• 4427 Citations
  • 35 h-Index
1978 …2019

Research output per year

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Research Output

2019

The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization

Szabó, Í., M. Tóth, O., Török, Z., Varga, D. P., Menyhárt, Á., Frank, R., Hantosi, D., Hunya, Á., Bari, F., Horváth, I., Vigh, L. & Farkas, E., May 2019, In : British journal of pharmacology. 176, 9, p. 1222-1234 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2018

Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection

Roe, M. S., Wahab, B., Török, Z., Horváth, I., Vigh, L. & Prodromou, C., Jun 7 2018, In : Frontiers in Molecular Biosciences. 5, JUN, 51.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis

Márton, J., Péter, M., Balogh, G., Bódi, B., Vida, A., Szántó, M., Bojcsuk, D., Jankó, L., Bhattoa, H. P., Gombos, I., Uray, K., Horváth, I., Török, Z., Balint, B. L., Papp, Z., Vígh, L. & Bai, P., Nov 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 11, p. 1399-1412 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Metabolic crosstalk between membrane and storage lipids facilitates heat stress management in Schizosaccharomyces pombe

Péter, M., Glatz, A., Gudmann, P., Gombos, I., Török, Z., Horváth, I., Võgh, L. & Balogh, G., Mar 1 2017, In : PLoS One. 12, 3, e0173739.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mild heat induces a distinct "eustress" response in Chinese Hamster Ovary cells but does not induce heat shock protein synthesis

Peksel, B., Gombos, I., Péter, M., Vigh, L., Tiszlavicz, Á., Brameshuber, M., Balogh, G., Schütz, G. J., Horváth, I., Veigh, L. & Török, Z., Dec 1 2017, In : Scientific Reports. 7, 1, 15643.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease

Kasza, Á., Hunya, Á., Frank, Z., Fülöp, F., Török, Z., Balogh, G., Sántha, M., Bálind, Á., Bernáth, S., Blundell, K. L. I. M., Prodromou, C., Horváth, I., Zeiler, H. J., Hooper, P. L., Vígh, L., Penke, B. & Abisambra, J., 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 557-571 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe

Glatz, A., Pilbat, A. M., Németh, G. L., Vince-Kontár, K., Jósvay, K., Hunya, Á., Udvardy, A., Gombos, I., Péter, M., Balogh, G., Horváth, I., Vígh, L. & Török, Z., Mar 1 2016, In : Cell Stress and Chaperones. 21, 2, p. 327-338 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Escribá, P. V., Busquets, X., Inokuchi, J. I., Balogh, G., Török, Z., Horváth, I., Harwood, J. L. & Vígh, L., Jun 11 2015, In : Progress in Lipid Research. 59, p. 38-53 16 p.

Research output: Contribution to journalReview article

64 Citations (Scopus)
2014

Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

Vigh, L., Török, Z., Crul, T., Maresca, B., Schütz, G. J., Viana, F., Dindia, L., Piotto, S., Brameshuber, M., Balogh, G., Péter, M., Porta, A., Trapani, A., Gombos, I., Glatz, A., Gungor, B., Peksel, B., Vigh, L., Csoboz, B., Horváth, I. & 3 others, Vijayan, M. M., Hooper, P. L. & Harwood, J. L., Jun 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 6, p. 1594-1618 25 p.

Research output: Contribution to journalReview article

48 Citations (Scopus)
13 Citations (Scopus)
2013

Heat stress management in synechocystis PCC 6803: The interplay between membranes and stress protein molecular chaperones

Glatz, A., Török, Z., Vígh, L. & Horváth, I., Jan 1 2013, Stress Biology of Cyanobacteria: Molecular Mechanisms to Cellular Responses. CRC Press, p. 145-154 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hydroximic acid derivatives: Pleiotropic Hsp co-inducers restoring homeostasis and robustness

