• 14834 Citations
  • 70 h-Index
1987 …2019
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Research Output 1987 2019

2012
347 Citations (Scopus)

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

Bala, S., Petrasek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J., Alao, H., Kodys, K. & Szabó, G., Nov 2012, In : Hepatology. 56, 5, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

Exosomes
Chemical and Drug Induced Liver Injury
MicroRNAs
Hepatocytes
Acetaminophen
89 Citations (Scopus)

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

Morin, T. J., Broering, T. J., Leav, B. A., Blair, B. M., Rowley, K. J., Boucher, E. N., Wang, Y., Cheslock, P. S., Knauber, M., Olsen, D. B., Ludmerer, S. W., Szabó, G., Finberg, R. W., Purcell, R. H., Lanford, R. E., Ambrosino, D. M., Molrine, D. C. & Babcock, G. J., Aug 2012, In : PLoS Pathogens. 8, 8, e1002895.

Research output: Contribution to journalArticle

Pan troglodytes
Virus Diseases
Hepacivirus
Monoclonal Antibodies
Viral Load
141 Citations (Scopus)

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

Nath, B. & Szabó, G., Feb 2012, In : Hepatology. 55, 2, p. 622-633 12 p.

Research output: Contribution to journalReview article

Liver Diseases
Inflammation Mediators
Liver Cirrhosis
Hepatocellular Carcinoma
Hypoxia
309 Citations (Scopus)

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S. Y., Kurt-Jones, E. A. & Szabó, G., Oct 1 2012, In : Journal of Clinical Investigation. 122, 10, p. 3476-3489 14 p.

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Inflammasomes
Interleukin-1 Receptors
Interleukin-1
Caspase 1
91 Citations (Scopus)

Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection

Bala, S., Tilahun, Y., Taha, O., Alao, H., Kodys, K., Catalano, D. & Szabó, G., Jul 30 2012, In : Journal of Translational Medicine. 10, 1, 151.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Virus Diseases
MicroRNAs
Viruses
Hepacivirus
19 Citations (Scopus)

Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance

Bala, S., Tang, A., Catalano, D., Petrasek, J., Taha, O., Kodys, K. & Szabó, G., Sep 2012, In : Journal of Leukocyte Biology. 92, 3, p. 611-620 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Alcohols
Macrophages
Nuclear Proteins
Genetic Promoter Regions
214 Citations (Scopus)

Inflammasomes in liver diseases

Szabó, G. & Csak, T., Sep 2012, In : Journal of Hepatology. 57, 3, p. 642-654 13 p.

Research output: Contribution to journalReview article

Inflammasomes
Interleukin-1
Liver Diseases
Inflammation
Fibrosis
58 Citations (Scopus)

Innate immunity and alcoholic liver disease

Szabó, G., Petrasek, J. & Bala, S., Oct 2012, In : Digestive Diseases. 30, SUPPL. 1, p. 55-60 6 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Innate Immunity
Inflammasomes
Caspase 1
Inflammation
22 Citations (Scopus)

MicroRNA silencing and the development of novel therapies for liver disease

Szabó, G., Sarnow, P. & Bala, S., Aug 2012, In : Journal of Hepatology. 57, 2, p. 462-466 5 p.

Research output: Contribution to journalReview article

MicroRNAs
Liver Diseases
Small Untranslated RNA
Therapeutics
29 Citations (Scopus)

Molecular hepatic carcinogenesis: Impact of inflammation

Szabó, G. & Lippai, D., Jun 2012, In : Digestive Diseases. 30, 3, p. 243-248 6 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Carcinogenesis
Inflammation
Liver
Pattern Recognition Receptors
15 Citations (Scopus)

Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes

Bukong, T. N., Lo, T., Szabó, G. & Dolganiuc, A., May 2012, In : Liver International. 32, 5, p. 732-741 10 p.

