• 12479 Citations
  • 39 h-Index
1973 …2019

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Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: Update of study BIG 1-98

Coates, A. S., Keshaviah, A., Thürlimann, B., Mouridsen, H., Mauriac, L., Forbes, J. F., Paridaens, R., Castiglione-Gertsch, M., Gelber, R. D., Colleoni, M., Láng, I., Del Mastro, L., Smith, I., Chirgwin, J., Nogaret, J. M., Pienkowski, T., Wardley, A., Jakobsen, E. H., Price, K. N. & Goldhirsch, A., Feb 10 2007, In : Journal of Clinical Oncology. 25, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

732 Citations (Scopus)

Free radicals in tissue damage in liver disease and therapeutic approach

Feher, J., Lang, I., Deak, G., Cornides, A., Nekam, K. & Gergely, P., Dec 1 1986, In : Tokai Journal of Experimental and Clinical Medicine. 11, SUPPL., p. 121-134 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary

Nagahashi, M., Ajioka, Y., Lang, I., Szentirmay, Z., Kasler, M., Nakadaira, H., Yokoyama, N., Watanabe, G., Nishikura, K., Wakai, T., Shirai, Y., Hatakeyama, K. & Yamamoto, M., Jan 7 2008, In : World journal of gastroenterology. 14, 1, p. 70-75 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Glutaurine enhances the depressed NK cell activity of tumor patients

Lang, I., Feuer, L., Nekam, K., Szigeti, A., Gergely, P. & Petrányi, G., Dec 1 1983, In : Immunological Communications. 12, 5, p. 519-527 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hemodialízis hatása urémiás betegek antitest-dependens és természetes citotoxicitására.

Translated title of the contribution: The effect of hemodialysis on antibody-dependent and natural cytotoxicity in uremic patientsLáng, I., Taraba, I. & Hering, A., Mar 6 1983, In : Orvosi hetilap. 124, 10, p. 559-562 4 p.

Research output: Contribution to journalArticle

Hepatoprotective and immunological effects of antioxidant drugs

Lang, I., Nekam, K., Gonzalez-Cabello, R., Muzes, G., Gergely, P. & Feher, J., Dec 1 1990, In : Tokai Journal of Experimental and Clinical Medicine. 15, 2-3, p. 123-127 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Hepatoprotective and immunomodulatory effects of antioxidant therapy

Lang, I., Deak, G. Y., Nekam, K., Muzes, G. Y., Gonzalez-Cabello, R., Gergely, P. & Feher, J., Dec 1 1988, In : Acta medica Hungarica. 45, 3-4, p. 287-295 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Immune responsiveness of patients with autoimmune diseases and immunodeficiency.

Gergely, P., Láng, I., Nékám, K., Kalmár, L., Török, K., Lévai, J., Gonzales-Cabello, R. & Petrányi, G., Dec 1 1979, In : Annales immunologiae Hungaricae. 19, p. 105-115 11 p.

Research output: Contribution to journalArticle

Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients

For the Central and East European Oncology Group (CEEOG), Jan 1 2016, In : Oncotarget. 7, 1, p. 550-564 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Immunomodulation in autoimmune diseases

Gergely, P., Lang, I., Gonzalez-Cabello, R. & Feher, J., Dec 1 1986, In : Tokai Journal of Experimental and Clinical Medicine. 11, SUPPL., p. 207-213 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers

Lang, I., Nekam, K., Deak, G., Muzes, G., Gonzales-Cabello, R., Gergely, P., Csomos, G. & Feher, J., Jan 1 1990, In : Italian Journal of Gastroenterology. 22, 5, p. 283-287 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Immunoreactiv insulin vizsgálatok.

Translated title of the contribution: Immunoreactive insulin studiesBalázsi, I., Stützel, M., Littmann, L. & Láng, I., Jan 14 1973, In : Orvosi hetilap. 114, 2, 1 p.

