• 15095 Citations
  • 70 h-Index
1987 …2019
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Research Output 1987 2019

2009
261 Citations (Scopus)

Signalling pathways in alcohol-induced liver inflammation

Mandrekar, P. & Szabó, G., Jun 2009, In : Journal of Hepatology. 50, 6, p. 1258-1266 9 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Alcohols
Inflammation
Lipopolysaccharides
Liver
1 Citation (Scopus)

The "health" and future of the physician-scientist in hepatology

Szabó, G., 2009, In : Hepatology. 49, 2, p. 341-343 3 p.

Research output: Contribution to journalComment/debate

Career Choice
National Institutes of Health (U.S.)
Gastroenterology
Physicians
Health
120 Citations (Scopus)

The opposite effects of acute and chronic alcohol on lipopolysaccharide- induced inflammation are linked to IRAK-M in human monocytes

Mandrekar, P., Bala, S., Catalano, D., Kodys, K. & Szabó, G., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1320-1327 8 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Monocytes
Phosphotransferases
Alcohols
Inflammation
168 Citations (Scopus)

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

Velayudham, A., Dolganiuc, A., Ellis, M., Petrasek, J., Kodys, K., Mandrekar, P. & Szabó, G., 2009, In : Hepatology. 49, 3, p. 989-997 9 p.

Research output: Contribution to journalArticle

Probiotics
Fatty Liver
Choline
Methionine
Fibrosis
2008
42 Citations (Scopus)

Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes

Norkina, O., Dolganiuc, A., Catalano, D., Kodys, K., Mandrekar, P., Syed, A., Efros, M. & Szabó, G., Sep 2008, In : Alcoholism: Clinical and Experimental Research. 32, 9, p. 1565-1573 9 p.

Research output: Contribution to journalArticle

Monocytes
Interleukin-6
Alcohols
Cytokines
Suppressor of Cytokine Signaling Proteins
18 Citations (Scopus)

Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion

Hritz, I., Velayudham, A., Dolganiuc, A., Kodys, K., Mandrekar, P., Kurt-Jones, E. & Szabó, G., Oct 2008, In : Hepatology. 48, 4, p. 1342-1347 6 p.

Research output: Contribution to journalArticle

Myeloid Differentiation Factor 88
Bone Marrow
Liver
Propionibacterium acnes
Wounds and Injuries
44 Citations (Scopus)

Hepatitis C and Innate Immunity: Recent Advances

Szabó, G. & Dolganiuc, A., Aug 2008, In : Clinics in Liver Disease. 12, 3, p. 675-692 18 p.

Research output: Contribution to journalReview article

Hepatitis C
Innate Immunity
Hepacivirus
Interferon Type I
Antigen Presentation
6 Citations (Scopus)

Hepatitis C core protein - The "core" of immune deception?

Szabó, G. & Dolganiuc, A., Jan 2008, In : Journal of Hepatology. 48, 1, p. 8-11 4 p.

Research output: Contribution to journalEditorial

Hepatitis C Antigens
Viral Core Proteins
Chronic Hepatitis C
Deception
Hepatitis C
101 Citations (Scopus)

Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial

Seeff, L. B., Curto, T. M., Szabó, G., Everson, G. T., Bonkovsky, H. L., Dienstag, J. L., Shiftman, M. L., Lindsay, K. L., Lok, A. S. F., Di Bisceglie, A. M., Lee, W. M. & Ghany, M. G., Feb 2008, In : Hepatology. 47, 2, p. 605-612 8 p.

Research output: Contribution to journalArticle

Silymarin
Hepatitis C
Antiviral Agents
Fibrosis
Chronic Hepatitis C

Human monocytes, macrophages, and dendritic cells: alcohol treatment methods.

Szabo, G. & Mandrekar, P., 2008, In : Methods in molecular biology (Clifton, N.J.). 447, p. 113-124 12 p.

