G. Szabó &ndash; Research Output

2012

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

Bala, S., Petrasek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J., Alao, H., Kodys, K. & Szabó, G., Nov 2012, In : Hepatology. 56, 5, p. 1946-1957 12 p.

Research output: Contribution to journal › Article

Exosomes

Chemical and Drug Induced Liver Injury

MicroRNAs

Hepatocytes

Acetaminophen

89 Citations (Scopus)

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

Morin, T. J., Broering, T. J., Leav, B. A., Blair, B. M., Rowley, K. J., Boucher, E. N., Wang, Y., Cheslock, P. S., Knauber, M., Olsen, D. B., Ludmerer, S. W., Szabó, G., Finberg, R. W., Purcell, R. H., Lanford, R. E., Ambrosino, D. M., Molrine, D. C. & Babcock, G. J., Aug 2012, In : PLoS Pathogens. 8, 8, e1002895.

Research output: Contribution to journal › Article

Pan troglodytes

Virus Diseases

Hepacivirus

Monoclonal Antibodies

Viral Load

141 Citations (Scopus)

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

Nath, B. & Szabó, G., Feb 2012, In : Hepatology. 55, 2, p. 622-633 12 p.

Research output: Contribution to journal › Review article

Liver Diseases

Inflammation Mediators

Liver Cirrhosis

Hepatocellular Carcinoma

Hypoxia

309 Citations (Scopus)

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S. Y., Kurt-Jones, E. A. & Szabó, G., Oct 1 2012, In : Journal of Clinical Investigation. 122, 10, p. 3476-3489 14 p.

Research output: Contribution to journal › Article

Alcoholic Fatty Liver

Inflammasomes

Interleukin-1 Receptors

Interleukin-1

Caspase 1

91 Citations (Scopus)

Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection

Bala, S., Tilahun, Y., Taha, O., Alao, H., Kodys, K., Catalano, D. & Szabó, G., Jul 30 2012, In : Journal of Translational Medicine. 10, 1, 151.

Research output: Contribution to journal › Article

Chronic Hepatitis C

Virus Diseases

MicroRNAs

Viruses

Hepacivirus

19 Citations (Scopus)

Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance

Bala, S., Tang, A., Catalano, D., Petrasek, J., Taha, O., Kodys, K. & Szabó, G., Sep 2012, In : Journal of Leukocyte Biology. 92, 3, p. 611-620 10 p.

Research output: Contribution to journal › Article

Toll-Like Receptor 4

Alcohols

Macrophages

Nuclear Proteins

Genetic Promoter Regions

214 Citations (Scopus)

Inflammasomes in liver diseases

Szabó, G. & Csak, T., Sep 2012, In : Journal of Hepatology. 57, 3, p. 642-654 13 p.

Research output: Contribution to journal › Review article

Inflammasomes

Interleukin-1

Liver Diseases

Inflammation

Fibrosis

58 Citations (Scopus)

Innate immunity and alcoholic liver disease

Szabó, G., Petrasek, J. & Bala, S., Oct 2012, In : Digestive Diseases. 30, SUPPL. 1, p. 55-60 6 p.

Research output: Contribution to journal › Article

Alcoholic Liver Diseases

Innate Immunity

Inflammasomes

Caspase 1

Inflammation

22 Citations (Scopus)

MicroRNA silencing and the development of novel therapies for liver disease

Szabó, G., Sarnow, P. & Bala, S., Aug 2012, In : Journal of Hepatology. 57, 2, p. 462-466 5 p.

Research output: Contribution to journal › Review article

MicroRNAs

Liver Diseases

Small Untranslated RNA

Therapeutics

29 Citations (Scopus)

Molecular hepatic carcinogenesis: Impact of inflammation

Szabó, G. & Lippai, D., Jun 2012, In : Digestive Diseases. 30, 3, p. 243-248 6 p.

Research output: Contribution to journal › Article

Liver Neoplasms

Carcinogenesis

Inflammation

Liver

Pattern Recognition Receptors

15 Citations (Scopus)

Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes

Bukong, T. N., Lo, T., Szabó, G. & Dolganiuc, A., May 2012, In : Liver International. 32, 5, p. 732-741 10 p.