Research output: Contribution to journalArticle

Impact of palbociclib plus letrozole on pain severity and pain interference with daily activities in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer as first-line treatment

Bell, T., Crown, J. P., Láng, I., Bhattacharyya, H., Zanotti, G., Randolph, S., Kim, S., Huang, X., Huang Bartlett, C., Finn, R. S. & Slamon, D., May 3 2016, In : Current Medical Research and Opinion. 32, 5, p. 959-965 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab

Budai, B., Komlósi, V., Adleff, V., Pap, É., Réti, A., Nagy, T., Kralovánszky, J., Láng, I. & Hitre, E., Jan 1 2012, In : Pharmacogenetics and Genomics. 22, 1, p. 69-72 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Indomethacin abrogates the suppression by cyclosporin A of lectin-dependent cell-mediated cytotoxicity to HEp-2 cells

Perl, A., Láng, I., Gonzalez-Cabello, R., Filep, J., Nékám, K., Gergely, P. & Fehér, J., Feb 1986, In : Immunopharmacology. 11, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
5 Citations (Scopus)

Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil

Hitre, E., Budai, B., Adleff, V., Czeglédi, F., Horváth, Z., Gyergyay, F., Lövey, J., Kovács, T., Orosz, Z., Láng, I., Kásler, M. & Kralovánszky, J., Oct 2005, In : Pharmacogenetics and Genomics. 15, 10, p. 723-730 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
9 Citations (Scopus)
1 Citation (Scopus)

In vitro effect of immune complex positive human sera on antibody dependent cellular cytotoxicity

Lang, I., Torok, K., Fekete, B., Gergely, P. & Petrányi, G., Dec 1 1977, In : Acta medica Academiae Scientiarum Hungaricae. 34, 3, p. 117-121 5 p.

Research output: Contribution to journalArticle

In vitro effect of transfer factor on active rosettes and leucocyte migration of patients with cancer

Nekam, K., Kalmar, L., Gergely, P., Kelemen, G., Fekete, B., Láng, I., Lévai, J. & Petrányi, G. Y., Oct 23 1977, In : Clinical and Experimental Immunology. 27, 3, p. 416-420 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Irinotecan combined with infusional 5-fluorouracil/folinic acid or capecitabine plus celecoxib or placebo in the first-line treatment of patients with metastatic colorectal cancer. EORTC study 40015

Köhne, C. H., De greve, J., Hartmann, J. T., Lang, I., Vergauwe, P., Becker, K., Braumann, D., Joosens, E., Müller, L., Janssens, J., Bokemeyer, C., Reimer, P., Link, H., Späth-Schwalbe, E., Wilke, H. J., Bleiberg, H., Van den Brande, J., Debois, M., Bethe, U. & Van Cutsem, E., May 1 2008, In : Annals of Oncology. 19, 5, p. 920-926 7 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Isoprinosine: Mechanism of the therapeutic effect and trial in recurrent herpes

Nekam, K., Torok, K. & Lang, I., Jan 1 1980, In : Orvosi hetilap. 121, 23, p. 1393-1395 3 p.

Research output: Contribution to journalArticle

Is risk of central nervous system (CNS) relapse related to adjuvant taxane treatment in node-positive breast cancer? Results of the CNS substudy in the intergroup phase III BIG 02-98 trial

Pestalozzi, B. C., Francis, P., Quinaux, E., Dolci, S., Azambuja, E., Gelber, R. D., Viale, G., Balil, A., Andersson, M., Nordenskjöd, B., Gnant, M., Gutierrez, J., Láng, I., Crown, J. P. A. & Piccart-Gebhart, M., Nov 3 2008, In : Annals of Oncology. 19, 11, p. 1837-1841 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Ketoconazole in vitro inhibits mitogen-induced blastogenesis, antibody-dependent cellular cytotoxicity, natural killer activity and random migration of human leukocytes

Gergely, P., Nékam, K., Láng, I., Kalmár, L., González-Cabello, R. & Perl, A., Jun 1984, In : Immunopharmacology. 7, 3-4, p. 167-170 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Lapatinib-related rash and breast cancer outcome in the ALTTO phase III randomized trial

Sonnenblick, A., De Azambuja, E., Agbor-Tarh, D., Bradbury, I., Campbell, C., Huang, Y., Dueck, A. C., Pritchard, K. I., Wolff, A. C., Jackisch, C., Lang, I., Untch, M., Smith, I., Boyle, F., Xu, B., Gomez, H., Perez, E. A., Piccart, M. & Azim, H. A., Jan 1 2016, In : Journal of the National Cancer Institute. 108, 8, djw037.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1 Citation (Scopus)

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): Survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response

De Azambuja, E., Holmes, A. P., Piccart-Gebhart, M., Holmes, E., Di Cosimo, S., Swaby, R. F., Untch, M., Jackisch, C., Lang, I., Smith, I., Boyle, F., Xu, B., Barrios, C. H., Perez, E. A., Azim, H. A., Kim, S. B., Kuemmel, S., Huang, C. S., Vuylsteke, P., Hsieh, R. K. & 7 others, Gorbunova, V., Eniu, A., Dreosti, L., Tavartkiladze, N., Gelber, R. D., Eidtmann, H. & Baselga, J., Jan 1 2014, In : The Lancet Oncology. 15, 10, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