Research output: Contribution to journalArticle

Developmental Biology
Embryonic Stem Cells
Cell Differentiation
Hepatocytes
Liver
25 Citations (Scopus)

Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study

Ward, J., Bala, S., Petrasek, J. & Szabó, G., Jun 2012, In : World Journal of Gastroenterology. 18, 22, p. 2798-2804 7 p.

Research output: Contribution to journalArticle

Acetaminophen
MicroRNAs
Wounds and Injuries
Research
Down-Regulation
13 Citations (Scopus)

Reduction in hepatic inflammation is associated with less fibrosis progression and fewer clinical outcomes in advanced hepatitis c

Morishima, C., Shiffman, M. L., Dienstag, J. L., Lindsay, K. L., Szabó, G., Everson, G. T., Lok, A. S., Di Bisceglie, A. M., Ghany, M. G., Naishadham, D., Morgan, T. R. & Wright, E. C., Sep 2012, In : American Journal of Gastroenterology. 107, 9, p. 1388-1398 11 p.

Research output: Contribution to journalArticle

Hepatitis
Fibrosis
Inflammation
Random Allocation
Liver
16 Citations (Scopus)

The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis

Levin, I., Petrasek, J. & Szabó, G., Aug 2012, In : Alcoholism: Clinical and Experimental Research. 36, 8, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

Fatty Liver
Liver
Bone
Alcohols
Acetyl-CoA Carboxylase
42 Citations (Scopus)

Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells

Dolganiuc, A., Kodys, K., Marshall, C., Saha, B., Zhang, S., Bala, S. & Szabó, G., Oct 10 2012, In : PLoS One. 7, 10, e44915.

Research output: Contribution to journalArticle

chronic hepatitis C
Hepatitis C virus
T-cells
Chronic Hepatitis C
Virus Diseases
2011

Advanced Molecular Biologic Techniques in Toxicologic Disease

Ward, J., Szabó, G., McManus, D. & Boyer, E., Dec 2011, In : Journal of Medical Toxicology. 7, 4, p. 288-294 7 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
MicroRNAs
Nanoparticles
Patient Care
Research Personnel
140 Citations (Scopus)

An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice

Mandrekar, P., Ambade, A., Lim, A., Szabó, G. & Catalano, D., Dec 2011, In : Hepatology. 54, 6, p. 2185-2197 13 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Alcohols
Cytokines
Liver
Wounds and Injuries
106 Citations (Scopus)

A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C

Dienstag, J. L., Ghany, M. G., Morgan, T. R., Di Bisceglie, A. M., Bonkovsky, H. L., Kim, H. Y., Seeff, L. B., Szabó, G., Wright, E. C., Sterling, R. K., Everson, G. T., Lindsay, K. L., Lee, W. M., Lok, A. S., Morishima, C., Stoddard, A. M. & Everhart, J. E., Aug 2011, In : Hepatology. 54, 2, p. 396-405 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Fibrosis
Prospective Studies
Disease Progression
Liver Diseases
127 Citations (Scopus)

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

Csak, T., Velayudham, A., Hritz, I., Petrasek, J., Levin, I., Lippai, D., Catalano, D., Mandrekar, P., Dolganiuc, A., Kurt-Jones, E. & Szabó, G., Mar 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 3, p. 433-441 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Fibrosis
Choline
Methionine
Genotype
22 Citations (Scopus)

Dendritic cells in hepatitis C infection: Can they (help) win the battle?

Dolganiuc, A. & Szabó, G., Apr 2011, In : Journal of Gastroenterology. 46, 4, p. 432-447 16 p.

Research output: Contribution to journalReview article

Hepatitis C
Hepacivirus
Dendritic Cells
Infection
Immunity
305 Citations (Scopus)

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

Csak, T., Ganz, M., Pespisa, J., Kodys, K., Dolganiuc, A. & Szabó, G., Jul 2011, In : Hepatology. 54, 1, p. 133-144 12 p.