Research output: Contribution to journal › Article

Developmental Biology

Embryonic Stem Cells

Cell Differentiation

Hepatocytes

Liver

25 Citations (Scopus)

Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study

Ward, J., Bala, S., Petrasek, J. & Szabó, G., Jun 2012, In : World Journal of Gastroenterology. 18, 22, p. 2798-2804 7 p.

Research output: Contribution to journal › Article

Acetaminophen

MicroRNAs

Wounds and Injuries

Research

Down-Regulation

13 Citations (Scopus)

Reduction in hepatic inflammation is associated with less fibrosis progression and fewer clinical outcomes in advanced hepatitis c

Morishima, C., Shiffman, M. L., Dienstag, J. L., Lindsay, K. L., Szabó, G., Everson, G. T., Lok, A. S., Di Bisceglie, A. M., Ghany, M. G., Naishadham, D., Morgan, T. R. & Wright, E. C., Sep 2012, In : American Journal of Gastroenterology. 107, 9, p. 1388-1398 11 p.

Research output: Contribution to journal › Article

Hepatitis

Fibrosis

Inflammation

Random Allocation

Liver

16 Citations (Scopus)

The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis

Levin, I., Petrasek, J. & Szabó, G., Aug 2012, In : Alcoholism: Clinical and Experimental Research. 36, 8, p. 1397-1406 10 p.

Research output: Contribution to journal › Article

Fatty Liver

Liver

Bone

Alcohols

Acetyl-CoA Carboxylase

42 Citations (Scopus)

Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells

Dolganiuc, A., Kodys, K., Marshall, C., Saha, B., Zhang, S., Bala, S. & Szabó, G., Oct 10 2012, In : PLoS One. 7, 10, e44915.

Research output: Contribution to journal › Article

chronic hepatitis C

Hepatitis C virus

T-cells

Chronic Hepatitis C

Virus Diseases

2011

Advanced Molecular Biologic Techniques in Toxicologic Disease

Ward, J., Szabó, G., McManus, D. & Boyer, E., Dec 2011, In : Journal of Medical Toxicology. 7, 4, p. 288-294 7 p.

Research output: Contribution to journal › Article

Point-of-Care Systems

MicroRNAs

Nanoparticles

Patient Care

Research Personnel

140 Citations (Scopus)

An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice

Mandrekar, P., Ambade, A., Lim, A., Szabó, G. & Catalano, D., Dec 2011, In : Hepatology. 54, 6, p. 2185-2197 13 p.

Research output: Contribution to journal › Article

Chemokine CCL2

Alcohols

Cytokines

Liver

Wounds and Injuries

106 Citations (Scopus)

A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C

Dienstag, J. L., Ghany, M. G., Morgan, T. R., Di Bisceglie, A. M., Bonkovsky, H. L., Kim, H. Y., Seeff, L. B., Szabó, G., Wright, E. C., Sterling, R. K., Everson, G. T., Lindsay, K. L., Lee, W. M., Lok, A. S., Morishima, C., Stoddard, A. M. & Everhart, J. E., Aug 2011, In : Hepatology. 54, 2, p. 396-405 10 p.

Research output: Contribution to journal › Article

Chronic Hepatitis C

Fibrosis

Prospective Studies

Disease Progression

Liver Diseases

127 Citations (Scopus)

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

Csak, T., Velayudham, A., Hritz, I., Petrasek, J., Levin, I., Lippai, D., Catalano, D., Mandrekar, P., Dolganiuc, A., Kurt-Jones, E. & Szabó, G., Mar 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 3, p. 433-441 9 p.

Research output: Contribution to journal › Article

Toll-Like Receptor 4

Fibrosis

Choline

Methionine

Genotype

22 Citations (Scopus)

Dendritic cells in hepatitis C infection: Can they (help) win the battle?

Dolganiuc, A. & Szabó, G., Apr 2011, In : Journal of Gastroenterology. 46, 4, p. 432-447 16 p.

Research output: Contribution to journal › Review article

Hepatitis C

Hepacivirus

Dendritic Cells

Infection

Immunity

305 Citations (Scopus)

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

Csak, T., Ganz, M., Pespisa, J., Kodys, K., Dolganiuc, A. & Szabó, G., Jul 2011, In : Hepatology. 54, 1, p. 133-144 12 p.