236 Citations (Scopus)

Lectin-dependent cell-mediated cytotoxicity and blastogenesis by large granular-enriched and depleted lymphocytes

Perl, A., Gonzalez-Cabello, R., Laskay, T., Benczur, M., Láng, I., Onódy, K., Nékám, K., Gergely, P. & Fehér, J., Mar 19 1986, In : Clinical and Experimental Immunology. 63, 1, p. 171-178 8 p.

Research output: Contribution to journalArticle

Lectin induced suppression of antibody dependent cellular cytotoxicity (ADCC) of human peripheral blood mononuclear cells

Gergely, P., Lang, I., Kalmar, L. & Gonzalez Cabello, R., Jan 1 1980, In : Acta medica Academiae Scientiarum Hungaricae. 37, 4, p. 359-394 36 p.

Research output: Contribution to journalArticle

Lehetôségek és eredmények a Taxol®- Herceptin® kombináció alkalmazásával

Translated title of the contribution: Possibilities and results with Herceptin®-Taxol® combination in the treatment of breast cancerIstván, L., Dec 1 2002, In : Magyar onkologia. 46, 2, p. 195-196 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: The BIG 1-98 trial

Crivellari, D., Sun, Z., Coates, A. S., Price, K. N., Thürlimann, B., Mouridsen, H., Mauriac, L., Forbes, J. F., Paridaens, R. J., Castiglione-Gertsch, M., Gelber, R. D., Colleoni, M., Láng, I., Del Mastro, L., Gladieff, L., Rabaglio, M., Smith, I. E., Chirgwin, J. H. & Goldhirsch, A., Jan 1 2008, In : Journal of Clinical Oncology. 26, 12, p. 1972-1979 8 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Litoralon kezelés hatása rosszindulatú daganatos betegek lymphocitotoxicitására.

Translated title of the contribution: Effect of Litoralon therapy on the lymphocytotoxicity in patients with malignant tumorsLáng, I., Feuer, L., Nékám, K., Perl, A., Szigeti, A., Gergely, P. & Fehér, J., Sep 2 1984, In : Orvosi hetilap. 125, 36, p. 2193-2196 4 p.

Research output: Contribution to journalArticle

Liver cell protection in toxic liver lesion

Feher, J., Cornides, A., Pal, J., Lang, I. & Csomos, G., Dec 1 1989, In : Acta physiologica Hungarica. 73, 2-3, p. 285-291 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Low-dose oral cyclophosphamide and methotrexate maintenance for hormone receptor-negative early breast cancer: International Breast Cancer Study Group Trial 22-00

Colleoni, M., Gray, K. P., Gelber, S., Láng, I., Thürlimann, B., Gianni, L., Abdi, E. A., Gomez, H. L., Linderholm, B. K., Puglisi, F., Tondini, C., Kralidis, E., Eniu, A., Cagossi, K., Rauch, D., Chirgwin, J., Gelber, R. D., Regan, M. M., Coates, A. S., Price, K. N. & 2 others, Viale, G. & Goldhirsch, A., Oct 1 2016, In : Journal of Clinical Oncology. 34, 28, p. 3400-3408 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Lymphogranulomatosisos betegek K (killer) sejt aktivitása.

Translated title of the contribution: K (killer) cell activity in lymphogranulomatosisLáng, I., Berényi, E., Szegedi, G., Fekete, B., Török, K., Kalmár, L. & Nékám, K., Sep 10 1978, In : Orvosi hetilap. 119, 37, p. 2249-2250 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Metothyrin indukált agranulocytosis kezelése granulocyta-macrophag colonia stimuláló faktorral.

Translated title of the contribution: Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factorSomogyi, A., Werling, K., Rosta, A. & Láng, I., Nov 6 1994, In : Orvosi hetilap. 135, 45, p. 2483-2485 3 p.