Research output: Contribution to journalArticle

Inflammasomes
Endotoxins
Hepatocytes
Fatty Acids
Interleukin-1
108 Citations (Scopus)

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

Nath, B., Levin, I., Csak, T., Petrasek, J., Mueller, C., Kodys, K., Catalano, D., Mandrekar, P. & Szabó, G., May 2011, In : Hepatology. 53, 5, p. 1526-1537 12 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Hepatocytes
Alcohols
Lipids
Liver
25 Citations (Scopus)

Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes

Pang, M., Bala, S., Kodys, K., Catalano, D. & Szabó, G., Sep 30 2011, In : BMC Immunology. 12, 55.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
Interferon Type I
Toll-Like Receptor 4
Monocytes
Alcohols
129 Citations (Scopus)

Innate immunity in alcoholic liver disease

Gao, B., Seki, E., Brenner, D. A., Friedman, S., Cohen, J. I., Nagy, L., Szabó, G. & Zakhari, S., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4

Research output: Contribution to journalReview article

Alcoholic Fatty Liver
Alcoholic Liver Diseases
Innate Immunity
Alcohol Drinking
Liver Cirrhosis
67 Citations (Scopus)

Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells

Petrasek, J., Dolganiuc, A., Csak, T., Nath, B., Hritz, I., Kodys, K., Catalano, D., Kurt-Jones, E., Mandrekar, P. & Szabó, G., Feb 2011, In : Hepatology. 53, 2, p. 649-660 12 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Interferon Type I
Myeloid Cells
Alcoholic Liver Diseases
Liver
68 Citations (Scopus)

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

Ganz, M., Csak, T., Nath, B. & Szabó, G., Nov 21 2011, In : World Journal of Gastroenterology. 17, 43, p. 4772-4778 7 p.

Research output: Contribution to journalArticle

Inflammasomes
Lipopolysaccharides
Caspase 1
Liver
Interleukin-18
18 Citations (Scopus)

Mechanisms of alcohol-mediated hepatotoxicity in humanimmunodeficiency-virus-infected patients

Szabó, G. & Zakhari, S., May 28 2011, In : World Journal of Gastroenterology. 17, 20, p. 2500-2506 7 p.

Research output: Contribution to journalReview article

Virus Diseases
Alcohols
HIV
Viruses
Liver Diseases
30 Citations (Scopus)

Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

Csak, T., Dolganiuc, A., Kodys, K., Nath, B., Petrasek, J., Bala, S., Lippai, D. & Szabó, G., Jun 2011, In : Hepatology. 53, 6, p. 1917-1931 15 p.

Research output: Contribution to journalArticle

Fatty Liver
Antiviral Agents
Liver
Wounds and Injuries
Receptor-Interacting Protein Serine-Threonine Kinases

Response to Dr. Wiwanitkit's Letter to the Editor

Szabó, G., May 2011, In : Alcoholism: Clinical and Experimental Research. 35, 5, p. 844 1 p.

Research output: Contribution to journalLetter

50 Citations (Scopus)

The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury

Szabó, G., Mandrekar, P., Petrasek, J. & Catalano, D., May 2011, In : Alcoholism: Clinical and Experimental Research. 35, 5, p. 782-786 5 p.

Research output: Contribution to journalArticle

Liver
Alcohols
Chemical activation
Wounds and Injuries
Toll-Like Receptor 4
62 Citations (Scopus)

Type i interferons protect from toll-like receptor 9associated liver injury and regulate IL-1 receptor antagonist in mice

Petrasek, J., Dolganiuc, A., Csak, T., Kurtjones, E. A. & Szabó, G., Feb 2011, In : Gastroenterology. 140, 2, p. 697-708 12 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Toll-Like Receptors
Interferon Type I
Interferons
Liver
250 Citations (Scopus)

Up-regulation of microRNA-155 in macrophages contributes to increased Tumor Necrosis Factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease

Bala, S., Marcos, M., Kodys, K., Csak, T., Catalano, D., Mandrekar, P. & Szabó, G., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1436-1444 9 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Macrophages
MicroRNAs
Liver
Half-Life
2010
29 Citations (Scopus)