Crul, T., Toth, N., Piotto, S., Literati-Nagy, P., Tory, K., Haldimann, P., Kalmar, B., Greensmith, L., Torok, Z., Balogh, G., Gombos, I., Campana, F., Concilio, S., Gallyas, F., Nagy, G., Berente, Z., Gungor, B., Peter, M., Glatz, A., Hunya, A. & 20 others, Literati-Nagy, Z., Vigh, L., Hoogstra-Berends, F., Heeres, A., Kuipers, I., Loen, L., Seerden, J. P., Zhang, D., Meijering, R. A. M., Henning, R. H., Brundel, B. J. J. M., Kampinga, H. H., Koranyi, L., Szilvassy, Z., Mandl, J., Sumegi, B., Febbraio, M. A., Horvath, I., Hooper, P. L. & Vigh, L., Jan 1 2013, In : Current pharmaceutical design. 19, 3, p. 309-346 38 p.

Research output: Contribution to journalReview article

40 Citations (Scopus)

Key role of lipids in heat stress management

Balogh, G., Péter, M., Glatz, A., Gombos, I., Török, Z., Horváth, I., Harwood, J. L. & Vígh, L., Jun 27 2013, In : FEBS letters. 587, 13, p. 1970-1980 11 p.

Research output: Contribution to journalReview article

63 Citations (Scopus)

Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma

Juhász, K., Thuenauer, R., Spachinger, A., Duda, E., Horváth, I., Vígh, L., Sonnleitner, A. & Balogi, Z., Jan 1 2013, In : Current pharmaceutical design. 19, 3, p. 430-440 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes

Csoboz, B., Balogh, G. E., Kusz, E., Gombos, I., Peter, M., Crul, T., Gungor, B., Haracska, L., Bogdanovics, G., Torok, Z., Horvath, I. & Vigh, L., Aug 2013, In : International Journal of Hyperthermia. 29, 5, p. 491-499 9 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)
2012

Heat shock response in photosynthetic organisms: Membrane and lipid connections

Horváth, I., Glatz, A., Nakamoto, H., Mishkind, M. L., Munnik, T., Saidi, Y., Goloubinoff, P., Harwood, J. L. & Vigh, L., Jul 1 2012, In : Progress in Lipid Research. 51, 3, p. 208-220 13 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)

Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture

Péter, M., Balogh, G., Gombos, I., Liebisch, G., Horváth, I., Török, Z., Nagy, E., Maslyanko, A., Benk, S., Schmitz, G., Harwood, J. L. & Vígh, L., Nov 1 2012, In : Molecular Membrane Biology. 29, 7, p. 274-289 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics

Literáti-Nagy, Z., Tory, K., Literáti-Nagy, B., Kolonics, A., Török, Z., Gombos, I., Balogh, G., Vígh, L., Horváth, I., Mandl, J., Sümegi, B., Hooper, P. L. & Vígh, L., Jul 1 2012, In : Cell Stress and Chaperones. 17, 4, p. 517-521 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells

Balogh, G., Maulucci, G., Gombos, I., Horváth, I., Török, Z., Péter, M., Fodor, E., Páli, T., Benko, S., Parasassi, T., de Spirito, M., Harwood, J. L. & Vígh, L., Jun 22 2011, In : PloS one. 6, 6, e21182.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Membrane-lipid therapy in operation: The HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts

Gombos, I., Crul, T., Piotto, S., Güngör, B., Török, Z., Balogh, G., Péter, M., Slotte, J. P., Campana, F., Pilbat, A. M., Hunya, Á., Tóth, N., Literati-Nagy, Z., Vígh, L., Glatz, A., Brameshuber, M., Schütz, G. J., Hevener, A., Febbraio, M. A., Horváth, I. & 1 others, Vígh, L., Dec 14 2011, In : PloS one. 6, 12, e28818.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2010

Atypical transcriptional regulation and role of a new toxin-antitoxin-like module and its effect on the lipid composition of Bradyrhizobium japonicum

Miclea, P. S., Péter, M., Végh, G., Cinege, G., Kiss, E., Váró, G., Horváth, I. & Dusha, L., May 1 2010, In : Molecular Plant-Microbe Interactions. 23, 5, p. 638-650 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cell biology: Stability in times of stress

Horváth, I. & Vígh, L., Jan 28 2010, In : Nature. 463, 7280, p. 436-438 3 p.