Research output: Contribution to journalArticle

Dendritic Cells
Monocytes
Macrophages
Alcohols
Lymphocyte Activation
17 Citations (Scopus)

Human monocytes, macrophages, and dendritic cells: Alcohol treatment methods

Szabo, G. & Mandrekar, P., 2008, Alcohol: Methods and Protocols. Humana Press, Vol. 447. p. 113-124 12 p. (Methods in Molecular Biology; vol. 447).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dendritic Cells
Monocytes
Macrophages
Alcohols
Lymphocyte Activation
43 Citations (Scopus)

Myeloid Dendritic Cells of Patients With Chronic HCV Infection Induce Proliferation of Regulatory T Lymphocytes

Dolganiuc, A., Paek, E., Kodys, K., Thomas, J. & Szabó, G., Dec 2008, In : Gastroenterology. 135, 6, p. 2119-2127 9 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Virus Diseases
Regulatory T-Lymphocytes
Myeloid Cells
Hepacivirus
133 Citations (Scopus)

Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C

Fontana, R. J., Goodman, Z. D., Dienstag, J. L., Bonkovsky, H. L., Naishadham, D., Sterling, R. K., Su, G. L., Ghosh, M., Wright, E. C., Szabó, G., Cormier, M., Giansiracusa, D., Kelley, M., Reid, A. E., Chung, R. T., Molchen, W. A., Di Giammarino, L., Richtmyer, P., Ford, E., Shiffman, M. L. & 9 others, Hofmann, C., Smith, P., Snow, K. K., Curto, T. M., Bell, M. C., Seeff, L. B., Robuck, P. R., Hoofnagle, J. H. & Everhart, J. E., Mar 2008, In : Hepatology. 47, 3, p. 789-798 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Liver Cirrhosis
Fibrosis
Collagen
Biomarkers
30 Citations (Scopus)

T cells with regulatory activity in hepatitis C virus infection: What we know and what we don't

Dolganiuc, A. & Szabó, G., Sep 1 2008, In : Journal of Leukocyte Biology. 84, 3, p. 614-622 9 p.

Research output: Contribution to journalReview article

Virus Diseases
Regulatory T-Lymphocytes
Hepacivirus
Multiple Abnormalities
Adaptive Immunity
257 Citations (Scopus)

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

Hritz, I., Mandrekar, P., Velayudham, A., Catalano, D., Dolganiuc, A., Kodys, K., Kurt-Jones, E. & Szabó, G., Oct 2008, In : Hepatology. 48, 4, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Myeloid Differentiation Factor 88
Alcoholic Liver Diseases
Toll-Like Receptor 4
Toll-Like Receptors
Alcohols
27 Citations (Scopus)

The role of plasmacytoid dendritic cell-derived IFNα in antiviral immunity

Szabó, G. & Dolganiuc, A., 2008, In : Critical Reviews in Immunology. 28, 1, p. 61-94 34 p.

Research output: Contribution to journalReview article

Interferon-alpha
Dendritic Cells
Antiviral Agents
Virus Diseases
Immunity
2007
49 Citations (Scopus)

Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes

Norkina, O., Dolganiuc, A., Shapiro, T., Kodys, K., Mandrekar, P. & Szabó, G., Sep 1 2007, In : Journal of Leukocyte Biology. 82, 3, p. 752-762 11 p.

Research output: Contribution to journalArticle

Sp1 Transcription Factor
src-Family Kinases
Transcription Factor AP-1
Interleukin-10
Monocytes
37 Citations (Scopus)

Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IκB kinase activity and p65 phosphorylation in human monocytes

Mandrekar, P., Jeliazkova, V., Catalano, D. & Szabó, G., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7686-7693 8 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Monocytes
Anti-Inflammatory Agents
Phosphorylation
Alcohols
31 Citations (Scopus)

Altered innate immunity in chronic hepatitis C infection: Cause or effect?

Szabó, G., Chang, S. & Dolganiuc, A., Oct 2007, In : Hepatology. 46, 4, p. 1279-1290 12 p.

Research output: Contribution to journalReview article

Chronic Hepatitis C
Innate Immunity
Cell Communication
Natural Killer Cells
Hepacivirus
49 Citations (Scopus)

Effect of ethanol on inflammatory responses: Implications for pancreatitis

Szabó, G., Mandrekar, P., Oak, S. & Mayerle, J., Jul 2007, In : Pancreatology. 7, 2-3, p. 115-123 9 p.