A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-α treatment

Pierucci-Lagha, A., Covault, J., Bonkovsky, H. L., Feinn, R., Abreu, C., Sterling, R. K., Fontana, R. J., Kranzler, H. R., Szabó, G., Cormier, M., Giansiracusa, D., Kelley, M., DiBisceglie, A. M., Bacon, B., Neuschwander-Tetri, B., King, D., Dienstag, J. L., Reid, A. E., Chung, R. T., Molchen, W. A. & 40 others, Everson, G. T., De-Santo, J., McKinley, C., Morgan, T. R., Hoefs, J. C., Park, C., Lee, W. M., Shelton, J., Crowder, N., Elbein, R., Lindsay, K. L., Jones, C. B., Milstein, S. L., Lok, A. S. F., Richtmyer, P. A., Shiffman, M. L., Hofmann, C., Smith, P., Ghany, M. G., Liang, T. J., Park, Y., Rivera, E., Haynes-Williams, V., Everhart, J. E., Seeff, L. B., Robuck, P. R., Hoofnagle, J. H., Wright, E. C., Morishima, C., Gretch, D. R., Chung, M., Padmanabhan, L., Curto, T. M., Massey, L. J., Goodman, Z. D., Davis, G. L., Garcia-Tsao, G., Kutner, M., Lemon, S. M. & Perrillo, R. P., Mar 2010, In : Psychosomatics. 51, 2, p. 137-148 12 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Interferons
Interferon-alpha
Depression
Genes
56 Citations (Scopus)

Alcohol and hepatitis C virus-interactions in immune dysfunctions and liver damage

Szabó, G., Wands, J. R., Eken, A., Osna, N. A., Weinman, S. A., MacHida, K. & Joe Wang, H., Oct 2010, In : Alcoholism: Clinical and Experimental Research. 34, 10, p. 1675-1686 12 p.

Research output: Contribution to journalReview article

Viruses
Hepacivirus
Liver
Liver Diseases
Alcohols
35 Citations (Scopus)

Alcohol Exposure as a Risk Factor for Adverse Outcomes in Elective Surgery

Nath, B., Li, Y. F., Carroll, J. E., Szabo, G., Tseng, J. F. & Shah, S. A., 2010, In : Journal of Gastrointestinal Surgery. 14, 11, p. 1732-1741 10 p.

Research output: Contribution to journalArticle

Alcohols
Length of Stay
Alcohol Drinking
Surgical Wound Infection
Wounds and Injuries
210 Citations (Scopus)

Alcoholic liver disease and the gut-liver axis

Szabó, G. & Bala, S., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, p. 1321-1329 9 p.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Lipopolysaccharides
Toll-Like Receptor 4
Liver
Kupffer Cells
29 Citations (Scopus)

Factors That Determine the Development and Progression of Gastroesophageal Varices in Patients With Chronic Hepatitis C

Fontana, R. J., Sanyal, A. J., Ghany, M. G., Lee, W. M., Reid, A. E., Naishadham, D., Everson, G. T., Kahn, J. A., Di Bisceglie, A. M., Szabó, G., Morgan, T. R. & Everhart, J. E., Jun 2010, In : Gastroenterology. 138, 7

Research output: Contribution to journalArticle

Varicose Veins
Chronic Hepatitis C
ROC Curve
Endoscopy
Fibrosis
17 Citations (Scopus)

Focus on: Alcohol and the liver

Szabó, G. & Mandrekar, P., 2010, In : Alcohol Research and Health. 33, 1-2, p. 87-96 10 p.