Research output: Contribution to journalShort survey

25 Citations (Scopus)

Genetic modification of the Salmonella membrane physical state alters the pattern of heat shock response

Porta, A., Török, Z., Horvath, I., Franceschelli, S., Vígh, L. & Maresca, B., Apr 1 2010, In : Journal of bacteriology. 192, 7, p. 1988-1998 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane

Brameshuber, M., Weghuber, J., Ruprecht, V., Gombos, I., Horváth, I., Vigh, L., Eckerstorfer, P., Kiss, E., Stockinger, H. & Schütz, G. J., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41765-41771 7 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line

Balogh, G., Péter, M., Liebisch, G., Horváth, I., Török, Z., Nagy, E., Maslyanko, A., Benk, S., Schmitz, G., Harwood, J. L. & Vígh, L., Sep 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 9, p. 1036-1047 12 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2008

A mutant small heat shock protein with increased thylakoid association provides an elevated resistance against UV-B damage in synechocystis 6803

Balogi, Z., Cheregi, O., Giese, K. C., Juhász, K., Vierling, E., Vass, I., Vígh, L. & Horváth, I., Aug 22 2008, In : Journal of Biological Chemistry. 283, 34, p. 22983-22991 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

HSP72 protects against obesity-induced insulin resistance

Chung, J., Nguyen, A. K., Henstridge, D. C., Holmes, A. G., Chan, M. H. S., Mesa, J. L., Lancaster, G. I., Southgate, R. J., Bruce, C. R., Duffy, S. J., Horvath, I., Mestril, R., Watt, M. J., Hooper, P. L., Kingwell, B. A., Vigh, L., Hevener, A. & Febbraio, M. A., Feb 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

320 Citations (Scopus)

Membrane-associated stress proteins: More than simply chaperones

Horváth, I., Multhoff, G., Sonnleitner, A. & Vígh, L., Jul 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 7-8, p. 1653-1664 12 p.

Research output: Contribution to journalReview article

137 Citations (Scopus)

Membranes: A meeting point for lipids, proteins and therapies: Translational Medicine

Escribá, P. V., González-Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez-Magraner, L., Fernández, A. M., Busquets, X., Horváth, I. & Barceló-Coblijn, G., Jun 1 2008, In : Journal of Cellular and Molecular Medicine. 12, 3, p. 829-875 47 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)
2007

Can the stress protein response be controlled by 'membrane-lipid therapy'?

Vigh, L., Horváth, I., Maresca, B. & Harwood, J. L., Aug 1 2007, In : Trends in Biochemical Sciences. 32, 8, p. 357-363 7 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line

Nagy, E., Balogi, Z., Gombos, I., Åkerfelt, M., Björkbom, A., Balogh, G., Török, Z., Maslyanko, A., Fiszer-Kierzkowska, A., Lisowska, K., Slotte, P. J., Sistonen, L., Horváth, I. & Vigh, L., May 8 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 19, p. 7945-7950 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Membrane-regulated stress response: A theoretical and practical approach

Vígh, L., Török, Z., Balogh, G., Glatz, A., Piotto, S. & Horváth, I., Jan 1 2007, Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Springer New York, p. 114-131 18 p. (Advances in Experimental Medicine and Biology; vol. 594).

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Citations (Scopus)

Membrane regulation of the stress response from prokaryotic models to mammalian cells

Vigh, L., Nakamoto, H., Landry, J., Gomez-Munoz, A., Harwood, J. L. & Horvath, I., Oct 2007, Stress Responses. Blackwell Publishing Inc., p. 40-51 12 p. (Annals of the New York Academy of Sciences; vol. 1113).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

53 Citations (Scopus)
2005

"Heat shock lipid" in cyanobacteria during heat/light-acclimation

Balogi, Z., Török, Z., Balogh, G., Jósvay, K., Shigapova, N., Vierling, E., Vígh, L. & Horváth, I., Apr 15 2005, In : Archives of Biochemistry and Biophysics. 436, 2, p. 346-354 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Membrane fluidization triggers membrane remodeling which affects the thermotolerance in Escherichia coli