Research output: Contribution to journalArticle

Pancreatitis
Ethanol
Alcohols
Interleukin-10
Monocytes
4 Citations (Scopus)

Hepatitis C virus infection - Pathobiology and implications for new therapeutic options

Davis, G. L., Krawczynski, K. & Szabo, G., Apr 2007, In : Digestive Diseases and Sciences. 52, 4, p. 857-875 19 p.

Research output: Contribution to journalReview article

Virus Diseases
Hepacivirus
Hepatitis C
Antiviral Agents
Liver Diseases
127 Citations (Scopus)

Innate immune response and hepatic inflammation

Szabó, G., Mandrekar, P. & Dolganiuc, A., Nov 2007, In : Seminars in Liver Disease. 27, 4, p. 339-350 12 p.

Research output: Contribution to journalArticle

Innate Immunity
Inflammation
Liver
CD27 Antigens
Chemical and Drug Induced Liver Injury
14 Citations (Scopus)

Moderate Drinking, Inflammation, and Liver Disease

Szabó, G., May 2007, In : Annals of Epidemiology. 17, 5 SUPPL.

Research output: Contribution to journalArticle

Drinking
Liver Diseases
Alcohols
Inflammation
Alcohol Drinking
102 Citations (Scopus)

TLR4, ethanol, and lipid rafts: A new mechanism of ethanol action with implications for other receptor-mediated effects

Szabó, G., Dolganiuc, A., Dai, Q. & Pruett, S. B., Feb 1 2007, In : Journal of Immunology. 178, 3, p. 1243-1249 7 p.

Research output: Contribution to journalShort survey

Ethanol
Lipids
Actin Cytoskeleton
Cluster Analysis
Immune System
138 Citations (Scopus)

Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins

Chang, S., Dolganiuc, A. & Szabó, G., Sep 1 2007, In : Journal of Leukocyte Biology. 82, 3, p. 479-487 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 6
Toll-Like Receptor 1
Macrophage Activation
Hepacivirus
Immune System
155 Citations (Scopus)

Viral and Host Factors Induce Macrophage Activation and Loss of Toll-Like Receptor Tolerance in Chronic HCV Infection

Dolganiuc, A., Norkina, O., Kodys, K., Catalano, D., Bakis, G., Marshall, C., Mandrekar, P. & Szabó, G., Nov 2007, In : Gastroenterology. 133, 5, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

Macrophage Activation
Toll-Like Receptors
Monocytes
Interferons
Infection
2006
46 Citations (Scopus)

Acute and chronic alcohol abuse modulate immunity

Brown, L. A. S., Cook, R. T., Jerrells, T. R., Kolls, J. K., Nagy, L. E., Szabó, G., Wands, J. R. & Kovacs, E. J., Sep 2006, In : Alcoholism: Clinical and Experimental Research. 30, 9, p. 1624-1631 8 p.

Research output: Contribution to journalArticle

Alcoholism
Immunity
Alcohols
Public Opinion
Ethanol
76 Citations (Scopus)

Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts

Dolganiuc, A., Bakis, G., Kodys, K., Mandrekar, P. & Szabó, G., Jan 2006, In : Alcoholism: Clinical and Experimental Research. 30, 1, p. 76-85 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Ethanol
Alcohols
Association reactions
Lipids
38 Citations (Scopus)

Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury

Velayudham, A., Hritz, I., Dolganiuc, A., Mandrekar, P., Kurt-Jones, E. & Szabo, G., Dec 2006, In : Journal of Hepatology. 45, 6, p. 813-824 12 p.

Research output: Contribution to journalArticle

Propionibacterium acnes
Toll-Like Receptors
Granuloma
Liver
Wounds and Injuries
262 Citations (Scopus)

Cytokines and alcohol

Crews, F. T., Bechara, R., Brown, L. A., Guidot, D. M., Mandrekar, P., Oak, S., Qin, L., Szabó, G., Wheeler, M. & Zou, J., Apr 2006, In : Alcoholism: Clinical and Experimental Research. 30, 4, p. 720-730 11 p.