Research output: Contribution to journal › Article

Inflammasomes

Endotoxins

Hepatocytes

Fatty Acids

Interleukin-1

108 Citations (Scopus)

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

Nath, B., Levin, I., Csak, T., Petrasek, J., Mueller, C., Kodys, K., Catalano, D., Mandrekar, P. & Szabó, G., May 2011, In : Hepatology. 53, 5, p. 1526-1537 12 p.

Research output: Contribution to journal › Article

Hypoxia-Inducible Factor 1

Hepatocytes

Alcohols

Lipids

Liver

25 Citations (Scopus)

Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes

Pang, M., Bala, S., Kodys, K., Catalano, D. & Szabó, G., Sep 30 2011, In : BMC Immunology. 12, 55.

Research output: Contribution to journal › Article

Toll-Like Receptor 8

Interferon Type I

Toll-Like Receptor 4

Monocytes

Alcohols

129 Citations (Scopus)

Innate immunity in alcoholic liver disease

Gao, B., Seki, E., Brenner, D. A., Friedman, S., Cohen, J. I., Nagy, L., Szabó, G. & Zakhari, S., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4

Research output: Contribution to journal › Review article

Alcoholic Fatty Liver

Alcoholic Liver Diseases

Innate Immunity

Alcohol Drinking

Liver Cirrhosis

67 Citations (Scopus)

Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells

Petrasek, J., Dolganiuc, A., Csak, T., Nath, B., Hritz, I., Kodys, K., Catalano, D., Kurt-Jones, E., Mandrekar, P. & Szabó, G., Feb 2011, In : Hepatology. 53, 2, p. 649-660 12 p.

Research output: Contribution to journal › Article

Interferon Regulatory Factor-3

Interferon Type I

Myeloid Cells

Alcoholic Liver Diseases

Liver

68 Citations (Scopus)

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

Ganz, M., Csak, T., Nath, B. & Szabó, G., Nov 21 2011, In : World Journal of Gastroenterology. 17, 43, p. 4772-4778 7 p.

Research output: Contribution to journal › Article

Inflammasomes

Lipopolysaccharides

Caspase 1

Liver

Interleukin-18

18 Citations (Scopus)

Mechanisms of alcohol-mediated hepatotoxicity in humanimmunodeficiency-virus-infected patients

Szabó, G. & Zakhari, S., May 28 2011, In : World Journal of Gastroenterology. 17, 20, p. 2500-2506 7 p.

Research output: Contribution to journal › Review article

Virus Diseases

Alcohols

HIV

Viruses

Liver Diseases

30 Citations (Scopus)

Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

Csak, T., Dolganiuc, A., Kodys, K., Nath, B., Petrasek, J., Bala, S., Lippai, D. & Szabó, G., Jun 2011, In : Hepatology. 53, 6, p. 1917-1931 15 p.

Research output: Contribution to journal › Article

Fatty Liver

Antiviral Agents

Liver

Wounds and Injuries

Receptor-Interacting Protein Serine-Threonine Kinases

Response to Dr. Wiwanitkit's Letter to the Editor

Szabó, G., May 2011, In : Alcoholism: Clinical and Experimental Research. 35, 5, p. 844 1 p.

Research output: Contribution to journal › Letter

50 Citations (Scopus)

The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury

Szabó, G., Mandrekar, P., Petrasek, J. & Catalano, D., May 2011, In : Alcoholism: Clinical and Experimental Research. 35, 5, p. 782-786 5 p.

Research output: Contribution to journal › Article

Liver

Alcohols

Chemical activation

Wounds and Injuries

Toll-Like Receptor 4

62 Citations (Scopus)

Type i interferons protect from toll-like receptor 9associated liver injury and regulate IL-1 receptor antagonist in mice

Petrasek, J., Dolganiuc, A., Csak, T., Kurtjones, E. A. & Szabó, G., Feb 2011, In : Gastroenterology. 140, 2, p. 697-708 12 p.

Research output: Contribution to journal › Article

Interleukin-1 Receptors

Toll-Like Receptors

Interferon Type I

Interferons

Liver

250 Citations (Scopus)

Up-regulation of microRNA-155 in macrophages contributes to increased Tumor Necrosis Factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease

Bala, S., Marcos, M., Kodys, K., Csak, T., Catalano, D., Mandrekar, P. & Szabó, G., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1436-1444 9 p.