Shigapova, N., Török, Z., Balogh, G., Goloubinoff, P., Vígh, L. & Horváth, I., Mar 25 2005, In : Biochemical and biophysical research communications. 328, 4, p. 1216-1223 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response

Balogh, G., Horváth, I., Nagy, E., Hoyk, Z., Benkõ, S., Bensaude, O. & Vígh, L., Dec 1 2005, In : FEBS Journal. 272, 23, p. 6077-6086 10 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

The significance of lipid composition for membrane activity: New concepts and ways of assessing function

Vigh, L., Escribá, P. V., Sonnleitner, A., Sonnleitner, M., Piotto, S., Maresca, B., Horváth, I. & Harwood, J. L., Sep 1 2005, In : Progress in Lipid Research. 44, 5, p. 303-344 42 p.

Research output: Contribution to journalReview article

163 Citations (Scopus)
2003

Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase

Török, Z., Tsvetkova, N. M., Balogh, G., Horváth, I., Nagy, E., Pénzes, Z., Hargitai, J., Bensaude, O., Csermely, P., Crowe, J. H., Maresca, B. & Vígh, L., Mar 18 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 6, p. 3131-3136 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Only one dnaK homolog, dnaK2, is active transcriptionally and is essential in Synechocystis

Varvasovszki, V., Glatz, A., Shigapova, N., Jósvay, K., Vígh, L. & Horváth, I., Jun 6 2003, In : Biochemical and biophysical research communications. 305, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2002

Heat shock response in Synechocystis

Glatz, A., Horvath, I., Török, Z., Varvasovszki, V., Kovacs, E., Balogh, G., Josvay, K., Natalia, S., Balogi, Z. & Vígh, L., Jan 1 2002, In : Acta Biologica Szegediensis. 46, 3-4, 1 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Small heat-shock proteins regulate membrane lipid polymorphism

Tsvetkova, N. M., Horváth, I., Török, Z., Wolkers, W. F., Balogi, Z., Shigapova, N., Crowe, L. M., Tablin, F., Vierling, E., Crowe, J. H. & Vígh, L., Oct 15 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 21, p. 13504-13509 6 p.

Research output: Contribution to journalArticle

231 Citations (Scopus)
2001

Synechocystis hsp17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding

Török, Z., Goloubinoff, P., Horváth, I., Tsvetkova, N. M., Glatz, A., Balogh, G., Varvasovszki, V., Los, D. A., Vierling, E., Crowe, J. H. & Vígh, L., Mar 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 6, p. 3098-3103 6 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)

The chaperonins of Synechocystis PCC 6803 differ in heat inducibility and chaperone activity

Kovács, E., Van Der Vies, S. M., Glatz, A., T̈r̈k, Z., Varvasovszki, V., Horváth, I. & Vígh, L., Dec 14 2001, In : Biochemical and biophysical research communications. 289, 4, p. 908-915 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2000

Expression of the gene for the Δ9 acyl-lipid desaturase in the thermophilic cyanobacterium

Kiseleva, L. L., Serebriiskaya, T. S., Horvàth, I., Vigh, L., Lyukevich, A. A. & Los, D. A., Jul 1 2000, In : Journal of Molecular Microbiology and Biotechnology. 2, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
1999

Temperature-induced specific lipid desaturation in the thermophilic cyanobacterium Synechococcus vulcanus

Kiseleva, L. L., Horvàth, I., Vigh, L. & Los, D. A., Jun 15 1999, In : FEMS microbiology letters. 175, 2, p. 179-183 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
1998
237 Citations (Scopus)
1997

Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein- inducing activity and cytoprotective effects

Vígh, L., Literáti, P. N., Horváth, I., Török, Z., Balogh, G., Glatz, A., Kovács, E., Boros, I., Ferdinándy, P., Farkas, B., Jaszlits, L., Jednákovits, A., Korányi, L. & Maresca, B., Oct 1 1997, In : Nature medicine. 3, 10, p. 1150-1154 5 p.

Research output: Contribution to journalArticle

237 Citations (Scopus)