Research output: Contribution to journalArticle

Liver Diseases
Alcohols
Liver
Research
Alcoholics
107 Citations (Scopus)

Gut-liver axis and sensing microbes

Szabo, G., Bala, S., Petrasek, J. & Gattu, A., Apr 2010, In : Digestive Diseases. 28, 6, p. 737-744 8 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Toll-Like Receptor 4
Liver
Liver Diseases
Alcoholic Liver Diseases
57 Citations (Scopus)

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

Chang, S., Kodys, K. & Szabó, G., Jan 2010, In : Hepatology. 51, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Virus Diseases
Hepacivirus
Hepatocellular Carcinoma
RNA
2 Citations (Scopus)

The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: The impact on liver disease

Szabó, G., Jul 2010, In : Hepatology. 52, 1, p. 10-12 3 p.

Research output: Contribution to journalEditorial

21st Century History
20th Century History
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Anniversaries and Special Events
Biomedical Research
2 Citations (Scopus)

Toll-like receptors

Szabó, G. & Mandrekar, P., 2010, Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, p. 149-159 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toll-Like Receptors
Liver Diseases
Pattern Recognition Receptors
Immunity
Homeostasis
6 Citations (Scopus)

Toll-like receptor signaling in liver diseases

Szabó, G., Billiar, T. R., MacHida, K., Crispe, I. N. & Seki, E., 2010, In : Gastroenterology Research and Practice. 971270.

Research output: Contribution to journalEditorial

Toll-Like Receptors
Liver Diseases
52 Citations (Scopus)

Toll-Like receptors in the pathogenesis of alcoholic liver disease

Szabó, G., Petrasek, J. & Mandrekar, P., 2010, In : Gastroenterology Research and Practice. 710381.

Research output: Contribution to journalReview article

Alcoholic Liver Diseases
Toll-Like Receptors
Liver Neoplasms
Endotoxins
Liver Cirrhosis
2009
41 Citations (Scopus)

Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: Implications for immunity

Nath, B. & Szabó, G., May 2009, In : Seminars in Liver Disease. 29, 2, p. 166-177 12 p.

Research output: Contribution to journalReview article

Immunity
Alcohols
Ethanol
Liver
Lipids
31 Citations (Scopus)

Antigen-presenting cells under the influence of alcohol

Lau, A. H., Szabó, G. & Thomson, A. W., Jan 2009, In : Trends in Immunology. 30, 1, p. 13-22 10 p.

Research output: Contribution to journalReview article

Antigen-Presenting Cells
Alcohols
Adaptive Immunity
Innate Immunity
Monocytes
238 Citations (Scopus)

A recent perspective on alcohol, immunity, and host defense

Szabó, G. & Mandrekar, P., Feb 2009, In : Alcoholism: Clinical and Experimental Research. 33, 2, p. 220-232 13 p.

Research output: Contribution to journalReview article

Immunity
Alcohols
Adaptive Immunity
Innate Immunity
Wounds and Injuries
112 Citations (Scopus)

Emerging role of microRNAs in liver diseases

Bala, S., Marcos, M. & Szabó, G., Dec 7 2009, In : World Journal of Gastroenterology. 15, 45, p. 5633-5640 8 p.

Research output: Contribution to journalReview article

MicroRNAs
Liver Diseases
Small Untranslated RNA
Therapeutic Uses
Hepatitis C
117 Citations (Scopus)

Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus

Broering, T. J., Garrity, K. A., Boatright, N. K., Sloan, S. E., Sandor, F., Thomas, W. D., Szabó, G., Finberg, R. W., Ambrosino, D. M. & Babcock, G. J., Dec 2009, In : Journal of Virology. 83, 23, p. 12473-12482 10 p.

Research output: Contribution to journalArticle

Hepatitis C virus
neutralization
glycoproteins
monoclonal antibodies
Monoclonal Antibodies
136 Citations (Scopus)

MicroRNA expression profile in lieber-decarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice

Dolganiuc, A., Petrasek, J., Kodys, K., Catalano, D., Mandrekar, P., Velayudham, A. & Szabó, G., Oct 2009, In : Alcoholism: Clinical and Experimental Research. 33, 10, p. 1704-1710 7 p.

Research output: Contribution to journalArticle

Nutrition
Choline
MicroRNAs
Methionine
Liver