In : PLoS One. 10, 2, e0117021.

Research output: Contribution to journalArticle

zoledronic acid
Prenylation
Cell death
melanoma
cell death
5 Citations (Scopus)

Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations

Garay, T., Molnár, E., Juhász, É., László, V., Barbai, T., Dobos, J., Schelch, K., Pirker, C., Grusch, M., Berger, W., Tímár, J. & Hegedűs, B., Sep 28 2015, In : Pathology and Oncology Research. 21, 4, p. 957-968 12 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Melanoma
Epidermal Growth Factor
Mutation
Fibroblast Growth Factor Receptors
2013
24 Citations (Scopus)
Vascular Endothelial Growth Factor A
Antidepressive Agents
Depression
Therapeutics
Mood Disorders
2012
21 Citations (Scopus)
Depression
Cytokines
Vascular Endothelial Growth Factor A
Tumor Necrosis Factor-alpha
Mood Disorders
2011
16 Citations (Scopus)
Glucocorticoid Receptors
Dexamethasone
Melanoma
Cell Line
Dacarbazine
36 Citations (Scopus)

Molecular characterization of 103 ovarian serous and mucinous tumors

Vereczkey, I., Serester, O., Dobos, J., Gallai, M., Szakács, O., Szentirmay, Z. & Tóth, E., Sep 2011, In : Pathology and Oncology Research. 17, 3, p. 551-559 9 p.

Research output: Contribution to journalArticle

Neoplasms
Mutation
p53 Genes
Carcinogenesis
Carcinoma
78 Citations (Scopus)

Prognostic impact of B-cell density in cutaneous melanoma

Ladányi, A., Kiss, J., Mohos, A., Somlai, B., Liszkay, G., Gilde, K., Fejös, Z., Gaudi, I., Dobos, J. & Tímár, J., Dec 2011, In : Cancer Immunology Immunotherapy. 60, 12, p. 1729-1738 10 p.

Research output: Contribution to journalArticle

Melanoma
B-Lymphocytes
Cell Count
Skin
T-Lymphocytes
2010
57 Citations (Scopus)

Apelin expression in human non-small cell lung cancer: Role in angiogenesis and prognosis

Berta, J., Kenessey, I., Dobos, J., Tóvári, J., Klepetko, W., Jan Ankersmit, H., Hegedűs, B., Renyi-Vamos, F., Varga, J., Lorincz, Z., Paku, S., Ostoros, G., Rozsas, A., Tímár, J. & Döme, B., Aug 2010, In : Journal of Thoracic Oncology. 5, 8, p. 1120-1129 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
Microvessels
Cell Line
Growth
24 Citations (Scopus)

Inhibition of c-met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma

Kenessey, I., Keszthelyi, M., Krámer, Z., Berta, J., Ádám, A., Dobos, J., Mildner, M., Flachner, B., Cseh, S., Barna, G., Szokol, B., Őrfi, L., Kéri, G., Döme, B., Klepetko, W., Tímár, J. & Tóvári, J., 2010, In : Current Cancer Drug Targets. 10, 3, p. 332-342 11 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Protein-Tyrosine Kinases
Melanoma
Neoplasm Metastasis
Hepatocyte Growth Factor
2009
2 Citations (Scopus)

A melanóma progresszióját befolyásoló endokrin tényezok

Translated title of the contribution: Endocrine factors influencing melanoma progressionDobos, J., Mar 2009, In : Magyar Onkologia. 53, 1, p. 47-50 4 p.

Research output: Contribution to journalArticle

Melanoma
Liver
Injections
SCID Mice
Gonadal Steroid Hormones
76 Citations (Scopus)

Circulating endothelial progenitor cells and depression: A possible novel link between heart and soul

Döme, P., Teleki, Z., Ríhmer, Z., Peter, L., Dobos, J., Kenessey, I., Tóvári, J., Tímár, J., Paku, S., Kovacs, G. & Döme, B., May 2009, In : Molecular Psychiatry. 14, 5, p. 523-531 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Flow Cytometry
Cell Count
Endothelial Progenitor Cells
Antibodies
41 Citations (Scopus)

High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer

Bogos, K., Renyi-Vamos, F., Dobos, J., Kenessey, I., Tóvári, J., Tímár, J., Strausz, J., Ostoros, G., Klepetko, W., Ankersmit, H. J., Lang, G., Hoda, M. A., Nierlich, P. & Döme, B., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1741-1746 6 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-3
Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor C
Endothelial Cells
Neoplasms

In response

Bogos, K., Renyi-Vamos, F., Dobos, J., Tóvári, J., Ostoros, G. & Döme, B., Nov 1 2009, In : Clinical Cancer Research. 15, 21, p. 6740-6741 2 p.

Research output: Contribution to journalArticle

2008
61 Citations (Scopus)
Bone Marrow
Antineoplastic Combined Chemotherapy Protocols
Therapeutics
Neoplasms
Angiogenesis Inhibitors
22 Citations (Scopus)
Erythropoietin
Microvessels
Heterografts
Radiotherapy
Neoplasms
2007
4 Citations (Scopus)

A rekombináns humán erythropoietin-α fokozza a humán laphámrák sugárérzékenysé gét preklinikai modellben

Translated title of the contribution: Human recombinant erythropoietin-a increases the efficacy of irradiation in preclinical modelLövey, J., Kenessey, I., Rásó, E., Dobos, J., Vágó, Á., Kásler, M., Futosi, K., Döme, B., Tímár, J. & Tóvári, J., 2007, In : Magyar Onkologia. 51, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Erythropoietin
Microvessels
Heterografts
Erythropoietin Receptors
Neoplasms
2006
Integrins
Melanoma
Up-Regulation
Phenotype
Neoplasms
163 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor Receptor-2
Messenger RNA
Cell Count
Bone Marrow
2005
18 Citations (Scopus)

Parallel expression of αIIβ3 and αvβ3 integrins in human melanoma cells upregulates bFGF expression and promotes their angiogenic phenotype

Döme, B., Rásó, E., Dobos, J., Mészáros, L., Varga, N., Puskás, L. G., Fehér, L. Z., Lörincz, T., Ladányi, A., Trikha, M., Honn, K. V. & T́imár, J., Aug 10 2005, In : International Journal of Cancer. 116, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Integrins
Melanoma
Intercellular Signaling Peptides and Proteins
Up-Regulation
Phenotype
2004
43 Citations (Scopus)

In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma

Dobos, J., Tímár, J., Bocsi, J., Burián, Z., Nagy, K., Barna, G., Peták, I. & Ladányi, A., Dec 10 2004, In : International Journal of Cancer. 112, 5, p. 771-776 6 p.

Research output: Contribution to journalArticle

Melanoma
Cell Proliferation
Neoplasm Metastasis
SCID Mice
Caspases