Research output: Contribution to journal › Article

Alcoholic Liver Diseases

Macrophages

MicroRNAs

Liver

Half-Life

2010

29 Citations (Scopus)

A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-α treatment

Pierucci-Lagha, A., Covault, J., Bonkovsky, H. L., Feinn, R., Abreu, C., Sterling, R. K., Fontana, R. J., Kranzler, H. R., Szabó, G., Cormier, M., Giansiracusa, D., Kelley, M., DiBisceglie, A. M., Bacon, B., Neuschwander-Tetri, B., King, D., Dienstag, J. L., Reid, A. E., Chung, R. T., Molchen, W. A. & 40 others, Everson, G. T., De-Santo, J., McKinley, C., Morgan, T. R., Hoefs, J. C., Park, C., Lee, W. M., Shelton, J., Crowder, N., Elbein, R., Lindsay, K. L., Jones, C. B., Milstein, S. L., Lok, A. S. F., Richtmyer, P. A., Shiffman, M. L., Hofmann, C., Smith, P., Ghany, M. G., Liang, T. J., Park, Y., Rivera, E., Haynes-Williams, V., Everhart, J. E., Seeff, L. B., Robuck, P. R., Hoofnagle, J. H., Wright, E. C., Morishima, C., Gretch, D. R., Chung, M., Padmanabhan, L., Curto, T. M., Massey, L. J., Goodman, Z. D., Davis, G. L., Garcia-Tsao, G., Kutner, M., Lemon, S. M. & Perrillo, R. P., Mar 2010, In : Psychosomatics. 51, 2, p. 137-148 12 p.

Research output: Contribution to journal › Article

Serotonin Plasma Membrane Transport Proteins

Interferons

Interferon-alpha

Depression

Genes

56 Citations (Scopus)

Alcohol and hepatitis C virus-interactions in immune dysfunctions and liver damage

Szabó, G., Wands, J. R., Eken, A., Osna, N. A., Weinman, S. A., MacHida, K. & Joe Wang, H., Oct 2010, In : Alcoholism: Clinical and Experimental Research. 34, 10, p. 1675-1686 12 p.

Research output: Contribution to journal › Review article

Viruses

Hepacivirus

Liver

Liver Diseases

Alcohols

35 Citations (Scopus)

Alcohol Exposure as a Risk Factor for Adverse Outcomes in Elective Surgery

Nath, B., Li, Y. F., Carroll, J. E., Szabo, G., Tseng, J. F. & Shah, S. A., 2010, In : Journal of Gastrointestinal Surgery. 14, 11, p. 1732-1741 10 p.

Research output: Contribution to journal › Article

Alcohols

Length of Stay

Alcohol Drinking

Surgical Wound Infection

Wounds and Injuries

210 Citations (Scopus)

Alcoholic liver disease and the gut-liver axis

Szabó, G. & Bala, S., Mar 21 2010, In : World Journal of Gastroenterology. 16, 11, p. 1321-1329 9 p.

Research output: Contribution to journal › Review article

Alcoholic Liver Diseases

Lipopolysaccharides

Toll-Like Receptor 4

Liver

Kupffer Cells

29 Citations (Scopus)

Factors That Determine the Development and Progression of Gastroesophageal Varices in Patients With Chronic Hepatitis C

Fontana, R. J., Sanyal, A. J., Ghany, M. G., Lee, W. M., Reid, A. E., Naishadham, D., Everson, G. T., Kahn, J. A., Di Bisceglie, A. M., Szabó, G., Morgan, T. R. & Everhart, J. E., Jun 2010, In : Gastroenterology. 138, 7

Research output: Contribution to journal › Article

Varicose Veins

Chronic Hepatitis C

ROC Curve

Endoscopy

Fibrosis

17 Citations (Scopus)

Focus on: Alcohol and the liver

Szabó, G. & Mandrekar, P., 2010, In : Alcohol Research and Health. 33, 1-2, p. 87-96 10 p.

Research output: Contribution to journal › Article

Liver Diseases

Alcohols

Liver

Research

Alcoholics

107 Citations (Scopus)

Gut-liver axis and sensing microbes

Szabo, G., Bala, S., Petrasek, J. & Gattu, A., Apr 2010, In : Digestive Diseases. 28, 6, p. 737-744 8 p.