Research output: Contribution to journalArticle

Alcohols
Cytokines
Ethanol
Pathogens
Liver
64 Citations (Scopus)

Distinct toll-like receptor expression in monocytes and T cells in chronic HCV infection

Dolganiuc, A., Garcia, C., Kodys, K. & Szabó, G., Feb 28 2006, In : World Journal of Gastroenterology. 12, 8, p. 1198-1204 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Monocytes
T-Lymphocytes
Infection
Toll-Like Receptor 6
12 Citations (Scopus)

HCV Immunopathogenesis: Virus-Induced Strategies against Host Immunity

Szabó, G. & Dolganiuc, A., Nov 2006, In : Clinics in Liver Disease. 10, 4, p. 753-771 19 p.

Research output: Contribution to journalReview article

Immunity
Viruses
T-Lymphocytes
Pattern Recognition Receptors
Virus Diseases
94 Citations (Scopus)

Heme oxygena-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes

Drechsler, Y., Dolganiuc, A., Norkina, O., Romics, L., Li, W., Kodys, K., Bach, F. H., Mandrekar, P. & Szabó, G., Aug 15 2006, In : Journal of Immunology. 177, 4, p. 2592-2600 9 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
p38 Mitogen-Activated Protein Kinases
Interleukin-10
Monocytes
Anti-Inflammatory Agents
47 Citations (Scopus)

Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity

Szabó, G., Aloman, C., Polyak, S. J., Weinman, S. A., Wands, J. & Zakhari, S., Apr 2006, In : Alcoholism: Clinical and Experimental Research. 30, 4, p. 709-719 11 p.

Research output: Contribution to journalArticle

Hepatitis C
Liver
Antiviral Agents
Immunity
Alcohols
170 Citations (Scopus)

Hepatitis C Virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-α and plasmacytoid dendritic cell loss in chronic HCV infection

Dolganiuc, A., Chang, S., Kodys, K., Mandrekar, P., Bakis, G., Cormier, M. & Szabó, G., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6758-6768 11 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Virus Diseases
Hepacivirus
Dendritic Cells
Monocytes
16 Citations (Scopus)

Hepatitis C virus NS5A protein-a master regulator?

Szabó, G., Mar 2006, In : Gastroenterology. 130, 3, p. 995-999 5 p.

Research output: Contribution to journalEditorial

Signal Transducing Adaptor Proteins
Viral Nonstructural Proteins
Neoplastic Cell Transformation
Tumor Suppressor Proteins
src Homology Domains
45 Citations (Scopus)

Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics

Spies, C., Eggers, V., Szabó, G., Lau, A., Von Dossow, V., Schoenfeld, H., Althoff, H., Hegenscheid, K., Bohm, B., Schroeder, T., Pfeiffer, S., Ziemer, S., Paschen, C., Klein, M., Marks, C., Miller, P., Sander, M., Wernecke, K. D., Achterberg, E., Kaisers, U. & 1 others, Volk, H. D., Aug 15 2006, In : American Journal of Respiratory and Critical Care Medicine. 174, 4, p. 408-414 7 p.

Research output: Contribution to journalArticle

Alcoholics
Pneumonia
Hypothalamus
Intensive Care Units
Ketoconazole
99 Citations (Scopus)
NF-kappa B
Interleukin-10
Monocytes
Alcohol Drinking
Alcohols
118 Citations (Scopus)

Pattern recognition receptors: A contemporary view on liver diseases

Szabo, G., Dolganiuc, A. & Mandrekar, P., Aug 2006, In : Hepatology. 44, 2, p. 287-298 12 p.

Research output: Contribution to journalShort survey

Pattern Recognition Receptors
Liver Diseases
Liver
Cholestasis
Vertebrates
10 Citations (Scopus)

The emerging role of toll-like receptor pathways in surgical diseases

Romics, L., Szabó, G., Coffey, J. C., Jiang, H. W. & Redmond, H. P., 2006, In : Archives of Surgery. 141, 6, p. 595-601 7 p.