Research output: Contribution to journalArticle

Molekulárisan célzott biológiai terápia a szolid tumorok kezelésében II. Gastrointestinalis stromatumor, hasnyálmirigyrák, fej-nyak laphámrák, nem kissejtes tüdorák, veserák

Translated title of the contribution: Molecularly targeted biological therapy in the treatment of solid tumours part two - Gastrointestinal stromal tumour, pancreatic cancer, head and neck cancer, non-small cell lung cancer, kidney cancerIstván, L. & Erika, H., Jan 1 2008, In : Lege Artis Medicinae. 18, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study

Martin, M., Roche, H., Pinter, T., Crown, J., Kennedy, M. J., Provencher, L., Priou, F., Eiermann, W., Adrover, E., Lang, I., Ramos, M., Latreille, J., Jagiełło-Gruszfeld, A., Pienkowski, T., Alba, E., Snyder, R., Almel, S., Rolski, J., Munoz, M., Moroose, R. & 9 others, Hurvitz, S., Baños, A., Adewoye, H., Hei, Y. J., Lindsay, M. A., Rupin, M., Cabaribere, D., Lemmerick, Y. & Mackey, J. R., Apr 2011, In : The Lancet Oncology. 12, 4, p. 369-376 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: The FLAGS trial

Ajani, J. A., Rodriguez, W., Bodoky, G., Moiseyenko, V., Lichinitser, M., Gorbunova, V., Vynnychenko, I., Garin, A., Lang, I. & Falcon, S., Mar 20 2010, In : Journal of Clinical Oncology. 28, 9, p. 1547-1553 7 p.

Research output: Contribution to journalArticle

422 Citations (Scopus)

Mutational analysis of triple-negative breast cancers within the International Breast Cancer Study Group (IBCSG) Trial 22-00

Munzone, E., Gray, K. P., Fumagalli, C., Guerini-Rocco, E., Láng, I., Ruhstaller, T., Gianni, L., Kammler, R., Viale, G., Di Leo, A., Coates, A. S., Gelber, R. D., Regan, M. M., Goldhirsch, A., Barberis, M. & Colleoni, M., Mar 27 2018, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Myasthenia in a patient with sarcoidosis and schizophrenia.

Rózsa, C., Kis, G., Komoly, S., Anselmo, V., Esik, O., Láng, I., Kas, J., Németh, G., Solymosi, D., Svasztics, E., Szentirmay, Z., Szobor, A. & Telekes, A., Jul 20 2004, In : Ideggyógyászati szemle. 57, 7-8, p. 242-244 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Null-sejtes Sezary-syndroma.

Translated title of the contribution: Sézary syndrome with null cellsSzigeti, A., Fazakas, L., Fekete, B., Nékám, K., Láng, I. & Gergely, P., Jul 29 1979, In : Orvosi hetilap. 120, 30, p. 1825-1827 3 p.

Research output: Contribution to journalArticle

O{double acute}rszemnyirokcsomó-biopszia neoadjuváns kemoterápiát igénylo{double acute} emlo{double acute}rákoknál

Translated title of the contribution: Sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancerMátrai, Z., Tóth, L., Polgár, C., Láng, I., Godény, M., Sinkovics, I., Horváth, Z., Bidlek, M., Udvarhelyi, N., Bartal, A., Sávolt, Á., Újhelyi, M. & Kásler, M., 2011, In : Magyar onkologia. 55, 2, p. 73-84 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial

Ewertz, M., Gray, K. P., Regan, M. M., Ejlertsen, B., Price, K. N., Thürlimann, B., Bonnefoi, H., Forbes, J. F., Paridaens, R. J., Rabaglio, M., Gelber, R. D., Colleoni, M., Láng, I., Smith, I. E., Coates, A. S., Goldhirsch, A. & Mouridsen, H. T., Nov 10 2012, In : Journal of Clinical Oncology. 30, 32, p. 3967-3975 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Phase II study on the efficacy and safety of Lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu- positive advanced breast cancer: Results of the CECOG LaVie trial

Thallinger, C., Lang, I., Kuhar, C. G., Bartsch, R., Singer, C. F., Petruzelka, L., Melichar, B., Knittelfelder, R., Brodowicz, T. & Zielinski, C., Feb 18 2016, In : BMC cancer. 16, 1, 121.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Poor Prognosis After Second Locoregional Recurrences in the CALOR Trial

On behalf of CALOR trial investigators, Feb 1 2017, In : Annals of Surgical Oncology. 24, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Predictive role of hand–foot syndrome in patients receiving first-line capecitabine plus bevacizumab for HER2-negative metastatic breast cancer

Zielinski, C., Láng, I., Beslija, S., Kahán, Z., Inbar, M. J., Stemmer, S. M., Anghel, R., Vrbanec, D., Messinger, D. & Brodowicz, T., Dec 10 2015, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

10 Citations (Scopus)