Research output: Contribution to journal › Article

Lipopolysaccharides

Toll-Like Receptor 4

Liver

Liver Diseases

Alcoholic Liver Diseases

57 Citations (Scopus)

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

Chang, S., Kodys, K. & Szabó, G., Jan 2010, In : Hepatology. 51, 1, p. 35-42 8 p.

Research output: Contribution to journal › Article

Toll-Like Receptor 7

Virus Diseases

Hepacivirus

Hepatocellular Carcinoma

RNA

2 Citations (Scopus)

The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: The impact on liver disease

Szabó, G., Jul 2010, In : Hepatology. 52, 1, p. 10-12 3 p.

Research output: Contribution to journal › Editorial

21st Century History

20th Century History

National Institute on Alcohol Abuse and Alcoholism (U.S.)

Anniversaries and Special Events

Biomedical Research

2 Citations (Scopus)

Toll-like receptors

Szabó, G. & Mandrekar, P., 2010, Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, p. 149-159 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Toll-Like Receptors

Liver Diseases

Pattern Recognition Receptors

Immunity

Homeostasis

6 Citations (Scopus)

Toll-like receptor signaling in liver diseases

Szabó, G., Billiar, T. R., MacHida, K., Crispe, I. N. & Seki, E., 2010, In : Gastroenterology Research and Practice. 971270.

Research output: Contribution to journal › Editorial

Toll-Like Receptors

Liver Diseases

52 Citations (Scopus)

Toll-Like receptors in the pathogenesis of alcoholic liver disease

Szabó, G., Petrasek, J. & Mandrekar, P., 2010, In : Gastroenterology Research and Practice. 710381.

Research output: Contribution to journal › Review article

Alcoholic Liver Diseases

Toll-Like Receptors

Liver Neoplasms

Endotoxins

Liver Cirrhosis

2009

41 Citations (Scopus)

Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: Implications for immunity

Nath, B. & Szabó, G., May 2009, In : Seminars in Liver Disease. 29, 2, p. 166-177 12 p.

Research output: Contribution to journal › Review article

Immunity

Alcohols

Ethanol

Liver

Lipids

31 Citations (Scopus)

Antigen-presenting cells under the influence of alcohol

Lau, A. H., Szabó, G. & Thomson, A. W., Jan 2009, In : Trends in Immunology. 30, 1, p. 13-22 10 p.

Research output: Contribution to journal › Review article

Antigen-Presenting Cells

Alcohols

Adaptive Immunity

Innate Immunity

Monocytes

238 Citations (Scopus)

A recent perspective on alcohol, immunity, and host defense

Szabó, G. & Mandrekar, P., Feb 2009, In : Alcoholism: Clinical and Experimental Research. 33, 2, p. 220-232 13 p.

Research output: Contribution to journal › Review article

Immunity

Alcohols

Adaptive Immunity

Innate Immunity

Wounds and Injuries

112 Citations (Scopus)

Emerging role of microRNAs in liver diseases

Bala, S., Marcos, M. & Szabó, G., Dec 7 2009, In : World Journal of Gastroenterology. 15, 45, p. 5633-5640 8 p.

Research output: Contribution to journal › Review article

MicroRNAs

Liver Diseases

Small Untranslated RNA

Therapeutic Uses

Hepatitis C

117 Citations (Scopus)

Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus

Broering, T. J., Garrity, K. A., Boatright, N. K., Sloan, S. E., Sandor, F., Thomas, W. D., Szabó, G., Finberg, R. W., Ambrosino, D. M. & Babcock, G. J., Dec 2009, In : Journal of Virology. 83, 23, p. 12473-12482 10 p.

Research output: Contribution to journal › Article

Hepatitis C virus

neutralization

glycoproteins

monoclonal antibodies

Monoclonal Antibodies

136 Citations (Scopus)

MicroRNA expression profile in lieber-decarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice

Dolganiuc, A., Petrasek, J., Kodys, K., Catalano, D., Mandrekar, P., Velayudham, A. & Szabó, G., Oct 2009, In : Alcoholism: Clinical and Experimental Research. 33, 10, p. 1704-1710 7 p.

Research output: Contribution to journal › Article

Nutrition

Choline

MicroRNAs

Methionine

Liver