Research output: Contribution to journalReview article

Toll-Like Receptors
Information Storage and Retrieval
Graft Rejection
Helicobacter Infections
Adaptive Immunity
63 Citations (Scopus)

TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes

Oak, S., Mandrekar, P., Catalano, D., Kodys, K. & Szabó, G., Jun 15 2006, In : Journal of Immunology. 176, 12, p. 7628-7635 8 p.

Research output: Contribution to journalArticle

Monocytes
Alcohols
Inflammation
Phosphotransferases
TNF Receptor-Associated Factor 6
2005
21 Citations (Scopus)

Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression

Romics, L., Mandrekar, P., Kodys, K., Velayudham, A., Drechsler, Y., Dolganiuc, A. & Szabó, G., Jun 2005, In : Alcoholism: Clinical and Experimental Research. 29, 6, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Toll-Like Receptor 4
Leptin
Liver
Lipopolysaccharides

Inhibitory effects of acute alcohol consumption on human monocyte functions

Szabó, G., 2005, In : Journal fur Anasthesie und Intensivbehandlung. 12, 2, p. 135-136 2 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Monocytes
94 Citations (Scopus)

Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: The role of toll-like receptors 2 and 4

Szabó, G., Velayudham, A., Romics, L. & Mandrekar, P., Nov 2005, In : Alcoholism: Clinical and Experimental Research. 29, 11 SUPPL.

Research output: Contribution to journalArticle

Pattern Recognition Receptors
Toll-Like Receptor 2
Toll-Like Receptor 4
Fatty Liver
Liver
2 Citations (Scopus)

RSA 2004: Combined Basic Research Satellite Symposium - Session two: Toll-like receptors and organ damage

Mandrekar, P., Pruett, S., Arteel, G., Thiele, G. & Szabó, G., Sep 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1744-1748 5 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Alcoholic Liver Diseases
Macrophage Activation
Toll-Like Receptors
Liver
6 Citations (Scopus)

RSA 2004: Combined Basic Research Satellite Symposium - Mechanisms of alcohol-mediated organ and tissue damage: Inflammation and immunity and alcohol and mitochondrial metabolism: At the crossroads of life and death. Session one: Alcohol, cellular and organ damage

Thiele, G. M., Mandrekar, P., Zakhari, S., Hoek, J., Cook, R. T., Ray, N. B., Happel, K. I., Kolls, J. K., Kovacs, E. J. & Szabó, G., Sep 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1735-1743 9 p.

Research output: Contribution to journalArticle

Metabolism
Immunity
Alcohols
Satellites
Tissue
7 Citations (Scopus)

RSA 2004: Combined Basic Research Satellite Symposium - Session three: Alcohol and mitochondrial metabolism: At the crossroads of life and death

Szabó, G., Hoek, J. B., Darley-Usmar, V., Hajnoczky, G., Knudsen, T., Mochly-Rosen, D. & Zakhari, S., Sep 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1749-1752 4 p.

Research output: Contribution to journalArticle

Metabolism
Alcohols
Satellites
Research
Energy Metabolism
4 Citations (Scopus)

RSA 2004: Combined Basic Research Satellite Symposium - Session four: Hepatitis virus and alcohol interactions in immunity and liver disease

Szabó, G., Weinman, S. A., Gao, B., Polyak, S. J., Mandrekar, P. & Thiele, G. M., Sep 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1753-1757 5 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
Viruses
Liver
Liver Diseases
Immunity
90 Citations (Scopus)

Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection

Szabó, G. & Dolganiuc, A., Aug 19 2005, In : Immunobiology. 210, 2-4, p. 237-247 11 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Virus Diseases
Myeloid Cells
Hepacivirus
Dendritic Cells
27 Citations (Scopus)

Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propionibacterium acnes

Romics, L., Dolganiuc, A., Velayudham, A., Kodys, K., Mandrekar, P., Golenbock, D., Kurt-Jones, E. & Szabó, G., Dec 2005, In : Journal of Leukocyte Biology. 78, 6, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Propionibacterium acnes
Cytokines
Liver
Wounds and Injuries